Assessment of GPS velocity accuracy for the Basin and Range Geodetic Network (BARGEN)

We assess the accuracy of horizontal velocity estimates from the Basin and Range Geodetic Network (BARGEN), a continuous GPS network that has been in operation since 1996. To make this quantitative assessment, we use a procedure that we term the “whole-error” method. In this method, the measure of the velocity errors is the root-mean-square (RMS) residual velocity relative to a simple geophysical model. This method produces a conservative estimate of the uncertainties, since errors in the geophysical models also contribute to the RMS residual. Using estimates from two different BARGEN subnetworks, the Northern Basin and Range and the Yucca Mountain Cluster, we determine velocity uncertainties of 0.1–0.2 mm yr^(−1). Since BARGEN covers a significant fraction of area of the proposed Plate Boundary Observatory component of EarthScope, our results indicate a good ability of this project to determine highly accurate long-term horizontal crustal velocities and deformation rates in this region

Autonomic cardiac control in animal models of cardiovascular diseases II. Variability analysis in transgenic rats with alpha-tropomyosin mutations Asp175Asn and Glu180Gly

Animal models of cardiovascular diseases allow to investigate relevant pathogenetic mechanisms in detail. In the present study, the mutations Asp175Asn and Glu180Gly in alpha-tropomyosin (TPM1), known cause familiar hypertrophic cardiomyopathy (FHC) were studied for changes in hemodynamic parameters and spontaneous baroreflex regulation in transgenic rats in comparison to transgenic and non-transgenic controls by telemetry. Heart rate variability (HRV) and blood pressure variability (BPV) were analyzed using time- and frequency domain, as well as non-linear measures. The dual sequence method was used for the estimation of the baroreflex regulation. In transgenic rats harboring mutated TPM1, changes in HRV were detected during exercise, but not at rest. Both mutations, Asp175Asn and Glu180Gly, caused increased low frequency power. In addition, in animals with mutation Asp175Asn a reduced total HRV was observed. BPV did not show any differences between all transgenic animal lines. During exercise, a strong increase in the number of bradycardic and tachycardic fluctuations accompanied with decreased baroreflex sensitivity (BRS) was detected in animals with either TPM1 mutation, Asp175Asn or Glu180Gly. These data suggest, that the analysis of cardiac autonomic control, particularly of baroreflex regulation, represents a powerful non-invasive approach to investigate the effects of subtle changes in sarcomeric architecture on cardiac physiology in vivo. In case of mutations Asp175Asn or Glu180Gly in TPM1, early detection of alterations in autonomic cardiac control could help to prevent sudden cardiac death in affected persons

Evidence for the Role of Mindfulness in Cancer: Benefits and Techniques.

Mindfulness is being used increasingly in various aspects of cancer management. Benefits of mindfulness practices are being observed to manage the adverse effects of treatment, symptoms from cancer progression, and the cost-effectiveness compared to conventional contemporary management strategies. In this review article, we present clinical trial data showing the benefits of mindfulness in various aspects of cancer management as well as techniques that have been commonly used in this practice

Spatial clustering of defect luminescence centers in Si-doped low resistivity Al0.82Ga0.18N

A series of Si-doped AlN-rich AlGaN layers with low resistivities was characterized by a combination of nanoscale imaging techniques. Utilizing the capability of scanning electron microscopy to reliably investigate the same sample area with different techniques, it was possible to determine the effect of doping concentration, defect distribution, and morphology on the luminescence properties of these layers. Cathodoluminescence shows that the dominant defect luminescence depends on the Si-doping concentration. For lower doped samples, the most intense peak was centered between 3.36 eV and 3.39 eV, while an additional, stronger peak appears at 3 eV for the highest doped sample. These peaks were attributed to the (VIII-ON)2− complex and the V3−III vacancy, respectively. Multimode imaging using cathodoluminescence, secondary electrons, electron channeling contrast, and atomic force microscopy demonstrates that the luminescence intensity of these peaks is not homogeneously distributed but shows a strong dependence on the topography and on the distribution of screw dislocations.DFG, 43659573, SFB 787: Halbleiter - Nanophotonik: Materialien, Modelle, BauelementeBMBF, 13N12587, Photonische Plattformtechnologie zur ultrasensitiven und hochspezifischen biochemischen Sensorik auf Basis neuartiger UV-LEDs (UltraSens

