19 research outputs found
Metacognition and Classroom Instruction
- Author
- Publication venue
- ScholarWorks at WMU
- Publication date
- 01/01/1987
- Field of study
When applied to the reading task, metacognition refers to the readers\u27 ability to monitor their own comprehension of material and to invoke the appropriate skills and strategies necessary for comprehension. The purpose of this article is to review some of the recent research on metacognition and to present some implications for its use in classroom instruction
Dialogue Journals as a Vehicle for Preservice Teachers to Experience the Writing Process (I Like Him; Should I Tell Him at Recess?)
- Publication venue
- ScholarWorks at WMU
- Publication date
- 01/10/1994
- Field of study
Basic to the tenets of wholistic literacy instruction are the beliefs that reading and writing should be relevant to the learner, should serve real-life purposes and, consequently, should be meaningful (Goodman, 1986). Dialogue journals, described as written conversations between two or more people over an extended period of time (Staton, 1988), fit this description. Communication within a dialogue journal is in formal and focuses on topics of mutual interest. They provide an arena for young students that is risk-free and empowering as new readers and writers are encouraged to use their invented spelling and to learn about literacy in an integrative manner (Bode, 1989). Dialogue journals serve as bridges between spoken conversation and written expression and help students develop an awareness of the real purposes of reading and writing (Gambrell, 1985). In addition, these journals provide a forum for sharing ideas, developing literacy skills and enhancing participants abilities to interact on paper in a warm and human way
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
- Author
- Abdukahil Sheryl Ann
- Abdukahil Sheryl,
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Abreu Julia,
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- Adrião Diana
- Ainscough Kate
- Akimoto Takako
- Al Qasim Eman
- Al-Dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Alidjnou Kazali Enagnon
- Alidjnou Kazali,
- Aliudin Jeffrey
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves Rita
- Amaral Maria
- Ammerlaan Heidi
- Ampaw Phoebe
- Andini Roberto
- Andrejak Claire
- Angheben Andrea
- ANGOULVANT François
- Ansart Séverine
- Antonelli Massimo
- Arabi Yaseen
- Aragao Irene
- Arcadipane Antonio
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Artaud-Macari Elise
- Asensio Angel
- Assie Jean Baptiste
- Assie Jean,
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Azemar Laurène
- Azoulay Cécile
- Bach Benjamin
- Bachelet Delphine
- Baillie J. Kenneth,
- Bak Erica
- Bakakos Agamemnon
- Banisadr Firouzé
- Barbalho Renata
- Barclay Wendy,
- Barnikel Michaela
- Barrelet Audrey
- Barrigoto Cleide
- Basmaci Romain
- Bassi Gianluigi Li
- Bassi Gianluigi,
- Bedossa Alexandra
- Behilill Sylvie
- Bekken Gry Kloumann
- Bekken Gry,
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bhavsar Krishna
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Blanco-Schweizer Pablo
- Blot Mathieu
- Boccia Filomena
- Bogaert Debby
- Bompart François
- Booth Gareth
- Borges Diogo
- Borie Raphaël
- Bos Jeannet
- Bosse Hans Martin
- Bosse Hans,
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camille
- Boureau Anne-Sophie
- Bouscambert Maude
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brozzi Nicolas
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Bustos Ingrid,
- Butnaru Denis
- Cabie André
- Cabral Susana
- Caceres Eder
- Callahan Mia
- Calligy Kate
- Calvache Jose Andres
- Calvache Jose,
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carney Gayle
- Carpenter Chloe
- Carret Marie-Christine
- Carrier François Martin
- Carrier François,
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavalli Giulio,
- Cavayas Alexandros
- Ceccato Adrian
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chas Julie
- Chassin Camille
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheng Matthew,
- Cheret Antoine
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Hwa Jin
- Cho Hwa,
- Cho Sung Min
- Cho Sung,
- Choez Xavier Sánchez
- Choez Xavier,
- Choileain Orna Ni
- Choileain Orna,
- Cholley Bernard
- Cidade Jose Pedro
- Cidade Jose,
- Citarella Barbara Wanjiru
- Citarella Barbara,
- Ciullo Anna
- Clarke Jennifer
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Colombo Sebastiano,
- Combs Pamela
- Connelly J.,
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Cooke Graham,
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cormican Sarah
- Cornelis Sabine
- Corpuz Arianne Joy
- Corpuz Arianne,
- Corvaisier Grégory
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cucino Alberto
- Cullen Caroline
- Cummings Matthew
- Curley Gerard
- Curlier Elodie
- Curto Elena Gallego
- Curto Elena,
- Custodio Paula
- Cárcel Sheila
- Da Silva Filipe Ana
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew,
- Dalton Heidi
- Dalton Jo
- Daneman Nick
- Dankwa Emmanuelle,
- Dantas Jorge
- De Araújo Mariz Carolline
- De Brito Carlos Alexandre Antunes
- De Brito Carlos,
- De Castro Nathalie
- De Mendoza Diego
- De Oliveira França Rafael Freitas
- De Oliveira França Rafael,
- De Rosa Rosanna
- De Silva Thushan
- De Vries Peter
- Dean David
- Debray Marie-Pierre
- Dechert William
- Deconninck Lauren
- Decours Romain
- Delacroix Isabelle
- Delavigne Karen
- Deligiannis Ionna
- Dell’amore Andrea
- Delobel Pierre
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallée Mathilde
- Devouge Eglantine Ferrand
- Devouge Eglantine,
- Dewayanti Santi Rahayu
- Dewayanti Santi,
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose Diaz
- Diaz Juan,
- DIAZ Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie,
- Dominguez Carmen Infante
- Dominguez Carmen,
- Dong Andy
- Donnelly Christl,
- Donnelly Maria
- Donohue Chloe
- Dorival Céline
- Douglas James Joshua
- Douglas James,
- Douma Renee
- Dournon Nathalie
- Downer Triona
- Downing Mark
- Drake Tom
- Dubee Vincent
- DUBOS François
- Ducancelle Alexandra
- Dudman Susanne
- Dunning Jake
- Duranti Silvia
- Durham Lucian
- Dussol Bertrand
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Dyrhol-Riise Anne,
- D’aragon Frédérick
- D’Orleans Charles Crepy
- D’orleans Charles,
- D’Ortenzio Eric
- Eid Charbel Maroun
- Eid Charbel,
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Elkheir Natalie
- Ellerbroek Jacobien
- Ellis Rachael
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Everding Anna,
- Evers Mirjam
- Fabre Isabelle
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron,
- Faria Pedro
- Farshait Nataly
- Fatoni Arie Zainul
- Fatoni Arie,
- Faure Karine
- Fayed Mohamed
- Feely Niamh
- Fernandes Jorge
- Fernandes Marília
- Fernandes Susana
- Ferraz Mário
- Ferreira Benigno
- Ferrer-Roca Ricard
- Ferrão Joana
- Figueiredo-Mello Claudia
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Florio Letizia,
- Foley Claire
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Claudio,
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foti Giuseppe
- Fourn Erwan
- Fowler Rob
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John
- Freire Marcela Vieira
- Freire Marcela,
- Friedrich Caren
- Fry Stéphane
- Fuentes Nora
- Fukuda Masahiro
- Gaborieau Valérie
- Gachet Benoît
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião Sérgio
- Gallagher Phil
- Gamble Carrol
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- GarcÍa Ruth Noemí Jorge
- García Ruth,
- Garot Denis
- Garrait Valérie
- Gault Nathalie
- Gavin Aisling
- Gaymard Alexandre
- Gebauer Johannes
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Giaquinto Carlo
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Giwangkancana Gezy
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gorenne Isabelle
- Goujard Cécile
- Goulenok Tiphaine
- Grable Margarite
- Grandin Edward Wilson
- Grandin Edward,
- Granier Pascal
- Grasselli Giacomo
- Green Christopher,
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Grieco Domenico,
- Griffee Matthew
- Griffiths Fiona
- Grigoras Ioana
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gómez-Junyent Joan
- Haber Daniel
- Hakak Sheeba
- Hall Matthew
- Halpin Sophie
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Hardwick Hayley
- Harley Kristen
- Harrison Ewen,
- Harrison Janet
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Henriquez-Trujillo Aquiles
- Hentzien Maxime
- Hernandez-Montfort Jaime
- Herreros Jose Miguel Cisneros
- Herreros Jose,
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhilin
- Hinton Samuel
- Hipólito-Reis Ana
- Hiraiwa Hiroaki
- Hiscox Julian,
- Ho Antonia Ying Wai
- Ho Antonia,
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holten Aleksander,
- Holter Jan Cato
- Holter Jan,
- Horby Peter
- Horcajada Juan Pablo
