Survival of the Likeliest?

This feature explores how the laws of thermodynamics to explain natural selection and life itself

Discovering Two New Solo Works for Trombone: A History, Summary, and Preparation of Frank Gulino’s Sonata No. 1: The Journey, and Joseph Buono’s Elegy for Trombone and Piano

This paper will serve as a guide to musicians for the preparation and performance of two recent solo compositions for trombone worthy of study and performance: Frank Gulino’s Sonata No. 1: The Journey (2019) and Joseph Buono’s Elegy for Trombone and Piano (2016). Included will be sections or chapters on the history and background of each work, biographical information about each composer, a detailed performer’s analysis of each work, exclusive interviews with the composers, and interviews with the trombonists who commissioned and/or premiered each work. Each individual interview will provide insight into the music, including information on personal inspirations and compositional processes, a focus on emotional content, thematic elements, and recommendations on preparing each piece. Recital programming suggestions have also been included. The pieces examined warrant serious study and performance, and this paper will inform future preparations of these two works

An Empirical Investigation of Factors Influencing Knowledge Management System Success

Knowledge has been viewed as a critical component for organizations. Consequently, organizations implement Knowledge Management Systems (KMSs) to seek competitive advantages, but they may encounter mixed results. This research draws on previous information system and knowledge management system success-related literature and selects eight factors that are believed to be critical for the successful implementation of a KMS. These factors were derived through a literature search of current KMS success-related literature. The purpose of this study is to identify factors that could have a clear influence on the development and implementation of KMSs. The study presents the empirical examination of a theoretical model of KMS success for predicting system use by law enforcement officers. The research findings were accomplished through a validated questionnaire that surveyed 10 law enforcement officers from various agencies. These results contribute to the literature by empirically supporting the hypothesized relationships between identified success factors and KMS success. Though limited in sample size, this research can serve as a foundation for future studies, which can help identify other factors critical for KMS success. The comprehensive model can be used to undertake further research and thus add value to knowledge management system-based literature. In addition to its theoretical contributions, the study also presents important practical implications through the identification of specific infrastructure capabilities leading to KMS success

All-cause and liver-related mortality risk factors in excessive drinkers: Analysis of data from the UK biobank

BACKGROUND High alcohol intake is associated with increased mortality. We aimed to identify factors affecting mortality in people drinking extreme amounts of alcohol. METHODS We obtained information from the UK Biobank on approximately 500,000 participants aged 40-70 years at baseline assessment in 2006-2010. Habitual alcohol intake, lifestyle and physiological data, laboratory test results, and hospital diagnoses and death certificate data (to June 2020) for 5136 men (2.20% of male participants) and 1504 women (0.60%) who reported consuming ≥80 or ≥50 g/day, respectively, were used in survival analysis. RESULTS Mortality hazard ratios for these excessive drinkers, compared to all other participants, were 2.02 (95% CI 1.89-2.17) for all causes, 1.89 (1.69-2.12) for any cancer, 1.87 (1.61-2.17) for any circulatory disease, and 9.40 (7.00-12.64) for any liver disease. Liver disease diagnosis or abnormal liver function tests predicted not only deaths attributed to liver disease but also those from cancers or circulatory diseases. Mortality among excessive drinkers was also associated with quantitative alcohol intake; diagnosed alcohol dependence, harmful use, or withdrawal syndrome; and current smoking at assessment. CONCLUSIONS People with chronic excessive alcohol intake experience decreased average survival, but there is substantial variation in their mortality, with liver abnormality and alcohol dependence or other alcohol use disorders associated with a worse prognosis. Clinically, patients with these risk factors and high alcohol intake should be considered for early or intensive management. Research can usefully focus on the factors predisposing to dependence or liver abnormality

On the spectrum G of a locally compact group G

Separation properties of the Fell topology, on the spectrum G of a locally compact group G, characterize important properties of G. We will develop three equivalent ways to describe the Fell topology on the spectrum  of any C* algebra A. Specifically, we show that both the relative weak*-topology on P(A), the set of pure states of A, and the Jacobson topology on Prim(A), the set of all primative ideals on A, can be mapped onto  so that both topologies agree with the Fell topology. We will also study the correspondences, both between the set of strongly continuous unitary representations of G and the irreducible representations of the group C*-algebra G*(G), and between the continuous functions of positive type on G and the set of pure states of G*(G). As well, we give a survey of results outlining the characterization of G by simple separation properties of the Fell topology on G

Development of deactivation of the default-mode network during episodic memory formation

Task-induced deactivation of the default-mode network (DMN) has been associated in adults with successful episodic memory formation, possibly as a mechanism to focus allocation of mental resources for successful encoding of external stimuli. We investigated developmental changes of deactivation of the DMN (posterior cingulate, medial prefrontal, and bilateral lateral parietal cortices) during episodic memory formation in children, adolescents, and young adults (ages 8–24), who studied scenes during functional magnetic resonance imaging (fMRI). Recognition memory improved with age. We defined DMN regions of interest from a different sample of participants with the same age range, using resting-state fMRI. In adults, there was greater deactivation of the DMN for scenes that were later remembered than scenes that were later forgotten. In children, deactivation of the default-network did not differ reliably between scenes that were later remembered or forgotten. Adolescents exhibited a pattern of activation intermediate to that of children and adults. The hippocampal region, often considered part of the DMN, showed a functional dissociation with the rest of the DMN by exhibiting increased activation for later remembered than later forgotten scene that was similar across age groups. These findings suggest that development of memory ability from childhood through adulthood may involve increased deactivation of the neocortical DMN during learning

Mitochondria as Nutritional Targets to Maintain Muscle Health and Physical Function During Ageing.

The age-related loss of skeletal muscle mass and physical function leads to a loss of independence and an increased reliance on health-care. Mitochondria are crucial in the aetiology of sarcopenia and have been identified as key targets for interventions that can attenuate declines in physical capacity. Exercise training is a primary intervention that reduces many of the deleterious effects of ageing in skeletal muscle quality and function. However, habitual levels of physical activity decline with age, making it necessary to implement adjunct treatments to maintain skeletal muscle mitochondrial health and physical function. This review provides an overview of the effects of ageing and exercise training on human skeletal muscle mitochondria and considers several supplements that have plausible mechanistic underpinning to improve physical function in ageing through their interactions with mitochondria. Several supplements, including MitoQ, urolithin A, omega-3 polyunsaturated fatty acids (n3-PUFAs), and a combination of glycine and N-acetylcysteine (GlyNAC) can improve physical function in older individuals through a variety of inter-dependent mechanisms including increases in mitochondrial biogenesis and energetics, decreases in mitochondrial reactive oxygen species emission and oxidative damage, and improvements in mitochondrial quality control. While there is evidence that some nicotinamide adenine dinucleotide precursors can improve physical function in older individuals, such an outcome seems unrelated to and independent of changes in skeletal muscle mitochondrial function. Future research should investigate the safety and efficacy of compounds that can improve skeletal muscle health in preclinical models through mechanisms involving mitochondria, such as mitochondrial-derived peptides and mitochondrial uncouplers, with a view to extending the human health-span