Correlation studies on surface particle detection methods

The accurate determination of dust levels on optical surfaces is necessary to assess sensor system performance. A comparison study was made on several particle measurement methods including those based on direct imaging and light scattering. The effectiveness of removing the particles from the surface prior to determining particle size distributions was also assessed. These studies revealed that some methods, especially those requiring particle removal before analysis, are subject to large systematic errors affecting particle size distributions. Thus, an understanding of the particle measurement methods employed is necessary before any surface cleanliness or obstruction value assignments are accepted as true representations of an optical surface contamination condition

Simulation of rapid startup in microwave magnetrons with azimuthally varying axial magnetic fields

A method is proposed whereby the startup of a magnetron may be hastened. For a N-cavity magnetron operating in the pi mode, the formation of the N/2 electron spokes is much more rapid when an azimuthally varying axial magnetic field of N/2 periodicity is employed. Electromagnetic particle-in-cell code simulations are presented that show electron prebunching by the azimuthally varying axial magnetic field, long before the pi mode is excited. © 2004 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70412/2/APPLAB-84-6-1016-1.pd

Cathode priming of a relativistic magnetron

A cathode priming technique of a relativistic magnetron is analyzed via a three-dimensional particle-in-cell simulation. By imposing a threefold azimuthal variation on the emitting cathode of a six-cavity relativistic magnetron, the electrons are prebunched at birth. This leads to fast startup of the pi mode with three electron spokes. Suppression of unwanted modes during startup is observed in the simulation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70492/2/APPLAB-85-26-6332-1.pd

Modeling and experimental studies of magnetron injection locking

A phase-locking model has been developed from circuit theory to qualitatively explain the various regimes observed in magnetron injection-locking experiments. The experiments utilize two continuous-wave oven magnetrons: one functions as an oscillator and the other as a driver. The model includes both magnetron-specific electronic conductance and frequency-pulling parameter. Both time and frequency domain solutions are developed from the model, allowing investigations into the growth and saturation as well as the frequency response of the output signal. This simplified model recovers qualitatively many of the phase-locking frequency characteristics observed in the experiments.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87313/2/114903_1.pd

Magnetron priming by multiple cathodes

A relativistic magnetron priming technique using multiple cathodes is simulated with a three-dimensional, fully electromagnetic, particle-in-cell code. This technique is based on electron emission from N/2N∕2 individual cathodes in an NN-cavity magnetron to prime the ππ mode. In the case of the six-cavity relativistic magnetron, ππ-mode start-oscillation times are reduced up to a factor of 4, and mode competition is suppressed. Most significantly, the highest microwave field power is observed by utilizing three cathodes compared to other recently explored priming techniques.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87840/2/081501_1.pd

Projection ablation lithography cathode for high-current, relativistic magnetron

Initial results are presented of an innovative cathode operating in a relativistic magnetron powered by an accelerator with parameters: −0.3 MV−0.3MV, 1–10 kA1–10kA, and 0.5 μs0.5μs pulse length. This cathode is fabricated by ablating a pattern on the cathode using a KrF laser. This projection ablation lithography (PAL) cathode has demonstrated fast current turn-on and microwave startup times have decreased from an average of 193 to 118 ns193to118ns. The pulselength of 1 GHz1GHz microwave oscillation has increased from a 144 ns144ns average to 217 ns217ns. With these improvements in microwave startup and pulse length, the microwave power has approximately remained the same compared to the previously used cloth cathodes. A new triple-azimuthal emission region is tested as means of prebunching the electrons (“cathode priming”) into the three spokes desired for pi mode operation in a six-cavity magnetron. The Tri-PAL cathode priming results in the fastest startup and highest efficiency of relativistic magnetron microwave generation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70745/2/RSINAK-75-9-2976-1.pd

Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D

<p>Abstract</p> <p>Background</p> <p>Surfactant protein D (SP-D) plays an important role in innate defense against influenza A viruses (IAVs) and other pathogens.</p> <p>Methods</p> <p>We tested antiviral activities of recombinant human SP-D against a panel of IAV strains that vary in glycosylation sites on their hemagglutinin (HA). For these experiments a recombinant version of human SP-D of the Met11, Ala160 genotype was used after it was characterized biochemically and structurally.</p> <p>Results</p> <p>Oligosaccharides at amino acid 165 on the HA in the H3N2 subtype and 104 in the H1N1 subtype are absent in collectin-resistant strains developed <it>in vitro </it>and are important for mediating antiviral activity of SP-D; however, other glycans on the HA of these viral subtypes also are involved in inhibition by SP-D. H3N2 strains obtained shortly after introduction into the human population were largely resistant to SP-D, despite having the glycan at 165. H3N2 strains have become steadily more sensitive to SP-D over time in the human population, in association with addition of other glycans to the head region of the HA. In contrast, H1N1 strains were most sensitive in the 1970s–1980s and more recent strains have become less sensitive, despite retaining the glycan at 104. Two H5N1 strains were also resistant to inhibition by SP-D. By comparing sites of glycan attachment on sensitive vs. resistant strains, specific glycan sites on the head domain of the HA are implicated as important for inhibition by SP-D. Molecular modeling of the glycan attachment sites on HA and the carbohydrate recognition domain of SPD are consistent with these observations.</p> <p>Conclusion</p> <p>Inhibition by SP-D correlates with presence of several glycan attachment sites on the HA. Pandemic and avian strains appear to lack susceptibility to SP-D and this could be a contributory factor to their virulence.</p

Epidural steroid injections compared with gabapentin for lumbosacral radicular pain: multicenter randomized double blind comparative efficacy study

Objective To evaluate whether an epidural steroid injection or gabapentin is a better treatment for lumbosacral radiculopathy. Design A multicenter randomized study conducted between 2011 and 2014. Computer generated randomization was stratified by site. Patients and evaluating physicians were blinded to treatment outcomes. Settings Eight military, Veterans Administration, and civilian hospitals. Participants 145 people with lumbosacral radicular pain secondary to herniated disc or spinal stenosis for less than four years in duration and in whom leg pain is as severe or more severe than back pain. Interventions Participants received either epidural steroid injection plus placebo pills or sham injection plus gabapentin. Main outcome measures Average leg pain one and three months after the injection on a 0-10 numerical rating scale. A positive outcome was defined as a ≥2 point decrease in leg pain coupled with a positive global perceived effect. All patients had one month follow-up visits; patients whose condition improved remained blinded for their three month visit. Results There were no significant differences for the primary outcome measure at one month (mean pain score 3.3 (SD 2.6) and mean change from baseline −2.2 (SD 2.4) in epidural steroid injection group versus 3.7 (SD 2.6) and −1.7 (SD 2.6) in gabapentin group; adjusted difference 0.4, 95% confidence interval −0.3 to 1.2; P=0.25) and three months (mean pain score 3.4 (SD 2.7) and mean change from baseline −2.0 (SD 2.6) versus 3.7 (SD 2.8) and −1.6 (SD 2.7), respectively; adjusted difference 0.3, −0.5 to 1.2; P=0.43). Among secondary outcomes, one month after treatment those who received epidural steroid injection had greater reductions in worst leg pain (−3.0, SD 2.8) than those treated with gabapentin (−2.0, SD 2.9; P=0.04) and were more likely to experience a positive successful outcome (66% v 46%; number needed to treat=5.0, 95% confidence interval 2.8 to 27.0; P=0.02). At three months, there were no significant differences between treatments. Conclusions Although epidural steroid injection might provide greater benefit than gabapentin for some outcome measures, the differences are modest and are transient for most people. Trial registration ClinicalTrials.gov Identifier: NCT01495923