- Horcajada Juan,
- Hoshino Koji
- Hoshino Kota
- Hough Catherine,
- Hssain Ali Ait
- Hssain Ali,
- Hsu Jimmy Ming-Yang
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Humaid Felwa,
- Ijaz Samreen
- Illes Hajnal-Gabriela
- Inácio Hugo
- Iosifidis Elias
- Irvine Lacey
- Isgett Sarah
- Isidoro Tiago
- Isnard Margaux
- Itai Junji
- Ivulich Daniel
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jamieson Nina
- Jaureguiberry Stéphane
- Javidfar Jeffrey
- Jean-Benoît Zabbe
- Jego Florence
- Jenum Synne
- Jimenez Juan Fernado Masa
- Jimenez Juan,
- Johal Simreen Kaur
- Johal Simreen,
- Joseph Cédric
- Joseph Mark
- Jouvet Philippe
- Jung Hanna
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabina
- Kalomoiri Smaragdi
- Kandamby Darshana Hewa
- Kandamby Darshana,
- Kandel Chris
- Kant Ravi
- Kartsonaki Christiana
- Kasugai Daisuke
- Katz Kevin
- Keating Sean
- Kelly Andrea
- Kelly Sadie
- Kennedy Lisa
- Kennon Kalynn
- Kerroumi Younes
- Kestelyn Evelyne
- Khalid Imrana
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Kho Michelle,
- Khoo Saye
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kildal Anders,
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Knight Stephen
- Kobbe Robin
- Korten Volkan
- Kosgei Caroline
- Krawczyk Karolina
- KUMAR Deepali
- Kurtzman Ethan
- Kutsogiannis Demetrios
- Kyriakoulis Konstantinos
- LACHATRE Marie
- Lacoste Marie
- Laffey John,
- Lagrange Marie
- Laine Fabrice
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Lantang Eka Yudha
- Lantang Eka,
- Lanza Marina
- Laouénan Cédric
- Laribi Samira
- Lariviere Delphine
- Launay Odile
- Lavie-Badie Yoan
- Law Andrew
- Le Bihan Clément
- Le Bris Cyril
- Le Coustumier Eve
- Le Falher Georges
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Maréchal Marion
- Le Mestre Soizic
- Le Moing Vincent
- Le Nagard Hervé
- Le Turnier Paul
- Le Van Tan
- Le Minh
- Leal Ema
- Lee James
- Lee Su Hwan
- Lee Su,
- Lee Todd
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefevre Benjamin
- Lellouche François
- Lemaignen Adrien
- Lemee Véronique
- Lemmink Gretchen
- Leone Michela
- Lepiller Quentin
- Lescure François-Xavier
- Lesens Olivier
- Lesouhaitier Mathieu
- Levy Bruno
- Levy Yves
- Levy-Marchal Claire
- León Rafael
- Liang Janet
- Lim Wei Shen
- Lim Wei,
- Lina Bruno
- Lind Andreas
- Lingas Guillaume
- Lion-Daolio Sylvie
- Liu Keibun
- Loforte Antonio
- Lolong Navy
- Lopes Diogo
- Lopez-Colon Dalia
- Lordemann Anja Grosse
- Lordemann Anja,
- Loubet Paul
- Lucet Jean Christophe
- Lucet Jean,
- Luna Carlos,
- Lungu Olguta
- Luong Liem
- Luton Dominique
- Lyons Ruth
- L’Her Erwan
- Maasikas Olavi
- Macdonald Sarah
- Machado Moïse
- Macheda Gabrielle
- Madhok Jai
- Mahieu Rafael
- Mahy Sophie
- Maier Lars Siegfrid
- Maier Lars,
- Maillet Mylène
- Maitre Thomas
- Malaque Ana
- Maldonado Hugo Miranda
- Maldonado Hugo,
- Malfertheiner Maximilian
- Malik Nadia
- Maltez Fernando
- Malvy Denis
- MAMBERT Marina
- Manda Victoria
- Mandei Jose,
- Mangoni Emanuele Durante
- Mangoni Emanuele,
- Manning Edmund
- Manuel Aldric
- Marino Flávio
- Marques Ana
- Marquis Catherine
- Marsh Brian
- Marsh Laura
- Marshall John
- Martelli Celina Turchi
- Martelli Celina,
- Martin Dori-Ann
- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martin-Quiros Alejandro
- Martinot Martin
- Martins Ana
- Martins João
- Martucci Gennaro
- Marwali Eva Miranda
- Marwali Eva,
- Maslove David
- Mason Sabina
- Matan Moshe
- Mathieu Daniel
- Mattei Mathieu
- Matulevics Romans
- Maulin Laurence
- Mc Evoy Natalie
- Mccarthy Aine
- Mccloskey Colin
- Mcconnochie Rachael
- Mcdermott Sherry
- McDonald Sarah
- Mcelwee Samuel
- Mcevoy Natalie
- McGeer Allison
- Mcguinness Niki
- Mclean Kenneth,
- Mcnicholas Bairbre
- Meaney Edel
- Mear-Passard Cécile
- Mechlin Maggie
- Mele Ferruccio
- Menon Kusum
- Mentré France
- Mentzer Alexander,
- Mercier Noémie
- Merckx Antoine
- Mergler Blake
- Merson Laura
- Mesquita António
- Meybeck Agnès
- Meynert Alison,
- Meyssonnier Vanina
- Meziane Amina
- Mezidi Medhi
- Michelanglei Céline
- Mihnovitš Vladislav
- Mohammed Nassima Si
- Mohammed Nassima,
- Moin Asma
- Molina David
- Molinos Elena
- Mone Mary
- Monteiro Agostinho
- Montes Claudia
- Montrucchio Giorgia
- Moore Sarah
- Moore Shona,
- Morales-Cely Lina
- Morlaes Louis Gerbaud
- Morlaes Louis,
- Moro Lucia
- Motos Ana
- Mouquet Hugo
- Moyet Julien
- Mullaert Jimmy
- Munblit Daniel
- Murphy Derek
- Murris Marlène
- Myrodia Dimitra Melia
- Myrodia Dimitra,
- Müller Fredrik
- Müller Karl Erik
- Müller Karl,
- Neant Nadège
- Neb Holger
- Nekliudov Nikita,
- Neto Raul
- Neumann Emily
- Neves Bernardo
- Ng Pauline Yeung
- Ng Pauline,
- Ng Wing Yiu
- Ng Wing,
- Nichol Alistair
- Nonas Stephanie
- Noret Marion
- Norman Lisa
- Notari Alessandra
- Noursadeghi Mahdad
- Nowicka Karolina
- Nseir Saad
- Nunez Jose,
- Nuñez Maria Angelica Rivera
- Nuñez Maria,
- Nyamankolly Elsa
- N’Guyen Yohan
- Occhipinti Giovanna
- Ogston Tawnya
- Ogura Takayuki
- Oh Tak-Hyuk
- Ohshimo Shinichiro
- Oinam Budha Charan Singh
- Oinam Budha,
- Oliveira Ana Pinho
- Oliveira Ana,
- Oliveira João
- Olliaro Piero
- Ong David,
- Oosthuyzen Wilna
- Openshaw Peter,
- Orozco-Chamorro Claudia Milena
- Orozco-Chamorro Claudia,
- Orquera Andrés
- Osatnik Javier
- Ouamara Nadia
- Ouissa Rachida
- Owyang Clark
- Oziol Eric
- O’donnell Max
- O’hearn Katie
- O’neil Conar
- Pagadoy Maïder
- Pages Justine
- Palacios Mario
- Palmarini Massimo
- Panarello Giovanna
- Panda Prasan Kumar
- Panda Prasan,
- Panigada Mauro
- Pansu Nathalie
- Papadopoulos Aurélie
- Parra Briseida
- Pasquier Jérémie
- Patauner Fabian
- Patrão Luís
- Paul Christelle
- Paul Mical
- Paulos Jorge
- Paxton William,
- Payen Jean-François
- Pearse India
- Peek Giles,
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Peltan Ithan,
- Pereira Rui
- Perez Daniel
- Perpoint Thomas
- Perrot Clara Mouton
- Perrot Clara,
- Pesenti Antonio
- Petroušová Lenka
- Petrov-Sanchez Ventzislava
- Peytavin Gilles
- Pharand Scott
- Piagnerelli Michael
- Picard Walter
- Picone Olivier
- Piel-Julian Marie
- Pierobon Carola
- Pimentel Carlos
- Piroth Lionel
- Pius Riinu
- Piva Simone
- Plantier Laurent
- Plotkin Daniel
- Poissy Julien
- Pokorska-Spiewak Maria
- Poli Sergio
- Pollakis Georgios
- Popielska Jolanta
- Postma Douwe,
- Povoa Pedro
- Powis Jeff
- Prapa Sofia
- Prebensen Christian
- Preiser Jean-Charles
- Prestre Vincent
- Price Nicholas
- Prinssen Anton
- Pritchard Mark,
- Proença Lúcia
- Purcell Gregory
- Puéchal Oriane
- Póvoas Diana
- Quesada Luisa
- Quist-Paulsen Else
- Quraishi Mohammed
- Rabaud Christian
- Rafiq Marie
- Ragazzo Gabrielle
- Rainieri Fernando
- Ramakrishnan Nagarajan
- Ramanathan Kollengode
- Rammaert Blandine
- Rapp Christophe
- Rasmin Menaldi
- Rau Cornelius
- Rebaudet Stanislas
- Redl Sarah
- Reeve Brenda
- Rego Caroline Martins
- Rego Caroline,
- Reid Liadain
- Reis Renato
- Remppis Jonathan
- Remy Martine
- Renk Hanna
- Resende Liliana
- Resseguier Anne-Sophie
- Revest Matthieu
- Rewa Oleksa
- Reyes Luis Felipe
- Reyes Luis,
- Ribeiro Ana Freitas
- Ribeiro Ana,
- Richardson David
- Richardson Denise
- Richier Laurent
- Riera Jordi
- Rincon Diego Fernando Bautista
- Rincon Diego,
- Rios Ana Lúcia
- Rios Ana,
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Roberto André
- Roberts Stephanie
- Robertson David,
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia Simão
- Roilides Emmanuel
- Rojek Amanda
- Romaru Juliette
- Roncon-Albuquerque Roberto
- Roriz Mélanie
- Rosa-Calatrava Manuel
- Rose Michael
- Rosenberger Dorothea
- Rossanese Andrea
- Rossignol Bénédicte
- Rossignol Patrick
- Roy Carine
- Roze Benoît
- Russell Clark,
- Ryckaert Steffi
- Rätsep Indrek
- Rössler Bernhard
- Saba Isabela
- Sadat Musharaf
- Saidani Nadia
- Salazar Leonardo
- Sales Gabriele
- Sallaberry Stéphane
- Salvator Hélène
- Sanchez Juan Macias
- Sanchez Juan,
- Sanchez Olivier
- Sanchez-Miralles Angel
- Sancho-Shimizu Vanessa
- Sandhu Gyan
- Sandulescu Oana
- Sanharawi Mohammed El
- Sanharawi Mohammed,
- Sant Ceila Maria
- Sant Ceila,
- Santos Marlene
- Santos Marta Leal
- Santos Marta,
- Santos-Olmo Rosario Maria Torres
- Santos-Olmo Rosario,
- Sarfo-Mensah Shirley
- Sarton Benjamine
- Saviciute Egle
- Savvidou Parthena
- Scarsbrook Joshua
- Schermer Tjard
- Scherpereel Arnaud
- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scott Janet,
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Semaille Caroline
- Semple Malcolm,
- Senneville Eric
- Sequeira Filipa
- Sequeira Tânia
- Shadowitz Ellen
- Shamsah Mohammad
- Sharma Pratima
- Shaw Catherine,
- Shaw Victoria
- Shiban Nisreen
- Shime Nobuaki
- Shimizu Hiroaki
- Shimizu Keiki
- Shrapnel Sally
- Shum Hoi Ping
- Shum Hoi,
- Sigfrid Louise
- Silva Catarina
- Silva Maria Joao
- Silva Maria,
- Sin Wai Ching
- Sin Wai,
- Skogen Vegard
- Smith Sue
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- Svistunov Magdalena Surovcová Andrey A.
