A production book for A streetcar named Desire

LD2668 .T4 1966 W752Master of Scienc

Impact of tumor size on outcomes after anatomic lung resection for stage 1A non–small cell lung cancer based on the current staging system

ObjectiveAnatomic segmentectomy may achieve results comparable to lobectomy for early-stage non–small cell lung cancer. The 7th edition of the AJCC Cancer Staging Handbook stratified the previous T1 tumor designation into T1a and T1b subsets, which still define stage 1A node-negative non–small cell lung cancer. We are left to hypothesize whether this classification may aid in directing the extent of surgical resection. We retrospectively reviewed our anatomic segmentectomy and lobectomy management of stage 1A non–small cell lung cancer to determine differences in survival and local recurrence rates based on the new stratification.MethodsWe performed a retrospective review of 429 patients undergoing resection of pathologically confirmed stage 1A non–small cell lung cancer via lobectomy or anatomic segmentectomy. Primary outcome variables included mortality, recurrence, and survival. Recurrence-free and cancer-specific survivals were estimated using the Kaplan–Meier method.ResultsPatients undergoing segmentectomy were older than patients undergoing lobectomy (mean age 69.2 vs 66.8 years, P < .006). The mean preoperative forced expiratory volume in 1 second was significantly lower in the segmentectomy group than in the lobectomy group (71.8% vs 81.1%, P = .02). Mortality was similar after segmentectomy (1.1%) and lobectomy (1.2%). There was no difference in mortality, recurrence rates (14.0% vs 14.7%, P = 1.00), or 5-year cancer-specific survival (T1a: 90% vs 91%, P = .984; T1b: 82% vs 78%, P = .892) when comparing segmentectomy and lobectomy for pathologic stage 1A non–small cell lung cancer, when stratified by T stage.ConclusionsAnatomic segmentectomy may achieve equivalent recurrence and survival compared with lobectomy for patients with stage 1A non–small cell lung cancer. Prospective studies will be necessary to delineate the potential merits of anatomic segmentectomy in this setting

The nature of the dwarf population in Abell 868

We present the results of a study of the morphology of the dwarf galaxy population in Abell 868, a rich, intermediate redshift (z=0.154) cluster which has a galaxy luminosity function with a steep faint-end slope (alpha=-1.26 +/- 0.05). A statistical background subtraction method is employed to study the B-R colour distribution of the cluster galaxies. This distribution suggests that the galaxies contributing to the faint-end of the measured cluster LF can be split into three populations: dIrrs with B-R<1.4; dEs with 1.4<B-R<2.5; and contaminating background giant ellipticals (gEs) with B-R>2.5. The remvoal of the contribution of the background gEs from the counts only marginally lessens the faint-end slope (alpha=-1.22 +/- 0.16). However, the removal of the contribution of the dIrrs from the counts produces a flat LF (alpha=-0.91 +/- 0.16). The dEs and the dIrrs have similar spatial distributions within the cluster except that the dIrrs appear to be totally absent within a central projected radius of about 0.2 Mpc (Ho=75 km/s /Mpc). The number density of both dEs and dIrrs appear to fall off beyond a projected radius of about 0.35 Mpc. We suggest that the dE and dIrr populations of A868 have been associated with the cluster for similar timescales but that evolutionary processes such as `galaxy harassment' tend to fade the dIrr galaxies while having much less effect on the dE galaxies. The harassement would be expected to have the greatest effect on dwarfs residing in the central parts of the cluster.Comment: 6 pages, 6 figures To be published in The Monthly Notices of the Royal Astronomical Societ

