The Radio Evolution of SN 2001gd

We present the results of observations of the radio emission from Supernova 2001gd in NGC 5033 from 2002 February 8 through 2006 September 25. The data were obtained using the Very Large Array at wavelengths of 1.3 cm (22.4 GHz), 2 cm (14.9 GHz), 3.6 cm (8.4 GHz), 6 cm (4.9 GHz), and 20 cm (1.5 GHz), with one upper limit at 90 cm (0.3 GHz). In addition, one detection has been provided by the Giant Metrewave Radio Telescope at 21 cm (1.4 GHz). SN 2001gd was discovered in the optical well past maximum light, so that it was not possible to obtain many of the early radio "turn-on" measurements which are important for estimating the local circumstellar medium (CSM) properties. Only at 20 cm were turn-on data available. However, our analysis and fitting of the radio light curves, and the assumption that the Type IIb SN 2001gd resembles the much better studied Type IIb SN 1993J, enables us to describe the radio evolution as being very regular through day ~550 and consistent with a nonthermal-emitting model with a thermal absorbing CSM. The presence of synchrotron-self absorption (SSA) at early times is implied by the data, but determination of the exact relationship between the SSA component from the emitting region and the free-free absorption component from the CSM is not possible as there are insufficient early measurements to distinguish between models. After day ~550, the radio emission exhibits a dramatically steeper decline rate which, assuming similarity to SN 1993J, can be described as an exponential decrease with an e-folding time of 500 days. We interpret this abrupt change in the radio flux density decline rate as implying a transition of the shock front into a more tenuous region of circumstellar material. A similar change in radio evolution has been seen earlier in other SNe such as SN 1988Z, SN 1980K, and SN 1993J.Comment: 3 tables, 2 figures, To appear in the Astrophysical Journa

Total synthesis of the post-translationally modified polyazole peptide antibiotic plantazolicin A

The power of rhodium carbene methodology in chemistry is demonstrated by the synthesis of a structurally complex polyazole antibiotic. Plantazolicin A, a novel soil bacterium metabolite, comprises a linear array of 10 five-membered rings in two pentacyclic regions that derive from ribosomal peptide synthesis followed by extensive post-translational modification. The compound possesses potent antimicrobial activity, and is selectively active against the anthrax causing organism. A conceptually different synthesis of plantazolicin A is reported in which the key steps are the use of rhodium(II)-catalyzed reactions of diazocarbonyl compounds to generate up to six of the seven oxazole rings of the antibiotic. NMR Spectroscopic studies and molecular modeling, reveal a likely dynamic hairpin conformation with a hinge region around the two isoleucine residues.The compound has modest activity against methicillin-resistant Staphylococcus aureus (MRSA)

α_1L-adrenoceptors mediate contraction of human erectile tissue

α1-adrenoceptor antagonists can impact upon sexual function and have potential in the treatment of erectile dysfunction. Human erectile tissue contains predominantly α1A-adrenoceptors, and here we examined whether contractions of this tissue are mediated by the functional phenotype, the α1L-adrenoceptor. Functional experiments using subtype selective agonists and antagonists, along with radioligand ([3H]tamsulosin) binding assays, were used to determine the α1-adrenoceptor population. A61603, a α1A-adrenoceptor agonist, was a full agonist with a potency 21-fold greater than that of noradrenaline. The α1A- and α1D-adrenoceptor antagonist tamsulosin antagonized noradrenaline responses with high affinity (pKD = 9.7 ± 0.3), whilst BMY7378 (100 nM) (α1D-adrenoceptor antagonist) failed to antagonize responses. In contrast, relatively low affinity estimates were obtained for both prazosin (pKD = 8.2 ± 0.1) and RS17053 (pKD = 6.9 ± 0.2), antagonists which discriminate between the α1A- and α1L-adrenoceptors. [3H]Tamsulosin bound with high affinity to the receptors of human erectile tissue (pKD = 10.3 ± 0.1) with a receptor density of 28.1 ± 1.4 fmol mg−1 protein. Prazosin displacement of [3H]tamsulosin binding revealed a single homogenous population of binding sites with a relatively low affinity for prazosin (pKi = 8.9). Taken together these data confirm that the receptor mediating contraction in human erectile tissue has the pharmacological properties of the α1L-adrenoceptor. Keywords: Erectile tissue, α1-adrenoceptor subtypes, α1L-adrenoceptor, Tamsulosin, Prazosi

