Realistic litz wire characterization using fast numerical simulations

The losses of realistic litz wires are characterized while explicitly accounting for their construction, using a procedure that computes the current-driven and magnetic-field-driven copper losses using fast numerical simulations. We present a case study that examines loss variation in one- and two-level litz wires as a function of twisting pitch, over a wide range of values and in small increments. Experimental confirmation is presented for predictions made by numerical simulations. Results confirm the capability and efficiency of numerical methods to provide valuable insights into the realistic construction of litz wire.MIT Energy InitiativeSingapore-MIT Allianc

Risk factors associated with Rift Valley fever epidemics in South Africa in 2008-11.

Rift Valley fever (RVF) is a zoonotic and vector-borne disease, mainly present in Africa, which represents a threat to human health, animal health and production. South Africa has experienced three major RVF epidemics (1950-51, 1973-75 and 2008-11). Due to data scarcity, no previous study has quantified risk factors associated with RVF epidemics in animals in South Africa. Using the 2008-11 epidemic datasets, a retrospective longitudinal study was conducted to identify and quantify spatial and temporal environmental factors associated with RVF incidence. Cox regressions with a Besag model to account for the spatial effects were fitted to the data. Coefficients were estimated by Bayesian inference using integrated nested Laplace approximation. An increase in vegetation density was the most important risk factor until 2010. In 2010, increased temperature was the major risk factor. In 2011, after the large 2010 epidemic wave, these associations were reversed, potentially confounded by immunity in animals, probably resulting from earlier infection and vaccination. Both vegetation density and temperature should be considered together in the development of risk management strategies. However, the crucial need for improved access to data on population at risk, animal movements and vaccine use is highlighted to improve model predictions

Cosmic microwave background snapshots: pre-WMAP and post-WMAP

Abbreviated: We highlight the remarkable evolution in the CMB power spectrum over the past few years, and in the cosmological parameters for minimal inflation models derived from it. Grand unified spectra (GUS) show pre-WMAP optimal bandpowers are in good agreement with each other and with the one-year WMAP results, which now dominate the L < 600 bands. GUS are used to determine calibrations, peak/dip locations and heights, and damping parameters. These CMB experiments significantly increased the case for accelerated expansion in the early universe (the inflationary paradigm) and at the current epoch (dark energy dominance) when they were combined with `prior' probabilities on the parameters. A minimal inflation parameter set is applied in the same way to the evolving data. Grid-based and and Monte Carlo Markov Chain methods are shown to give similar values, highly stable over time and for different prior choices, with the increasing precision best characterized by decreasing errors on uncorrelated parameter eigenmodes. After marginalizing over the other cosmic and experimental variables for a weak+LSS prior, the pre-WMAP data of Jan03 cf. the post-WMAP data of Mar03 give Omega_{tot} =1.03^{+0.05}_{-0.04} cf. 1.02^{+0.04}_{-0.03}. Adding the flat prior, n_s =0.95^{+0.07}_{-0.04} cf. 0.97^{+0.02}_{-0.02}, with < 2\sigma evidence for a log variation of n_s. The densities have concordance values. The dark energy pressure-to-density ratio is not well constrained by our weak+LSS prior, but adding SN1 gives w_Q < -0.7. We find \sigma_8 = 0.89^{+0.06}_{-0.07} cf. 0.86^{+0.04}_{-0.04}, implying a sizable SZ effect; the high L power suggest \sigma_8 \sim 0.94^{+0.08}_{-0.16} is needed to be SZ-compatible.Comment: 36 pages, 5 figures, 5 tables, Jan 2003 Roy Soc Discussion Meeting on `The search for dark matter and dark energy in the Universe', published PDF (Oct 15 2003) is http://www.cita.utoronto.ca/~bond/roysoc03/03TA2435.pd

The Impact of Antiretroviral Therapy on Mortality in HIV Positive People during Tuberculosis Treatment: A Systematic Review and Meta-Analysis

