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11 research outputs found

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Author: Abani O.
Abbas A.
Abbas F.
Abbas M.
Abbasi S.
Abbass H.
Abbott A.
Abdallah N.
Abdelaziz A.
Abdelfattah M.
Abdelqader B.
Abdo D.
Abdul Rasheed A.
Abdul B.
Abdul-Kadir R.
Abdul-Raheem R.
Abdulakeem A.
Abdulle A.
Abdulmumeen A.
Abdulshukkoor N.
Abdusamad K.
Abed El Khaleq Y.
Abedalla M.
Abeer Ul Amna A.U.A.
Abernethy K.
Abo-Leyah H.
Aboaba A.
Abou-Haggar A.
Abouibrahim M.
Abraham M.
Abraham T.
Abraheem A.
Abrams J.
Abu H.-J.
Abu-Arafeh A.
Abubacker S.M.
Abung A.
Aceampong Y.
Achara A.
Acharya D.
Acheampong S.
Acheson J.
Acosta A.
Acton C.
Adabie-Ankrah J.
Adair S.
Adam F.
Adam M.
Adamali H.
Adams C.
Adams C.
Adams K.
Adams L.
Adams R.
Adams T.
Adcock K.
Addai J.
Adebiyi A.
Adegoke K.
Adell V.
Ademokun D.
Adenwalla S.
Adesemoye O.A.
Adewunmi E.O.
Adeyemi J.
Adhikary R.
Adkins G.
Adnan A.
Aeron-Thomas J.
Affleck D.
Affron D.
Afnan C.
Afridi M.
Aftab Z.A.
Agarwal M.
Agbeko R.
Agbo C.
Agent P.
Aggarwal S.
Aghababaie A.
Ahamed Sadiq S.
Ahammed Nazeer M.H.
Ahmad H.
Ahmad M.
Ahmad S.
Ahmed Ali R.
Ahmed A.
Ahmed B.
Ahmed F.
Ahmed H.
Ahmed I.
Ahmed I.
Ahmed K.
Ahmed L.
Ahmed M.
Ahmed M.C.
Ahmed M.S.
Ahmed N.
Ahmed N.
Ahmed O.
Ahmed R.
Ahmed R.A.
Ahmed S.
Ahmed S.
Ahmed S.
Ahmed S.
Ahmed S.
Ahmed S.
Ahmed S.H.
Ahmer S.
Ail D.
Ainsworth M.
Airoldi G.
Aissa M.
Aitken L.
Ajay B.
Ajeneye F.
Ajibode A.
Ajmi A.
Akbar T.
Akhtar N.
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Akhtar N.
Akili S.
Akindolie O.
Akinfenwa Y.
Akinkugbe O.
Akinpelu I.
Akinwumiju O.
Aktinade O.
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Al-Shamkhani W.
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Aneke K.
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Zulfikar S.
Zullo C.
Zuriaga-Alvaro A.
Zuurbier W.
Zyengi S.
Publication venue: 'Elsevier BV'
Publication date: 29/05/2021
Field of study

Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Enlighten

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Author: Abani O.
Abbas A.
Abbas F.
Abbas M.
Abbasi S.
Abbass H.
Abbott A.
Abdallah N.
Abdelaziz A.
Abdelfattah M.
Abdelqader B.
Abdul Rasheed A.
Abdul B.
Abdul-Kadir R.
Abdul-Raheem R.
Abdulakeem A.
Abdulmumeen A.
Abdulshukkoor N.
Abdusamad K.
Abed El Khaleq Y.
Abedalla M.
Abeer Ul Amna A.
Abernethy K.
Abo-Leyah H.
Aboaba A.
Abou-Haggar A.
Abouibrahim M.
Abraham M.
Abraham T.
Abraheem A.
Abrams J.
Abu H.-J.
Abu-Arafeh A.
Abubacker S.M.
Abung A.
Aceampong Y.
Achara A.
Acharya D.
Acheampong S.
Acheson J.
Acosta A.
Acton C.
Adabie-Ankrah J.
Adam F.
Adam M.
Adamali H.
Adams C.
Adams C.
Adams K.
Adams R.
Adams T.
Adcock K.
Addai J.
Adebiyi A.
Adegoke K.
Adell V.
Adenwalla S.
Adesemoye O.A.
Adewunmi E.O.
Adeyemi J.
Adhikary R.
Adkins G.
Adnan A.
Aeron-Thomas J.
Affleck D.
Afnan C.
Afridi M.
Aftab Z.A.
Agarwal M.
Agbeko R.
Agbo C.
Agent P.
Aggarwal S.
Aghababaie A.
Ahamed Sadiq S.
Ahammed Nazeer M.H.
Ahmad M.
Ahmad S.
Ahmed Ali R.
Ahmed A.
Ahmed B.
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Ahmed H.
Ahmed I.
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Ahmed K.
Ahmed L.
Ahmed M.
Ahmed M.C.
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Publication venue: 'Elsevier BV'
Publication date: 01/05/2021
Field of study

Background: In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). Findings: Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001). Interpretation: In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

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Author: A A Adebayo
A A Gonzalez Ruiz
A A Khetarpal
A A Thevathasan
A A Zhang
A Abdulmajid
A Abid
A Adlan
A Ahmad
A Akdogan
A Al-Mousawi
A Al-Nasser
A Al-Robeye
A Ali
A Aljbour
A Amajuoyi
A Ang
A Anilkumar
A Arezzo
A Arrigo
A Aslanyan
A Asma
A Asmadi
A Atayi
A Aytekin
A B Bayoumy
A B Bolat
A Badran
A Bakhsh
A Baldwin
A Batho
A Bell
A Benevento
A Bhangu
A Borrellas
A Brogan
A Broyd
A Burgess
A C D Smith
A C Ozsipahi
A C van der Hoeven
A Cammarota
A Campion
A Capozzolo
A Charania
A Chhabra
A Chung
A Coates
A Cody
A Collins
A Costa
A Cotton
A Craig-McQuaide
A Croall
A Curran
A D Greenhalgh
A D Hacioglu
A D Henson
A D Semana
A D Wood
A Daoub
A Decorato
A Delport
A Demirci
A Dhanji
A Díaz Padillo
A Doshi
A Duffy
A Durr
A E Barthorpe
A E Cardwell
A E Gezen
A E Lim
A E Logan
A E M van der Pool
A E Salih
A E Ward
A Espí Macías
A F Carroll
A F K Gok
A Facchiano
A Falcon Cazas
A Fasano
A Favero
A G Smith
A G Unal
A Garcia Torres
A Ghaffar
A Giuffrida
A Gonzalez-Martinez
A González-Crespo
A Guner
A H Amphlett
A H Y Lee
A Hague
A Harikrishnan
A He
A Heaney
A Hibberd
A Higgins
A Hill
A I Tavuz
A Ibrahim
A Ilbak
A Iqbal
A Isaac
A J Ashton
A J Boulton
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A Jaitley
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Y H Tan
Y I Z Acherman
Y Kelesoglu
Y Liew
Y Maheswaran
Y N Löwensteyn
Y N Neo
Y N Suleman
Y Narang
Y P Mogan
Y R Willems
Y S Mugurtay
Y Sinha
Y Tan
Y Taşçı
Y Yalcin
Z A Saglam
Z Abbas
Z Afzal
Z Al-Nasser
Z B Ekinci
Z Gok
Z H Sam
Z H Siddiqui
Z Kazmi
Z Khonat
Z Momoh
Z O B B Soylemez
Z O Belibagli
Z P Polat
Z Parinisi
Z R Bakewell
Z S Demirci
Z Yazkan
Publication venue
Publication date: 01/01/2018
Field of study

Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data.Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results.Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49-2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46-0.75, P < 0.001) compared to normal weight patients.Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease

Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"

Safety of Nonsteroidal Anti-inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study

Author: Abbas Z
Abburu S
Abdelhadi M
Abdikadir HR
Abdulmajid A
Abid A
Abid H
Abuhussein N
Abul MH
Acquaah F
Acres M
Adams R
Adams RD
Adebayo AA
Adeleja I
Adjei H
Afzal Z
Agarwal V
Ahern N
Ahmad K
Ahmad S
Ahmed F
Ahmed H
Ahmed M
Ahmed N
Ahmed S
Ahmed S
Ahn JS
Aidoo-Micah GE
Aildasani L
Aithie JM
Akhtar S
Al-Mousawi A
Al-Obaedi O
Al-Obaedi O
Al-Robeye A
Ali A
Ali B
Ali H
Ali M
Ali S
Alizadeh M
Allan C
Allen JLY
Allot R
Allot R
Allot R
Amajuoyi A
Amin H
Amin H
Amin O
Amphlett AH
Anandarajah C
Anderson L
Anderson LB
Anderson SM
Ang A
Angelov S
Anilkumar A
Anim-Addo N
Ansari N
Antoniou I
Archer CH
Arif T
Arif T
Asbjoernsen CA
Ashfaq U
Ashken L
Ashraf S
Ashraf SF
Ashton AJ
Ashwood J
Aslanyan A
Asmadi A
Assadullah S
Atayi A
Atraszkiewicz BA
Attalla M
Austreng L
Auyoung E
Avery P
Axelson T
Aziz H
Aziz N
Baker AN
Bakewell ZR
Bakhsh A
Bakhsh A
Balaji S
Balian V
Balian V
Balian V
Bamgbose FA
Barai I
Barnes J
Barrow TR
Barthorpe AE
Bartlett J
Bartlett RD
Barton EC
Bassam N
Bassett J
Bassiony S
Bath MF
Batho A
Batt E
Bazeer HZ
Beckett J
Beecroft S
Behar N
Bell A
Bell L
Bell N
Bemand TP
Bergara T
Bernstein I
Bethell GS
Bhanderi S
Bhangu A
Bhangu A
Bhangu A
Bhaskaran G
Bhatt N
Bhatti M
Bhome R
Bhudia R
Bingham G
Blege HK
Blessed R
Bloomer J
Bloomfield T
Blore CD
Bolton L
Bolton W
Bonsu S
Bookless LR
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Botchey S
Boulton AJ
Boxall N
Boyle J
Braganza L
Brathwaite-Shirley C
Bravo M
Brecher J
Bremner RH
Brennan C
Brennan E
Brennan K
Brent G
Brewer CF
Brewster O
Bright M
Brown D
Brown E
Brown E
Brown EJ
Brown FS
Broyd A
Brzyska K
Buakuma P
Buchan AM
Buckle RT
Bucko AM
Bulley F
Bullman LM
Bullock NP
Burgess A
Burke D
Burke D
Burke E
Burke J
Burney LJ
Callan R
Campbell J
Canning E
Canning N
Cao Y
Cardwell AE
Carr L
Carr R
Carroll AF
Carter D
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Chamberlain M
Chan C
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Chapman SJ
Charalambos MA
Charalambous G
Charania A
Charavanamuttu V
Chaudhary M
Chaudhry FI
Chaudhry WW
Cheema H
Chen JH
Chen M
Chen X
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Chervenkoff J
Cheskes L
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Chew L
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Chhabra A
Chhina C
Chilima CP
Chillarge G
Chilvers NJ
Chin H
Chin R
Chisholm EG
Chitnis AR
Chiu SM
Chong BF
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Chrastek D
Chua EY
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Claireaux HA
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Ziprin P
Zuhair M
Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2017
Field of study

Background Significant safety concerns remain surrounding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) following gastrointestinal surgery, leading to wide variation in their use. This study aimed to determine the safety profile of NSAIDs after major gastrointestinal surgery. Methods Consecutive patients undergoing elective or emergency abdominal surgery with a minimum one-night stay during a 3-month study period were eligible for inclusion. The administration of any NSAID within 3 days following surgery was the main independent variable. The primary outcome measure was the 30-day postoperative major complication rate, as defined by the Clavien–Dindo classification (Clavien–Dindo III–V). Propensity matching with multivariable logistic regression was used to produce odds ratios (OR) and 95 % confidence intervals. Results From 9264 patients, 23.9 % (n = 2212) received postoperative NSAIDs. The overall major complication rate was 11.5 % (n = 1067). Following propensity matching and adjustment, use of NSAIDs were not significantly associated with any increase in major complications (OR 0.90, 0.60–1.34, p = 0.560). Conclusions Early use of postoperative NSAIDs was not associated with an increase in major complications following gastrointestinal surgery

Online Research @ Cardiff

Queen Mary Research Online

Critical care usage after major gastrointestinal and liver surgery: a prospective, multicentre observational study

