Fuzzy Bayesian inference for mapping vague and place-based regions: a case study of sectarian territory

The problem of mapping regions with socially-derived boundaries has been a topic of discussion in the GIS literature for many years. Fuzzy approaches have frequently been suggested as solutions, but none have been adopted. This is likely due to difficulties associated with determining suitable membership functions, which are often as arbitrary as the crisp boundaries that they seek to replace. This paper presents a novel approach to fuzzy geographical modelling that replaces the membership function with a possibility distribution that is estimated using Bayesian inference. In this method, data from multiple sources are combined to estimate the degree to which a given location is a member of a given set and the level of uncertainty associated with that estimate. The Fuzzy Bayesian Inference approach is demonstrated through a case study in which census data are combined with perceptual and behavioural evidence to model the territory of two segregated groups (Catholics and Protestants) in Belfast, Northern Ireland, UK. This novel method provides a robust empirical basis for the use of fuzzy models in GIS, and therefore has applications for mapping a range of socially-derived and otherwise vague boundaries

Evaluation of the performance of different atmospheric chemical transport models and inter-comparison of nitrogen and sulphur deposition estimates for the UK

An evaluation has been made of a number of contrasting atmospheric chemical transport models, of varying complexity, applied to estimate sulphur and nitrogen deposition in the UK. The models were evaluated by comparison with annually averaged measurements of gas, aerosol and precipitation concentrations from the national monitoring networks. The models were evaluated in relation to performance criteria. They were generally able to satisfy a criterion of ‘fitness for purpose’ that at least 50% of modelled concentrations should be within a factor of two of measured values. The second criterion, that the magnitude of the normalised mean bias should be less than 20%, was not always satisfied. Considering known uncertainties in measurement techniques, this criterion may be too strict. Overall, simpler models were able to give a good representation of measured gas concentrations whilst the use of dynamic meteorology, and complex photo-chemical reactions resulted in a generally better representation of measured aerosol and precipitation concentrations by more complex models. The models were compared graphically by plotting maps and cross-country transects of wet and dry deposition as well as calculating budgets of total wet and dry deposition to the UK for sulphur, oxidised nitrogen and reduced nitrogen. The total deposition to the UK varied by ±22–36% amongst the different models depending on the deposition component. At a local scale estimates of both dry and wet deposition for individual 5 km × 5 km model grid squares were found to vary between the different models by up to a factor of 4.This work was funded by the Department for the Environment, Food and Rural Affairs. Additional support was provided by the Joint Environmental Program, the Natural Environment Research Council and the Environment Agency.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.atmosenv.2015.08.00

Direct Binding of pRb/E2F-2 to GATA-1 Regulates Maturation and Terminal Cell Division during Erythropoiesis

Cell differentiation is often coupled with cell cycle arrest. Here, we show that direct binding of the erythroid transcription factor GATA-1 to the retinoblastoma protein and the pRb/E2F transcription factor complex is critical for red blood cell formation

Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals

Background: Vertebrate alpha (α)- and beta (β)-globin gene families exemplify the way in which genomes evolve to produce functional complexity. From tandem duplication of a single globin locus, the α- and β-globin clusters expanded, and then were separated onto different chromosomes. The previous finding of a fossil β-globin gene (ω) in the marsupial α-cluster, however, suggested that duplication of the α-β cluster onto two chromosomes, followed by lineage-specific gene loss and duplication, produced paralogous α- and β-globin clusters in birds and mammals. Here we analyse genomic data from an egg-laying monotreme mammal, the platypus (Ornithorhynchus anatinus), to explore haemoglobin evolution at the stem of the mammalian radiation. Results: The platypus α-globin cluster (chromosome 21) contains embryonic and adult α- globin genes, a β-like ω-globin gene, and the GBY globin gene with homology to cytoglobin, arranged as 5'-ζ-ζ'-αD-α3-α2-α1-ω-GBY-3'. The platypus β-globin cluster (chromosome 2) contains single embryonic and adult globin genes arranged as 5'-ε-β-3'. Surprisingly, all of these globin genes were expressed in some adult tissues. Comparison of flanking sequences revealed that all jawed vertebrate α-globin clusters are flanked by MPG-C16orf35 and LUC7L, whereas all bird and mammal β-globin clusters are embedded in olfactory genes. Thus, the mammalian α- and β-globin clusters are orthologous to the bird α- and β-globin clusters respectively. Conclusion: We propose that α- and β-globin clusters evolved from an ancient MPG-C16orf35-α-β-GBY-LUC7L arrangement 410 million years ago. A copy of the original β (represented by ω in marsupials and monotremes) was inserted into an array of olfactory genes before the amniote radiation (>315 million years ago), then duplicated and diverged to form orthologous clusters of β-globin genes with different expression profiles in different lineages.Vidushi S. Patel, Steven J.B. Cooper, Janine E. Deakin, Bob Fulton, Tina Graves, Wesley C. Warren, Richard K. Wilson and Jennifer A.M. Grave