Crustal loading near Great Salt Lake, Utah

Two sites of the BARGEN GPS network are located ∼30 km south of Great Salt Lake (GSL). Lake-level records since mid-1996 indicate seasonal water elevation variations of ∼0.3 m amplitude superimposed on a roughly “decadal” feature of amplitude ∼0.6 m. Using an elastic Green's function and a simplified load geometry for GSL, we calculate that these variations translate into radial crustal loading signals of ±0.5 mm (seasonal) and ±1 mm (decadal). The horizontal loading signals are a factor of ∼2 smaller. Despite the small size of the expected loading signals, we conclude that we can observe them using GPS time series for the coordinates of these two sites. The observed amplitudes of the variations agree with the predicted decadal variations to <0.5 mm. The observed annual variations, however, disagree; this difference may be caused by some combination of local precipitation-induced site motion, unmodeled loading from other nearby sources, errors in the GSL model, and atmospheric errors

Contemporary strain rates in the northern Basin and Range province from GPS data

We investigate the distribution of active deformation in the northern Basin and Range province using data from continuous GPS (CGPS) networks, supplemented by additional campaign data from the Death Valley, northern Basin and Range, and Sierra Nevada–Great Valley regions. To understand the contemporary strain rate field in the context of the greater Pacific (P)–North America (NA) plate boundary zone, we use GPS velocities to estimate the average relative motions of the Colorado Plateau (CP), the Sierra Nevada–Great Valley (SNGV) microplate, and a narrow north-south elongate region in the central Great Basin (CGB) occupying the longitude band 114–117°W. We find that the SNGV microplate translates with respect to the CP at a rate of 11.4 ± 0.3 mm yr^(−1) oriented N47 ± 1°W and with respect to NA at a rate of ∼12.4 mm yr^(−1) also oriented N47°W, slower than most previous geodetic estimates of SNGV-NA relative motion, and nearly 7° counterclockwise from the direction of P-NA relative plate motion. We estimate CGB-CP relative motion of 2.8 ± 0.2 mm yr^(−1) oriented N84 ± 5°W, consistent with roughly east-west extension within the eastern Great Basin (EGB). Velocity estimates from the EGB reveal diffuse extension across this region, with more rapid extension of 20 ± 1 nstr yr^(−1) concentrated in the eastern half of the region, which includes the Wasatch fault zone. We estimate SNGV-CGB relative motion of 9.3 ± 0.2 mm yr^(−1) oriented N37 ± 2°W, essentially parallel to P-NA relative plate motion. This rate is significantly slower than most previous geodetic estimates of deformation across the western Great Basin (WGB) but is generally consistent with paleoseismological inferences. The WGB region accommodates N37°W directed right lateral shear at rates of (1) 57 ± 9 nstr yr^(−1) across a zone of width ∼125 km in the south (latitude ∼36°N), (2) 25 ± 5 nstr yr^(−1) in the central region (latitude ∼38°N), and (3) 36 ± 1 nstr yr^(−1) across a zone of width ∼300 km in the north (latitude ∼40°N). By construction there is no net extension or shortening perpendicular to SNGV-CGB relative motion. However, we observe about 8.6 ± 0.5 nstr yr^(−1) extension on average in the direction of shear from southeast to northwest within the Walker Lane belt, comparable to the average east-west extension rate of 10 ± 1 nstr yr^(−1) across the northern Basin and Range but implying a distinctly different mechanism of deformation from extension on north trending, range-bounding normal faults. An alternative model for this shear parallel deformation, in which extension is accommodated across a narrow, more rapidly extending zone that coincides with the central Nevada seismic belt, fits the WGB data slightly better. Local anomalies with respect to this simple kinematic model may reveal second-order deformation signals related to more local crustal dynamic phenomena, but significant improvements in velocity field resolution will be necessary to reveal this second-order pattern