- Svistunov Magdalena,
- Syrigos Konstantinos
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- Thompson Shaun
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- Thwaites Ryan,
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- Timsit Jean-François
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- Tutillo Diego Rolando Morocho
- Tutillo Diego,
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uva Maria,
- Val-Flores Luís
- Van De Velde Stijn
- Van Den Berge Marcel
- Van Der Feltz Machteld
- Van Der Vekens Nicky
- Van Der Voort Peter
- Van Der Werf Sylvie
- Van Dyk Marlice
- Van Gulik Laura
- Van Hattem Jarne
- Van Lelyveld Steven
- Van Netten Carolien
- Van Vinh Chau Nguyen
- Vanel Noémie
- Vanoverschelde Henk
- Vasconcelos Malte Kohns
- Vasconcelos Malte,
- Vauchy Charline
- Vecham Pavan Kumar
- Vecham Pavan,
- Veislinger Aurélie
- Velazco Jorge
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vidal José,
- Vieira César
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath,
- Villanueva Joy Ann
- Villanueva Joy,
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vuorinen Aapeli
- Vuotto Fanny
- Wang Chih-Hsien
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wiedemann Aurélie
- Wille Keith
- Wils Evert-Jan
- Xynogalas Ioannis
- Yacoub Sophie
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Young Paul
- Yuliarto Saptadi
- Zabbe Marion
- Zacharowski Kai
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zawadka Konrad
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
Mapping the human genetic architecture of COVID-19
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
A multi-country analysis of COVID-19 hospitalizations by vaccination status
- Author
- Aasmine Kaur
- Abby Hurd
- Abdulrahman Al-Fares
- Aditya John Anchan
- Adrian Streinu-Cercel
- Adrienne Chan
- Agostinho Monteiro
- Aidan Burrell
- Aisling Gavin
- Alan Hartman
- Aldo Rafael
- Alejandro Martín-Quiros
- Aleksander Rygh Holten
- Alessandra Notari
- Alexander J Mentzer
- Alexandros Cavayas
- Alexis F Turgeon
- Ali Ait Hssain
- Alina Kalicinska
- Alison M Meynert
- Alistair D Nichol
- Allison McGeer
- Amanda Corley
- Amna Faheem
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Martins
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Tveita
- Andra-Maris Post
- Andrea Angheben
- Andrea Cortegiani
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Dagens
- Andrew Law
- Andrew Letizia
- Andy Law
- Angela Alberti
- Anika Atique
- Anjellica Chen
- Anna Beltrame
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne-Marie Guerguerian
- Annemarie B Docherty
- Antonia Ho
- Antonia Ricchiuto
- Antonio Arcadipane
- António Mesquita
- Anuraj Shankar
- Argin G
- Asfia Sultana
- Asgar Rishu
- Atie Suwarti
- Audrey Dubot-Pérès
- Ayodhia Pitaloka
- Bailey Williams
- Bambang Pujo Semedi
- Baruch Joaquín
- Beathe Kiland Granerud
- Beatrice Alex
- Ben Morton
- Benjamin Bach
- Bernardo Ferreira
- Bernhard Roessler
- Bianca Boxma-de Klerk
- Birgitte Stiksrud
- Bisoffi Zeno
- Bounthavy Chaleunphon
- Bountoy Sibounheuang
- Brenda Reeve
- Brigid Flynn
- Cameron J Fairfield
- Caren Friedrich
- Carlos Cañada Illana
- Carlos Pimentel
- Caroline Kosgei
- Caroline Martins Rego
- Caroline Mudara
- Carrol Gamble
- Cassidy Codan
- Catarina Espírito Santo
- Catarina Pires
- Catherine A Shaw
- Catherine Blier
- Catherine Marquis
- Cecilia Canepa
- Ceila Maria Sant Ana Malaque
- Charlotte Summers
- Chiara Simona Cardellino
- Chiara Vitiello
- Chika Akwani
- Chloe Donohue
- Chris Kandel
- Chris McKay
- Christina Matthew
- Christl A Donnelly
- Christophe Fraser
- Christopher A Green
- Citarella Barbara Wanjiru
- Clare Jackson
- Clark D Russell
- Claudia Bianco
- Claudia Figueiredo-Mello
- Claudina Cruz
- Colin McArthur
- Cristina De Rose
- César Vieira
- Dag Henrik Reikvam
- Dan Meyer
- Dana Mustafa
- Daniel Haber
- Daniela Guerreiro
- Danilo Buonsenso
- Danoy Chommanam
- Dario Sinatti
- Dasgupta Abhishek
- Dave Nagpal
- David Bellemare
- David L Robertson
- David Maslove
- David S Y Ong
- David Stuart
- Dawn Higgins
- Debby Bogaert
- Decy Subekti
- Deepali Kumar
- Demetrios Kutsogiannis
- Denise Jaworsky
- Diana Póvoas
- Diego Franch-Llasat
- Diogo Borges
- Diogo Lopes
- Dounia Bouhmani
- Dr Rajesh Mohan Shetty
- Dwi Utomo Nusantara
- Eder Caceres
- Efstathia Mihelis
- Egle Saviciute
- Eka Airlangga
- Elisabetta Spinuzza
- Elizabeth A Ashley
- Ellen Shadowitz
- Else Quist-Paulsen
- Eman Al Qasim
- Emely Sanchez
- Emily Neumann
- Emma C Thomson
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Esteban Garcia-Gallo
- Evert-Jan Wils
- Felwa Bin Humaid
- Ferran Roche-Campo
- Filipa Brás Monteiro
- Filipa Cardoso
- Filipe Cardoso
- Fiona Griffiths
- Frank Manetta
- Frank Olav Pettersen
- François Lamontagne
- François Martin Carrier
- Fredrik Müller
- Frédérick D'Aragon
- Gabriele Sales
- Gail Carson
- Gary Leeming
- Gary Schwartz
- Gayle Carney
- Gennaro Martucci
- Georgios Pollakis
- Geraldine Goco
- Gianluigi Li Bassi
- Giorgia Montrucchio
- Giovanna Occhipinti
- Giovanna Panarello
- Giulia Bertoli
- Giuseppe Foti
- Gloria Crowl
- Gonçalves Bronner P
- Graham S Cooke
- Gregory Purcell
- Gry Kloumann Bekken
- Gyan Sandhu
- Hamza Jaber
- Hannah Habraken
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- Hashmi Madiha
- Hayley Hardwick
- Heidi Dalton
- Heidi Gruner
- Hongru Ren
- Horby Peter
- Hubert Tessier-Grenier
- Hugo Inácio
- Husna Begum
- Iam Claire E Sarmiento
- Imrana Khalid
- Indrek Rätsep
- Ingrid G Bustos
- Isabela Saba
- ISARIC Clinical Characterisation Group: Sheryl Ann Abdukahil
- J Kevin Baird
- Jacky Y Suen
- Jake Dunning
- James Joshua Douglas
- James Lee
- James Scott-Brown
- Jan Cato Holter
- Janet Harrison
- Janet Liang
- Janet T Scott
- Janice Caoili
- Jaques Sztajnbok
- Jassat Waasila
- Jeff Powis
- Jeffrey Aliudin
- Jennifer Lee
- Jess Gibson
- Jessica Wittman
- Jia Wei
- Jimmy Ming-Yang Hsu
- Jo Dalton
- Joan Gómez-Junyent
- Joana Alves Cabrita
- Joana Cabrita
- Joana Ferrão
- John F Fraser
- John Kenneth Baillie
- John Marshall
- Jonathan Bitton
- Jorge Dantas
- Jorge Fernandes
- Jorge Paulos
- Joshua Solomon
- Josie Campisi
- José Casimiro
- José Ernesto Vidal
- José Ramalho
- Joy Ann Villanueva
- João Estevão
- João Teixeira
- Juan Pablo Horcajada
- Judit Villar
- Julia Garcia-Diaz
- Juliana Damas
- Justin Schaffer
- K Dhangar
- Kalynn Kennon
- Kamal Abu Jabal
- Karl Erik Müller
- Kartsonaki Christiana
- Katie O'Hearn
- Kenneth A McLean
- Kevin Katz
- Kraemer Moritz U G
- Kristian Tonby
- Kusum Menon
- Lana Almasri
- Lance C W Turtle
- Larissa Oliveira
- Lars Heggelund
- Latsaniphone Bountthasavong
- Laura Marsh
- Laveena Munshi
- Lefèvre Benjamin
- Leonardo Salazar
- Lina Morales Cely
- Linda Gail Skeie
- Lisa Norman
- Lisa Patterson
- Liv Hesstvedt
- Louise Sigfrid
- Luca Brazzi
- Lucia Moro
- Lucian Durham 3rd
- Luisa Quesada
- Lukas Arenz
- Lunn Miles
- Luís Val-Flores
- López Revilla José W
- Mahdad Noursadeghi
- Mahendra Singh
- Malcolm G Semple
- Mangala Narasimhan
- Manivanh Vongsouvath
- Maram Zahran
- Marc Csete
- Marco Giani
- Mare Pejkovska
- Margarite Grable
- Maria Amaral
- Maria Angelica Rivera Nuñez
- Maria de Piero
- Maria Zambon
- Mariachiara Ippolito
- Mariana Cascão
- Mariano Esperatti
- Marie Connor
- Marina Lanza
- Marina Wainstein
- Mark Downing
- Mark G Pritchard
- Marlene Santos
- Marta Alessi
- Marta Torre
- Martin-Loeches Ignacio
- Martina Escher
- Martina Hennessy
- Mary Copland
- Marília Andreia Fernandes
- Massimo Palmarini
- Mathew Thorpe
- Mathilde Duplaix
- Matteo Rossetti
- Matthew Hall
- Matthew Nelder
- Matthew Pellan Cheng
- Mayfong Mayxay
- Meera Chand
- Merson Laura
- Mical Paul
- Michael Edelstein
- Michael Schwameis
- Michael Varrone
- Michaela Barnikel
- Michele Petrovic
- Michelle E Kho
- Michelle Girvan
- Mo'nes Muhaisen
- Moad Atlowly
- Mohammed Alkahlout
- Moji Ghadimi
- Muge Cevik
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Mutia Rahardjani
- Mário Ferraz
- Nashat Abu Salah
- Nataly Farshait
- Nathaniel Christy
- Netta Beer
- Nicholas Yuri Barbosa
- Nick Daneman
- Nicole White
- Nidyanara Castanheira
- Nimisha Abdul Majeed
- Nina Buchtele
- Nora Fuentes
- Nuno Germano
- Oana Sandulescu
- Oleksa Rewa
- Olliaro Piero L
- Ooyanong Phonemixay
- Osama Aldabbourosama
- Paola Rodari
- Paolo Cattaneo
- Patricia Fontela
- Patricia Patricio
- Patrick Archambault
- Paul Klenerman
- Paula Custodio
- Pauline Yeung Ng
- Pawel Twardowski
- Pedro Faria
- Peter Daley
- Peter Kiiza
- Peter Openshaw
- Philippe Jouvet
