No-Core Shell Model for Nuclear Systems with Strangeness

We report on a novel ab initio approach for nuclear few- and many-body systems with strangeness. Recently, we developed a relevant no-core shell model technique which we successfully applied in first calculations of lightest $\Lambda$ hypernuclei. The use of a translationally invariant finite harmonic oscillator basis allows us to employ large model spaces, compared to traditional shell model calculations, and use realistic nucleon-nucleon and nucleon-hyperon interactions (such as those derived from EFT). We discuss formal aspects of the methodology, show first demonstrative results for ${}_{\Lambda}^3$H, ${}_{\Lambda}^4$H and ${}^4_\Lambda$He, and give outlook.Comment: 4 pages, 3 figures; Proceedings of the 22nd European Conference on Few Body Problems in Physics, 9 - 13 September, 2013, Cracow, Polan

Drugs for neglected diseases: a failure of the market and a public health failure?

Infectious diseases cause the suffering of hundreds of millions of people, especially in tropical and subtropical areas. Effective, affordable and easy-to-use medicines to fight these diseases are nearly absent. Although science and technology are sufficiently advanced to provide the necessary medicines, very few new drugs are being developed. However, drug discovery is not the major bottleneck. Today's R&D-based pharmaceutical industry is reluctant to invest in the development of drugs to treat the major diseases of the poor, because return on investment cannot be guaranteed. With national and international politics supporting a free market-based world order, financial opportunities rather than global health needs guide the direction of new drug development. Can we accept that the dearth of effective drugs for diseases that mainly affect the poor is simply the sad but inevitable consequence of a global market economy? Or is it a massive public health failure, and a failure to direct economic development for the benefit of society? An urgent reorientation of priorities in drug development and health policy is needed. The pharmaceutical industry must contribute to this effort, but national and international policies need to direct the global economy to address the true health needs of society. This requires political will, a strong commitment to prioritize health considerations over economic interests, and the enforcement of regulations and other mechanisms to stimulate essential drug development. New and creative strategies involving both the public and the private sector are needed to ensure that affordable medicines for today's neglected diseases are developed. Priority action areas include advocating an essential medicines R&D agenda, capacity-building in and technology transfer to developing countries, elaborating an adapted legal and regulatory framework, prioritizing funding for essential drug development and securing availability, accessibility, distribution and rational use of these drugs

Thermo-elasticity for anisotropic media in higher dimensions

In this note we develop tools to study the Cauchy problem for the system of thermo-elasticity in higher dimensions. The theory is developed for general homogeneous anisotropic media under non-degeneracy conditions. For degenerate cases a method of treatment is sketched and for the cases of cubic media and hexagonal media detailed studies are provided.Comment: 33 pages, 5 figure

Global Operator Calculus on Spin Groups

Acknowledgements The work of P. Cerejeiras, M. Ferreira, and U. Kähler was supported by Portuguese funds through CIDMA-Center for Research and Development in Mathematics and Applications, and FCT– “Fundação para a Ciência e a Tecnologia”, within project UIDB/04106/2020 and UIDP/04106/2020. The present paper was supported by the project “Global operator calculi on compact and non-compact Lie groups”, Ações Integradas Luso-Alemãs – Acção No. A-42/16. Funding Open access funding provided by FCT|FCCN (b-on).n this paper, we use the representation theory of the group Spin(m) to develop aspects of the global symbolic calculus of pseudo-differential operators on Spin(3) and Spin(4) in the sense of Ruzhansky–Turunen–Wirth. A detailed study of Spin(3) and Spin(4)-representations is made including recurrence relations and natural differential operators acting on matrix coefficients. We establish the calculus of left-invariant differential operators and of difference operators on the group Spin(4) and apply this to give criteria for the subellipticity and the global hypoellipticity of pseudo-differential operators in terms of their matrix-valued full symbols. Several examples of first and second order globally hypoelliptic differential operators are given, including some that are locally neither invertible nor hypoelliptic. The paper presents a particular case study for higher dimensional spin groups.info:eu-repo/semantics/publishedVersio