Radar-derived statistics of convective storms in southeast Queensland

The aim of this study is to examine the statistics of convective storms and their concomitant changes with thermodynamic variability. The thermodynamic variability is analyzed by performing a cluster analysis on variables derived from radiosonde releases at Brisbane Airport in Australia. Three objectively defined regimes are found: a dry, stable regime with mainly westerly surface winds, a moist northerly regime, and a moist trade wind regime. S-band radar data are analyzed and storms are identified using objective tracking software [Thunderstorm Identification, Tracking, Analysis, and Nowcasting (TITAN)]. Storm statistics are then investigated, stratified by the regime subperiods. Convective storms are found to form and maintain along elevated topography. Probability distributions of convective storm size and rain rate are found to follow lognormal distributions with differing mean and variance among the regimes. There was some evidence of trimodal storm-top heights, located at the trade inversion (1.5–2 km), freezing level (3.6–4 km), and near 6 km, but it was dependent on the presence of the trade inversion. On average, storm volume and height are smallest in the trade regime and rain rate is largest in the westerly regime. However, westerly regime storms occur less frequently and have shorter lifetimes, which were attributed to the enhanced stability and decreased humidity profiles. Furthermore, time series of diurnal rain rate exhibited early morning and midafternoon maxima for the northerly and trade regimes but were absent for the westerly regime. The observations indicate that westerly regime storms are primarily driven by large-scale forcing, whereas northerly and trade wind regime storms are more responsive to surface characteristics

The Antarctic Submillimeter Telescope and Remote Observatory (AST/RO)

AST/RO, a 1.7 m diameter telescope for astronomy and aeronomy studies at wavelengths between 200 and 2000 microns, was installed at the South Pole during the 1994-1995 Austral summer. The telescope operates continuously through the Austral winter, and is being used primarily for spectroscopic studies of neutral atomic carbon and carbon monoxide in the interstellar medium of the Milky Way and the Magellanic Clouds. The South Pole environment is unique among observatory sites for unusually low wind speeds, low absolute humidity, and the consistent clarity of the submillimeter sky. Four heterodyne receivers, an array receiver, three acousto-optical spectrometers, and an array spectrometer are installed. A Fabry-Perot spectrometer using a bolometric array and a Terahertz receiver are in development. Telescope pointing, focus, and calibration methods as well as the unique working environment and logistical requirements of the South Pole are described.Comment: 57 pages, 15 figures. Submitted to PAS

Uses of innovative modeling tools within the implementation of the marine strategy framework directive

© 2016 Lynam, Uusitalo, Patrício, Piroddi, Queirós, Teixeira, Rossberg, Sagarminaga, Hyder, Niquil, Möllmann, Wilson, Chust, Galparsoro, Forster, Veríssimo, Tedesco, Revilla and Neville. In Europe and around the world, the approach to management of the marine environment has developed from the management of single issues (e.g., species and/or pressures) toward holistic Ecosystem Based Management (EBM) that includes aims to maintain biological diversity and protect ecosystem functioning. Within the European Union, this approach is implemented through the Marine Strategy Framework Directive (MSFD, 2008/56/EC). Integrated Ecosystem Assessment is required by the Directive in order to assess Good Environmental Status (GES). Ecological modeling has a key role to play within the implementation of the MSFD, as demonstrated here by case studies covering a range of spatial scales and a selection of anthropogenic threats. Modeling studies have a strong role to play in embedding data collected at limited points within a larger spatial and temporal scale, thus enabling assessments of pelagic and seabed habitat. Furthermore, integrative studies using food web and ecosystem models are able to investigate changes in food web functioning and biological diversity in response to changes in the environment and human pressures. Modeling should be used to: support the development and selection of specific indicators; set reference points to assess state and the achievement of GES; inform adaptive monitoring programs and trial management scenarios. The modus operandi proposed shows how ecological modeling could support the decision making process leading to appropriate management measures and inform new policy

Bridging Alone: Religious Conservatism, Marital Homogamy, and Voluntary Association Membership

This study characterizes social insularity of religiously conservative American married couples by examining patterns of voluntary associationmembership. Constructing a dataset of 3938 marital dyads from the second wave of the National Survey of Families and Households, the author investigates whether conservative religious homogamy encourages membership in religious voluntary groups and discourages membership in secular voluntary groups. Results indicate that couples’ shared affiliation with conservative denominations, paired with beliefs in biblical authority and inerrancy, increases the likelihood of religious group membership for husbands and wives and reduces the likelihood of secular group membership for wives, but not for husbands. The social insularity of conservative religious groups appears to be reinforced by homogamy—particularly by wives who share faith with husbands

Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

SummaryAmong the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives many of the cancer “hallmarks” through downstream activation of the gp130/STAT3 signaling pathway. However, we show that the related cytokine IL-11 has a stronger correlation with elevated STAT3 activation in human gastrointestinal cancers. Using genetic mouse models, we reveal that IL-11 has a more prominent role compared to IL-6 during the progression of sporadic and inflammation-associated colon and gastric cancers. Accordingly, in these models and in human tumor cell line xenograft models, pharmacologic inhibition of IL-11 signaling alleviated STAT3 activation, suppressed tumor cell proliferation, and reduced the invasive capacity and growth of tumors. Our results identify IL-11 signaling as a potential therapeutic target for the treatment of gastrointestinal cancers

The effectiveness of ENAR® for the treatment of chronic neck pain in Australian adults: a preliminary single-blind, randomised controlled trial

<p>Abstract</p> <p>Background</p> <p>Current evidence on electrotherapies for the management of chronic neck pain is either lacking or conflicting. New therapeutic devices being introduced to the market should be investigated for their effectiveness and efficacy. The ENAR^®(Electro Neuro Adaptive Regulator) therapy device combines Western biofeedback with Eastern energy medicine.</p> <p>Methods</p> <p>A small, preliminary randomised and controlled single-blinded trial was conducted on 24 participants (ten males, 14 females) between the ages of 18 to 50 years (median age of 40.5) Consent was obtained and participants were randomly allocated to one of three groups – ENAR, Transcutaneous Electrical Nerve Stimulation (TENS), or control therapy – to test the hypothesis that ENAR therapy would result in superior pain reduction/disability and improvements in neck function compared with TENS or control intervention. The treatment regimen included twelve 15-minute treatment sessions over a six week period, followed by two assessment periods. Visual Analogue Scale (VAS) pain scores, Neck Disability Index (NDI) scores, Patient Specific Functional Scale (PSFS) scores and Short Form 36v1 (SF-36) quality of life scores reported by participants were collected at each of the assessments points throughout the trial (0, 6, 12, 18 and 24 weeks).</p> <p>Results</p> <p>Eligible participants (n = 30) were recruited and attended clinic visits for 6 months from the time of randomisation. Final trial sample (n = 24) comprised 9 within the ENAR group, 7 within the TENS group and 8 within the control group. With an overall study power of 0.92, the ENAR group showed a decrease in mean pain score from measurement at time zero (5.0 ± 0.79 95%CI) to the first follow-up measurement at six weeks (1.4 ± 0.83 95%CI). Improvement was maintained until week 24 (1.75 ± 0.9 95%CI). The TENS and control groups showed consistent pain levels throughout the trial (3.4 ± 0.96 95%CI and 4.1 ± 0.9 95%CI respectively). Wald analysis for pain intensity was significant for the ENAR group (p = 0.01). Six month NDI scores showed the disability level of the ENAR group (11.3 ± 4.5 95%CI) was approximately half that of either the TENS (22.9 ± 4.8 95%CI) or the control (29.4 ± 4.5 95%CI) groups. NDI analysis using the Wald method, indicated significant reductions in disability only for the ENAR group (p = 0.022). PSFS results also demonstrated significantly better performance of ENAR (p = 0.001) compared to both alternative interventions. Differential means analysis of the SF-36 results favoured ENAR for all of the subscales. Six of the initial 30 participants discontinued the trial protocol.</p> <p>Conclusion</p> <p>ENAR therapy participants reported a significant reduction in the intensity of neck pain (VAS) and disability (NDI), as well as a significant increased function (PSFS) and overall quality of life (SF-36) than TENS or control intervention participants. Due to the modest sample size and restricted cohort characteristics, future larger and more comprehensive trials are required to better evaluate the potential efficacy of the ENAR device in a more widely distributed sample population.</p> <p>Trial Registration</p> <p>This study has been registered with the Australian Clinical Trials Registry (ACTR): ACTRN012606000438550.</p