The Winthrop College Farm: Nutrition, Nourishment, and Knowledge

The Farm was a part of Winthrop from 1895 to 1957. Designed to supply food for the College, it also provided an observational classroom for students, and interaction with the community through surplus sales. A brief history of the farm will be presented and a panel will discuss the farm\u27s impact on the Winthrop and Rock Hill communities

The Grizzly, March 3, 1992

Buchanan vs. Bush: The Republican Race Heats Up • Tensions Continue to Run High in Middle East • Tri-Lambda • U.S.G.A. Minutes • Comedy and Harmony Interspersed in Lower Lounge • The Gung-ho Guardians • Clifford Jordan Quintet Performs • Movie Review: Naked Gun 2 1/2 • Walk a Mile for Understanding • Letters: Responses to Airband Controversy; What\u27s Up Zack\u27s • Flannery Going to Nationals • Derstine, Swimmers Strong at MACs • Lady Hoopsters Lose Tough Onehttps://digitalcommons.ursinus.edu/grizzlynews/1292/thumbnail.jp

The Grizzly, November 5, 1991

Red and Gold Day • Changes for Education Majors • Golf Cart Stolen • Unrest in the Quad • Alcohol Update • Fourth Annual Grizzly Network Career Day • U.S.G.A. Minutes • Chemical Awareness • Biology Department Update • Environmental Notes • Fraternities Experience Humanity of Habitat • The Winner Is: Mudslinger #1 • The Harm of Rumors • Priorities in College Athletics • Feed Your Mind • Halloween Flop • Soviet Art at Ursinus • The Quad Peacock • College Choir Performs Requiem • Senior Barn Bash • Goodfellas • Bears Rush by the Mules in 13-9 Upset • Volleyball Ends Season with a Loss • Field Hockey Passes by Princeton • Senior Runners Reflect on Seasonhttps://digitalcommons.ursinus.edu/grizzlynews/1282/thumbnail.jp

The Grizzly, February 4, 1992

\u2792 Enrollment Promising • Iraq: One Year Later • Famed Author to Speak • Spend a Year in Scotland • U.S.G.A. Minutes • Chez Wismer • Dave Binder Returns • The Library\u27s Functional Art: The Bearkeeper • Blockbuster Hits Coming to Wismer: Terminator & T2 • Sams Exhibit Opens • Psychic Madman Amazes and Entertains • Roger Guenveur Smith to Perform in Lower Lounge • Two New Sculptures Grace Campus • No Term Limitations • Don\u27t Bash Criticism • Letter: $0.50 Pool • Year in Review • Ursinus Gets Pinned By Muhlenberg • Rypien: Mark of Excellence • Men Hoopsters Net Losses • Aquamen Swim Upstream • Lady \u27Mers Win Three in a Row • Gymnasts Tumble Into Action • Lady Bears Back on Track • Step Aerobics Class to be Offered • Medieval Sports Festival Cominghttps://digitalcommons.ursinus.edu/grizzlynews/1288/thumbnail.jp

The Grizzly, October 22, 1991

Alumni Return for Homecoming Celebration • Phi Beta Kappa Charter Approved for Ursinus • Thomas Confirmed to Supreme Court • Gibson to Speak at Ursinus • GALA Seeks Recognition • U.S.G.A. Minutes • GALA Comes Out • Modern Medical Imaging • The Vision of Science Through Art • Beware of Bad Moods • Woman Fixing Her Hair? • Critics\u27 Corner: The Fisher King; Sleeping With the Enemy • Giggles Night Club Comedians • Letters: In Defense of Harley; Harassment Response; An Appeal for the Trees • Apples and Oranges • Dining Turf • Bears Blank the Bullets in Homecoming Game • Cross Country Runs to Victory • Field Hockey Strikes Back, Raises Record to 5-5-2 • Volleyball Spikes Cabrini • Lady Bears Cruise to 1st Place • Winds Fill Ursinus\u27 Sails • Soccer Bounces Back with Three Straight Winshttps://digitalcommons.ursinus.edu/grizzlynews/1280/thumbnail.jp

The Grizzly, September 24, 1991

Ursinus Day Academic Convocation Changes Face • Alcohol Policy Enforcement Tightens • Freshman Class Elections Held • Dr. Hall Honored • U.S.G.A. Minutes • Student Response Team Regroups • Demas Presents... Barry Hixson • Sororities Begin Formal Rushing • Finally! Student Center Opens • Golf Gets New Head Coach • Paul Harryn Launches Berman Season • DeLuca Hypnotizes Audience • Movie Reviews: Pacific Heights; New Jack City; Hot Shots • Volleyball Nets a Win • Lady Bears Stick It to Opponents • Nick\u27s NFL Notes • Bears Harass Hoyas in Opener • Soccer Kicks Off Season with Win • U.C. Tavern? • Questions of Freedom • Defense of History • Life Science Building Upgraded to State-Of-The-Art Facility • Pre-med Committee Evaluation Meeting • Medicine in The Gulf Warhttps://digitalcommons.ursinus.edu/grizzlynews/1277/thumbnail.jp

