13 research outputs found
The Potential Role of Management Regulations in Controlling Consumer Exposure to Contaminated Fishery Products
Food Security and Poverty,
The Public Health and Economic Impacts of Persistent, Bioaccumulative, and Toxic (PBT) Contaminants on U.S. Fisheries
Widely dispersed information from the public health, economic, and fisheries management literature is synthesized to examine the impacts of PBT contamination, including current and potential impacts on public health and the ongoing economic impacts this contamination has on the U.S. fishing industry.Environmental Economics and Policy,
The Role of Local Policies on Resource Utilization: Timber Harvesting in St. Tammany Parish, Louisiana
Seemingly unrelated regression was used to investigate if the passage of forestry-related ordinances has had an effect upon timber harvesting activities in St. Tammany Parish, Louisiana. Results indicate that a significant negative relationship exists between a $10,000 road bond ordinance and the level of timber harvest in the Parish.Resource /Energy Economics and Policy,
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
The Potential Role of Management Regulations in Controlling Consumer Exposure to Contaminated Fishery Products
The Public Health and Economic Impacts of Persistent, Bioaccumulative, and Toxic (PBT) Contaminants on U.S. Fisheries
Widely dispersed information from the public health, economic, and fisheries management literature is synthesized to examine the impacts of PBT contamination, including current and potential impacts on public health and the ongoing economic impacts this contamination has on the U.S. fishing industry
The Role of Local Policies on Resource Utilization: Timber Harvesting in St. Tammany Parish, Louisiana
Seemingly unrelated regression was used to investigate if the passage of forestry-related ordinances has had an effect upon timber harvesting activities in St. Tammany Parish, Louisiana. Results indicate that a significant negative relationship exists between a $10,000 road bond ordinance and the level of timber harvest in the Parish
Data, modeling, or policy approaches used to inform equitable public health interventions while responding to emergent viral pathogens with pandemic potential: a scoping review protocol.
A first step in improving the use of mathematical modeling for current and future potential viral pandemics includes cataloging the types of modeling strategies employed, parameters estimated and associated uncertainties, and the assumptions made in the models. This scoping review will enable us to systematically catalog such features of models used in the current SARS-CoV-2 pandemic, clarify how modeling parameters are defined and estimated, better understand how viruses with pandemic potential should be modeled, and how modeling approaches may need to change throughout the course of a pandemic. The review will also enable us to identify and analyze existing knowledge gaps in the application of mathematical modeling to viruses with pandemic potential.
** See PDF file for full scoping review protoco