Repercussion of megakaryocyte-specific Gata1 Loss on megakaryopoiesis and the hematopoietic precursor compartment

During hematopoiesis, transcriptional programs are essential for the commitment and differentiation of progenitors into the different blood lineages. GATA1 is a transcription factor expressed in several hematopoietic lineages and essential for proper erythropoiesis and megakaryopoiesis. Megakaryocyte-specific genes, such as GP1BA, are known to be directly regulated by GATA1. Mutations in GATA1 can lead to dyserythropoietic anemia and pseudo gray-platelet syndrome. Selective loss of Gata1 expression in adult mice results in macrothrombocytopenia with platelet dysfunction, characterized by an excess of immature megakaryocytes. To specifically analyze the impact of Gata1 loss in mature committed megakaryocytes, we generated Gata1-Lox|Pf4-Cre mice (Gata1cKOMK). Consistent with previous findings, Gata1cKOMK mice are macrothrombocytopenic with platelet dysfunction. Supporting this notion we demonstrate that Gata1 regulates directly the transcription of Syk, a tyrosine kinase that functions downstream of Clec2 and GPVI receptors in megakaryocytes and platelets. Furthermore, we show that Gata1cKOMK mice display an additional aberrant megakaryocyte differentiation stage. Interestingly, these mice present a misbalance of the multipotent progenitor compartment and the erythroid lineage, which translates into compensatory stress erythropoiesis and splenomegaly. Despite the severe thrombocytopenia, Gata1cKOMK mice display a mild reduction of TPO plasma levels, and Gata1cK-OMK megakaryocytes show a mild increase in Pf4 mRNA levels; such a misbalance might be behind the general hematopoietic defects observed, affecting locally normal TPO and Pf4 levels at hematopoietic stem cell niches. © 2016 Meinders et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Biophilic architecture: a review of the rationale and outcomes

Contemporary cities have high stress levels, mental health issues, high crime levels and ill health, while the built environment shows increasing problems with urban heat island effects and air and water pollution. Emerging from these concerns is a new set of design principles and practices where nature needs to play a bigger part called “biophilic architecture”. This design approach asserts that humans have an innate connection with nature that can assist to make buildings and cities more effective human abodes. This paper examines the evidence for this innate human psychological and physiological link to nature and then assesses the emerging research supporting the multiple social, environmental and economic benefits of biophilic architecture

Modelling future acid deposition:A critical loads approach

An atmospheric pollution model, the Harwell Trajectory Model, is used to explore the effects of a range of possible future emissions scenarios on levels of sulphur deposition and critical loads exceedence across the UK. The structure of the HTM and the basis of the critical loads concept are described. Model output is illustrated for emissions scenarios which reflect the possible effects of the 30% reduction in SO2 emissions demanded by the Helsinki Protocol and the UK's current commitments under the LCPD to a 60% reduction by 2003. Emissions reductions are achieved both by blanket reductions and by targeting reductions on particular large sources. An emissions reduction of 30% would have little environmental benefit for the UK as a whole. A 60% reduction leads to a much clearer change in the pattern of critical loads exceedence; targeted emissions reductions appear to be more effective still and point the way for future policy

Assessing the impact of international emissions reduction scenarios to combat the acidification of freshwaters in Great Britain with the First-order Acidity Balance (FAB) model and the Hull Acid Rain Model (HARM)

of acid deposition through emissions controls. In Great Britain and Scandinavia, critical loads for freshwater ecosystems are calculated with the First-order Acidity Balance (F AB) model, which provides a catchment based estimate of deposition reduction requirements of both sulphur and nitrogen species in order to protect a selected aquatic target organism. The F AB model is here applied to a national freshwaters database for Great Britain using three deposition scenarios generated with the Hull Acid Rain Model (HARM). Critical load exceedance and changes in two important chemical indicators (nitrate and acid neutralizing capacity) are assessed for 1990 baseline deposition levels, planned emissions reductions under existing international commitments (REF scenario), and a potential stringent deposition reduction scenario under a multi-pollutant, multi-effect strategy (EI O scenario). Model outputs indicate that the proportion of sampled sites exceeding their critical load will be reduced by sixty-four and seventy-eight percent respectively under the two future deposition scenarios. Planned reductions in emissions under the REF scenario will protect most Scottish freshwaters, but substantial areas of the English and Welsh uplands will remain exceeded. Most of the required reductions in acid deposition for both Scotland and Wales would be met by the more stringent EI O scenario. In the most sensitive areas of northern England, even greater reductions in both S and N emissions than those described under the EI O scenario are required. While S remains the most important source of acid deposition even after future reductions, freshwaters in sensitive areas cannot be protected by abatement of S emissions alone. There is a clear need for a strategy to reduce N deposition if British freshwaters in sensitive areas are to be protected