Author: Abbas Z.
Abburu S.
Abdelhadi M.
Abdikadir H.R.
Abdulmajid A.
Abid A.
Abid H.
Abuhussein N.
Abul M.H.
Acquaah F.
Acres M.
Adams R.
Adams R.D.
Adebayo A.A.
Adeleja I.
Adjei H.
Afzal Z.
Agarwal V.
Ahern N.
Ahmad K.
Ahmad S.
Ahmed F.
Ahmed H.
Ahmed M.
Ahmed N.
Ahmed S.
Ahn J.S.
Aidoo-Micah G.E.
Aildasani L.
Aithie J.M.
Akhtar S.
Al-Mousawi A.
Al-Obaedi O.
Al-Robeye A.
Ali A.
Ali B.
Ali H.
Ali M.
Ali S.
Alizadeh M.
Allan C.
Allen J.L.Y.
Allot R.
Amajuoyi A.
Amin H.
Amin O.
Amphlett A.H.
Anandarajah C.
Anderson L.
Anderson L.B.
Anderson S.M.
Ang A.
Angelov S.
Anilkumar A.
Anim-Addo N.
Ansari N.
Antoniou I.
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Publication venue: 'Elsevier BV'
Publication date: 01/01/2019
Field of study

Background Patient selection for critical care admission must balance patient safety with optimal resource allocation. This study aimed to determine the relationship between critical care admission, and postoperative mortality after abdominal surgery. Methods This prespecified secondary analysis of a multicentre, prospective, observational study included consecutive patients enrolled in the DISCOVER study from UK and Republic of Ireland undergoing major gastrointestinal and liver surgery between October and December 2014. The primary outcome was 30-day mortality. Multivariate logistic regression was used to explore associations between critical care admission (planned and unplanned) and mortality, and inter-centre variation in critical care admission after emergency laparotomy. Results Of 4529 patients included, 37.8% (n=1713) underwent planned critical care admissions from theatre. Some 3.1% (n=86/2816) admitted to ward-level care subsequently underwent unplanned critical care admission. Overall 30-day mortality was 2.9% (n=133/4519), and the risk-adjusted association between 30-day mortality and critical care admission was higher in unplanned [odds ratio (OR): 8.65, 95% confidence interval (CI): 3.51–19.97) than planned admissions (OR: 2.32, 95% CI: 1.43–3.85). Some 26.7% of patients (n=1210/4529) underwent emergency laparotomies. After adjustment, 49.3% (95% CI: 46.8–51.9%, P<0.001) were predicted to have planned critical care admissions, with 7% (n=10/145) of centres outside the 95% CI. Conclusions After risk adjustment, no 30-day survival benefit was identified for either planned or unplanned postoperative admissions to critical care within this cohort. This likely represents appropriate admission of the highest-risk patients. Planned admissions in selected, intermediate-risk patients may present a strategy to mitigate the risk of unplanned admission. Substantial inter-centre variation exists in planned critical care admissions after emergency laparotomies

Online Research @ Cardiff

Body mass index and complications following major gastrointestinal surgery: a prospective, international cohort study and meta-analysis.

Author: 6rhalmi J
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Mirallas Vi\uf1as O
Miranda Bh
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Mirza M
Mishra A
Mistry Bd
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Mitchell H
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Morley R
Moroni P
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O'Carroll O
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O'Connor S
O'Dwyer M
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Raji K
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Ramana A
Ramjeeawon N
Ramnarine A
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Rampulla V
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Shanahan D
Sharifpour M
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Shepherd R
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Sim P
Simioni A
Simon Frapolli V
Simpson A
Simpson R
Singagireson S
Singh B
Singh K
Singh R
Singh S
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Sinha Y
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Smith Ag
Smith Dne
Smith N
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Stanley S
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Steel M
Stein J
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Stewart Ge
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Trist Aj
Troia A
Trompetto M
Truma A
Truss A
Tsui Ay
Tulum H
Tung L
Turaga S
Turati L
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Turley H
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Turner Ejh
Turner J
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Turpan M
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Uittenbogaart M
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Unal Ag
Ungcharoen N
Uppal E
Urquhart A
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Uzun O
Uzun S
Uzunoglu Ec
Vable T
Valderrama P\ue9rez A
Valli A
Vallve-Bernal M
Van Bruggen D
van Dalen Ashm
van de Ven Awh
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van der Hoeven Ac
Van der Lubbe M
van der Pool Aem
van der Zee C
Van Dijck Wpm
van Elst Tr
van Engelenburg T
van Geloven A
Van Grevenstein Wmu
Van Heumen Tm
van Leeuwen Bl
van Rijckevorsel Vajim
van Steensel L
Van Tol Rr
van Verschuer Vmt
van Wijnbergen Jwm
Vanmali P
Varley R
Varma D
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Varo Mu\uf1oz A
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Vazquez-Gonzalez I
Veenker Cgh
Vela Polanco Ff
Vendramin E
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Verboeket B
Verma K
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Vernon Ok
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Villarejo Campos P
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Vivekanantham S
Vives-Rodriguez E
Vries Jjm
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Waldron Rm
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Warwick Hl
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Weaver R
Webb E
Weinberg D
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White U
Whitehurst K
Whitham Rdj
Whittingham H
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Wynell-Mayow Wm
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Zegeye Mi
Zengin T
Zhang Aa
Zhao J
Ziff O
Zigiotto D
Zijlmans Jl
Zimmerman D
Ziprin P
Zope S
Zuhair M
Publication venue: 'Wiley'
Publication date: 01/01/2018
Field of study

AIM: Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data. METHODS: This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. RESULTS: This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49-2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46-0.75, P < 0.001) compared to normal weight patients. CONCLUSIONS: In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease

Archivio istituzionale della ricerca - Università di Trieste

Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis

Author: Aarts E
Abbas Z
Abburu S
Abd Ghaffar Mk
Abdelgalil R
Abdelhadi M
Abdikadir Hr
Abdulmajid A
Abdulrahman N
Abid A
Abid H
Abrisqueta Carrion J
Abuhussein N
Abul Mh
Acar S
Acherman Yiz
Acquaah F
Acres M
Adams R
Adams Rd
Adebayo Aa
Adeleja I
Adiyaman C
Adjei H
Adlan A
Afzal Z
Agalar C
Agarwal V
Agrawal M
Ahern N
Ahmad A
Ahmad K
Ahmad S
Ahmed F
Ahmed H
Ahmed M
Ahmed N
Ahmed S
Ahn Js
Aidoo-Micah Ge
Aildasani L
Aithie Jm
Akbulut F
Akcaoglu T
Akdogan A
Akhtar S
Akkaya E
Akkucuk S
Akpunarli B
Aksoy K
Aktas Mk
Aktekin H
Al-Mousawi A
Al-Nasser A
Al-Nasser Z
Al-Obaedi O
Al-Robeye A
Albayrak D
Alberdi San Roman I
Alberti Delgado P
Alcazar Montero Ja
Alcocer Bp
Alconchel-Gago F
Aldrey I
Ali A
Ali B
Ali H
Ali M
Ali S
Alim Ye
Aliseda-Jover D
Alizadeh M
Aljbour A
Aljbour I
Allan C
Allen Jly
Allot R
Alonso Gonçalves S
Alonso Hernandez N
Altintas O
Altomare Df
Alvarez Reyes I
Amajuoyi A
Amarelo Garcia M
Ambrona-Zafra D
Amelung Fj
Amin H
Amin O
Amphlett Ah
Anabitarte O
Anakwenze V
Anandarajah C
Anania G
Anconelli D
Anderson L
Anderson Lb
Anderson Rgj
Anderson Sm
Ang A
Angelov S
Anilkumar A
Anim-Addo N
Ankarali T
Ansari N
Antoniou I
Anyan-Brown J
Aonzo P
Apicella M
Aquilino F
Aray E
Archer Ch
Archer M
Arcudi C
Arenal Jj
Arezzo A
Argenti F
Arif T
Arora E
Arrigo A
Arslan E
Arslan U
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Asbjoernsen Ca
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Ashraf S
Ashraf Sf
Ashton Aj
Ashwood J
Asik M
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Aslanyan A
Asma A
Asmadi A
Assadullah S
Atalay H
Atasoy H
Atayi A
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Atif M
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Attalla M
Austreng L
Auyoung E
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Baker An
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Balian V
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Bamgbose Fa
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Barmayehvar B
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Bartlett Rd
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Bartrina Soler P
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Bastiaansen Ajnm
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Bazeer Hz
Beaver D
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Belia F
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Bemand Tp
Bemelman Wa
Benevento A
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Bergara T
Bernstein I
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Besısık Hm
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Chong Bf
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Chrastek D
Chua Ey
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Ciftci E
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Copley Hc
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Costa-Navarro D
Cotton A
Coughlan G
Coulson R
Cox Se
Coyne P
Craig Ar
Craig E
Craig-McQuaide A
Craven K
Cremers D
Crewdson Ja
Croall A
Crozier L
Cruciani C
Cruz Reyes Ja
Cuckow L
Cullen C
Cullen S
Culleton G
Cumber E
Cumber Em
Cumen Ec
Cumming S
Cundy Oj
Cunha P
Curletti G
Curran A
Cuthbert G
Cymes W
Córdoba-Díaz de Laspra E
Dalci K
Danalıoglu An
Daoub A
Darr S
Das M
Datta U
Davies J
Davies Je
Davies K
Davies N
Davies Sc
Davis-Hall M
Dawar R
Dawson Pm
de Andres Olabarria U
de Bernier Gl
de Boer Dv
De Boni D
de Bruin M
de Castro Smm
de Gooyer Jm
de Groof Ej
de Groof J
de Guerre Levm
de Hingh I
de Jesus Rodriguez Perdomo M
de la Portilla de Juan F
de la Rosa-Estadella M
De la Torre Conde C
De Luca E
De Manzini N
de Mees T
De Nardi P
de Roy van Zuidewijn D
De Serra Tejada I
de Vos Tot Nederveen Cappel Rj
de Wilt H
de Zeeuw S
Deall C
Dean R
Dean S
Dean W
Dear K
Deas G
Debenham R
Decorato A
Deekonda P
Del Coco F
Del Mar López-Cuevas M
Delf J
Delgado At
Deliktas Ts
Delport A
Demetri Am
Demir F
Demirci A
Demirci K
Demirci Zs
Demirtas B
Dennis R
Dennis Yf
Derbyshire L
Detmers Blom Fpn
Devabalan Y
Devlin E
Dewdney Cj
Dhanji A
Dhar M
Dhutia Aj
Di Benedetto L
Di Girolami L
Diaper C
Diaz-Jover P
Dickson J
Din W
Dindyal S
Dinsmore L
Doan L
Dobson J
Dogan H
Dogra T
Doherty C
Dolaghan M
Dolbec Ks
Dominguez Jimenez M
Dominguez Rodriguez Lm
Dominguez Sanchez Jm
Dominguez-Prieto V
Dorman C
Dosa T
Doshi A
Doyle J
Drake Tm
Drislane C
Dronkers Wj
Dube P
Duffy A
Duinhouwer Le
Duke K
Duncumb Jw
Dunn Ce
Duran Muñoz-Cruzado Vm
Durmaz H
Durr A
Durrani B
Durán-Martínez M
Dutt S
