Understanding adaptation to first episode psychosis through the creation of images

This article aims to understand and explore the meaning of adaptation to First Episode Psychosis (FEP). An innovative method of data collection was used with ten participants who experienced FEP which integrated drawings of their lived experience within semi-structured interviews. The data were analysed through Interpretative Phenomenological Analysis and hermeneutic-phenomenological image analysis. Participants’ experience was captured in four superordinate themes which identified that adaptation to FEP entailed: ‘Finding out how psychosis fits into my story’, ‘Breaking free from psychosis’, ‘Fighting my way through psychosis’, and ‘Finding a new way of being ‘me’’. The participants’ path of adaptation to FEP was an interplay of pains, challenges, and gains, and there was resonance with posttraumatic growth in their accounts. This article illustrates that creating images may offer a powerful way of conveying the multifaceted aspects of adaptation to FEP and could help individuals in communicating and processing their experience

A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution

Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-inflammatory MERTKlowCD48+ macrophages and MERTK + LYVE1 + MRC1+ macrophages enriched for negative regulators of inflammation which co-exist in frozen shoulder capsule tissues. Micro-cultures of patient-derived cells identify integrin-mediated cell-matrix interactions between MERTK+ macrophages and pro-resolving DKK3+ and POSTN+ fibroblasts, suggesting that matrix remodelling plays a role in frozen shoulder resolution. Cross-tissue analysis reveals a shared gene expression cassette between shoulder capsule MERTK+ macrophages and a respective population enriched in synovial tissues of rheumatoid arthritis patients in disease remission, supporting the concept that MERTK+ macrophages mediate resolution of inflammation and fibrosis. Single-cell transcriptomic profiling and spatial analysis of human foetal shoulder tissues identify MERTK + LYVE1 + MRC1+ macrophages and DKK3+ and POSTN+ fibroblast populations analogous to those in frozen shoulder, suggesting that the template to resolve fibrosis is established during shoulder development. Crosstalk between MerTK+ macrophages and pro-resolving DKK3+ and POSTN+ fibroblasts could facilitate resolution of frozen shoulder, providing a basis for potential therapeutic resolution of persistent fibrotic diseases

No century for old philosophy

This paper introduces the reader to some of the central themes and tenets of Slavoj Zizek's magnusm opus, Less than Nothing. Why does Zizek ascribe fundamental importance to the "old philosophy" Hegel? Relatedly. Why do we need to move beyond the Kantian universe

Improving evaluation of nonlethal tools for carnivore management and conservation: evaluating fladry to protect an endangered species from a generalist mesocarnivore

Carnivore conservation and management are global research priorities focused on reversing population declines of imperiled species and identifying more effective and humane management of generalist carnivores with thriving populations. Nonlethal methods to mitigate conflict are increasingly used to advance conservation objectives; however, there is limited knowledge about the effectiveness of many nonlethal methods. We tested a nonlethal tool (fladry), that serves as a barrier to deter wolves Canis lupus and coyotes Canis latrans, for its efficacy at preventing coyotes from using prairie dog Cynomys ludovicianus colonies, the primary prey for critically endangered black-footed ferrets Mustela nigripes. We used camera trap data and an occupancy approach to evaluate the tool’s efficacy. We measured coyote response to fladry at both a coarse monthly scale (via use, attraction and avoidance probabilities) and a fine scale (via daily activity). Overall, use of areas inside exclosures declined by 60% after 60 days of fladry application and coyotes avoided some previously used areas both within and outside exclosures. Interestingly, coyotes were attracted to previously unused areas surrounding exclosures and increased activity around the periphery of fladry exclosures by 170% immediately after fladry installation, suggesting coyotes actively explored these areas and may have responded to fladry in a way that is counterintuitive to management expectations. Occupancy models provided more robust evaluation of fladry and revealed important behavioral responses relative to other common evaluation techniques (i.e. time until first detected crossing). Our results have implications for future development and evaluation of nonlethal tools for carnivore conservation and management globally