- Phoebe Ampaw
- Phouvieng Douangdala
- Piero Valentini
- Piret Sillaots
- Piubelli Chiara
- Prasan Kumar Panda
- Prashant Nasa
- Praveen Kumar Ghisulal
- Rachael McConnochie
- Rachael Parke
- Rajavardhan Rangappa
- Rakesh Arora
- Raph L Hamers
- Renata Barbalho
- Reyes Luis Felipe
- Richard S Tedder
- Riinu Pius
- Rima Song
- Rita Alves
- Robert A Fowler
- Roberta Cavalin
- Rojek Amanda
- Rolando Claure-Del Granado
- Roman Ullrich
- Rosario Maria Torres Santos-Olmo
- Ross Hendry
- Rui Caetano Garcês
- Rui Garcês
- Rui Pereira
- Rupert Higgins
- Ruth Lyons
- Ryan S Thwaites
- Sadie Kelly
- Samantha Lissauer
- Samreen Ijaz
- Samuel Hinton
- Sanne Wesselius
- Sara Clohisey
- Sara Machado
- Sara Taleb
- Sarah E McDonald
- Sarah Moore
- Saye Khoo
- Scott Pharand
- Sergio Poli
- Seán Keating
- Shaher Hamdan
- Shaun Thompson
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shona C Moore
- Shrapnel Sally
- Silvia Castañeda
- Simon Forsyth
- Sofia Cardoso
- Sommay Keomany
- Sophie Halpin
- Soulichanya Phoutthavong
- Srinivas Murthy
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen R Knight
- Steve Webb
- Sue Smith
- Sue Willems
- Summer Hamza
- Susanne Dudman
- Synne Jenum
- Teresa Lawrence
- Thipsavanh Bounphiengsy
- Thomas Drake
- Thomas Staudinger
- Thushan de Silva
- Tiago Isidoro
- Timothy M Uyeki
- Todd C Lee
- Tom Fletcher
- Tom Solomon
- Touxiong Yiaye
- Triona Downer
- Trude Steinsvik
- Tânia Sequeira
- Valeria Balan
- Valla Sahraei
- Vanessa Sancho-Shimizu
- Vegard Skogen
- Victoria Shaw
- Viladeth Praphasiri
- Virginie Williams
- Volkan Korten
- Wael Hafez
- Wai Ching Sin
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Yael Dishon
- Yaseen Arabi
- Yock Ping Chow
- Yousef Al-Saba'a
- Yusing Gu
- Zaina Dalloul
- Publication venue
- Publication date
- 12/09/2023
- Field of study
Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes. Methods: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed. Findings: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed. Conclusions: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. Funding: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the "acknowledgments" section
An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients
- Author
- A M Udara Lakshan Attanyake
- Aasiyah Rashan
- Aasiyah Rashan
- Abby Hurd
- Abdulrahman Al-Fares
- Abhishek Dasgupta
- Abigail Beane
- Adrian Streinu-Cercel
- Adrienne Chan
- Aidan Burrell
- Alan Hartman
- Alberto Uribe
- Alejandro Martin-Quiros
- Alejandro Martín-Quiros
- Alejandro Martín-Quiros
- Aleksander Rygh Holten
- Alexander J Mentzer
- Alfredo Antonio Chetta
- Ali Abbas
- Alicia Gonzalez
- Alison M Meynert
- Alistair Nichol
- Allison McGeer
- Ama Kwakyewaa Bedu-Addo
- Amanda Corley
- Amanda Rojek
- Amanda Rojek
- Amar Bhatt
- Amna Faheem
- Amy Lester-Grant
- Ana Aroca
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Anais Rampello
- Anant Kataria
- Anca Streinu-Cercel
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Kildal
- Anders Tveita
- Andra-Maris Post
- Andrea Angheben
- Andrea Ticinesi
- Andrea Villoldo
- Andreas Lind
- Andrew Dagens
- Andrew Letizia
- Andy Law
- Angela Alberti
- Anja Grosse Lordemann
- Anna Berenguera
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne-Marie Guerguerian
- Annemarie B Docherty
- Antonia Ho
- Antonio Arcadipane
- Arabella Fahy
- Ardiyan Apriyana
- Arjen M Dondorp
- Asgar Rishu
- Asgar Rishu
- Astarini Hidayah
- Audrey Dubot-Pérès
- B P Sanka Ruwan Sri Darshana
- Barbara Wanjiru Citarella
- Barbara Wanjiru Citarella
- Beathe Kiland Granerud
- Beatrice Alex
- Benjamin Bach
- Bianca Boxma
- Birgitte Stiksrud
- Bounthavy Chaleunphon
- Bountoy Sibounheuang
- Brenda Molloy
- Brenda Reeve
- Brigid Flynn
- Bronner P Gonçalves
- Bronner P Gonçalves
- Budha Charan Singh
- Cameron J Fairfield
- Carlo Ferrari
- Carlos Cañada Illana
- Carlotta Mutti
- Caroline Martins Rego
- Caroline Mudara
- Carrol Gamble
- Cassidy Codan
- Caterina Caminiti
- Catherine A Shaw
- Catherine Blier
- Catherine Marquis
- Cecilia Canepa
- Ceila Maria Sant Ana Malaque
- Chamira Kodippily
- Charlotte Summers
- Chiara Vitiello
- Chloe Donohue
- Chris Kandel
- Christel Arnold-Day
- Christiana Kartsonaki
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christopher A Green
- Clare Jackson
- Clark D Russell
- Claudia Bianco
- Claudia Figueiredo-Mello
- Claudia Figueiredo-Mello
- Claudia Montes
- Colin McArthur
- Cornelius Rau
- Dafsah Juzar
- Dag Henrik Reikvam
- Dan Meyer
- Daniel Haber
- Daniel Marino
- Danoy Chommanam
- David Bellemare
- David L Robertson
- David Maslove
- David S Y Ong
- David S Y Ong
- David Stuart
- David Thomson
- Debby Bogaert
- Deepali Kumar
- Demetrios Kutsogiannis
- Derbrenn OConnor
- Diego Fernando Bautista Rincon
- Diego Franch-Llasat
- Diptesh Aryal
- Diptesh Aryal
- Dori-Ann Martin
- Dounia Bouhmani
- Edel Meaney
- Eder Caceres
- Efstathia Mihelis
- Egle Saviciute
- Elaine McPartlan
- Elena Molinos
- Elena Ranza
- Elizabeth A Ashley
- Ellen Shadowitz
- Else Quist-Paulsen
- Eman Al Qasim
- Emily Neumann
- Emma C Thomson
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Enrico Adriano
- Esteban Garcia-Gallo
- Eva Miranda Marwali
- Evert-Jan Wils
- Evert-Jan Wils
- Ewen M Harrison
- Ewen M Harrison
- Federica Fogliazza
- Federica Garofalo
- Felwa Bin Humaid
- Ferran Roche-Campo
- Fiona Griffiths
- Francesca Carlacci
- Francesco Rausa
- Francisca Adewhajah
- Frank Manetta
- Frank Olav Pettersen
- Franklina Korkor Abebrese
- François Lamontagne
- François Martin Carrier
- François Martin Carrier
- Fredrik Müller
- Frédérick D'Aragon
- G Argin
- Gail Carson
- Gail Carson
- Gamage Dona Dilanthi Priyadarshani
- Gary Leeming
- Gary Schwartz
- Gayle Carney
- Gennaro Martucci
- Georgios Pollakis
- Geraldine Goco
- Gianluigi Li Bassi
- Giorgio Economopoulos
- Giovanna Occhipinti
- Giovanna Panarello
- Giuseppe Maglietta
- Gloria Crowl
- Graham S Cooke
- Gry Kloumann Bekken
- Gyan Sandhu
- Haixia Shi
- Hannah Habraken
- Hannah Keane
- Hannah Marrinan
- Hayley Hardwick
- Hazel Bergin
- Heidi Dalton
- Hem Paneru
- Henrique Mateus Fernandes
- Himasha Muvindi
- Himed Musaab
- Hubert Tessier-Grenier
- Husna Begum
- Iam Claire E Sarmiento
- Ignacio Martin-Loeches
- Ilaria Valzano
- Imrana Khalid
- Indrek Rätsep
- Ingrid G Bustos
- Inês Carqueja
- Irene Bandoh
- ISARIC Clinical Characterisation Group
- J Kenneth Baillie
- J Kenneth Baillie
- Jacky Y Suen
- Jake Dunning
- Jake Dunning
- James Joshua Douglas
- James Joshua Douglas
- James Lee
- James Scott-Brown
- James Vickers
- Jan Cato Holter
- Janet Diaz
- Janet Harrison
- Janet Liang
- Janet T Scott
- Janice Caoili
- Janice Caoili
- Jaques Sztajnbok
- Jeff Powis
- Jennifer Lee
- Jess Gibson
- Jia Wei
- Jillian Deacon
- Jo Dalton
- Joan Gómez-Junyent
- Joan Gómez-Junyent
- Joanne Downey
- Joaquín Baruch
- Joaquín Baruch
- John Beca
- John F Fraser
- John Marshall
- Johnny McKeown
- Jonathan Bitton
- Jordi Rello
- José Antonio Lepe
- José Ernesto Vidal
- João Camões
- Juan Fiorda
- Juan Pablo Horcajada
- Judit Villar
- Julia Garcia-Diaz
- Julian Chica
- Kalynn Kennon
- Kamal Abu Jabal
- Karl Erik Müller
- Karolina Krawczyk
- Kate Ainscough
- Kathy Brickell
- Katie O'Hearn
- Kenneth A McLean
- Kevin Katz
- Kizy Sanchez de Oliveira
- Kristian Tonby
- Kusum Menon
- Lance C W Turtle
- Lars Hegelund
- Lars Heggelund
- Latsaniphone Bountthasavong
- Laura Feeney
- Laura Marsh
- Laura Merson
- Laura Merson
- Laura Patrizi
- Laveena Munshi
- Leanne Hays
- Leonardo Salazar
- Leonardo Salazar
- Liadain Reid
- Lina Morales Cely
- Linda Gail Skeie
- Linda O'Shea
- Lisa Norman
- Lisa Patterson
- Liv Hesstvedt
- Lorinda Essuman
- Lorna Murphy
- Louise Sigfrid
- Luca Sacchelli
- Lucian Durham
- Lucille Blumberg
- Luis Felipe Reyes
- Luis Felipe Reyes
- Luis Periel
- Lukas Arenz
- Madiha Hashmi
- Madiha Hashmi
- Mahdad Noursadeghi
- Malcolm G Semple
- Malcolm G Semple
- Mangala Narasimhan
- Manivanh Vongsouvath
- Maram Zahran
- Marco Echeverria-Villalobos
- Mare Pejkovska
- Margarite Grable
- Maria Angelica Rivera Nuñez
- Maria Donnelly
- Maria Lawrensia Tampubolon
- Maria Majori
- Maria Zambon
- Marianne Fraher
- Mariano Esperatti
- Marie Connor
- Marina Aiello
- Marina Lanza
- Mark G Pritchard
- Mark Pritchard
- Marlene Santos
- Martina Escher
- Mary Copland
- Massimo Palmarini
- Matteo Puntoni
- Matteo Rossetti
- Matthew Hall
- Matthew Hall
- Matthew Nelder
- Mayfong Mayxay
- Meera Chand
- Melissa Parker
- Mical Paul
- Michael Edelstein
- Michael Varrone
- Michaela Barnikel
