5,068 research outputs found

    Political Participation and Quality of Life

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    Theoretical literatures on procedural utility and the psychological benefits of political participation suggest that people who participate in political activities will be more satisfied with their lives because of the resulting feelings of autonomy, competence and relatedness. Individual-level data from Latin America show—in one dataset under study but not in another—a positive and statistically significant relationship between voting and life satisfaction. Variation in desire to vote as measured in Costa Rica, however, suggests that the causal arrow may run from happiness to voting. The use of multilevel models further reveals a consistent—but untheorized—cross-country negative relationship between enforced compulsory voting and happiness. Only preliminary results are found regarding the relationship between some other forms of political participation and life satisfaction.

    Toward an environmental conservatism

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    The Evangelical Climate Initiative (ECI) argues that climate change is real and human-induced and represents a moral challenge for Christians to which an urgent response is required. The ECI demonstrates that there is common ground between conservatism and environmentalism. The actions of the ECI fit within an environmental conservatism whose elements have historical precedence. We find the seeds of parallel ideas in the writings of the Southern Agrarians in the 1920s and 1930s---ideas that were brought to full flower by Richard Weaver, an important figure in the development of a post-World War II traditional conservatism. We also find a similar environmental conservatism in the ideas of Aldo Leopold, a leader of the wilderness preservation movement and conservationist whose ideas influenced the modern environmental movement. These ideas together form a framework of thought that anticipates the ECI and other conservative expressions of concern about the environment

    Analysis of nanopore detector measurements using Machine-Learning methods, with application to single-molecule kinetic analysis

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    <p>Abstract</p> <p>Background</p> <p>A nanopore detector has a nanometer-scale trans-membrane channel across which a potential difference is established, resulting in an ionic current through the channel in the pA-nA range. A distinctive channel current blockade signal is created as individually "captured" DNA molecules interact with the channel and modulate the channel's ionic current. The nanopore detector is sensitive enough that nearly identical DNA molecules can be classified with very high accuracy using machine learning techniques such as Hidden Markov Models (HMMs) and Support Vector Machines (SVMs).</p> <p>Results</p> <p>A non-standard implementation of an HMM, emission inversion, is used for improved classification. Additional features are considered for the feature vector employed by the SVM for classification as well: The addition of a single feature representing spike density is shown to notably improve classification results. Another, much larger, feature set expansion was studied (2500 additional features instead of 1), deriving from including all the HMM's transition probabilities. The expanded features can introduce redundant, noisy information (as well as diagnostic information) into the current feature set, and thus degrade classification performance. A hybrid Adaptive Boosting approach was used for feature selection to alleviate this problem.</p> <p>Conclusion</p> <p>The methods shown here, for more informed feature extraction, improve both classification and provide biologists and chemists with tools for obtaining a better understanding of the kinetic properties of molecules of interest.</p

    Determination of Select Metal Ions in Commercially Available Conventional and Organic Baby Foods.

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    The goal of this study is to determine whether or not there is an appreciable difference between concentrations of various metal ions present in conventionally grown and processed and organically grown and processed baby foods. Two prominent, commercially available brands were chosen to undergo comparative studies between both their own conventional and organic varieties of second stage green beans and carrots. Samples were tested for cadmium, calcium, iron, lead, nickel, and zinc. Two containers of each variety of baby food were sampled in triplicate, with purchases of foods being made in separate areas to ensure that each set came from different batches. Samples were digested with nitric acid, appropriately diluted, and analyzed for metal content by flame atomic absorption spectroscopy with the regular standard calibration curve and standard addition method. There was little overall difference in metal content between the conventional and organic foods tested

    The NTD Nanoscope: potential applications and implementations

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    <p>Abstract</p> <p>Background</p> <p>Nanopore transduction detection (NTD) offers prospects for a number of highly sensitive and discriminative applications, including: (i) single nucleotide polymorphism (SNP) detection; (ii) targeted DNA re-sequencing; (iii) protein isoform assaying; and (iv) biosensing via antibody or aptamer coupled molecules. Nanopore event transduction involves single-molecule biophysics, engineered information flows, and nanopore cheminformatics. The NTD Nanoscope has seen limited use in the scientific community, however, due to lack of information about potential applications, and lack of availability for the device itself. Meta Logos Inc. is developing both pre-packaged device platforms and component-level (unassembled) kit platforms (the latter described here). In both cases a lipid bi-layer workstation is first established, then augmentations and operational protocols are provided to have a nanopore transduction detector. In this paper we provide an overview of the NTD Nanoscope applications and implementations. The NTD Nanoscope Kit, in particular, is a component-level reproduction of the standard NTD device used in previous research papers.</p> <p>Results</p> <p>The NTD Nanoscope method is shown to functionalize a single nanopore with a channel current modulator that is designed to transduce events, such as binding to a specific target. To expedite set-up in new lab settings, the calibration and troubleshooting for the NTD Nanoscope kit components and signal processing software, the NTD Nanoscope Kit, is designed to include a set of test buffers and control molecules based on experiments described in previous NTD papers (the model systems briefly described in what follows). The description of the Server-interfacing for advanced signal processing support is also briefly mentioned.</p> <p>Conclusions</p> <p>SNP assaying, SNP discovery, DNA sequencing and RNA-seq methods are typically limited by the accuracy of the error rate of the enzymes involved, such as methods involving the polymerase chain reaction (PCR) enzyme. The NTD Nanoscope offers a means to obtain higher accuracy as it is a single-molecule method that does not inherently involve use of enzymes, using a functionalized nanopore instead.</p

    Examination of Sedentary Time, Physical Activity, and Body Mass Index (BMI) in College-Aged Students

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    Please view abstract in the attached PDF file

    Laser spectroscopy of hyperfine structure in highly-charged ions: a test of QED at high fields

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    An overview is presented of laser spectroscopy experiments with cold, trapped, highly-charged ions, which will be performed at the HITRAP facility at GSI in Darmstadt (Germany). These high-resolution measurements of ground state hyperfine splittings will be three orders of magnitude more precise than previous measurements. Moreover, from a comparison of measurements of the hyperfine splittings in hydrogen- and lithium-like ions of the same isotope, QED effects at high electromagnetic fields can be determined within a few percent. Several candidate ions suited for these laser spectroscopy studies are presented.Comment: 5 pages, 1 figure, 1 table. accepted for Canadian Journal of Physics (2006
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