Magnitude and Timing of Extreme Continental Extension, Central Death Valley Region, California

New geochronologic, stratigraphic, and sedimentologic data indicate extreme late Cenozoic extension across the central Death Valley region (fig. 9). ^(40)Ar/^(39)Ar geochronology of sanidine from tuffs intercalated with steeply tilted sediments along the eastern margin of the central Death Valley region, including sections near Chicago Pass and at Eagle Mountain, indicates deposition from approximately 15 to 11.7 Ma (fig. 10). Clasts of marble, orthoquartzite, fusilinid limestone, and leucogabbro are prominent at both locations. The only known source in the Death Valley region for this clast assemblage is in the southern Cotton wood Mountains, more than 100 km away on the western flank of the Death Valley region. U/Pb geochronology of baddeleyite confirms that leucogabbro clasts from both sections have the same igneous crystallization age (~180 Ma) as the leucogabbroic phase of the Hunter Mountain batholith, in the southern Cottonwood Mountains. The sediments include debris flows, flood deposits, and monolithic boulder beds of large leucogabbro clasts (>1 m), suggesting deposition in an alluvial fan setting. Sedimentary transport of these deposits is unlikely to have exceeded 20 km. Restoration of the Eagle Mountain and Chicago Valley deposits to a position just east of the southern Cotton wood Mountains results in approximate net translations of 80 km and 104 km, respectively, at an azimuth of N. 67° W. (fig. 11). This suggests overall extension magnitudes of at least 500 percent across the Death Valley region since 12 Ma, with strain rates that approached 10^(-14)/s during maximum extension. These results support previous reconstructions based on isopachs and Mesozoic structural features. (See, for example, Wernicke and others, 1988.

A Fast Counting Method for 6-motifs with Low Connectivity

A $k$-motif (or graphlet) is a subgraph on $k$ nodes in a graph or network. Counting of motifs in complex networks has been a well-studied problem in network analysis of various real-word graphs arising from the study of social networks and bioinformatics. In particular, the triangle counting problem has received much attention due to its significance in understanding the behavior of social networks. Similarly, subgraphs with more than 3 nodes have received much attention recently. While there have been successful methods developed on this problem, most of the existing algorithms are not scalable to large networks with millions of nodes and edges. The main contribution of this paper is a preliminary study that genaralizes the exact counting algorithm provided by Pinar, Seshadhri and Vishal to a collection of 6-motifs. This method uses the counts of motifs with smaller size to obtain the counts of 6-motifs with low connecivity, that is, containing a cut-vertex or a cut-edge. Therefore, it circumvents the combinatorial explosion that naturally arises when counting subgraphs in large networks

Colored Motifs Reveal Computational Building Blocks in the C. elegans Brain

Background: Complex networks can often be decomposed into less complex sub-networks whose structures can give hints about the functional organization of the network as a whole. However, these structural motifs can only tell one part of the functional story because in this analysis each node and edge is treated on an equal footing. In real networks, two motifs that are topologically identical but whose nodes perform very different functions will play very different roles in the network. Methodology/Principal Findings: Here, we combine structural information derived from the topology of the neuronal network of the nematode C. elegans with information about the biological function of these nodes, thus coloring nodes by function. We discover that particular colorations of motifs are significantly more abundant in the worm brain than expected by chance, and have particular computational functions that emphasize the feed-forward structure of information processing in the network, while evading feedback loops. Interneurons are strongly over-represented among the common motifs, supporting the notion that these motifs process and transduce the information from the sensor neurons towards the muscles. Some of the most common motifs identified in the search for significant colored motifs play a crucial role in the system of neurons controlling the worm's locomotion. Conclusions/Significance: The analysis of complex networks in terms of colored motifs combines two independent data sets to generate insight about these networks that cannot be obtained with either data set alone. The method is general and should allow a decomposition of any complex networks into its functional (rather than topological) motifs as long as both wiring and functional information is available