An Exploratory Study of the Career Drivers of Accounting Students

The purpose of this study was to assess the relative importance of nine career drivers of undergraduate accounting students. Career drivers are motivational factors that influence students’ choices of careers. Faculty, academic advisors, and employment recruiters, among others, can benefit from knowing what accounting students consider to be important career factors. The three most important career drivers are expertise, security, and search for meaning. We also attempted to assess if there are significant differences in the career drivers of male and female students. Our results indicated that there are statistically significant differences between male and female respondents in the career drivers of expertise, security, and search for meaning

Policy and Procedure: Clinical Management of Human Trafficking Patients and/or Those at Risk for Exploitation

The Ohio Attorney General’s Office in its fight against human trafficking has created a Human Trafficking Initiative. Part of this initiative is the development of publications to assist providers in the care of and/or recognition of trafficked patients, data collection, and/or standards of service. This healthcare policy template is both evidence based and survivor informed. It will help to assist providers in understanding the basic guidelines of clinical management for human trafficking patients and/or those at risk for exploitation. This resource in addition to others can be found on the Ohio Attorney General’s website and is available to download and adopt as a reference/template for the development of healthcare policy and procedures

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD

Speech Communication

Contains table of contents for Part V, table of contents for Section 1, reports on six research projects and a list of publications.C.J. Lebel FellowshipDennis Klatt Memorial FundNational Institutes of Health Grant R01-DC00075National Institutes of Health Grant R01-DC01291National Institutes of Health Grant R01-DC01925National Institutes of Health Grant R01-DC02125National Institutes of Health Grant R01-DC02978National Institutes of Health Grant R01-DC03007National Institutes of Health Grant R29-DC02525National Institutes of Health Grant F32-DC00194National Institutes of Health Grant F32-DC00205National Institutes of Health Grant T32-DC00038National Science Foundation Grant IRI 89-05249National Science Foundation Grant IRI 93-14967National Science Foundation Grant INT 94-2114

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention

A SURVEY OF THE ATTITUDES OF SOUTH DAKOTA SMALL BUSINESS OWNERS AND/OR MANAGERS TOWARDS SOCIAL RESPONSIBILITY ACCOUNTING

The purpose of this dissertation is to survey the attitudes of small business owners and/or managers concerning social responsibility accounting (SRA). SRA is the act of selecting, measuring, recording and reporting activities of business enterprises having both social and economic impacts. The study group used to accomplish the survey is the small business firms in the State of South Dakota. The survey method used was a questionnaire mailed to a random sample of South Dakota small business firms. The questionnaire queried the sample over general social responsibility actions, community involvement actions, human resource actions, physical resource uses, environmental considerations and product or service considerations (also included was a section on demographics). Each social action included in the questionnaire is some activity that business could be engaged in; but the sample was asked whether business should be engaged in the activity. In general the respondents agreed that business organizations should act as concerned citizens, but they did not agree that business should be encouraged to collect or report social responsibility data. If business did collect and report social responsibility information, respondents agreed that this information could not be limited to financial amounts or financial statement form. The respondents did agree that organizational goals should include social goals. The study group responded very favorably to many specific social actions in the areas queried. Some of these actions agreed to by respondents included: allowing both managers and employees to engage in community activities during business hours; providing for community planning and improvement by business firms; the support of education (private and public); providing prompt responses to customer complaints; and several other social actions. The respondents reacted least favorably to governmental regulation, governmental paperwork, going beyond the law in pollution abatement (air, water, sound), providing direct assistance to disadvantaged persons, and providing counseling for employees who have alcohol or drug problems. Respondents agreed that business should assist in improving the efficiency of government but disagreed with the act of supporting adequate compensation for government employees