Dušek T
Dyal Ar
Dynes K
Díaz Padillo A
Echazarreta-Gallego E
Edison Ma
Edozie F
Edwards Ja
Edwards L
Edwards S
Egan Rj
Eger M
Egerton C
Eggen Y
Ekin B
Ekinci Zb
Ekrem M
El Mabruk M
El-Atmani S
Elangovan V
Elf D
Elkatroushi T
Elkawafi M
Elliott Le
Elorza Echaniz G
Elseedawy M
Elía-Guedea M
Embury-Young Y
Empey J
Emral C
Emre Baki B
Endo Y
English W
Enriquez-Navascues Jm
Entwisle Jh
Eparh K
Eragat M
Eraifej J
Erdem S
Erdogan P
Erel T
Ergul B
Erol Hi
Eroz E
Erozgur B
Ersoy T
Ertekin C
Escalona Canal Mg
Espin-Basany E
Esposto R
Espí Macías A
Esteban Sinovas O
Esteve L
Fa Binefa M
Facchiano A
Falcon Cazas A
Fares Da
Farina V
Farmer Jd
Fasano A
Fautz T
Favero A
Favero N
Fawaz As
Fazzotta S
Fearnhead N
Fenn J
Feo C
Fergurson P
Fern J
Fernandez Nieto D
Fernandez C
Fernández-Domper L
Ferrara D
Filby Jj
Filipescu T
Firat O
Fitzgerald Je
Fitzpatrick D
Fleck R
Fletcher L
Fliers Jm
Fliers Jm
Flores Funes D
Fong J
Fontanet-Soler S
Foppa C
Forrest Pr
Forte B
Foschi D
Foster Nl
Franceschilli M
Francescon Ct
Franco Chacón M
Frank Al
Frasson M
Fulgencio Barbarin J
Fung Tmp
Gabriel J
Gaffney S
Gallagher S
Galleano R
Gallo G
Galloway E
Gandhi K
Garcia Cruz G
Garcia Florez Lj
Garcia Garcia J
Garcia Garrido M
Garcia Torres A
Garcia-Olmo D
Garcia-Perez Jm
García Galocha Jl
Gardiner N
Gardner E
Gardner H
Gaskell P
Gastel Mda
Gatfield Wa
Gauntlett L
Gavagna L
Gawria L
Gecim Ie
Geerlings M
Gentry S
George D
Geraghty Jm
Gerardi S
Gezen Ae
Ghaffar A
Ghignone F
Giacca M
Giardino Fr
Giavarini L
Gil Barrionuevo E
Gilbert H
Giles Je
Gilissen V
Gill Ck
Gill P
Gilroy D
Giordano F
Girling C
Girones J
Giuffrida A
Glasbey Jc
Glover Te
Glynn M
Goble M
Goel S
Goh Awj
Goh B
Goh Rw
Goh W
Gohil K
Gok Afk
Gok Z
Gokani S
Gokce K
Goksoy B
Gold D
Goldin E
Golding D
Golding Dm
Goldsmith T
Gommers J
Gonzalez Arribas M
Gonzalez de Chaves Pe
Gonzalez Ruiz Aa
Gonzalez-Argente Xf
Gonzalez-Martinez A
González-Crespo A
Goodier R
Gooiker Ga
Gooszen Jah
Goradia H
Gorguner F
Gorini L
Gouda P
Gouldthrope C
Govil S
Govinden S
Gozubuyuk Y
Graafland M
Graham Cj
Grandi S
Gratton R
Graus Sa
Gray L
Greenhalgh Ad
Greig Rj
Griffin Ej
Grossart Cm
Grundy L
Gubbiotti F
Guerero D
Guerra F
Guinness F
Gulati J
Guler Sa
Gunay M
Gunaydin Y
Gundogan B
Guner A
Gupta V
Gursoy F
Guzel M
Gwozdz Am
Gómez-López de San Román C
Güven H
Hacioglu Ad
Hacking S
Hague A
Hameed M
Hanrahan M
Haq H
Harbhajan Singh Gs
Hardaman B
Harder G
Hardie J
Harding F
Hardy Mr
Harikrishnan A
Harms J
Harries P
Harris Aj
Harris Ln
Harris Rt
Harrison Em
Harrison Plm
Hartley J
Hartley S
Harvey J
Hassan S
Hayat J
Hayat M
Hayat U
Hayes Jdb
Hazenberg P
He A
Healy L
Heaney A
Heath H
Heathcote E
Heer Rs
Heesakkers H
Heiloo S
Heminway R
Henderson C
Henderson I
Henderson La
Heneghan H
Hengeveld E
Henson Ad
Heppenstall-Harris G
Herken M
Hernandez Kakauridze S
Hernandez Ros Mi
Hernandez-Lizoáin Jl
Hernon J
Herron J
Heskin J
Hester E
Hewitt Cm
Heywood E
Heywood Eg
Hibberd A
Hickling Sl
Hidalgo Pujol M
Hidding E
Higgins A
Higgins P
Higgs L
Hill A
Hill F
Hindle Fisher I
Hirani S
Hirst F
Hitchen N
Ho S
Ho W
Hoban Ka
Hoffman Rpc
Hogendoorn W
Holliday Rbs
Holloway C
Holmes C
Holmes Mjv
Holton P
Holyoak H
Home J
Horgan Pg
Horne L
Horst C
Horth D
Hoskins Tc
Hourston Gjm
Howard James N
Howells L
Hu L
Huang Hc
Hudson-Phillips S
Hughes Ba
Hughes F
Hughes Rk
Hulley K
Hung G
Hurný M
Hurst Pc
Huseynova S
Husnoo Sb
Hussain N
Hussain O
Hutchings I
Huzmeli E
Ibrahim A
Ibrahim I
Ilbak A
Inci Et
Ingham R
Ingram E
Innocenti P
Iorga R
Iqbal A
Iqbal S
Isaac A
Isler Vc
Iyer S
Jackson Hr
Jackson S
Jacob L
Jafree Dj
Jaitley A
Jalota P
Jamal N
Janssen Tl
Jaroš J
Jathanna N
Jawad As
Jayakody N
Jenkin Sl
Jenvey C
Jewell Pd
Jeyabraba S
Jhala H
Jimenez Escovar F
Jimenez-Gomez Lm
Jimenez-Segovia M
Jiménez-Morillas P
Jiménez-Viñas C
Jindal A
Johnston A
Johnston J
Johnstone M
Jones Cs
Jong N
Jordan Hem
Joshi D
Joshi Kr
Joyce Hl
Joyner C
Jubainville Cl
Jull P
Jurgens J
Kabariti R
Kadicheeni M
Kahar A
Kakil E
Kalra N
Kamarajah Sk
Kanabar S
Kane T
Kankam Hkn
Kara B
Kara C
Kara E
Karabacak U
Karabulut E
Karahan B
Karia M
Karia P
Karsan Rb
Karunakaran P
Karásek D
Kasap S
Kasar P
Kaushal A
Kaya A
Kayacan S
Kayaci Durak M
Kazmi Z
Keane Cp
Keane N
Keane P
Kee Jy
Keeling Re
Keelty N
Keevil H
Kelesoglu Y
Kelly M
Kelly Me
Kelly N
Kennedy Ed
Kennedy Hr
Kerai A
Kerimova N
Kerin Mj
Kerr Al
Keyif Mf
Khaing Ph
Khajuria A
Khalid H
Khan A
Khan I
Khan M
Khan S
Khan T
Khan U
Khangura J
Khanijau R
Khatri C
Khattak M
Khetarpal Aa
Khokhar Ha
Khonat Z
Khonsari P
Kiely A
Kiff R
Kilic E
Kilinc C
Kim Jw
Kim S
Kimani L
King M
Kip M
Kishore A