Radio Emission from Supernovae

Study of radio supernovae over the past 27 years includes more than three dozen detected objects and more than 150 upper limits. From this work it is possible to identify classes of radio properties, demonstrate conformance to and deviations from existing models, estimate the density and structure of the circumstellar material and, by inference, the evolution of the presupemova stellar wind, and reveal the last stages of stellar evolution before explosion. It is also possible to detect ionized hydrogen along the line of sight, to demonstrate binary properties of the presupemova stellar system, and to detect dumpiness of the circumstellar material. Along with reviewing these general properties of the radio emission from supernovae, we present our extensive observations of the radio emission from supemova (SN) 1993J in M 81 (NGC 3031) made with the Very Large Array and other radio telescopes. The SN 1993J radio emission evolves regularly in both time and frequency, and the usual interpretation in terms of shock interaction with a circumstellar medium (CSM) formed by a pre-supernova stellar wind describes the observations rather well considering the complexity of the phenomenon. However: 1) The highest frequency measurements at 85 - 110 GHz at early times (< 40 days) are not well fitted by the parameterization which describes the cm wavelength measurements rather well. 2) At mid-cm wavelengths there is often deviation from the fitted radio light curves, particularly near the peak flux density, and considerable shorter term deviations in the declining portion when the emission has become optically thin. 3) At a time ~3100 days after shock breakout, the decline rate of the radio emission steepens from (t^(+β))β ~ 0.7 to β ~ —2.7 without change in the spectral index (v^(+α); α ~ -0.81). However, this decline is best described not as a power-law, but as an exponential decay starting at day ~3100 with an e-folding time of ~1100 days. 4) The best overall fit to all of the data is a model including both non-thermal synchrotron self-absorption (SSA) and a thermal free-free absorbing (FFA) components at early times, evolving to a constant spectral index, optically thin decline rate, until a break in that decline rate at day ~3100, as mentioned above. Moreover, neither a purely SSA nor a purely FFA absorbing model can provide a fit that simultaneously reproduces the light curves, the spectral index evolution, and the brightness temperature evolution

A Cross-Institutional Perspective of Pre Laboratory Activities in Undergraduate Chemistry

Pre-laboratory exercises may help reduce cognitive load in the laboratory, boost confidence, develop theoretical understanding and skills, and improve grades on assessment tasks. This study compared pre-laboratory activities at two institutions, Go8-1 and Go8-2, to evaluate which attributes of pre-laboratory activities were perceived by students to best prepare them for laboratory classes. Students were surveyed towards the end of their laboratory course, and were asked a series of Likert-style and open response questions. Factor analysis was used to construct three scales, incorporating items relating to performance and understanding, items relating to affective and personal laboratory experience, and items relating to requiring support with laboratory equipment. No difference between cohorts was observed between the two institutions regarding requiring support with equipment. While Go8-1 students rated performance and understanding more highly than Go8-2 students, the opposite result was observed for affective and personal factors. The factor analysis results and responses to the open response questions indicated that students felt most prepared for laboratory exercises when the pre-class activities touched upon all aspects of the laboratory class. It is recommended that quizzes and video be used in pre-laboratory activities, with these resources covering theory, aims, methods, calculations and data analysis

Long Term Radio Monitoring of SN 1993J

We present our observations of the radio emission from supernova (SN) 1993J, in M 81 (NGC 3031), made with the VLA, from 90 to 0.7 cm, as well as numerous measurements from other telescopes. The combined data set constitutes probably the most detailed set of measurements ever established for any SN outside of the Local Group in any wavelength range. Only SN 1987A in the LMC has been the subject of such an intensive observational program. The radio emission evolves regularly in both time and frequency, and the usual interpretation in terms of shock interaction with a circumstellar medium (CSM) formed by a pre-SN stellar wind describes the observations rather well considering the complexity of the phenomenon. However: 1) The 85 - 110 GHz measurements at early times are not well fitted by the parameterization, unlike the cm wavelength measurements. 2) At mid-cm wavelengths there is some deviation from the fitted radio light curves. 3) At a time ~3100 days after shock breakout, the decline rate of the radio emission steepens without change in the spectral index. This decline is best described as an exponential decay starting at day 3100 with an e-folding time of ~1100 days. 4) The best overall fit to all of the data is a model including both non-thermal synchrotron self-absorption (SSA) and a thermal free-free absorbing (FFA) components at early times, evolving to a constant spectral index, optically thin decline rate, until the break in that decline rate. Moreover, neither a purely SSA nor a purely FFA absorbing models can provide a fit that simultaneously reproduces the light curves, the spectral index evolution, and the brightness temperature evolution. 5) The radio and X-ray light curves exhibit similar behavior and suggest a sudden drop in the SN progenitor mass-loss rate at ~8000 years prior to shock breakout.Comment: 45 pages, 13 figures, accepted for Ap