Impacto das Piores Experiências Escolares em Estudantes: Um Estudo Retrospectivo Sobre Trauma

AbstractThe literature indicates damage to students' mental health in cases of school violence. The aim of this retrospective study was to evaluate the psychological impact of school victimization in university students, and to analyze the association between PTSD symptoms and variables related to school victimization. 691 University students responded to the Portuguese version of the Student Alienation and Trauma Survey (SATS). Clinically significant scores in the subscales ranged from 4.7% (somatic symptoms) to 20% (hypervigilance), with frequent symptoms described in the literature resulting from school victimization, such as depression, hopelessness, cognitive difficulties, and traumatic event recollection. Additionally, 7.8% of participants presented PTSD symptoms after suffering their "worst school experience". Associations were found between PTSD symptoms and the level of distress after the experience, as well as the perceived benefits after the event, and duration. The results confirm the potential detrimental effects of school victimization, and may be useful to further investigations on this topic.ResumenLa literatura indica que casos de violencia en el contexto escolar causan daños a la salud mental de los estudiantes. El objetivo de este estudio retrospectivo fue evaluar el impacto psicológico de la victimización escolar en estudiantes universitarios y analizar la asociación de los síntomas de TEPT con variables relacionadas a la victimización. Un total de 691 estudiantes universitarios respondieron a la Escala de Experiencias Traumáticas en los Estudiantes. Puntuaciones clínicamente significativas en las subescalas oscilaron entre el 4,7% (síntomas somáticos) y el 20% (hipervigilancia), y se encontraran síntomas frecuentes descritos en la literatura resultante de victimización, tales como: depresión, desesperanza, problemas cognitivos y recuerda excesiva del evento traumático. Además, el 7,8% tenía síntomas de TEPT un mes después de su peor experiencia escolar. Se encontraran asociaciones con los síntomas de TEPT y el malestar que se siente después de la experiencia; beneficios percibidos después del evento y su duración. Los resultados indican el potencial nocivo de las experiencias de victimización escolar y pueden contribuir a investigaciones futuras.ResumoA literatura indica a existência de danos para a saúde mental de estudantes em casos de violência no contexto escolar. O objetivo deste estudo retrospectivo foi avaliar o impacto psicológico da vitimização escolar em estudantes universitários e analisar a associação dos sintomas de TEPT com variáveis relacionadas à vitimização. No total, 691 estudantes universitários responderam à Escala sobre Experiências Traumáticas em Estudantes. Escores clinicamente significativos nas subescalas variaram de 4,7% (sintomas somáticos) a 20% (hipervigilância), sendo frequentes sintomas descritos na literatura resultantes de vitimização, como: depressão, desesperança, dificuldades cognitivas e rememoração do evento traumático. Adicionalmente, 7,8% apresentaram sintomas de TEPT após a sua pior experiência escolar. Foram encontradas associações entre os sintomas de TEPT e o incômodo sentido após a experiência, benefícios percebidos após o evento e duração do mesmo. Tais dados indicam o potencial nocivo das experiências de vitimização escolar, podendo contribuir para futuras pesquisas em tal área

Pathological findings in a natural outbreak of aflatoxicosis in dogs

The gross and histopathological lesions of 10 cases in a natural outbreak of aflatoxicosis amongst dogs in the Republic of South Africa are reported. The 10 cases were classified as acute (1 case), subacute (7 cases) and chronic (2 cases) on the basis of the nature, degree and extent of the following histopathological feactures : hepatocellular fatty degeneration, necrosis or regeneration ; proliferation of bile ductules ; accumulation of bile within the canaliculi ; fibroplasia; and, mucoid degeneration, necrosis or segmental atrophy of the larger intrahepatic bile ducts. Fatty degeneration was noted grossly in the Iivers of all 10 cases and bile stasis in 4. Varying degrees of fibrosis were present depending on the stage of the disease. In the 2 chronic cases in which nodular regeneration was also observed fibrosis was pronounced. Other macroscopic findings included icterus, anaemia, ascites, hydrothorax, hydropericardium, anasarca, pulmonary oedema, gastro-enterorrhagia and nephrosis.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.lmchunu2014mn201

Evolution of the Red Sequence Giant to Dwarf Ratio in Galaxy Clusters out to z ~ 0.5

We analyze deep g' and r' band data of 97 galaxy clusters imaged with MegaCam on the Canada-France-Hawaii telescope. We compute the number of luminous (giant) and faint (dwarf) galaxies using criteria based on the definitions of de Lucia et al. (2007). Due to excellent image quality and uniformity of the data and analysis, we probe the giant-to-dwarf ratio (GDR) out to z ~ 0.55. With X-ray temperature (Tx) information for the majority of our clusters, we constrain, for the first time, the Tx-corrected giant and dwarf evolution separately. Our measurements support an evolving GDR over the redshift range 0.05 < z < 0.55. We show that modifying the (g'-r'), m_r' and K-correction used to define dwarf and giant selection do not alter the conclusion regarding the presence of evolution. We parameterize the GDR evolution using a linear function of redshift (GDR = alpha * z + beta) with a best fit slope of alpha = 0.88 +/- 0.15 and normalization beta = 0.44 +/- 0.03. Contrary to claims of a large intrinsic scatter, we find that the GDR data can be fully accounted for using observational errors alone. Consistently, we find no evidence for a correlation between GDR and cluster mass (via Tx or weak lensing). Lastly, the data suggest that the evolution of the GDR at z < 0.2 is driven primarily by dry merging of the massive giant galaxies, which when considered with previous results at higher redshift, suggests a change in the dominant mechanism that mediates the GDR.Comment: 20 pages, 15 figures. Accepted to MNRA