Objective: To quantify the impact of antiretroviral therapy (ART) on mortality in HIV-positive people during tuberculosis (TB) treatment. Design: We conducted a systematic literature review and meta-analysis. Studies published from 1996 through February 15, 2013, were identified by searching electronic resources (Pubmed and Embase) and conference books, manual searches of references, and expert consultation. Pooled estimates for the outcome of interest were acquired using random effects meta-analysis. Subjects The study population included individuals receiving ART before or during TB treatment. Main Outcome Measures: Main outcome measures were: (i) TB-case fatality ratio (CFR), defined as the proportion of individuals dying during TB treatment and, if mortality in HIV-positive people not on ART was also reported, (ii) the relative risk of death during TB treatment by ART status. Results: Twenty-one studies were included in the systematic review. Random effects pooled meta-analysis estimated the CFR between 8% and 14% (pooled estimate 11%). Among HIV-positive TB cases, those receiving ART had a reduction in mortality during TB treatment of between 44% and 71% (RR = 0.42, 95%CI: 0.29–0.56). Conclusion: Starting ART before or during TB therapy reduces the risk of death during TB treatment by around three-fifths in clinical settings. National programmes should continue to expand coverage of ART for HIV positive in order to control the dual epidemic

The Intrinsic Absorber in QSO 2359-1241: Keck and HST Observations

We present detailed analyses of the absorption spectrum seen in QSO 2359-1241 (NVSS J235953-124148). Keck HIRES data reveal absorption from twenty transitions arising from: He I, Mg I, Mg II, Ca II, and Fe II. HST data show broad absorption lines (BALs) from Al III 1857, C IV 1549, Si IV 1397, and N V 1240. Absorption from excited Fe II states constrains the temperature of the absorber to 2000K < T < 10,000K and puts a lower limit of 10^5 cm^{-3} on the electron number density. Saturation diagnostics show that the real column densities of He I and Fe II can be determined, allowing to derive meaningful constraints on the ionization equilibrium and abundances in the flow. The ionization parameter is constrained by the iron, helium and magnesium data to -3.0 < log(U) < -2.5 and the observed column densities can be reproduced without assuming departure from solar abundances. From comparison of the He I and Fe II absorption features we infer that the outflow seen in QSO 2359-1241 is not shielded by a hydrogen ionization front and therefore that the existence of low-ionization species in the outflow (e.g., Mg II, Al III, Fe II) does not necessitate the existence of such a front. We find that the velocity width of the absorption systematically increases as a function of ionization and to a lesser extent with abundance. Complementary analyses of the radio and polarization properties of the object are discussed in a companion paper (Brotherton et al. 2000).Comment: 30 pages, 9 figures, in press with the Ap

Population-level impact of shorter-course regimens for tuberculosis: a model-based analysis.

Despite current control efforts, global tuberculosis (TB) incidence is decreasing slowly. New regimens that can shorten treatment hold promise for improving treatment completion and success, but their impact on population-level transmission remains unclear. Earlier models projected that a four-month regimen could reduce TB incidence by 10% but assumed that an entire course of therapy must be completed to derive any benefit. We constructed a dynamic transmission model of TB disease calibrated to global estimates of incidence, prevalence, mortality, and treatment success. To account for the efficacy of partial treatment, we used data from clinical trials of early short-course regimens to estimate relapse rates among TB patients who completed one-third, one-half, two-thirds, and all of their first-line treatment regimens. We projected population-level incidence and mortality over 10 years, comparing standard six-month therapy to hypothetical shorter-course regimens with equivalent treatment success but fewer defaults. The impact of hypothetical four-month regimens on TB incidence after 10 years was smaller than estimated in previous modeling analyses (1.9% [95% uncertainty range 0.6-3.1%] vs. 10%). Impact on TB mortality was larger (3.5% at 10 years) but still modest. Transmission impact was most sensitive to the proportion of patients completing therapy: four-month therapy led to greater incidence reductions in settings where 25% of patients leave care ("default") over six months. Our findings remained robust under one-way variation of model parameters. These findings suggest that novel regimens that shorten treatment duration may have only a modest effect on TB transmission except in settings of very low treatment completion

Control theory for principled heap sizing

We propose a new, principled approach to adaptive heap sizing based on control theory. We review current state-of-the-art heap sizing mechanisms, as deployed in Jikes RVM and HotSpot. We then formulate heap sizing as a control problem, apply and tune a standard controller algorithm, and evaluate its performance on a set of well-known benchmarks. We find our controller adapts the heap size more responsively than existing mechanisms. This responsiveness allows tighter virtual machine memory footprints while preserving target application throughput, which is ideal for both embedded and utility computing domains. In short, we argue that formal, systematic approaches to memory management should be replacing ad-hoc heuristics as the discipline matures. Control-theoretic heap sizing is one such systematic approach