- Michele Petrovic
- Michelle E Kho
- Michelle Girvan
- Michelle Smyth
- Mohd Basri Mat Nor
- Mohiuddin Shiekh
- Moirangthem Bikram Singh
- Moritz U G Kraemer
- Moses Siaw-Frimpong
- Muge Cevik
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Nashat Abu Salah
- Nathaniel Christy
- Netta Beer
- Nick Daneman
- Nicola Latronico
- Nicole White
- Nidyanara Castanheira
- Nina Jamieson
- Nora Fuentes
- Oana Sandulescu
- Obada Yousif
- Oleksa Rewa
- Ooyanong Phonemixay
- P G Ishara Udayanga
- Paa Kobina Forson
- Paddy Mallon
- Paolo Parducci
- Pathik Dhanger
- Patricia Fontela
- Patricia Gordon
- Patrick Archambault
- Patrizia Bonelli
- Patrizia Mammi
- Paul Klenerman
- Paul Tierney
- Paula Custodio
- Perren J Cobb
- Peter Daley
- Peter Doran
- Peter Horby
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Phil Gallagher
- Philippe Jouvet
- Phoebe Ampaw
- Phouvieng Douangdala
- Piero L Olliaro
- Piero L Olliaro
- Piret Sillaots
- Pompini Agustina Sitompul
- Pooja Varghese
- Prasan Kumar Panda
- Rachael McConnochie
- Rachael Parke
- Rajavardhan Rangappa
- Rajavardhan Rangappa
- Rajesh Mohan Shetty
- Rakesh Arora
- Rashan Haniffa
- Renata Barbalho
- Richard S Tedder
- Riinu Pius
- Rima Song
- Rob Fowler
- Robert A Fowler
- Roberta Cavalin
- Roberta Pisi
- Roberto Roncon-Albuquerque
- Robin Kobbe
- Romans Matulevics
- Rosario Maria Torres Santos-Olmo
- Ross Hendry
- Rumaisah Satyawati
- Rupert Higgins
- Ruth Lyons
- Ryan S Thwaites
- Sabina Mason
- Sadie Kelly
- Sally Shrapnel
- Samreen Ijaz
- Samuel Hinton
- Sandra Rossi
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sarah E McDonald
- Sarah Moore
- Saye Khoo
- Scott Pharand
- Sebastian Vencken
- Seán Keating
- Shaikh Sharjeel
- Sharma Keshav
- Shaun Thompson
- Sheryl Ann Abdukahil
- Shiranee Sriskandan
- Shirley Sarfo-Mensah
- Shona C Moore
- Silvia Bertagnolio
- Silvia Castañeda
- Simon Forsyth
- Simone Piva
- Soe Soe Thwin
- Sophia Ankrah
- Sophie Halpin
- Soulichanya Phoutthavong
- Sree Satyapriya
- Srinivas Murthy
- Srinivas Murthy
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen R Knight
- Steve Webb
- Sue Smith
- Summer Hamza
- Surya Otto Wijaya
- Susanne Dudman
- Synne Jenum
- Sérgio Gaião
- Sílvia Ferreira
- Teresa Lawrence
- Thalha Rashan
- Thipsavanh Bounphiengsy
- Thushan de Silva
- Timothy M Uyeki
- Tirupakuzhi Vijayaraghavan
- Tiziana Meschi
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Touxiong Yiaye
- Trude Steinsvik
- Uluhan Sili
- Valeria Balan
- Valeria Balan
- Valla Sahraei
- Vanessa Sancho-Shimizu
- Vegard Skogen
- Victoria Shaw
- Viladeth Praphasiri
- Vilmaris Quinones-Cardona
- Volkan Korten
- Waasila Jassat
- Waasila Jassat
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Xin Ci Wong
- Xin Ci Wong
- Yael Dishon
- Yaseen Arabi
- Yaseen Arabi
- Yock Ping Chow
- Yock Ping Chow
- Yvelynne Kelly
- Zulfiqar Sandhu
- Publication venue
- 'eLife Sciences Publications, Ltd'
- Publication date
- 01/01/2022
- Field of study
Background: Whilst timely clinical characterisation of infections caused by novel SARS-CoV-2 variants is necessary for evidence-based policy response, individual-level data on infecting variants are typically only available for a minority of patients and settings.
Methods: Here, we propose an innovative approach to study changes in COVID-19 hospital presentation and outcomes after the Omicron variant emergence using publicly available population-level data on variant relative frequency to infer SARS-CoV-2 variants likely responsible for clinical cases. We apply this method to data collected by a large international clinical consortium before and after the emergence of the Omicron variant in different countries.
Results: Our analysis, that includes more than 100,000 patients from 28 countries, suggests that in many settings patients hospitalised with Omicron variant infection less often presented with commonly reported symptoms compared to patients infected with pre-Omicron variants. Patients with COVID-19 admitted to hospital after Omicron variant emergence had lower mortality compared to patients admitted during the period when Omicron variant was responsible for only a minority of infections (odds ratio in a mixed-effects logistic regression adjusted for likely confounders, 0.67 [95% confidence interval 0.61-0.75]). Qualitatively similar findings were observed in sensitivity analyses with different assumptions on population-level Omicron variant relative frequencies, and in analyses using available individual-level data on infecting variant for a subset of the study population.
Conclusions: Although clinical studies with matching viral genomic information should remain a priority, our approach combining publicly available data on variant frequency and a multi-country clinical characterisation dataset with more than 100,000 records allowed analysis of data from a wide range of settings and novel insights on real-world heterogeneity of COVID-19 presentation and clinical outcome
Liver injury in hospitalized patients with COVID-19: An International observational cohort study
- Author
- Abby Hurd
- Abdulrahman Al-Fares
- Abhijit Duggal
- Abigail Beane
- Adam Hall
- Adam Nowinski
- Adhikari Neill K. J.
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agnès Meybeck
- Agnès Sommet
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Haji Ab Rahman
- Ahmed Farooq
- Aidan Burrell
- Ailbhe Hayes
- Aine McCarthy
- Aisling Gavin
- Aisling Murphy
- Akram Zaaqoq
- Al-Awwab Dabaliz
- Al-Fares Abdulrahman
- Alan Hartman
- Alasdair Nazerali-Maitland
- Albert Groenendijk
- Albert Sotto
- Alberto Uribe
- Alberto Zanella
- Albertus Beishuizen
- Aldo Rafael
- Aldric Manuel
- Alejandro Martín-Quiros
- Aleksander Rygh Holten
- Aleksandr Beljantsev
- Alessandra Notari
- Alex Nagrebetsky
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J. Mentzer
- Alexander King
- Alexandra Bedossa
- Alexandra Coelho
- Alexandra Sperry
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Alexandros Cavayas
- Ali Ait Hssain
- Ali Hachemi
- Alicia Gonzalez
- Alif Adlan Mohd Thabit
- Aline-Marie Florence
- Alison M. Meynert
- Alistair Nichol
- Allison McGeer
- Alpha Diallo
- Alphonsine Diouf
- Amal Abrous
- Amanda Corley
- Amanda Palacios
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amar Bhatt
- Amélie Valran
- Ami Stuart
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amy Lester-Grant
- Amy Stone
- Ana Chora Sousa
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Isabel de Pinho Oliveira
- Ana L Rios
- Ana Martins
- Ana Motos
- Ana Raquel Maia
- Anant Kataria
- Anatoliy Gavrylov
- Anca Streinu-Cercel
- Anders Tveita
- Andra-Maris Post
- Andrea Angheben
- Andrea Cortegiani
- Andrea Dell’Amore
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Acker
- Andrew Dagens
- Andrew Hershey
- Andrew Law
- Andrew Udy
- Andrey Svistunov
- André Cabie
- André Roberto
- Andriy Bal
- Angela Alberti
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anna Ciullo
- Anna Greti Everding
- Anna Jung
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne-Hélène Boivin
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O Callaghan
- Annmarie O’Callaghan
- Ansley Hamer
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Anton Prinssen
- Antoni Torres
- Antonia Ho
- Antonio Arcadipane
- Antonio Pesenti
- António Mesquita
- Aquiles Henriquez
- Ardiyan Apriyana
- Arfan Ikram
- Argin G
- Arianne Joy Corpuz
- Arie Zainul Fatoni
- Arnaud Scherpereel
- Arsène Kpangon
- Arthur Garan
- Ary Serpa Neto
- Asad Usman
- Asfia Sultana
- Asgar Rishu
- Asim Rana
- Asma Moin
- Audrey Barrelet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Aurore Bousquet
- Axelle Braconnier
- Azlan Mat Soom
- Bailey Cassandra
- Bairbre McNicholas
- Bambang Pujo Semedi
- Barbara Wanjiru Citarella
- Baruch Joaquin
- Basri Mat Nor
- Beathe Kiland Granerud
- Beatrice Alex
- Beatriz Amorim Beltrão
- Ben Morton
- Benedict Sim Lim Heng
- Benigno Ferreira
- Benjamin Bach
- Benjamin Lefèvre
- Benjamin Smood
- Benjamine Sarton
- Benoit Visseaux
- Benoît Roze
- Benoît Thill
- Bernard Cholley
- Bernardo Ferreira
- Bernhard Roessler
- Bertrand Dussol
- Bénédicte Lefebvre
- Bénédicte Rossignol
- Bharath Kumar Tirupakuzhi Vijayaraghavan
- Bianca Boxma
- Biing Horng Lee
- Birgitte Stiksrud
- Bishnu Saptarshi
- Blake Mergler
- Blandine Rammaert
- Bouchra Loufti
- Brenda Molloy
- Brenda Reeve
- Brigitte Elharrar
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bruno Sarmento Banheiro
- Bryan Whelan
- Budha Charan Singh
- Calvache Jose A.
