How Music Therapy Effects the Traumatized Brain: Neurorehabilitation for Posttraumatic Stress Disorder through Music Therapy

This review discusses the neurological components of posttraumatic stress disorder (PTSD) and how both structures and processes in the brain are altered in individuals with the disorder, specifically the neural network that includes the prefrontal cortex, the hippocampus, and the amygdala. This impacts awareness and responsiveness to stimuli. After examining these aspects, invasive and non-invasive treatment approaches are examined, with a specific emphasis on the treatment approach of music therapy. Musical stimuli are processed in many areas of the brain, so it has therapeutic potential for modulating neurological changes. Music therapy applies music clinically to address a variety of goals for clients with PTSD, including emotional, social, and cognitive objectives. Music therapists with an understanding of neuroplasticity and neurological impairments associated with PTSD can approach their practice with more specific goals and strategies for helping clients recover

Effects of Pine Litter Raking on Plant Community Composition and Soil Seed Banks in Longleaf Pine Savannas

Longleaf pine (Pinus palustris) savannas have been reduced to a small percentage of their original range in the southeastern United States. These savannas are fire-reliant and require frequent, low-intensity fires to maintain understory plant diversity. Currently, many landowners rake pine litter off the forest floor of longleaf pine savannas for subsequent sale in horticulture. Though raking is a common practice, little is known about the effects of raking on the understory plant community, the soil seed bank, or fire intensity. I conducted my research in two longleaf pine savanna sites where raking has occurred. At the McCain Forest Management Area in Hoke County, North Carolina, I investigated the effect of raking on the understory plant community and soil seed banks. I hypothesized that raked areas would have lower species richness and percent cover of understory species than unraked areas. I also hypothesized that raked areas would have a less dense soil seed bank than unraked areas. I worked in five sites (in two study areas) at the McCain Forest Management Area with various raking and burning management histories. Ten plots were established in each study site to estimate understory cover and community composition. Soil samples were taken from each plot twice, four months apart, and soil samples were spread across pots, placed under lights, and monitored for germinants. No differences in species richness or total understory cover were found between raked and unraked sites. The cover of wiregrass (Aristida stricta) was higher in the raked site than the unraked site in one study area. Moderate differences in the cover of wiregrass and dwarf huckleberry (Gaylussacia dumosa) were found in the other study area. A total of 24 germinants were recorded from both seed bank studies. iii At the Sand Hills State Forest located across Chesterfield and Darlington Counties, South Carolina, I aimed to determine if pine litter raking affects understory plant cover, plant size, and fire temperature. I hypothesized that raked stands would have a lower maximum fire temperature than unraked stands. I placed temperature-indicating pyrometers in a raked and unraked stand and measured litter depth and size of longleaf pines, wiregrass, and turkey oaks (Quercus laevis) in each stand. The unraked stand had a deeper litter depth and larger wiregrass and turkey oak individuals than the raked stand. Due to extensive pyrometer damage, differences in fire temperature could not be analyzed. This study found minimal long-term effects of pine litter raking on the composition of the understory community and soil seed bank in longleaf pine savannas. Differences in understory cover found at the Sand Hills State Forest may be due to differences in fire history between sites rather than raking. This study contributes further evidence that longleaf pine savannas do not have a dense long-lasting seedbank

Metabolic Dependencies in Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer with a long-term survival rate under 10%. Available cytotoxic chemotherapies have significant side effects, and only marginal therapeutic efficacy. FDA approved drugs currently used against PDA target DNA metabolism and DNA integrity. However, alternative metabolic targets beyond DNA may prove to be much more effective. PDA cells are forced to live within a particularly severe microenvironment characterized by relative hypovascularity, hypoxia, and nutrient deprivation. Thus, PDA cells must possess biochemical flexibility in order to adapt to austere conditions. A better understanding of the metabolic dependencies required by PDA to survive and thrive within a harsh metabolic milieu could reveal specific metabolic vulnerabilities. These molecular requirements can then be targeted therapeutically, and would likely be associated with a clinically significant therapeutic window since the normal tissue is so well-perfused with an abundant nutrient supply. Recent work has uncovered a number of promising therapeutic targets in the metabolic domain, and clinicians are already translating some of these discoveries to the clinic. In this review, we highlight mitochondria metabolism, non-canonical nutrient acquisition pathways (macropinocytosis and use of pancreatic stellate cell-derived alanine), and redox homeostasis as compelling therapeutic opportunities in the metabolic domain

Alton Ochsner, MD (1896-1981): surgical pioneer and legacy linking smoking and disease.