Kisyov I
Kitt H
Kleine E
Klinkert M
Kloppenberg Fwh
Knight Cl
Kobal Bb
Koc Ge
Kocapinar S
Kocer Md
Koksal G
Koksal S
Kong C
Kong Cy
Konsten J
Kopac O
Koppe M
Kosasih Sr
Koshy Rm
Kotecha D
Koumpa F
Kow K
Koysombat K
Koç F
Koç M
Kreibich A
Kretzmer L
Kucukdiler E
Kuiper J
Kuiper Sz
Kullac S
Kumar An
Kumaran G
Kurklu O
Kurt A
Kuzey A
Kwan Ml
Kwang P
Laguna Román S
Lakhani M
Lakhani Sm
Lakshmipathy G
Lalor P
Lamont J
Langenhoff B
Lankage Cm
Lap Cr
Larotonda C
Laterza V
Latras-Cortés I
Laurino A
Lavery J
Lazenby D
Leafe O
Ledsam A
Lee Ahy
Lee J
Lee S
Lees Dm
Lek C
Leong S
Leslie Ke
Leung W
Leventoglu S
Lewis T
Li Hi Shing S
Li Mm
Li N
Licari L
Liew W
Liew Y
Lim Ae
Lim D
Lim E
Lim J
Lim K
Lim S
Lim Sj
Linton A
Liu C
Liu S
Livesey A
Lo Secco G
Lo T
Lockey Jw
Logan Ae
Loke W
Long F
Long K
Longstaff L
Loo J
Looijen Rc
Lopes S
Lopez Garcia Mc
Lopez G
Lotfallah A
Lou Cn
Loughran D
Loveday J
Low Jyl
Lowe R
Lu Q
Lua Boon Xuan J
Lucas de Carvalho J
Luehrman A
Luhishi A
Lujan Mompean Ja
Luk Cy
Lunawat S
Lwin Kn
Lykoudis Pm
Lynch As
Lynne S
Lyons A
Lyons R
López-Mármol R
López-Vendrell L
Löwensteyn Yn
Maamari R
Maan Ds
Macaskill A
Macdonald A
Macdonald J
Machačová A
Mackin S
Maclennan D
Magnoli M
Mah J
Mahboob S
Mahesh S
Maheswaran Y
Mahmood J
Majid S
Major C
Malaj M
Malak M
Malik A
Mallick S
Malys Mk
Manson R
Mansoor S
Manvydas V
Maple N
Marchal St
Marchese N
Marcos Rodrigo A
Mariani F
Markham Rm
Marsden M
Marsh A
Marsh L
Marshall Dc
Marti Gelonch L
Martin Morales E
Martin Al
Martin R
Martinez Diaz Jm
Martinez Rios Ce
Martorana M
Martí Fernández Rm
Martínez Chillarón E
Maru D
Mason Jd
Masood M
Mastan A
Mastandrea Bonaviri Gn
Mate-Mate P
Matheson J
Matthams J
Matthews Bw
Matthews Jh
Mauro D
Maxwell-Armstrong C
Mayes Jw
Mazan K
Mazumdar E
Mcaleer E
Mcaleer S
Mcallister R
Mcauley D
Mcbride A
Mccabe G
Mccance E
Mccann M
Mcclymont Lf
Mccormack Dr
Mccrann C
Mcdowell M
Mcenhill Pm
Mcfarlane H
Mcgalliard Rj
Mcgarrigle C
Mcgarvie S
Mcgenity C
Mcgowan C
Mcgrath A
Mcgregor Rj
Mcintyre Cj
Mckean E
Mckelvey Ll
Mckerr Cn
Mckevitt Kl
Mclaughin C
Mclean Rc
Mclure Sw
Mcmenamin M
Mcmullan R
Mcnamee L
Mcrobbie Hd
Medina-Fernández Fj
Meek J
Mehdi A
Mehta Jk
Meijerink Wjhj
Menduni N
Menon A
Mensink G
Mericliler M
Mermer S
Messina F
Mestres Petit N
Metcalf P
Mian A
Milana F
Milazzo Lf
Millan M
Mills Ed
Mills H
Mills M
Milne S
Minhas M
Mirallas Viñas O
Miranda Bh
Mirdavoudi V
Mirza M
Mishra A
Mistry Bd
Mistry S
Mitchell H
Mitha N
Mithrakumar P
Mitrasinovic S
Mittapalli D
Mitxelena Elosegi L
Mizan Sr
Mogan Yp
Mohamed Us
Mohamud M
Mohan K
Mohan M
Mohite A
Momoh Z
Montanelli P
Montuori M
Monzonis Hernandez X
Moody N
Moon Rdc
Moradzadeh J
Moran D
Morandi V
Moratilla Lapeña L
Morgan C
Morgan F
Morino M
Morley R
Moroni P
Morris F
Morris S
Morrison Cj
Morrison P
Mortimer A
Morton D
Mosterd Cm
Mugurtay Ys
Mulder Im
Muller S
Mural-Krishnan S
Muriel P
Murkin C
Muro M
Murphy L
Murray Se
Murtaza A
Murtaza Mi
Mushtaq J
Mustafa S
Musters Gd
Mutlu B
Mutlu D
Myers L
Naccari P
Naccari Pm
Nachiappan R
Nadanakumaran K
Naqib S
Narain A
Naran P
Narang Y
Narayan P
Narramore R
Narwani V
Navayogaarajah V
Naveed H
Nayee H
Neary A
Nehikhare I
Nelaj S
Nelli T
Neo Yn
Neophytou C
Nepogodiev D
Nesargikar Pn
Ng Ayl
Ng Gs
Ng Jck
Ng Jq
Ng K
Ng L
Ng S
Ngaage M
Nicholls K
Nixon G
Noone Tm
Norris Jm
North As
Norton J
Nota Clma
Notarnicola M
Ntala C
O'Bryan M
O'Byrne L
O'Carroll O
O'Connell C
O'Connor A
O'Connor S
O'Dwyer M
O'Flynn Ld
O'Kane A
O'Loughlin Ra
O'Neill Em
O'Neill S
O'Reilly D
O'Sullivan Da
O'Sullivan H
O'Sullivan K
Oakley T
Obute Rd
Odeleye A
Ogunleye O
Olivier J
Omar A
Omara S
Omer Hm
Onar D
Oncel M
Ong Kk
Onsal U
Oostendorp Se
Oremule B
Orhalmi J
Orhan K
Osei-Kuffour D
Osman S
Oudman Ts
Oun H
Owasil R
Owczarek S
Ozbalci Gs
Ozben V
Ozgencil B
Ozmen Bb
Ozsipahi Ac
Padilla Valverde D
Paine Hr
Pal S
Palanivail N
Palkhi E
Pallara E
Palmer C
Palmieri A
Palmisano S
Palos Campos Mc
Palyzová H
Pandey A
Pandey G
Pando Ruiz B
Pang G
Pantalone Mr
Paolo G
Papandrea M
Papazachariou Sk
Parajo A
Paraoan V
Parimli H
Parinisi Z
Park Jh
Parker J
Parker O
Parkin J
Parmar E
Parsons S
Parthiban S
Pasquali S
Pasqualoni M
Pastor-Riquelme P
Pata F
Patel B
Patel Ba
Patel By
Patel Jb
Patel K
Patel M
Patel N
Patel P
Patel S
Patel T
Patel V
Pattapola V
Patturelli M
Paul J
Pearce J
Pearse Rj
Peck Fs
Pehlivan M
Peinado Iribar B
Pektas Am
Pellino G
Perera M
Perez Arias H
Perez Costoya C
Perez Febles M
Perez Jl
Perez-Gandara B
Pericleous A
Peroos S
Perrotta G
Persiani R
Pesser N
Peters M
Petra H
Petrarca M
Petrov G
Pezas Tp
Pezzuto R
Phan Pn
Phillips C