- Calvin Wong
- Cameron J. Fairfield
- Camile Bouisse
- Camille Couffignal
- Caren Friedrich
- Carine Roy
- Carla Eira
- Carlo Giaquinto
- Carlos Alexandre Antunes de Brito
- Carlos M. Luna
- Carlos Pimentel
- Carola Pierobon
- Carolien van Netten
- Caroline Kosgei
- Caroline Martins Rego
- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
- Cassidy Codan
- Catarina Espírito Santo
- Catarina Pires
- Catherine A. Shaw
- Catherine Blier
- Catherine Chakveatze
- Catherine Chirouze
- Catherine L. Hough
- Cecile Azoulay
- Cecilia Canepa
- Ceila Maria Sant`Ana Malaque
- Celina Turchi Martelli
- Cécile Goujard
- Cécile Mear-Passard
- Cécile Tromeur
- Cécile Yelnik
- Cédric Joseph
- Cédric Laouénan
- Céline Dorival
- Céline Ficko
- Céline Michelanglei
- César Vieira
- Chan Chee Eng
- Chantre Lima
- Charbel Maroun Eid
- Charlene Da Silveira
- Charline Vauchy
- Charlotte Charpentier
- Charlotte Salmon Gandonniere
- Charlotte Summers
- Chian Hui Yeoh
- Chiara Simona Cardellino
- Chiara Vitiello
- Chih-Hsien Wang
- Chloe Donohue
- Chris Kandel
- Christel Arnold-Day
- Christelle Chantalat Auger
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Prebensen
- Christian Rabaud
- Christiana Kartsonaki
- Christl A. Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A. Green
- Christy Kay
- Citarella Barbara Wanjiru
- Claire Andrejak
- Claire Kelly
- Claire Levy-Marchal
- Clara Flateau
- Clara Mouton Perrot
- Clare Jackson
- Clark D. Russell
- Claudia Bianco
- Claudia Figueiredo-Mello
- Claudia Milena Orozco-Chamorro
- Claudia Montes
- Claudia Sepulveda
- Claudina Cruz
- Claudine Badr
- Claudio Duarte Fonseca
- Cleide Barrigoto
- Clément Le Bihan
- Clotilde Allavena
- Colin McArthur
- Colin McCloskey
- Coline Jaud-Fischer
- Colleen Curran
- Conar O’Neil
- Coralie Khan
- Coralie Tardivon
- Corine Delsing
- Corinne Daniel
- Cornelius Rau
- Courtney Greene
- Craig French
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- Dafsah Juzar
- Dag Henrik Reikvam
- Daisuke Kasugai
- Damien Bouhour
- Dan Meyer
- Daniel Glikman
- Daniel Haber
- Daniel Ivulich
- Daniel Mathieu
- Daniel Munblit
- Daniel Perez
- Daniela Guerreiro
- Danielle Jaafar
- Darren Dahly
- David Bellemare
- David Dean
- David L. Robertson
- David Maslove
- David Richardson
- David S. Y. Ong
- David Stuart
- David Thomson
- David Zucman.
- Davide Chiumello
- Dawn Higgins
- Debby Bogaert
- Deepak Vijayan
- Deepali Kumar
- Deepashankari Suppiah
- Dehbia Benkerrou
- Deirdre Flynn
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Demetrios Kutsogiannis
- Denis Butnaru
- Denis Garot
- Denis Malvy
- Denisa Khoo
- Denise Richardson
- Derbrenn OConnor
- Dewi Guellec
- Diana Adrião
- Diana Hernandez
- Diana Póvoas
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Diego Bastos Porto
- Diego Fernando Bautista Rincon
- Diego Franch-Llasat
- Diogo Borges
- Diogo Lopes
- Diptesh Aryal
- Djura Piersma
- Dominique Deplanque
- Dominique Luton
- Dori-Ann Martin
- Dorothea Rosenberger
- Dorothy Breen
- Dounia Bouhmani
- Douwe F. Postma
- Duc Nguyen
- Dzawani Muhamad
- Edel Meaney
- Eder Caceres
- Edmund Manning
- Edouard Soum
- Edward Wilson Grandin
- Efstathia Mihelis
- Eglantine Ferrand Devouge
- Egle Saviciute
- Eibhlin Higgins
- Eka Yudha Lantang
- Elaine McPartlan
- Elena Molinos
- Elias Iosifidis
- Elisa Demonchy
- Elisabeth Adam
- Elisabeth Botelho-Nevers
- Elisabetta Spinuzza
- Elise Artaud-Macari
- Ellen Shadowitz
- Elmi Theron
- Elodie Curlier
- Elsa Nyamankolly
- Else Quist-Paulsen
- Eman Al Qasim
- Emily Martin
- Emily Neumann
- Emily Somers
- Emma C. Thomson
- Emma Clarke
- Emma Costigan
- Emmanuel Roilides
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Emmanuelle Mercier
- Eric Delaveuve
- Eric D’Ortenzio
- Eric Gnall
- Eric Oziol
- Eric Senneville
- Erica Bak
- Erlina Burhan
- Ernita Akmal
- Erwan Fourn
- Erwan L’Her
- Esteban Garcia-Gallo
- Ethan Kurtzman
- Etienne De Montmollin
- Eva Geraud
- Eva Miranda Marwali
- Eve Defous
- Evert-Jan Wils
- Ewen M. Harrison
- Fabio S. Taccone
- Fabrice Laine
- Fadi-Fadi Qutishat
- Fanny Vuotto
- Fara Diop
- Farah Nadiah Bidin
- Felwa Bin Humaid
- Fernanda Dias Da Silva
- Fernando Augusto Bozza
- Fernando Rainieri
- Ferran Roche-Campo
- Félix Djossou
- Filipa Brás Monteiro
- Filipa Cardoso
- Filipa Sequeira
- Filipe Cardoso
- Fiona Griffiths
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- Sudhir Krishnan
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- Sylvie Van Der Werf
- Synne Jenum
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- Tae Song
- Tahira Jamal Mohamed
- Takako Akimoto
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- Tarek Elshazly
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- Thavamany Kaleesvran
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- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomas Staudinger
- Thushan de Silva
- Tiago Isidoro
- Tiago Reyes
- Tiffany Trouillon
- Timothy M. Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Tirupakuzhi Vijayaraghavan Bharath Kumar
- Tjard Schermer
- Todd C. Lee
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Toni Duculan
- Tony Trapani
- Toshiki Yokoyama
- Triona Downer
- Tristan Gigante
- Trude Steinsvik
- Tze Vee Soh
- Tze Yuan Tee
- Vadim Tieroshyn
- Valentine Campana
- Valentine Piquard
- Valeria Balan
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Valla Sahraei
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Ventzislava Petrov-Sanchez
- Vera Irawany
- Véronique Lemee
- Vicente Souza-Dantas
- Victor Fomin
- Victoria Manda
- Victoria Shaw
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinothini Krishnan
- Virginie Williams
- Vladislav Mihnovit
- Waasila Jassat
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Yih-Sharng Chen
- Ymkje Stienstra
- Yoan Lavie-Badie
- Yoann Donohue
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yuri Kida
- Yusing Gu
- Yves Levy
- Zhang Duan Tham
- Zul Amali Che Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- PUBLIC LIBRARY SCIENCE
- Publication date
- 01/10/2023
- Field of study
Background: Using a large dataset, we evaluated prevalence and severity of alterations in liver enzymes in COVID-19 and association with patient-centred outcomes.MethodsWe included hospitalized patients with confirmed or suspected SARS-CoV-2 infection from the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) database. Key exposure was baseline liver enzymes (AST, ALT, bilirubin). Patients were assigned Liver Injury Classification score based on 3 components of enzymes at admission: Normal; Stage I) Liver injury: any component between 1-3x upper limit of normal (ULN); Stage II) Severe liver injury: any component & GE;3x ULN. Outcomes were hospital mortality, utilization of selected resources, complications, and durations of hospital and ICU stay. Analyses used logistic regression with associations expressed as adjusted odds ratios (OR) with 95% confidence intervals (CI).ResultsOf 17,531 included patients, 46.2% (8099) and 8.2% (1430) of patients had stage 1 and 2 liver injury respectively. Compared to normal, stages 1 and 2 were associated with higher odds of mortality (OR 1.53 [1.37-1.71]; OR 2.50 [2.10-2.96]), ICU admission (OR 1.63 [1.48-1.79]; OR 1.90 [1.62-2.23]), and invasive mechanical ventilation (OR 1.43 [1.27-1.70]; OR 1.95 (1.55-2.45). Stages 1 and 2 were also associated with higher odds of developing sepsis (OR 1.38 [1.27-1.50]; OR 1.46 [1.25-1.70]), acute kidney injury (OR 1.13 [1.00-1.27]; OR 1.59 [1.32-1.91]), and acute respiratory distress syndrome (OR 1.38 [1.22-1.55]; OR 1.80 [1.49-2.17]).ConclusionsLiver enzyme abnormalities are common among COVID-19 patients and associated with worse outcomes
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Absil Lara
- Acharya Subhash
- Acker Andrew
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Altaf Aneela
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
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- Darshana B. P. Sanka Ruwan Sri
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- Fraher Marianne
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- Greene Courtney
- Greenhalf William
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- Harrison Janet
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- Hough Catherine L.
- Hssain Ali Ait
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- Hulot Jean-Sébastien
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- Hussain Iqbal
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- Ijaz Samreen
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- Ivulich Daniel
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- Kho Michelle E.
- Khoo Saye
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- Kida Yuri
- Kiiza Peter
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- Klont Rob
- Knight Stephen R.
- Kobbe Robin
- Kodippily Chamira
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- Kurtzman Ethan
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- Lachatre Marie
- Lacoste Marie
- Laffey John G.
- Lagrange Marie
- Laine Fabrice
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- Lakhey Sanjay
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- Lee Todd C.
- Leeming Gary
- Lefebvre Bénédicte
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- Lordemann Anja Grosse
- Loschner Anthony L.
- Loubet Paul
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- Lucet Jean Christophe
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- Maier Lars S.
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- Marshall John C.
- Martelli Celina Turchi
- Martin Emily
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- Nurnaningsih Nurnaningsih
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- Oliveira Larissa
- Olliaro Piero L.
- Ong David S. Y.
- Oosthuyzen Wilna
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- Payen Jean-François
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- Postma Douwe F.
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- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
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- Rehman Attaur
- Reid Liadain
- Reid Liadain
- Reikvam Dag Henrik
- Reis Renato
- Rello Jordi
- Remppis Jonathan
- Remy Martine
- Ren Hongru
- Renk Hanna
- Resseguier Anne-Sophie
- Revest Matthieu
- Rewa Oleksa
- Reyes Luis Felipe
- Reyes Tiago
- Ribeiro Ana Freitas
- Ribeiro Maria Ines
- Richardson David
- Richardson Denise
- Richier Laurent
- Riera Jordi
- Rincon Diego Fernando Bautista
- Rios Ana L.