Domain wall dynamics in a single CrO2_2 grain

Recently we have reported on the magnetization dynamics of a single CrO$_2$ grain studied by micro Hall magnetometry (P. Das \textit{et al.}, Appl. Phys. Lett. \textbf{97} 042507, 2010). For the external magnetic field applied along the grain's easy magnetization direction, the magnetization reversal takes place through a series of Barkhausen jumps. Supported by micromagnetic simulations, the ground state of the grain was found to correspond to a flux closure configuration with a single cross-tie domain wall. Here, we report an analysis of the Barkhausen jumps, which were observed in the hysteresis loops for the external field applied along both the easy and hard magnetization directions. We find that the magnetization reversal takes place through only a few configuration paths in the free-energy landscape, pointing to a high purity of the sample. The distinctly different statistics of the Barkhausen jumps for the two field directions is discussed.Comment: JEMS Conference, to appear in J. Phys. Conf. Se

Attosecond control of electron dynamics in carbon monoxide

Laser pulses with stable electric field waveforms establish the opportunity to achieve coherent control on attosecond timescales. We present experimental and theoretical results on the steering of electronic motion in a multi-electron system. A very high degree of light-waveform control over the directional emission of C+ and O+ fragments from the dissociative ionization of CO was observed. Ab initio based model calculations reveal contributions to the control related to the ionization and laser-induced population transfer between excited electronic states of CO+ during dissociation

An experimental study of the rearrangements of valence protons and neutrons amongst single-particle orbits during double {\beta} decay in 100Mo

The rearrangements of protons and neutrons amongst the valence single-particle orbitals during double {\beta} decay of 100Mo have been determined by measuring cross sections in (d,p), (p,d), (3He,{\alpha}) and (3He,d) reactions on 98,100Mo and 100,102Ru targets. The deduced nucleon occupancies reveal significant discrepancies when compared with theoretical calculations; the same calculations have previously been used to determine the nuclear matrix element associated with the decay probability of double {\beta} decay of the 100Mo system.Comment: 18 pages, 13 figures, 37 pages of supplemental informatio

The use of arts-based methodologies and methods with young people with complex psychosocial needs: A systematic narrative review

Background: Arts-based methodologies and methods (ABM) can elicit rich and meaningful data with seldom-heard groups and empower participants in research. Young people with complex psychosocial needs could be better engaged in research using arts-based approaches to overcome communication and literacy issues as well as distrust of those with power, including researchers. A critical review of the use and impact of ABM among this population is timely. The purpose of this review is to synthesize and examine the experience and use of ABM with young people with complex psychosocial needs. Methods: A systematic narrative literature review was conducted with a search of the literature from 2009 to 2021. All abstracts were reviewed independently by two authors and full papers were screened for eligibility against inclusion and exclusion criteria. Data synthesis focused on a descriptive numerical summary and a thematic analysis focused on key patterns across papers relating to the review objectives. Results and Discussion: A total of 25 papers were included. The most common issues of focus were mental health (n = 10) and homelessness (n = 11) and methods using Photovoice (n = 12) and Body Mapping (n = 5). Individual interview data (n = 20) were the most commonly analysed, followed by created works (n = 19). Less than half the studies involved young people in the interpretation of the data collected. Knowledge translation was not described in almost half the studies, with public exhibits (n = 7) and forums with service providers (n = 4) being the most common activities. Key themes across the studies were valued over traditional methods in eliciting data, ABM as an approach to engage these young people in research and the impact of the use of ABM on participants and on key stakeholders through knowledge translation. Conclusions: The growing field of ABM presents opportunities to enhance research with young people with complex psychosocial needs by promoting meaningful exploration of experiences, engaging participants in research and strengthening knowledge translation. The involvement of young people in the interpretation of data and ensuring that knowledge translation occurs are key areas for future attention. Patient or Public Contribution: The findings of this review will inform future research to improve the engagement of young people with complex psychosocial needs in research and promote power sharing between researchers and research participants

Radiation zoning for vacuum equipment of the CERN Large Hadron Collider

Beam losses in high-energy particle accelerators are responsible for beam lifetime degradation. In the LHC beam losses will create a shower of particles while interacting with materials from the beam pipes and surroundings, resulting in a partial activation of material in the tunnel. Efforts have been made during the accelerator design to monitor and to reduce the activation induced by beam losses. Traceability for all vacuum components has been established providing a tool to follow-up individually each component or subcomponents installed in the tunnel, regardless of their future destination e.g. recycling or disposal. In the latter case, the history of vacuum components will allow calculating the beam-induced activation and permit comparisons with in-situ and ex-situ measurements. This zoning will also help to reduce collective and individual radiation doses to personnel during interventions. The paper presents the vacuum system layout and describes the LHC vacuum zoning and its implementation using an ORACLE© database