Picciariello A
Pickard J
Pietrabissa A
Pike G
Pineño-Flores C
Pinkney Td
Pinto R
Piquet A
Piraliyev E
Piran G
Pistola I
Pitts-Tucker T
Pizzolato A
Pla Seró S
Player C
Plomer-Sanchez M
Poacher A
Poelman M
Polat F
Polat Zp
Ponweera A
Poo Sx
Pope S
Portugal Porras V
Posada M
Posteki G
Poyato Nuñez Fj
Prabhudesai A
Prado Perez R
Prakash E
Preece R
Prest-Smith J
Priani P
Priestland R
Prieto-Nieto Mi
Pronk A
Protti Ruiz Gp
Prys-Jones O
Ptacek Ib
Puan L
Puccioni C
Pujol-Cano N
Pulpito S
Punj R
Punjabi N
Pös M
Qamar Ma
Quill S
Quinn K
Qureshi A
Qureshi S
Qureshi U
Rabinthiran S
Radotra A
Rafiq Nm
Raghuvir V
Raghvani T
Rahmee Cns
Raimondi P
Raina V
Rajan N
Raji K
Rakhimov I
Raman Kp
Ramana A
Ramjeeawon N
Ramnarine A
Rampal R
Rampulla V
Ramsay N
Ramtoola T
Randisi B
Rangan T
Rangedara A
Raphael M
Rashid M
Rashid S
Rasiah Mg
Ratnakumaran R
Rattan G
Ratu Sg
Raurich-Leandro J
Raut P
Reakes T
Realis Luc A
Redgrave Na
Redmond A
Reed A
Reeder C
Reehal Rs
Rees C
Rees S
Reeves T
Reggiani L
Reid Kg
Reid Nb
Reid R
Rejayee M
Remedios J
Remore Lm
Reynolds J
Rhema Ia
Ribbink Me
Ridgway P
Rinkoff S
Ripa M
Riva L
Riva M
Rizzi A
Rob T
Roberts Aw
Roberts C
Roberts Ej
Roberts Hf
Robertson Dt
Robertson Kl
Robertson V
Robinson C
Robinson M
Robson J
Rocco I
Roche D
Rocke As
Rodrigues Silva K
Rodriguez Garcia R
Rogers Je
Rogers S
Rojoa D
Romano F
Romeo F
Romero-Simó M
Rookes Cw
Roquet Puigneró E
Rosati G
Rosati R
Rosen O'Sullivan H
Ross H
Ross T
Rossi E
Rothwell L
Roura J
Roy Csd
Rubbini M
Rubio-Perez I
Ruiz Montesinos I
Ruiz Em
Russell G
Ryan M
Saat Mi
Sabine Lm
Sacco R
Sagar R
Saglam Za
Sagmeister M
Sahathevan A
Sahin A
Sait Ms
Sajjad U
Sakman G
Salam Gj
Salamone G
Salazar-García C
Sale T
Salem M
Salih Ae
Salman M
Salmon D
Sam Zh
Sammarco G
Sampietro G
San Martín Bragado M
Sanchez Cambronero M
Sanchez A
Sanchez-Guillen L
Sanders Ja
Sandhu Kk
Sandhu S
Sandison L
Sangal P
Santocchi P
Sanz Ortega G
Sapci I
Saraceno F
Sari V
Sartori A
Sarvanandan T
Sarwar S
Sasapu K
Satterthwaite L
Schasfoort Ra
Schiphorst A
Schizas A
Schmidt Pa
Schofield E
Schok T
Schulz Tm
Schulzová M
Scotcher Se
Seager E
Sebaoui S
Secilmis E
Sedee Wja
Seedat M
Segall E
Segura-Sampedro Jj
Sellathurai J
Selvachandran H
Selvaggi F
Selvaggi L
Semana Ad
Semiz A
Semnani Sa
Semple E
Sen Ay
Sena-Ruiz F
Senay Bb
Seneviratne N
Sengul N
Sensi B
Senturk E
Sethi Rk
Sette M
Seyhan U
Seyrek N
Sgroi G
Sgrò A
Shafi Ama
Shafiq Nm
Shah A
Shah Jp
Shah R
Shah S
Shaheen H
Shahid S
Shahidi S
Shakweh E
Shamsul Badrin Ak
Shanahan D
Sharifpour M
Sharma Khatiwada A
Shatkar V
Shaunak R
Sheikh Imi
Sheldon A
Shepherd P
Shepherd R
Sherif Ma
Sherliker Gxj
Sheth S
Shoa M
Shufflebotham H
Shuker Ba
Shukla A
Shumon S
Shurovi B
Shurovi Bn
Shuttleworth Rh
Sica G
Siddiqui M
Siddiqui Zh
Sii S
Sim D
Sim Nk
Sim P
Simioni A
Simon Frapolli V
Simpson A
Simpson R
Singagireson S
Singh B
Singh K
Singh R
Singh S
Sinha A
Sinha Y
Sirakaya M
Sitta O
Sivrikaya T
Skalamera I
Slade R
Slieker Fjb
Smart Nj
Smeets Hj
Smet M
Smith Acd
Smith Ag
Smith Dne
Smith N
Smolák P
Sng S
Soldevila-Verdeguer C
Soo Yh
Soon Wc
Sorah T
Soria Aledo V
Sotona O
Soylemez Zobb
Sozuer Em
Spence O
Spencer T
Spijkerman R
Springford Lr
Sproule L
Sreh A
Srikantharajah M
Sritharan P
Staderini F
Stanger Sa
Stanley Gh
Stanley S
Stassen Lps
Stather Pw
Steccanella F
Stechman M
Steel M
Stein J
Stellingwerf Me
Steup Wh
Stevens S
Stewart Ge
Stezaker S
Stijns Rch
Stoddart Mt
Stokes S
Stone Ej
Stott Gd
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Ter Bruggen Ffja
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Van Bruggen D
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van der Pool Aem
van der Zee C
Van Dijck Wpm
van Elst Tr
van Engelenburg T
van Geloven A
Van Grevenstein Wmu
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van Leeuwen Bl
van Rijckevorsel Vajim
van Steensel L
Van Tol Rr
van Verschuer Vmt
van Wijnbergen Jwm
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Varma D
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Xiao C
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Yilmaz I
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Yilmaz T
Yim N
Yoganathan S
Yong Cs
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Yoruk I
Yousif A
Yow L
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Yuksek B
Yuksek Ma
Yuksel A
Yurdaor Ss
Yurekli Am
Zaidi R
Zegeye Mi
Zengin T
Zhang Aa
Zhao J
Ziff O
Zigiotto D
Zijlmans Jl
Zimmerman D
Ziprin P
Zope S
Zuhair M
Örhalmi J
Özkan Bb
Šimáčková B
Široká M
Žebrák R
Publication venue: 'Wiley'
Publication date: 01/01/2018
Field of study

Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien\u2013Dindo Grades III\u2013V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49\u20132.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46\u20130.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease

Archivio istituzionale della ricerca - Università di Trieste

PubliCatt

Florence Research

Archivio istituzionale della ricerca - Università dell'Insubria

Archivio istituzionale della ricerca - Università di Ferrara

ART

Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"

Archivio istituzionale della ricerca - Università di Palermo

Body mass index and complications following major gastrointestinal surgery: a prospective, international cohort study and meta-analysis

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Abbas Z.
Abburu S.
Abd Ghaffar M.K.
Abdelgalil R.
Abdelhadi M.
Abdikadir H.R.
Abdulmajid A.
Abdulrahman N.
Abid A.
Abid H.
Abrisqueta Carrion J.
Abuhussein N.
Abul M.H.
Acar S.
Acherman Y.I.Z.
Acquaah F.
Acres M.
Adams R.
Adams R.D.
Adebayo A.A.
Adeleja I.
Adiyaman C.
Adjei H.
Adlan A.
Afzal Z.
Agalar C.
Agarwal V.
Agrawal M.
Ahern N.
Ahmad A.
Ahmad K.
Ahmad S.
Ahmed F.
Ahmed H.
Ahmed M.
Ahmed N.
Ahmed S.
Ahn J.S.
Aidoo-Micah G.E.
Aildasani L.
Aithie J.M.
Akbulut F.
Akcaoglu T.
Akdogan A.
Akhtar S.
Akkaya E.
Akkucuk S.
Akpunarli B.
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Aktekin H.
Al-Mousawi A.
Al-Nasser A.
Al-Nasser Z.
Al-Obaedi O.
Al-Robeye A.
Albayrak D.
Alberdi San Roman I.
Alberti Delgado P.
Alcazar Montero J.A.
Alcocer B.P.
Alconchel-Gago F.
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Alizadeh M.
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Publication venue
Publication date: 01/01/2018
Field of study

Aim: Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data. Methods: This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results: This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49-2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46-0.75, P < 0.001) compared to normal weight patients. Conclusions: In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease

Archivio Istituzionale della Ricerca- Università del Salento

Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis

Author: Aarts E.
Abbas Z.
Abburu S.
Abd Ghaffar M.K.
Abdelgalil R.
Abdelhadi M.
Abdikadir H.R.
Abdulmajid A.
Abdulrahman N.
Abid A.
Abid H.
Abrisqueta Carrion J.
Abuhussein N.
Abul M.H.
Acar S.
Acherman Y.I.Z.
Acquaah F.
Acres M.
Adams R.
Adams R.D.
Adebayo A.A.
Adeleja I.
Adiyaman C.
Adjei H.
Adlan A.
Afzal Z.
Agalar C.
Agarwal V.
Agrawal M.
Ahern N.
Ahmad A.
Ahmad K.
Ahmad S.
Ahmed F.
Ahmed H.
Ahmed M.
Ahmed N.
Ahmed S.
Ahn J.S.
Aidoo-Micah G.E.
Aildasani L.
Aithie J.M.
Akbulut F.
Akcaoglu T.
Akdogan A.
Akhtar S.
Akkaya E.
Akkucuk S.
Akpunarli B.
Aksoy K.
Aktas M.K.
Aktekin H.
Al-Mousawi A.
Al-Nasser A.
Al-Nasser Z.
Al-Obaedi O.
Al-Robeye A.
Albayrak D.
Alberdi San Roman I.
Alberti Delgado P.
Alcazar Montero J.A.
Alcocer B.P.
Alconchel-Gago F.
Aldrey I.
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Alizadeh M.
Aljbour A.
Aljbour I.
Allan C.
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Alonso Hernandez N.
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Alvarez Reyes I.
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van Engelenburg T.
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Van Grevenstein W.M.U.
Van Heumen T.M.
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Vernon O.K.
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Vithanage N.A.
Vivekanantham S.
Vives-Rodriguez E.
Viñas-Salas J.
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Waldron R.M.
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Wilson R.
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Wynell-Mayow W.M.
Xiao C.
Xu G.X.
Xylas D.
Yalcin Y.
Yaman S.
Yan A.
Yang T.
Yasar C.
Yates J.A.
Yauw S.
Yavuz G.
Yazkan Z.
Yekenkurul E.
Yener A.
Yeoh T.S.L.
Yetiskin E.
Yıgman S.
Yildirim N.
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Yildiz S.S.
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Yilmaz I.
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Yilmaz T.
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Yoganathan S.
Yong C.S.
Yong N.
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Yousif A.
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Yurdaor S.S.
Yurekli A.M.
Zaidi R.
Zegeye M.I.
Zengin T.
Zhang A.A.
Zhao J.
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Zigiotto D.
Zijlmans J.L.
Zimmerman D.
Ziprin P.
Zope S.
Zuhair M.
Örhalmi J.
Örhalmi J.
Özkan B.B.
Šimáčková B.
Široká M.
Žebrák R.
Publication venue
Publication date: 01/08/2018
Field of study

Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien–Dindo Grades III–V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49–2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46–0.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease

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