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Robba Chiara
- Roberto André
- Roberts Stephanie
- Robertson David L.
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia Simão
- Roessler Bernhard
- Roger Pierre-Marie
- Rojek Amanda
- Rojo Jaime Cruz
- Romaru Juliette
- Roncon-Albuquerque Roberto
- Roriz Mélanie
- Rosa-Calatrava Manuel
- Rose Michael
- Rosenberger Dorothea
- Rossanese Andrea
- Rossetti Matteo
- Rossignol Bénédicte
- Rossignol Patrick
- Rousset Stella
- Roy Carine
- Roze Benoît
- Rusmawatiningtyas Desy
- Russell Clark D.
- Ryan Maeve
- Ryan Maria
- Ryckaert Steffi
- Rätsep Indrek
- Saba Isabela
- Sadaf Sairah
- Sadat Musharaf
- Sahraei Valla
- Saidani Nadia
- Saint-Gilles Maximilien
- Sakiyalak Pranya
- Salahuddin Nawal
- Salazar Leonardo
- Saleem Jodat
- Sales Gabriele
- Sallaberry Stéphane
- Salvator Hélène
- Sanchez Olivier
- Sanchez-Miralles Angel
- Sancho-Shimizu Vanessa
- Sandhu Gyan
- Sandhu Zulfiqar
- Sandrine Pierre-François
- Sandulescu Oana
- Sanharawi Mohammed El
- Sant Ceila Maria
- Santo Catarina Espírito
- Santos Marlene
- Santos Marta Leal
- Sarfo-Mensah Shirley
- Sarton Benjamine
- Satyapriya Sree
- Satyawati Rumaisah
- Saviciute Egle
- Schaffer Justin
- Schermer Tjard
- Scherpereel Arnaud
- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scott Janet T.
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Selvanayagam Jaganathan
- Semaille Caroline
- Semedi Bambang Pujo
- Semple Malcolm G.
- Senneville Eric
- Sequeira Filipa
- Sequeira Tânia
- Shadowitz Ellen
- Shah Naseem Ali
- Shamsah Mohammad
- Sharjeel Shaikh
- Sharma Pratima
- Shaw Catherine A.
- Shaw Victoria
- Sheharyar Ashraf
- Shetty Rajesh Mohan
- Shi Haixia
- Shiekh Mohiuddin
- Shimizu Keiki
- Shrapnel Sally
- Shrestha Pramesh Sundar
- Shrestha Shubha Kalyan
- Shukeri Wan Fadzlina Wan Muhd
- Shum Hoi Ping
- Sibiude Jeanne
- Siddiqui Atif
- Sigfrid Louise
- Sikander Rana Imran
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- Silva Maria Joao
- Silva Rogério
- Sin Wai Ching
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- Singh Punam
- Sitompul Pompini Agustina
- Skeie Linda Gail
- Skogen Vegard
- Smith Sue
- Smood Benjamin
- Smyth Coilin
- Smyth Michelle
- Smyth Michelle
- Snacken Morgane
- So Dominic
- Sobrino José Luis Bernal
- Solomon Joshua
- Solomon Tom
- Somers Emily
- Sommet Agnès
- Song Myung Jin
- Song Rima
- Song Tae
- Sotto Albert
- Soum Edouard
- Sousa Ana Chora
- Sousa Marta
- Sperry Alexandra
- Spinuzza Elisabetta
- Sriskandan Shiranee
- Stabler Sarah
- Staudinger Thomas
- Stecher Stephanie-Susanne
- Stienstra Ymkje
- Stiksrud Birgitte
- Stolz Eva
- Stone Amy
- Streinu-Cercel Adrian
- Streinu-Cercel Anca
- Stuart Ami
- Stuart David
- Suen Gabriel
- Suen Jacky Y.
- Sultana Asfia
- Summers Charlotte
- Supic Dubravka
- Surovcová Magdalena
- Svistunov Andrey
- Syrigos Konstantinos
- Sztajnbok Jaques
- Szuldrzynski Konstanty
- Tabrizi Shirin
- Taccone Fabio S.
- Tagherset Lysa
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tampubolon Maria Lawrensia
- Tanaka Hiroyuki
- Taqdees Huda
- Taqi Arshad
- Tardivon Coralie
- Tattevin Pierre
- Taufik M. Azhari
- Tawfik Hassan
- Tedder Richard S.
- Teixeira João
- Tejada Sofia
- Tellier Marie-Capucine
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Tey Adrian
- Thakur Anand
- Thibault Vincent
- Thiberville Simon-Djamel
- Thill Benoît
- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
- Tissot Noémie
- Toki Maria
- Tonby Kristian
- Torre Marta
- Torres Antoni
- Torres Margarida
- Torres-Zevallos Hernando
- Towers Michael
- Trapani Tony
- Treoux Théo
- Tromeur Cécile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turmel Jean-Marie
- Turtle Lance C. W.
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udayanga P. G. Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- Van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- Van Der Vekens Nicky
- Van der Voort Peter
- Van Der Werf Sylvie
- van Gulik Laura
- Van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Vasconcelos Malte Kohns
- Vauchy Charline
- Vecham Pavan Kumar
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira César
- Vijayan Deepak
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wong Calvin
- Xynogalas Ioannis
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yerkovich Stephanie
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/09/2022
- Field of study
Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs).
Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support.
Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]).
Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Absil Lara
- Acharya Subhash
- Acker Andrew
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre K. vin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Altaf Aneela
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart S. verine
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Argin G.
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asensio Angel
- Asif Namra
- Asim Mohammad
- Assie Jean Baptiste
- Atif Minahel
- Atique Anika
- Attanyake A. M. Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bal Andriy
- Balan Valeria
- Balazote Pablo Serrano
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barclay Wendy S.
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bermúdez Juan Luis Cruz
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bissuel François
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-H. lène
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller K. vin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brien Fionnuala O.
- Browne Alex
- Browne Shaunagh
- Brusse-Keizer Marjolein
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Ceccato Adrian
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Chas Julie
- Chaudry Mobin
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clohisey Sara
- Cobb Perren J.
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew J.
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- Cárcel Sheila
- da Silva Filipe Ana
- da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A.
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de la Calle Guillermo Maestro
- de Loughry Gillian
- de Mendoza Diego
- de Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Pinho Oliveira Ana Isabel
- de Rosa Rosanna
- de Silva Thushan
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Dell’Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Didier K. vin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet J. rôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou F. lix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M.
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival C. line
- Douglas James Joshua
- Dournon Nathalie
- Dow Denisse Bazan
- Downer Triona
- Downey Joanne
- Downing Mark
- Drake Tom
- Driscoll Aoife
- Dubee Vincent
- Dubos François
- Ducancelle Alexandre
- Dudman Susanne
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Duque Sara
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- D’Aragon Frédérick
- D’Ortenzio Eric
- Echeverria-Villalobos Marco
- Egan Siobhan
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Ellerbroek Jacobien
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Endo Tomoyuki
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou H. lène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Fakar Zul
- Fareed Komal
- Faria Pedro
- Farooq Ahmed
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Fernandes Jorge
- Fernandes Marília Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferraz M. rio
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Isabel
- Ferreira S. lvia
- Ferrer-Roca Ricard
- Ferriere Nicolas
- Ferrão Joana
- Ficko C. line
- Figueiredo-Mello Claudia
- Fiorda Juan
- Flament Thomas
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Flynn Deirdre
- Foley Claire
- Foley Jean
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F.
- Freire Marcela Vieira
- French Craig
- Friedrich Caren
- Fry Stéphanie
- Fuentes Nora
- Fuentes Yuli V.
- Fukuda Masahiro
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião S. rgio
- Gallagher Phil
- Gamble Carrol
- Gandonniere Charlotte Salmon
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- Garcês Rui Caetano
- García Ruth N. Jorge
- Garimella Navya
- Garot Denis
- Garrait Valérie
- Gauli Basanta
- Gault Nathalie
- Gavin Aisling
- Gavrylov Anatoliy
- Gaymard Alexandre
- Gebauer Johannes
- Geraud Eva
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Gilroy Elaine
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gominet Marie
- Gonzalez Alicia
- González V. ctor Quirós
- Gonçalves Bronner P.
- Gordon Patricia
- Gorenne Isabelle
- Goubert Laure
- Goujard C. cile
- Goulenok Tiphaine
- Grable Margarite
- Graf Jeronimo
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A.
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffiths Fiona
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj J. rémie
- Guego Martin
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gómez-Junyent Joan
- Haalboom Marieke
- Haber Daniel
- Habraken Hannah
- Hachemi Ali
- Hadri Nadir
- Haidri Fakhir
- Hakak Sheeba
- Hall Adam
- Hall Matthew
- Halpin Sophie
- Hameed Jawad
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Haniffa Rashan
- Hardwick Hayley
- Harrison Ewen M.
- Harrison Janet
- Harrison Samuel Bernard Ekow
- Hasan Mohd Shahnaz
- Hashmi Junaid
- Hashmi Madiha
- Hayat Muhammad
- Hayes Ailbhe
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Hentzien Maxime
- Herreros José Miguel Cisneros
- Hershey Andrew
- Hesstvedt Liv
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhilin
- Higgins Rupert
- Hinchion Rita
- Hinton Samuel
- Hitoto Hikombo
- Ho Antonia
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holter Jan Cato
- Horby Peter
- Horcajada Juan Pablo
- Hoshino Koji
- Hoshino Kota
- Houas Ikram
- Hough Catherine L.
- Hssain Ali Ait
- Hsu Jimmy Ming-Yang
- Hulot Jean-S. bastien
- Humaid Felwa Bin
- Huo Stella
- Hurd Abby
- Hussain Iqbal
- Ibáñez-Prada Elsa D.
- Ijaz Samreen
- Ikram Arfan
- Illes Hajnal-Gabriela
- Imbert Patrick
- Imran Mohammad
- Imtiaz Aftab
- Inácio Hugo
- Ippolito Mariachiara
- Isgett Sarah
- Isidoro Tiago
- Isnard Margaux
- Ivulich Daniel
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- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
- Proença Lucia
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- Pulicken Mathew
- Purcell Gregory
- Puéchal Oriane
- Póvoas Diana
- Quesada Luisa
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- Quraishi Mohammed
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- Semaille Caroline
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- Semple Malcolm G.