The Frontier Fields Lens Modeling Comparison Project

Gravitational lensing by clusters of galaxies offers a powerful probe of their structure and mass distribution. Deriving a lens magnification map for a galaxy cluster is a classic inversion problem and many methods have been developed over the past two decades to solve it. Several research groups have developed techniques independently to map the predominantly dark matter distribution in cluster lenses. While these methods have all provided remarkably high precision mass maps, particularly with exquisite imaging data from the Hubble Space Telescope (HST), the reconstructions themselves have never been directly compared. In this paper, we report the results of comparing various independent lens modeling techniques employed by individual research groups in the community. Here we present for the first time a detailed and robust comparison of methodologies for fidelity, accuracy and precision. For this collaborative exercise, the lens modeling community was provided simulated cluster images -- of two clusters Ares and Hera -- that mimic the depth and resolution of the ongoing HST Frontier Fields. The results of the submitted reconstructions with the un-blinded true mass profile of these two clusters are presented here. Parametric, free-form and hybrid techniques have been deployed by the participating groups and we detail the strengths and trade-offs in accuracy and systematics that arise for each methodology. We note in conclusion that lensing reconstruction methods produce reliable mass distributions that enable the use of clusters as extremely valuable astrophysical laboratories and cosmological probes.Comment: 38 pages, 25 figures, submitted to MNRAS, version with full resolution images can be found at http://pico.bo.astro.it/~massimo/papers/FFsims.pd

Is the Milky Way ringing? The hunt for high velocity streams

We perform numerical simulations of a stellar galactic disk with initial conditions chosen to represent an unrelaxed population which might have been left following a merger. Stars are unevenly distributed in radial action angle, though the disk is axisymmetric. The velocity distribution in the simulated Solar neighborhood exhibits waves traveling in the direction of positive v, where u,v are the radial and tangential velocity components. As the system relaxes and structure wraps in phase space, the features seen in the uv-plane move closer together. We show that these results can be obtained also by a semi-analytical method. We propose that this model could provide an explanation for the high velocity streams seen in the Solar neighborhood at approximate v in km/s, of -60 (HR 1614), -80 (Arifyanto and Fuchs 2006), -100 (Arcturus), and -160 (Klement et al. 2008). In addition, we predict four new features at v ~ -140, -120, 40 and 60 km/s. By matching the number and positions of the observed streams, we estimate that the Milky Way disk was strongly perturbed ~1.9 Gyr ago. This event could have been associated with Galactic bar formation.Comment: 5 pages, 4 figures, Accepted to MNRAS Letters, added reference

Are ‘Endurance’ Alleles ‘Survival’ Alleles? Insights from the ACTN3 R577X Polymorphism

Exercise phenotypes have played a key role for ensuring survival over human evolution. We speculated that some genetic variants that influence exercise phenotypes could be associated with exceptional survival (i.e. reaching ≥100years of age). Owing to its effects on muscle structure/function, a potential candidate is the Arg(R)577Ter(X) polymorphism (rs1815739) in ACTN3, the structural gene encoding the skeletal muscle protein α-actinin-3. We compared the ACTN3 R577X genotype/allele frequencies between the following groups of ethnically-matched (Spanish) individuals: centenarians (cases, n = 64; 57 female; age range: 100–108 years), young healthy controls (n = 283, 67 females, 216 males; 21±2 years), and humans who are at the two end-points of exercise capacity phenotypes, i.e. muscle endurance (50 male professional road cyclists) and muscle power (63 male jumpers/sprinters). Although there were no differences in genotype/allele frequencies between centenarians (RR:28.8%; RX:47.5%; XX:23.7%), and controls (RR:31.8%; RX:49.8%; XX:18.4%) or endurance athletes (RR:28.0%; RX:46%; XX:26.0%), we observed a significantly higher frequency of the X allele (P = 0.019) and XX genotype (P = 0.011) in centenarians compared with power athletes (RR:47.6%; RX:36.5%;XX:15.9%). Notably, the frequency of the null XX (α-actinin-3 deficient) genotype in centenarians was the highest ever reported in non-athletic Caucasian populations. In conclusion, despite there were no significant differences with the younger, control population, overall the ACTN3 genotype of centenarians resembles that of world-class elite endurance athletes and differs from that of elite power athletes. Our preliminary data would suggest a certain ‘survival’ advantage brought about by α-actinin-3 deficiency and the ‘endurance’/oxidative muscle phenotype that is commonly associated with this condition

