4,458 research outputs found
The nature and formation of cristobalite at the Soufrière Hills volcano, Montserrat: implications for the petrology and stability of silicic lava domes
Cristobalite is commonly found in the dome lava of silicic volcanoes but is not a primary magmatic phase; its presence indicates that the composition and micro-structure of dome lavas evolve during, and after, emplacement. Nine temporally and mineralogically diverse dome samples from the Soufrière Hills volcano (SHV), Montserrat, are analysed to provide the first detailed assessment of the nature and mode of cristobalite formation in a volcanic dome. The dome rocks contain up to 11 wt.% cristobalite, as defined by X-ray diffraction. Prismatic and platy forms of cristobalite, identified by scanning electron microscopy (SEM), are commonly found in pores and fractures, suggesting that they have precipitated from a vapour phase. Feathery crystallites and micro-crystals of cristobalite and quartz associated with volcanic glass, identified using SEM-Raman, are interpreted to have formed by varying amounts of devitrification. We discuss mechanisms of silica transport and cristobalite formation, and their implications for petrological interpretations and dome stability. We conclude: (1) that silica may be transported in the vapour phase locally, or from one part of the magmatic system to another; (2) that the potential for transport of silica into the dome should not be neglected in petrological and geochemical studies because the addition of non-magmatic phases may affect whole rock composition; and (3) that the extent of cristobalite mineralisation in the dome at SHV is sufficient to reduce porosity—hence, permeability—and may impact on the mechanical strength of the dome rock, thereby potentially affecting dome stability
Surface matching for high-accuracy registration of the lateral skull base
PURPOSE
The accuracy achievable when utilizing image guidance depends to a large extent on the accuracy with which the patient can be registered to preoperative image data. This work proposes a method for the registration of the temporal bone based on surface matching and investigates the achievable accuracy of the technique.
METHODS
Fourteen human temporal bones were utilized for evaluation; incisions were made, fiducial screws were implanted to act as a ground truth, and imaging was performed. The positions of the fiducials and surface of the mastoid were extracted from image data and reference positions defined at the round window and the mastoid surface. The surface of the bone was then digitized using a tracked pointer within the region exposed by the incisions and the physical and image point clouds registered, with the result compared to the fiducial-based registration.
RESULTS
Results of one case were excluded due to a problem with the ground truth registration. In the remaining cases an accuracy of [Formula: see text] and [Formula: see text]Â mm was observed relative to the ground truth at the surface of the mastoid and round window, respectively.
CONCLUSIONS
A technique for the registration of the temporal bone was proposed, based on surface matching after exposure of the mastoid surface, and evaluated on human temporal bone specimens. The results reveal that high-accuracy patient-to-image registration is possible without the use of fiducial screws
The structure of volcanic cristobalite in relation to its toxicity; relevance for the variable crystalline silica hazard
BACKGROUND: Respirable crystalline silica (RCS) continues to pose a risk to human health worldwide. Its variable toxicity depends on inherent characteristics and external factors which influence surface chemistry. Significant population exposure to RCS occurs during volcanic eruptions, where ashfall may cover hundreds of square km and exposure may last years. Occupational exposure also occurs through mining of volcanic deposits. The primary source of RCS from volcanoes is through collapse and fragmentation of lava domes within which cristobalite is mass produced. After 30 years of research, it is still not clear if volcanic ash is a chronic respiratory health hazard. Toxicological assays have shown that cristobalite-rich ash is less toxic than expected. We investigate the reasons for this by determining the physicochemical/structural characteristics which may modify the pathogenicity of volcanic RCS. Four theories are considered: 1) the reactivity of particle surfaces is reduced due to co-substitutions of Al and Na for Si in the cristobalite structure; 2) particles consist of aggregates of cristobalite and other phases, restricting the surface area of cristobalite available for reactions in the lung; 3) the cristobalite surface is occluded by an annealed rim; 4) dissolution of other volcanic particles affects the surfaces of RCS in the lung. METHODS: The composition of volcanic cristobalite crystals was quantified by electron microprobe and differences in composition assessed by Welch's two sample t-test. Sections of dome-rock and ash particles were imaged by scanning and transmission electron microscopy, and elemental compositions of rims determined by energy dispersive X-ray spectroscopy. RESULTS: Volcanic cristobalite contains up to 4 wt. % combined Al(2)O(3) and Na(2)O. Most cristobalite-bearing ash particles contain adhered materials such as feldspar and glass. No annealed rims were observed. CONCLUSIONS: The composition of volcanic cristobalite particles gives insight into previously-unconsidered inherent characteristics of silica mineralogy which may affect toxicity. The structural features identified may also influence the hazard of other environmentally and occupationally produced silica dusts. Current exposure regulations do not take into account the characteristics that might render the silica surface less harmful. Further research would facilitate refinement of the existing simple, mass-based silica standard by taking into account composition, allowing higher standards to be set in industries where the silica surface is modified.Natural Environment Research Council (NERC)Moyes Foundation - studentshi
Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born
We present an implementation of generalized Born implicit
solvent
all-atom classical molecular dynamics (MD) within the AMBER program
package that runs entirely on CUDA enabled NVIDIA graphics processing
units (GPUs). We discuss the algorithms that are used to exploit the
processing power of the GPUs and show the performance that can be
achieved in comparison to simulations on conventional CPU clusters.
The implementation supports three different precision models in which
the contributions to the forces are calculated in single precision
floating point arithmetic but accumulated in double precision (SPDP),
or everything is computed in single precision (SPSP) or double precision
(DPDP). In addition to performance, we have focused on understanding
the implications of the different precision models on the outcome
of implicit solvent MD simulations. We show results for a range of
tests including the accuracy of single point force evaluations and
energy conservation as well as structural properties pertainining
to protein dynamics. The numerical noise due to rounding errors within
the SPSP precision model is sufficiently large to lead to an accumulation
of errors which can result in unphysical trajectories for long time
scale simulations. We recommend the use of the mixed-precision SPDP
model since the numerical results obtained are comparable with those
of the full double precision DPDP model and the reference double precision
CPU implementation but at significantly reduced computational cost.
Our implementation provides performance for GB simulations on a single
desktop that is on par with, and in some cases exceeds, that of traditional
supercomputers
Automatic Item Text Generation in Educational Assessment
We present an automatic text generation system (ATG) developed for the generation of natural language text for automatically produced test items. This ATG has been developed to work with an automatic item generation system for analytical reasoning items for use in tests with high-stakes outcomes (such as college admissions decisions). As such, the development and implementation of this ATG is couched in the context and goals of automated item generation for educational assessment
Quality indicators for dementia and older people nearing the end of life: A systematic review
Background: Robust quality indicators (QIs) are essential for monitoring and improving the quality of care and learning from good practice. We aimed to identify and assess QIs for the care of older people and people with dementia who are nearing the end of life and recommend QIs for use with routinely collected electronic data across care settings. //
Methods: A systematic review was conducted, including five databases and reference chaining. Studies describing the development of QIs for care of older people and those with dementia nearing the end of life were included. QIs were categorized as relating to processes or outcomes, and mapped against six care domains. The psychometric properties (acceptability, evidence base, definition, feasibility, reliability, and validity) of each QI were assessed; QIs were categorized as robust, moderate, or poor. //
Results: From 12,980 titles and abstracts screened, 37 papers and 976 QIs were included. Process and outcome QIs accounted for 780 (79.7%) and 196 (20.3%) of all QIs, respectively. Many of the QIs concerned physical aspects of care (n = 492, 50.4%), and very few concerned spiritual and cultural aspects of care (n = 19, 1.9%). Three hundred and fifteen (32.3%) QIs were robust and of those 220 were measurable using routinely collected electronic data. The final shortlist of 71 QIs came from seven studies. //
Conclusions: Of the numerous QIs developed for care of older adults and those with dementia nearing the end of life, most had poor or moderate psychometric properties or were not designed for use with routinely collected electronic datasets. Infrastructure for data availability, combined with use of robust QIs, is important for enhancing understanding of care provided to this population, identifying unmet needs, and improving service provision
Low-field H-1 NMR spectroscopy for distinguishing between arabica and robusta ground roast coffees
This work reports a new screening protocol for addressing issues of coffee authenticity using low-field (60 MHz) bench-top H-1 NMR spectroscopy. Using a simple chloroform-based extraction, useful spectra were obtained from the lipophilic fraction of ground roast coffees. It was found that 16-O-methylcafestol (16-OMC, a recognized marker compound for robusta beans) gives rise to an isolated peak in the 60 MHz spectrum, which can be used as an indicator of the presence of robusta beans in the sample. A total of 81 extracts from authenticated coffees and mixtures were analysed, from which the detection limit of robusta in arabica was estimated to be between 10% and 20% w/w. Using the established protocol, a surveillance exercise was conducted of 27 retail samples of ground roast coffees which were labelled as "100% arabica". None were found to contain undeclared robusta content above the estimated detection limit. (C) 2016 Published by Elsevier Ltd
Voicebox: Text-Guided Multilingual Universal Speech Generation at Scale
Large-scale generative models such as GPT and DALL-E have revolutionized
natural language processing and computer vision research. These models not only
generate high fidelity text or image outputs, but are also generalists which
can solve tasks not explicitly taught. In contrast, speech generative models
are still primitive in terms of scale and task generalization. In this paper,
we present Voicebox, the most versatile text-guided generative model for speech
at scale. Voicebox is a non-autoregressive flow-matching model trained to
infill speech, given audio context and text, trained on over 50K hours of
speech that are neither filtered nor enhanced. Similar to GPT, Voicebox can
perform many different tasks through in-context learning, but is more flexible
as it can also condition on future context. Voicebox can be used for mono or
cross-lingual zero-shot text-to-speech synthesis, noise removal, content
editing, style conversion, and diverse sample generation. In particular,
Voicebox outperforms the state-of-the-art zero-shot TTS model VALL-E on both
intelligibility (5.9% vs 1.9% word error rates) and audio similarity (0.580 vs
0.681) while being up to 20 times faster. See voicebox.metademolab.com for a
demo of the model
- …