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- Stuart Ami
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- Tagherset Lysa
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- Taqdees Huda
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- Tattevin Pierre
- Taufik M. Azhari
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- Teixeira João
- Tejada Sofia
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- Thakur Anand
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- Thill Benoît
- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
- Tissot Noémie
- Toki Maria
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- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turmel Jean-Marie
- Turtle Lance C. W.
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udayanga P. G. Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- van der Vekens Nicky
- van der Voort Peter
- van der Werf Sylvie
- van Gulik Laura
- van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Vasconcelos Malte Kohns
- Vauchy Charline
- Vecham Pavan Kumar
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira C. sar
- Vijayan Deepak
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wong Calvin
- Xynogalas Ioannis
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik C. cile
- Yerkovich Stephanie
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2022
- Field of study
Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable
Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity
- Author
- Aasiyah Rashan
- Abid Khatak
- Abigail Beane
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agnes Meybeck
- Agnes Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Rahman
- Ahmed Farooq
- Aidan Burrell
- Albert Groenendijk
- Albert Sotto
- Albertus Beishuizen
- Aldric Manuel
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexandra Bedossa
- Alexandra Coelho
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Ali Hachemi
- Alif Adlan Thabit
- Alison M. Meynert
- Alistair Nichol
- Alpha Diallo
- Alphonsine Diouf
- AM Udara Attanyake
- Amanda Corley
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amélie Valran
- Ana Freitas Ribeiro
- Ana L Rios
- Ana Martins
- Ana Silva Filipe
- Anant Kataria
- Anca Streinu-Cercel
- Andrea Angheben
- Andrea Rossanese
- Andrew Dagens
- Andrew Udy
- Andrey Svistunov
- André Cabié
- André Dias
- Andy Law
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anne Conrad
- Anne Guillaumot
- Anne McCarthy
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O'Callaghan
- Ansley Hamer
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Antonia Ho
- Antonio Lalueza
- António Mesquita
- Arabella Fahy
- Ardiyan Apriyana
- Arfan Ikram
- Aria Kekalih
- Arianne Joy Corpuz
- Arjen M Dondorp
- Arnaud Scherpereel
- Arsene Kpangon
- Ary Serpa Neto
- Asgar Rishu
- Ashraf Sheharyar
- Asma Moin
- Astarini Hidayah
- Attaur Rehman
- Audrey Barrelet
- Aurore Bousquet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Axelle Braconnier
- Azlan Mat Soom
- B. P Edouard Soum
- Barbara Wanjiru Citarella
- Basri Mat Nor
- Beatrice Alex
- Benedict Sim Heng
- Benjamin Bach
- Benjamin Lefèvre
- Benjamine Sarton
- Benoit Thill
- Benoit Visseaux
- Benoît Roze
- Bernard Cholley
- Bernardo Ferreira
- Bertrand Dussol
- Bharath Kumar Vijayaraghavan
- Bianca Boxma
- Biing Horng Lee
- Blandine Rammaert
- Bouchra Loufti
- Brenda Reeve
- Brigitte Elharrar
- Bronner P Gonçalves
- Bronner P. Gonçalves
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bénédicte Lefebvre
- Bénédicte Rossignol
- Calum Semple
- Calvin Wong
- Cameron J. Fairfield
- Camile Bouisse
- Camille Couffignal
- Carine Roy
- Carlo Giaquinto
- Carlos Alexandre Brito
- Carlos Lumbreras Bermejo
- Carlos Pimentel
- Carola Pierobon
- Carolien van Netten
- Caroline Martins Rego
- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
- Catarina Espírito Santo
- Catarina Pires
- Catherine A. Shaw
- Catherine Chakveatze
- Catherine Chirouze
- Catherine L. Hough
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- M Azhari Taufik
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- Maire-Laure Casanova
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- Masliza Zahid
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- Mathieu Blot
- Mathieu Lesouhaitier
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- Matthew Hall
- Matthew Pellan Cheng
- Matthieu Revest
- Maude Bouscambert
- Maureen Masha
- Maxime Hentzien
- Maximilien Saint-Gilles
- Mayka Mergeay-Fabre
- Meera Chand
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- Mehdi Mezidi
- Melissa Parker
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- Michael Rose
- Michele Petrovic
- Michelle Girvan
- Miguel Pedrera Jiménez
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- Minh Le
- Mirjam Evers
- Mohammad Shamsah
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- Mohd Nazlin Kamarudin
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- Moshe Matan
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- Muhammad Aisar Kamaluddin
- Muhammad Ashraf
- Muhammad Fadhli Basri
- Muhammad Rayhan
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- Nadirah Abdul Wahid
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- Navy Lolong
- Nazreen Abu Bakar
- Neerusha Kaisbain
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- Paula Custodio
- Pauline Caraux-Paz
- Pavan Kumar Vecham
- Pedro Faria
- Peter de Vries
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Peter S Timashev
- Peter Van der Voort
- Petr Glybochko
- PG Ishara Udayanga
- Philippe Jouvet
- Philippine Eloy
- Phoebe Ampaw
- Piero L Olliaro
- Piero L. Olliaro
- Pierre Delobel
- Pierre Jaquet
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-François Sandrine
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- Pieter Depuydt
- Polina Bugaeva
- Prasan Kumar Panda
- Pratap Karpayah
- Quentin Le Hingrat
- Quentin Lepiller
- Quratul Ain Khan
- Rachael Parke
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- Rachida Ouissa
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- Rafael Mahieu
- Raphael Favory
- Raphaël Borie
- Raquel Pinto
- Rashan Haniffa
- Rasidah Bt Senian
- Raul Neto
- Rebecca Hamidfar
- Renata Barbalho
- Richard S. Tedder
- Riinu Pius
- Rima Song
- Rita Alves
- Rob Klont
- Robert A Fowler
- Robert A. Fowler
- Roberta Cavalin
- Robin Kobbe
- Rodrigo Díaz
- Romain Basmaci
- Romain Decours
- Romain Guery
- Romans Matulevics
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rozanah Abd Rahman
- Rui Caetano Garcês
- Rui Pereira
- Rupert Higgins
- Ruth Lyons
- Ryadh Pokeerbux
- Ryan Khoo
- Ryan S Thwaites
- Saad Nseir
- Sabelline Bouchez
- Sabina Kali
- Sabina Mason
- Sabine Cornelis
- Sabine Croonen
- Sadie Kelly
- Saef Umar Barnett
- Saijad Orakzai
- Sally Shrapnel
- Salma Jaafoura
- Samantha Lissauer
- Samira Laribi
- Samreen Ijaz
- Samuel Hinton
- Samuel Markowicz
- Sandrine Couffin-Cadiergues
- Sanka Sri Darshana
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sara Machado
- Sarah E McDonald
- Sarah Isgett
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Syahrin
- Sarah Tubiana
- Saye Khoo
- Scott Pharand
- Sebastien Preau
- Segolène Greffe
- Seán Keating
- Shahdattul Mawarni Taib
- Shaikh Sharjeel
- Shaminee Veeran
- Sharma Keshav
- Sheryl Ann Abdukahil
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shoban Raj Vasudayan
- Shona C Moore
- Sia Loong Tonnii
- Sim Choon Ean
- Simon Bessis
- Simon Forsyth
- Simon-Djamel Thiberville
- Siri Goepel
- Siti Nurul Ridzuan
- Siti Rohani Yakop
- Siti Zubaidah Othman
- Sivanesen Anthonidass
- Sobia Masood
- Sofia Cardoso
- Soizic Le Mestre
- Sophie Halpin
- Sophie Mahy
- Srinivas Murthy
- Stanislas Rebaudet
- Stella Rousset
- Stephanie Roberts
- Stephanie Yerkovich
- Stephen R Knight
- Steve Webb
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Subhash Acharya
- Sue Smith
- Suhaila Abdul Wahab
- Surain Raaj Thurai
- Suresh Kumar Chidambaram
- Sushil Khanal
- Suvintheran Thangavelu
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Sze Kye Teoh
- Séverine Ansart
- Tae Song
- Tahira Jamal Mohamed
- Tala Al-Dabbous
- Tan Pei Wen
- Tatiana Fonseca
- Teck Fung Wong
- Teresa Lawrence
- Thalha Rashan
- Tharmini Ravi
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thushan de Silva
- Théo Treoux
- Tiago Isidoro
- Tiffany Trouillon
- Timo Brandenburger
- Timothy M. Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Todd C Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tony Trapani
- Tristan Gigante
- Tze Vee Soh
- Tze Yuan Tee
- Tânia Sequeira
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Ventzislava Petrov-Sanchez
- Victor Fomin
- Victoria Manda
- Victoria Shaw
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubée
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinod Kumar
- Vinothini Krishnan
- Véronique Lemee
- Víctor Quirós González
- Waasila Jassat
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Ymkje Stienstra
- Yoan Lavie-Badie
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zul Amali Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- 'BMJ'
- Publication date
- 01/10/2022
- Field of study
Background The impact of the COVID-19 pandemic on paediatric populations varied between high-income countries (HICs) versus low-income to middle-income countries (LMICs). We sought to investigate differences in paediatric clinical outcomes and identify factors contributing to disparity between countries.Methods The International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) COVID-19 database was queried to include children under 19 years of age admitted to hospital from January 2020 to April 2021 with suspected or confirmed COVID-19 diagnosis. Univariate and multivariable analysis of contributing factors for mortality were assessed by country group (HICs vs LMICs) as defined by the World Bank criteria.Results A total of 12 860 children (3819 from 21 HICs and 9041 from 15 LMICs) participated in this study. Of these, 8961 were laboratory-confirmed and 3899 suspected COVID-19 cases. About 52% of LMICs children were black, and more than 40% were infants and adolescent. Overall in-hospital mortality rate (95% CI) was 3.3% [=(3.0% to 3.6%), higher in LMICs than HICs (4.0% (3.6% to 4.4%) and 1.7% (1.3% to 2.1%), respectively). There were significant differences between country income groups in intervention profile, with higher use of antibiotics, antivirals, corticosteroids, prone positioning, high flow nasal cannula, non-invasive and invasive mechanical ventilation in HICs. Out of the 439 mechanically ventilated children, mortality occurred in 106 (24.1%) subjects, which was higher in LMICs than HICs (89 (43.6%) vs 17 (7.2%) respectively). Pre-existing infectious comorbidities (tuberculosis and HIV) and some complications (bacterial pneumonia, acute respiratory distress syndrome and myocarditis) were significantly higher in LMICs compared with HICs. On multivariable analysis, LMIC as country income group was associated with increased risk of mortality (adjusted HR 4.73 (3.16 to 7.10)).Conclusion Mortality and morbidities were higher in LMICs than HICs, and it may be attributable to differences in patient demographics, complications and access to supportive and treatment modalities