The Grizzly, November 19, 1991

Founders\u27 Day Excitement • Grizzly Network Career Day • Women\u27s Choices • Volksmarching • Louisiana Election • Service Opportunities for Students • The European Situation • Jonas Salk Addresses Founders Day Convocation • Dr. Takats Awarded the Clamer Chair • Wellness Services Proposal • U.S.G.A. Minutes • Ursinus Continues Helping Habitat • Turkey Drive Needs You • Zack: The Man, The Myth, The Statue • Hocus Pocus a Success • Ursinus Students in Community Production of Gypsy • Movie Review: Hamlet • Battle of the Bands • Rollins Rocks Lower Lounge • Branker Tours to St. Petersburg • CAB Trip to New York • Writing in Good Taste • Magic: One Trick Too Many • Letters: Faculty Members Speak Out; GALA Replies to Letter; Call for Diversity; Publishing the Truth?; Student Reaction to Ronning; Response to Black Hole ; Students React to Social Life • No More Crap! • Filling in the Black Hole • One Professor\u27s Awakening • Lady Bears End Season • Men\u27s Lacrosse Awaits Chance • Women Swimmers Wash Out Washington • Spinella Takes Over as Head Coach of Basketball Team • Dickinson Defeats the Bearshttps://digitalcommons.ursinus.edu/grizzlynews/1284/thumbnail.jp

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains. In total, we identify 67 candidate hearing loss genes. We detect known hearing loss genes, but the vast majority, 52, of the candidate genes were novel. Our analysis reveals a large and unexplored genetic landscape involved with auditory function

Leuprorelin Acetate Long-Lasting Effects on GnRH Receptors of Prostate Cancer Cells: An Atomic Force Microscopy Study of Agonist/Receptor Interaction

High cell-surface GnRH receptor (GnRH-R) levels have been shown to have a major influence on the extent of GnRH agonist-mediated tumor growth inhibition. The ability of the GnRH agonist leuprorelin acetate (LA) to induce a post-transcriptional upregulation of GnRH-R at the plasma membrane of androgen-sensitive (LNCaP) and -insensitive (PC-3) prostate cancer (PCa) cells has been previously demonstrated by Western blotting. Here we performed single molecule force spectroscopy by using Atomic Force Microscopy (AFM), which has proven to be a powerful tool allowing for investigation of living cell surface biological features, such as the so far unclear GnRH agonist/receptor interaction. Thus, in the hormone-insensitive PC-3 cells, we characterized the strength of the LA-receptor binding, and the amount and distribution of the functional receptor molecules on the cell surface. The effect of a long and continuous treatment (up to 30 days) with the agonist (10-11 and 10-6 M) on the same parameters was also investigated. A GnRH-R increase was observed, reaching the maximum (~80%) after 30 days of treatment with the highest dose of LA (10-6 M). The analogue-induced increase in GnRH-R was also demonstrated by Western blotting. In addition, two different receptor bound strengths were detected by AFM, which suggests the existence of two GnRH-R classes. A homogeneous distribution of the unbinding events has been found on untreated and treated PC-3 cell surfaces. The persistence of high receptor levels at the membrane of these living cells may warrant the maintenance of the response to LA also in androgen-unresponsive PCa. Moreover, the determination of ligand/receptor bond strength could shed light on the poorly understood event of LA/GnRH-R interaction and/or address structural/chemical agonist optimizations. \ua9 2013 Lama et al

Immunization with Radiation-Attenuated Plasmodium berghei Sporozoites Induces Liver cCD8α+DC that Activate CD8+T Cells against Liver-Stage Malaria

Immunization with radiation (γ)-attenuated Plasmodia sporozoites (γ-spz) confers sterile and long-lasting immunity against malaria liver-stage infection. In the P. berghei γ-spz model, protection is linked to liver CD8+ T cells that express an effector/memory (TEM) phenotype, (CD44hiCD45RBloCD62Llo ), and produce IFN-γ. However, neither the antigen presenting cells (APC) that activate these CD8+ TEM cells nor the site of their induction have been fully investigated. Because conventional (c)CD8α+ DC (a subset of CD11c+ DC) are considered the major inducers of CD8+ T cells, in this study we focused primarily on cCD8α+ DC from livers of mice immunized with Pb γ-spz and asked whether the cCD8α+ DC might be involved in the activation of CD8+ TEM cells. We demonstrate that multiple exposures of mice to Pb γ-spz lead to a progressive and nearly concurrent accumulation in the liver but not the spleen of both the CD11c+NK1.1− DC and CD8+ TEM cells. Upon adoptive transfer, liver CD11c+NK1.1− DC from Pb γ-spz-immunized mice induced protective immunity against sporozoite challenge. Moreover, in an in vitro system, liver cCD8α+ DC induced naïve CD8+ T cells to express the CD8+ TEM phenotype and to secrete IFN-γ. The in vitro induction of functional CD8+ TEM cells by cCD8α+ DC was inhibited by anti-MHC class I and anti-IL-12 mAbs. These data suggest that liver cCD8α+ DC present liver-stage antigens to activate CD8+ TEM cells, the pre-eminent effectors against pre-erythrocytic malaria. These results provide important implications towards a design of anti-malaria vaccines