Edward William Alton Ochsner kept a plain, metal card file in which he recorded close to 50 years worth of medical experiences, research, and insights. The most populated topics were filed as Cancer, Lung and Cancer, Bronchogenic. These reflected his areas of greatest interest, for which he would go on to produce groundbreaking work. Of his many lifetime accomplishments, he is perhaps best known for being the first to report a link between cigarette smoking and lung cancer. This was just one of the many ways in which Ochsner worked to effect social change. The establishment of the Ochsner Health System in New Orleans was born from this similar passion. Ochsner went on to become one of the giants of his generation as a result of this tireless work as a leader, educator, and mentor

Moving Toward a Personalized Approach for Cancer a Scientific Discussion: Mechanisms of Chemoresistance in Pancreatic Cancer

*Supported by the Gail V. Coleman – Kenneth M. Bruntel Pancreatic Research Fund PowerPoint slides. No audio

Patient Attitudes Toward a Physician Led Radiology Review: Improved Understanding of Medical Conditions and a Potential New Quality Metric

Objectives: We were interested in understanding patient perspectives regarding the importance of reviewing their imaging studies with a surgeon. Specific Aims: 1. What value do patients place on viewing their imaging? 2. Do patients have a better understanding of their disease and planned operation after a surgeon led review of imaging studies? 3. Do patients find viewing images an accessible educational tool?https://jdc.jefferson.edu/patientsafetyposters/1022/thumbnail.jp

Device independent quantum key distribution secure against coherent attacks with memoryless measurement devices

Device independent quantum key distribution aims to provide a higher degree of security than traditional QKD schemes by reducing the number of assumptions that need to be made about the physical devices used. The previous proof of security by Pironio et al. applies only to collective attacks where the state is identical and independent and the measurement devices operate identically for each trial in the protocol. We extend this result to a more general class of attacks where the state is arbitrary and the measurement devices have no memory. We accomplish this by a reduction of arbitrary adversary strategies to qubit strategies and a proof of security for qubit strategies based on the previous proof by Pironio et al. and techniques adapted from Renner.Comment: 13 pages. Expanded main proofs with more detail, miscellaneous edits for clarit

Epidemiological information in sheep health management

We use epidemiology whenever we consider the management of sheep health. To measure a disease, we need a precise and unique case definition and we often use diagnostic tests to assist in defining a disease. Diagnostic tests are not always accurate. Thus, it is necessary to consider the decisions that will be taken, based on the result of testing, in order to decide the most useful approach to interpret a test based on its test sensitivity and specificity and the prevalence of the disease in a flock. This is particularly important when decisions on culling or selection of sheep to attain, e.g. freedom from disease, are made on the basis of test results. Infectious diseases spread within and between flocks in a variety of ways; brought-in sheep are the most likely source for introduction of a new pathogen or strain of a pathogen. When a pathogen enters a naïve flock, it spreads through susceptible sheep and persists in the flock, whilst there are susceptible sheep that can be infected. Pathogens use a variety of techniques to persist, including changes in the pathogen itself, alterations in infected hosts enabling them to remain infectious for prolonged periods or to be re-infected, persistence in other host species or in the environment. We need to consider these strategies to decide whether elimination or control of a particular pathogen is more likely to be effective. Whatever the flock control strategy, treatment of diseased individuals is essential for their welfare and can also protect the rest of the flock, if treatment reduces the infectious period. Decisions on management of disease are based on our knowledge of the flock and its management and the evidence base for various control strategies. There are now formal techniques for evaluating the evidence base that can assist in evaluating evidence. One area where we need to evaluate evidence is on cause. It is not possible to prove anything, but we can use the weight of evidence to evaluate likely cause. There are nine aspects of association with which we can evaluate a piece of evidence; these are: strength, consistency, specificity, temporality, dose–response, plausibility, coherence, experiment and analogy

A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of-Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2.

BACKGROUND: Variation in an individual\u27s genetic status can impact the development of pancreatic ductal adenocarcinoma; however, the majority of familial pancreatic cancers (FPC) cannot yet be attributed to a specific inherited mutation. We present data suggesting a correlation between loss-of-function single nucleotide polymorphisms (SNPs) in an immune regulator gene, indoleamine-2,3-dioxygenase-2 (IDO2), and an increased risk of FPC. STUDY DESIGN: Germline DNA from patients who underwent resection for pancreatic ductal adenocarcinoma (n = 79) was sequenced for the IDO2 SNPs R248W and Y359Stop. Genotypes resulting in inactivation of IDO2 (Y325X homozygous, R248W homozygous) were labeled as homozygous, and the other genotypes were grouped as wild-type or heterozygous. Genotype distributions of each SNP were analyzed for Hardy-Weinberg deviation. A genotype frequency set from the 1000 Genomes Project (n = 99) was used as a genetic control for genotype distribution comparisons. RESULTS: A significant 2-fold increase in the overall prevalence of the Y359Stop homozygous genotype compared with the expected Hardy-Weinberg equilibrium was noted (p \u3c 0.05). Familial pancreatic cancer was noted in 15 cases (19%) and comparison of the FPC cohort set to the genetic control set showed a 3-fold increase in Y359Stop homozygous rates (p = 0.054). Overall in our cohort, the homozygous genotype group was associated with increased risk of FPC (odds ratio 5.4; 95% CI 1.6 to 17.6; p \u3c 0.01). Sex, age at diagnosis, and history of tobacco use were not found to be significantly associated with FPC. CONCLUSIONS: Our preliminary data suggest a strong association between the IDO2 inactivating Y359Stop SNP and an increased risk of FPC when compared with the control group. Future studies will evaluate the value of IDO2 genotyping as a prognostic, early detection marker for pancreatic ductal adenocarcinoma and a predictive marker for novel immune checkpoint therapies