Cost keeping in the leather belting industry

Revised copy of a paper read by Mr. Wm. F. Carroll of the L. L. Harr Corporation of New York at a meeting of the Leather Belting Exchange held at the Hotel Biltmore, New York, Wednesday, December 20, 1916. Our object in visiting the plants and making the investigations was to obtain sufficient information relative to the manufacture and sale of leather belting to enable us to design a uniform cost system for use in all of the plants of the members of the Leather Belting Exchange. Our object is not to attempt to make costs uniform in all plants, but instead, to start with the assumption that the manager of each of the plants is a practical leather belting manufacturer and knows what he is doing, and to design for use in all of the plants a simple, common-sense cost system which can be operated with the least possible amount of clerical labor and which will be absolutely devoid of red tape, but which will make it possible for each manager to know absolutely what it is costing him to produce the belting manufactured in his plant, and to know also that he is including in his costs all of the items of cost which should be included in them and which are being included by all of the other manufacturers of leather belting in the Leather Belting Exchange

Relationship Between Foveal Cone Specialization and Pit Morphology in Albinism

Purpose.Albinism is associated with disrupted foveal development, though intersubject variability is becoming appreciated. We sought to quantify this variability, and examine the relationship between foveal cone specialization and pit morphology in patients with a clinical diagnosis of albinism. Methods. We recruited 32 subjects with a clinical diagnosis of albinism. DNA was obtained from 25 subjects, and known albinism genes were analyzed for mutations. Relative inner and outer segment (IS and OS) lengthening (fovea-to-perifovea ratio) was determined from manually segmented spectral domain-optical coherence tomography (SD-OCT) B-scans. Foveal pit morphology was quantified for eight subjects from macular SD-OCT volumes. Ten subjects underwent imaging with adaptive optics scanning light ophthalmoscopy (AOSLO), and cone density was measured. Results. We found mutations in 22 of 25 subjects, including five novel mutations. All subjects lacked complete excavation of inner retinal layers at the fovea, though four subjects had foveal pits with normal diameter and/or volume. Peak cone density and OS lengthening were variable and overlapped with that observed in normal controls. A fifth hyper-reflective band was observed in the outer retina on SD-OCT in the majority of the subjects with albinism. Conclusions. Foveal cone specialization and pit morphology vary greatly in albinism. Normal cone packing was observed in the absence of a foveal pit, suggesting a pit is not required for packing to occur. The degree to which retinal anatomy correlates with genotype or visual function remains unclear, and future examination of larger patient groups will provide important insight on this issue

A New/Old Ontology of Film

The purpose of this article is to examine the ontological effects of digital technology, and determine whether digital films, traditional films, and pretraditional motion pictures belong to the same category. I begin by defining the parameters of my inquiry, and then consider the two most significant consequences of the new technology. §2 proposes a decisive refutation of the causal relationship between reality and photography. §3 identifies an end to the dominance of photorealistic film over animation, and argues for an inversion of that relationship, whereby animation is paramount. Finally, I consider the implications of these consequences for film ontology, compare theories, and conclude in favour of Berys Gaut, for whom digital film is the latest incarnation of a history of moving pictures that stretches back for centuries

Multilocus Sequence Typing Methods for the Emerging Campylobacter Species C. hyointestinalis, C. lanienae, C. sputorum, C. concisus, and C. curvus

Multilocus sequence typing (MLST) systems have been reported previously for multiple food- and food animal-associated Campylobacter species (e.g., C. jejuni, C. coli, C. lari, and C. fetus) to both differentiate strains and identify clonal lineages. These MLST methods focused primarily on campylobacters of human clinical (e.g., C. jejuni) or veterinary (e.g., C. fetus) relevance. However, other, emerging, Campylobacter species have been isolated increasingly from environmental, food animal, or human clinical samples. We describe herein four MLST methods for five emerging Campylobacter species: C. hyointestinalis, C. lanienae, C. sputorum, C. concisus, and C. curvus. The concisus/curvus method uses the loci aspA, atpA, glnA, gltA, glyA, ilvD, and pgm, whereas the other methods use the seven loci defined for C. jejuni (i.e., aspA, atpA, glnA, gltA, glyA, pgm, and tkt). Multiple food animal and human clinical C. hyointestinalis (n = 48), C. lanienae (n = 34), and C. sputorum (n = 24) isolates were typed, along with 86 human clinical C. concisus and C. curvus isolates. A large number of sequence types were identified using all four MLST methods. Additionally, these methods speciated unequivocally isolates that had been typed ambiguously using other molecular-based speciation methods, such as 16S rDNA sequencing. Finally, the design of degenerate primer pairs for some methods permitted the typing of related species; for example, the C. hyointestinalis primer pairs could be used to type C. fetus strains. Therefore, these novel Campylobacter MLST methods will prove useful in differentiating strains of multiple, emerging Campylobacter species

Recurrent Modification of a Conserved Cis-Regulatory Element Underlies Fruit Fly Pigmentation Diversity