Cluster galaxies in XMMU J2235-2557: galaxy population properties in most massive environments at z~1.4

We present a multi-wavelength study of galaxy populations in the core of the massive, X-ray luminous cluster XMMU J2235 at z=1.39, based on VLT and HST optical and near-infrared photometry. Luminosity functions in the z, H, and Ks bands show a faint-end slope consistent with being flat, and a characteristic magnitude M* close to passive evolution predictions of M* of local massive clusters, with a formation redshift z>2. The color-magnitude and color-mass diagrams show evidence of a tight red sequence of massive galaxies, with overall old stellar populations, generally early-type morphology, typically showing early-type spectral features and rest-frame far-UV emission consistent with very low star formation rates (SFR<0.2Msun/yr). Star forming spectroscopic members, with SFRs of up to ~100Msun/yr, are all located at clustercentric distances >~250kpc, with the central cluster region already appearing effectively quenched. Massive galaxies in the core of this cluster appear to be in an advanced evolutionary stage in terms of both star formation and mass assembly. The high-mass end of the galaxy stellar mass function is essentially already in place, and the stellar mass fraction estimated within r500 (~1%, Kroupa IMF) is already similar to that of local massive clusters. On the other hand, morphological analysis of the massive red sequence galaxies suggests that they are smaller than similarly massive local early-types. While possibly affected by systematics and biases, this result might imply that, in spite of the overall early assembly of these sources, their evolution is not complete, and processes like minor (and likely dry) merging might still shape their structural properties to resemble those of their local counterparts, without substantially affecting their stellar mass or host stellar populations.[abridged]Comment: 14 pages, 9 figures, accepted for publication in Astronomy & Astrophysic

The near-infrared luminosity function of cluster galaxies beyond redshift one

We determined the K band luminosity function (LF) of cluster galaxies at redshift z~1.2, using near-infrared images of three X-ray luminous clusters at z=1.11,1.24,1.27. The composite LF was derived down to M*+4, by means of statistical background subtraction, and is well described by a Schechter function with K*=20.5 AB mag and alpha=-1. From the K band composite LF we derived the stellar mass function of cluster galaxies. Using available X-ray mass profiles we determined the M/L ratios of these three clusters, which tend to be lower than those measured in the local universe. With these data, no significant difference can be seen between the shapes of the cluster galaxies LF and the LF of field galaxies at similar redshift. We also found no significant evolution out to z ~1.2 in the bright (<M*+4) part of the cluster galaxies LF probed in this study, apart from a brightening of ~1.3 mag of the characteristic magnitude of the high redshift LF. We confirm, and extend to higher redshift, the result from previous work that the redshift evolution of the characteristic magnitude M* is consistent with passive evolution of a stellar population formed at z>2. The results obtained in this work support and extend previous findings that most of the stars in bright galaxies were formed at high redshift, and that K-bright (M>10^11 Msun) galaxies were already in place at z ~ 1.2, at least in the central regions of X-ray luminous clusters. Together with recent results on the field galaxies stellar mass function, this implies that most of the stellar mass is already assembled in massive galaxies by z ~ 1, both in low and high density environments.Comment: 16 pages, 10 figures, to appear in A&

"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence

Latently infected, resting memory CD4+ T cells and macrophages represent a major obstacle to the eradication of HIV-1. For this purpose, "shock and kill" strategies have been proposed (activation of HIV-1 followed by stimuli leading to cell death). Histone deacetylase inhibitors (HDACIs) induce HIV-1 activation from quiescence, yet class/isoform-selective HDACIs are needed to specifically target HIV-1 latency. We tested 32 small molecule HDACIs for their ability to induce HIV-1 activation in the ACH-2 and U1 cell line models. In general, potent activators of HIV-1 replication were found among non-class selective and class I-selective HDACIs. However, class I selectivity did not reduce the toxicity of most of the molecules for uninfected cells, which is a major concern for possible HDACI-based therapies. To overcome this problem, complementary strategies using lower HDACI concentrations have been explored. We added to class I HDACIs the glutathione-synthesis inhibitor buthionine sulfoximine (BSO), in an attempt to create an intracellular environment that would facilitate HIV-1 activation. The basis for this strategy was that HIV-1 replication decreases the intracellular levels of reduced glutathione, creating a pro-oxidant environment which in turn stimulates HIV-1 transcription. We found that BSO increased the ability of class I HDACIs to activate HIV-1. This interaction allowed the use of both types of drugs at concentrations that were non-toxic for uninfected cells, whereas the infected cell cultures succumbed more readily to the drug combination. These effects were associated with BSO-induced recruitment of HDACI-insensitive cells into the responding cell population, as shown in Jurkat cell models for HIV-1 quiescence. The results of the present study may contribute to the future design of class I HDACIs for treating HIV-1. Moreover, the combined effects of class I-selective HDACIs and the glutathione synthesis inhibitor BSO suggest the existence of an Achilles' heel that could be manipulated in order to facilitate the "kill" phase of experimental HIV-1 eradication strategies