The development of morphological traits occurs through the collective action of networks of genes connected at the level of gene expression. As any node in a network may be a target of evolutionary change, the recurrent targeting of the same node would indicate that the path of evolution is biased for the relevant trait and network. Although examples of parallel evolution have implicated recurrent modification of the same gene and cis-regulatory element (CRE), little is known about the mutational and molecular paths of parallel CRE evolution. In Drosophila melanogaster fruit flies, the Bric-à-brac (Bab) transcription factors control the development of a suite of sexually dimorphic traits on the posterior abdomen. Female-specific Bab expression is regulated by the dimorphic element, a CRE that possesses direct inputs from body plan (ABD-B) and sex-determination (DSX) transcription factors. Here, we find that the recurrent evolutionary modification of this CRE underlies both intraspecific and interspecific variation in female pigmentation in the melanogaster species group. By reconstructing the sequence and regulatory activity of the ancestral Drosophila melanogaster dimorphic element, we demonstrate that a handful of mutations were sufficient to create independent CRE alleles with differing activities. Moreover, intraspecific and interspecific dimorphic element evolution proceeded with little to no alterations to the known body plan and sex-determination regulatory linkages. Collectively, our findings represent an example where the paths of evolution appear biased to a specific CRE, and drastic changes in function were accompanied by deep conservation of key regulatory linkages. © 2013 Rogers et al

Macrohabitat Composition Surrounding Successful and Depredated Northern Bobwhite Nests

Relationships among macrohabitat and depredation of northern bobwhite (Colinus virginianus) nests are poorly understood. Yet, macrohabitat composition may influence the nest predator community and, therefore, the vulnerability of northern bobwhite nests to depredation. We determined if macrohabitat composition surrounding bobwhite nests influenced nest placement, nest success, and which predators were responsible for depredating nests. We characterized macrohabitats at 2 scales, 8 and 16 ha, by surrounding both bobwhite nests, and an equal number of random locations, with a circular buffer. Random points were placed within the area used by bobwhites on our study area. We then determined the acreage of each macrohabitat category within each circular buffer to determine the macrohabitat composition. Macrohabitat categories included hardwood forested drains, upland pine forests burned in March of the same calendar year, upland pine forests burned in March of the previous calendar year, and fields. We documented nest predators using infrared video cameras placed at the nest site. We monitored 104 bobwhite nests on Tall Timbers Research Station (TTRS) during 1999 and 2000. Size of the circular buffer around nests did not qualitatively affect results. Area (ha) of upland pine forests and fields were similar at depredated nests, hatched nests, and random locations. However, there was an average of 81% and 56% more area of hardwood drain in the circular buffers associated with random locations than at successful and depredated nests, respectively. Area of upland pine forests and fields were similar for nests depredated by raccoon (Procyon lotor), armadillo (Dasypus novemcinctus) and snake (Elaphus spp.). However, there was an average of 6.1 and 3.3 times more area of hardwood drain surrounding nests that were depredated by snakes relative to nests depredated by raccoons and armadillos, respectively. While our sample sizes were low, bobwhites exhibited a tendency to place nests in landscapes with less hardwood drain than were generally available on the study area. Macrohabitat surrounding nests influenced the type of nest predator to depredate nests. To minimize depredation of bobwhite nests by snakes, we suggest nesting cover should be developed away from drain edges

Towards a pan-Arctic inventory of the species diversity of the macro- and megabenthic fauna of the Arctic shelf seas

Although knowledge of Arctic seas has increased tremendously in the past decade, benthic diversity was investigated at regional scales only, and no attempt had been made to examine it across the entire Arctic. We present a first pan-Arctic account of the species diversity of the macro- and megabenthic fauna of the Arctic marginal shelf seas. It is based on an analysis of 25 published and unpublished species-level data sets, together encompassing 14 of the 19 marine Arctic shelf ecoregions and comprising a total of 2636 species, including 847 Arthropoda, 668 Annelida, 392 Mollusca, 228 Echinodermata, and 501 species of other phyla. For the four major phyla, we also analyze the differences in faunal composition and diversity among the ecoregions. Furthermore, we compute gross estimates of the expected species numbers of these phyla on a regional scale. Extrapolated to the entire fauna and study area, we arrive at the conservative estimate that 3900 to 4700 macro- and megabenthic species can be expected to occur on the Arctic shelves. These numbers are smaller than analogous estimates for the Antarctic shelf but the difference is on the order of about two and thus less pronounced than previously assumed. On a global scale, the Arctic shelves are characterized by intermediate macro- and megabenthic species numbers. Our preliminary pan-Arctic inventory provides an urgently needed assessment of current diversity patterns that can be used by future investigations for evaluating the effects of climate change and anthropogenic activities in the Arctic

Catalysis of Stark-Tuned Interactions Between Ultracold Rydberg Atoms

We have experimentally investigated a catalysis effect in the resonant energy transfer between ultracold 85Rb Rydberg atoms. We studied the time dependence of the process, 34p+34p→34s+35s, and observed an enhancement of 34s state population when 34d state atoms are added. We have also performed numerical model simulations, which are in qualitative agreement with experiment and indicate that the enhancement arises from a redistribution of p-state atoms due to the presence of the d-state atoms

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN