2 research outputs found
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
- Davidsson K
- Davies M
- Davies N
- Davis B
- Davis M
- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
- Duhan S
- Dunhurst F
- Dussan Ma
- Dutka C
- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
- Eaton C
- Eaves W
- Ebeling K
- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
- Edwards T
- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
- Facello M
- Faghih M
- Fail P
- Falcon D
- Fang C
- Fang Cy
- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
- Ferraz R
- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
- Fintel D
- Firek C
- Fischer Sm
- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
- Flores E
- Flores Gs
- Flores H
- Floro T
- Foerster A
- Folkeringa Rj
- Fonseca A
- Fontaine S
- Forgon T
- Forgosh L
- Forker A
- Forster T
- Foster M
- Foucauld J
- Fowler V
- Fox B
- Franco M
- Francoeur L
- Frandsen B
- Frandsen B
- Frankenstein L
- Fratczak M
- Freitas E
- French J
- Frivold G
- Fruchter G
- Fu G
- Fucak E
- Fuchs R
- Fucili A
- Fukuike C
- Fullerton D
- Fulop P
- Fulop T
- Fulwani M
- Furch G
- Furuseth B
- G Gacioch
- G Gosselin
- Gabito A
- Gabor M
- Gabriel J
- Gabrielli D
- Gaeb-Strasas B
- Gamba C
- Ganau A
- Gapon L
- Garas S
- Garcia Duran R
- Garcia Pinna J
- Garcia Rinaldi R
- Garcia F
- Garcia N
- Garcia-Fragoso V
- Garcia-Portela M
- Garner K
- Gazizianova V
- Gelb R
- Genest J
- Genova D
- George F
- Germann H
- Gersh B
- Gervais B
- Ghali J
- Ghondale N
- Ghosh N
- Ghosh S
- Giese C
- Gilbert J
- Gilley J
- Gits F
- Glancy R
- Glenny J
- Glover J
- Glynn Rj
- Godoy Sanchez M
- Goette A
- Goff R
- Goffinet C
- Gohel P
- Goldberg N
- Gomez Sanchez J
- Gonsorcik J
- Gonzales D
- Gonzales V
- Gonzalez E
- Gordeev I
- Gorges R
- Gospodinov K
- Gotcheva N
- Goudev A
- Gould R
- Govindaraj D
- Goyal B
- Goyal S
- Grabeau R
- Grable M
- Graham J
- Graham Ja
- Graif J
- Gralow J
- Gravellone M
- Gravenhorst-Muenter U
- Green E
- Greener R
- Greenway F
- Grieshaber V
- Griffin S
- Grigaraviciene I
- Grigorova V
- Gros C
- Grosse A
- Grover A
- Grundtvig M
- Gudipati Rvc
- Guerrero A
- Guillinta P
- Gundala Ak
- Gupta A
- Gupta A
- Gupta M
- Gupta V
- Gutmann J
- Guzman I
- Guzman P
- Gwyn M
- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
- H Hill
- Haase F
- Haege R
- Haenel T
- Hage F
- Hageman T
- Hagemann D
- Hagenow A
- Hagiwara Y
- Haidar A
- Haider K
- Hakas J
- Haldis T
- Hall C
- Hall L
- Hall S
- Halliwell Tc
- Halpern S
- Hamer Bjb
- Hamud-Socoro A
- Han B
- Han S
- Hanak P
- Hanefeld M
- Hangyal T
- Hansson A
- Hanustiakova A
- Hao Y
- Hardas S
- Hardee L
- Harrell W
- Harrington A
- Harris B
- Hartleib M
- Hartwell J
- Hasan F
- Hasbani E
- Hasegawa K
- Hattler B
- Haughton G
- Haynes E
- Haywood A
- He Y
- He Z
- Heaney L
- Hecht J
- Heeren G
- Hegedus V
- Heider J
- Heisters J
- Henley L
- Hennig D
- Henriksson A
- Hermans K
- Hernandez E
- Hernandez I
- Hernandez M
- Hernández N
- Herrman Jp
- Herzog W
- Hess E
- Hettwer Magedanz E
- Hickey L
- Hiden C
- Hielscher S
- Higuchi T
- Higuchi Y
- Hilkert R
- Hilton T
- Himpel-Boenninghoff A
- Hinderaker P
- Hioki M
- Hirayama A
- Hiroma J
- Ho Cj
- Hodnett P
- Hoffman M
- Hofsoey K
- Hogan C
- Hollanders G
- Holmes Z
- Holoubek D
- Holscher A
- Hominal M
- Homza M
- Hong T
- Hong T
- Hoogslag Pam
- Horackova K
- Horak A
- Hornig M
- Horvat P
- Hosokawa S
- Hotchkiss D
- Houra M
- Hristova K
- Hsieh Ic
- Huang A
- Huang P
- Huang Ph
- Humbert J
- Hurtig U
- Hutchens E
- Huynh T
- Hwang Jj
- Hwang Jj
- Hyun K
- Härstedt N
- Høivik Ho
- I Ilic
- I Ivanov
- Iachini K
- Iannopollo G
- Ibarra J
- Ibarra M
- Ibañez J
- Iby M
- Ichisawa M
- Igbokidi O
- Iijima T
- Ilahi T
- Ilic S
- Ilsley M
- Imbrognio M
- Imre Bs
- Inada T
- Inagaki M
- Indolfi C
- Infusino F
- Invitti C
- Ipp E
- Isaza D
- Istratoaie O
- Istvan Kp
- Iteld B
- Ito K
- Ivan P
- Iveta H
- Izmozherova N
- J Jiang
- J Johnson
- J Johnston
- J Jose
- Jacques G
- Jafri A
- Jafry B
- Jagtap P
- Jaguszewska G
- Jain A
- Jansen M
- Jardula M
- Jayasinghe R
- Jefferson D
- Jenkins R
- Jensen Ed
- Jeric M
- Jerzewski A
- Jeserich M
- Jia Z
- Jiang T
- Jiang X
- Jimenez D
- Jirvankar P
- Johansen Bb
- Johansen E
- Johansson K
- Johnson E
- Jones S
- Jonsson Je
- Joosten C
- Joshi U
- Julien Ve
- Julião K
- Jure D
- Jure H
- Jutrisa N
- K Kaigawa
- K Katahira
- K Kiroglu
- K Kordic
- K Kostov
- Kabakchieva Vm
- Kaczmarek N
- Kafarakis P
- Kaiserova L
- Kajihara S
- Kala P
- Kaldara E
- Kalina A
- Kalkman C
- Kam J
- Kamensky G
- Kamiya H
- Kamiya J
- Kan G
- Kaneno Y
- Kanitz S
- Kapp I
- Kara Yd
- Karakai H
- Karel I
- Karpuram M
- Karsai Xz
- Kastelein Jjp
- Kataoka M
- Katona A
- Katova T
- Kaur H
- Kawahara M
- Kawai M
- Kawasaki T
- Kawka-Urbanek T
- Kazanskay E
- Ke Y
- Keba E
- Keenan S
- Kelehan S
- Kellnerova I
- Kelly R
- Kelt T
- Kendall T
- Kereiakes D
- Khan A
- Khan M
- Khan R
- Khan S
- Khariouzov A
- Khirmanov V
- Khromtsova O
- Kick J
- Kiefer R
- Kietselaer B
- Kim B
- Kim Ks
- Kim M
- Kimmel M
- King A
- King T
- Kirkland S
- Kiss Rg
- Kissel S
- Kitchens D
- Klamm M
- Klein C
- Klein P
- Klemsdal To
- Kleve R
- Klugherz B
- Knight J
- Knutsson A
- Koba M
- Kobalava Z
- Kodem Dr
- Koeitti P
- Koenig W
- Kojima E
- Kok M
- Koldas N
- Koleckar P
- Kolikova V
- Kolleroy C
- Kolokathis F
- Komati S
- Komura Y
- Kondagunta V
- Konradi A
- Kooiman E
- Kopaczewski J
- Kopczyńska M
- Korban E
- Koren M
- Kormann A
- Korte M
- Korth-Wiemann B
- Kose V
- Kosmacheva E
- Kostakou P
- Kostis J
- Kotek L
- Kouz Sm
- Kovacic D
- Kovacs A
- Kozak M
- Kozlova S
- Krapivsky A
- Kreckova M
- Kreutter F
- Krupciakova B
- Krupicka J
- Kuenzler J
- Kulibaba E
- Kulkarni L
- Kullal P
- Kultursay H
- Kumar Ks
- Kumbla M
- Kuntzsch A
- Kuo Jy
- Kuramochi T
- Kuruma T
- Kusnick B
- Kuzin A
- Kyo E
- L Levinson
- L Lim
- L Link
- L Liu
- Laane E
- Labovitz R
- Lachance P
- Lai Wt
- Lail J
- Lainscak M
- Lake J
- Lal S
- Lamance J
- Lamas G
- Lambert C
- Lambert J
- Lameira A
- Lamontagne C
- Landers B
- Landolfi A
- Landzberg J
- Lang C
- Langdon J
- Laniec M
- Lappo M
- Lardinois R
- Laszlo Z
- Latheef K
- Laube S
- Lauzon C
- Lavoie W
- Lazov P
- Ledger G
- Lee Hn
- Lee J
- Lee Jh
- Lee K
- Lee K
- Lee Kr
- Lee Sc
- Lee Sh
- Lee T
- Leggewie S
- Lehman Kf
- Lehman R
- Lehmann D
- Leimbach W
- Lekakis J
- Lembo G
- Lenderink T
- Lennard M
- Lenner E
- Lennerova J
- Leon S
- Lepage S
- Lepor N
- Lepp H
- Lester F
- Levin P
- Levine D
- Lewis D
- Li W
- Li X
- Li Y
- Li Y
- Li Y
- Li Yh
- Li Z
- Libby P
- Liberato Nl
- Libov I
- Lierse T
- Ligueros M
- Lillo J
- Lima F
- Limaye Ap
- Lin T
- Lindholm Cj
- Lindner C
- Liniado G
- Lino E
- Lipchenko A
- Liu B
- Liu B
- Liu Hm
- Liu P
- Liu S
- Liu Y
- Liviu C
- Lock E
- Lohkare M
- Lok Dja
- Long C
- Longaker R
- Lopes R
- Lopez P
- Lorch G
- Lorenc Z
- Lorenzatti A
- Lousberg A
- Lozhkina N
- Lu Z
- Luciardi H
- Lucksinger G
- Luecke-Uzar M
- Luedemann J
- Lukac J
- Lundqvist M
- Lupkovics G
- Luquez H
- Luz Serrano H
- Lv Y
- Lynd S
- Lysek R
- Lönnberg I
- M Malek
- M Mallagray
- M Mandati
- M Mandviwala
- M Marsters
- M Mays
- M Mcdonald
- M Medvegy
- M Meinrich
- M Mikus
- M Milanova
- M Moustafa
- Ma C
- Ma G
- Maboyi S
- Macdonald J
- Macfadyen Jg
- Machova V
- Madder R
- Maehara G
- Maffei L
- Magness K
- Maheshwari A
- Maheux K
- Maia L
- Majercak I
- Majul C
- Makedonska Jj
- Makhe B
- Makotoko E
- Malchikova S
- Maletz L
- Malhotra S
- Malhotra V
- Malik J
- Mancikova I
- Mandic L
- Manenti E
- Manfreda S
- Manga P
- Mani Ck
- Mani H
- Manne S
- Manning B
- Mannucci E
- Manolis A
- Manolis Aj
- Manov E
- Mantas I
- Manuel J
- Manukov D
- Manukov I
- Manyari D
- Manzur F
- Marcela Wenetz Lm
- Marchelletta N
- Marchi Al
- Marcinkeviciene J
- Marcun R
- Marengo Garcia De Carvalho L
- Marinaro S
- Marino P
- Mariottoni B
- Maron B
- Marschke T
- Marshall L
- Martin E
- Martin L
- Martinez E
- Martinez J
- Maruzzo S
- Marziali A
- Masarikova L
- Massaccesi R
- Mathew A
- Matyasek I
- Mauersberger K
- Maus O
- Mavromatis K
- Maximov D
- Mayer T
- Maynard R
- Mays B
- Mazutavicius R
- Mbulaiteye A
- Mcalister R
- Mccoy C
- Mccrary D Jr
- Mccullough-O'Brien H
- Mcgill J
- Mcgrew F
- Mcintosh C
- Mckenzie A
- Mckenzie C
- Mckibbin A
- Mclaurin B
- Mclellan Ba
- Mcmahon G
- Mcneil D
- Mcneill R
- Mcpherson C
- Medina F
- Megalou A
- Mehrle A
- Mehta A
- Mehta S
- Meijlis P
- Meissner A
- Mejia I
- Melbie K
- Mellberg L
- Melliza T
- Mendoza N
- Mendoza Y
- Mercuro G
- Merkely B
- Messina T
- Mestdagh I
- Meyer R
- Michalaros Y
- Michalska A
- Michaud N
- Michel K
- Mickel C
- Micko K
- Mihaly N
- Mikdadi G
- Mikusova T
- Milicic D
- Militaru C
- Miliuniene R
- Milkas A
- Miller A
- Miller C
- Miller G
- Miller R
- Miller W
- Minescu B
- Minocha G
- Mitchell J
- Mittal A
- Miyamoto T
- Moats Djr
- Modi R
- Mody F
- Moehring B
- Moen S
- Moffat J
- Mohan K
- Molina Di
- Molk B
- Molter D
- Monroe T
- Montana O
- Montenegro E
- Montenegro P
- Montero H
- Montgomery R
- Monti L
- Moodh J
- Mooe T
- Mookherjee D
- Moon K
- Moraes J Jr
- Moran J
- Moreira L
- Morell Y
- Moriarty P
- Morii I
- Morinaga Y
- Morisawa T
- Morozov E
- Morrison J
- Morton D
- Mos L
- Moshayedi P
- Mosley J
- Motiejuniene R
- Muehlhaus J
- Mueller S
- Muenter Kc
- Muenzel T
- Mulder R
- Munoz N
- Munoz R
- Munshi K
- Muntaner J
- Mureddu V
- Murphy G
- Murray A
- Mustafa J
- Musumeci Mb
- Muñoz W
- Myslyaeva L
- Nadar V
- Nagai Y
- Nagele-Luse I
- Nagy Ac
- Naidu R
- Naka T
- Nakamura S
- Nakamura Y
- Nakayoshi K
- Nalley J
- Nanas J
- Nandy P
- Naumann R
- Navarrete S
- Navy S
- Nebel J
- Neil L
- Nema D
- Neumann J
- Neutel Jm
- Niblack P
- Nicely V
- Nicolai M
- Nicolau J
- Nijmeh G
- Nikas A
- Nikoletta P
- Nikolic L
- Nikyar A
- Nilsen V
- Ning M
- Nishibe A
- Nixon S
- Nociar J
- Noori E
- Norin V
- Norkiene S
- Norkute-Macijauske U
- Norman L
- Noto G
- Nour K
- Novo S
- Nuding S
- Nugent A
- Nugteren Skz
- Ocman B
- Odegard A
- Ogawa H
- Ogawa M
- Okada Y
- Okawa M
- Okeefe D
- Olenchock B
- Olmedo M
- Olofsson M
- Olsen S
- Olsson Gh
- Olympios Cd
- Ondrasik J
- Onuchina E
- Oomman A
- Ord M
- Ortiz-Carrasquillo R
- Ossino N
- Otasevic P
- Otava M
- Otis R
- Otterstad Je
- Ouimet F
- Overhoff U
- Ozcan It
- O’Neil G
- P Pais
- P Peters
- P Piatti
- P Poliacik
- P Povolny
- P Purnell
- Pacora Ff
- Paez H
- Paganini M
- Page A
- Pagett K
- Pagnan M
- Pai R
- Pai V
- Palaniswami N
- Palatkina T
- Palchick B
- Pales J
- Paliwal Y
- Palka J Jr
- Palubova L
- Pande R
- Pandey S
- Paniagua A
- Pannell R
- Panov A
- Pansheriya A
- Panzarino C
- Papke B
- Parekh N
- Parente A
- Parepa I
- Parfait V
- Park B
- Park C
- Parmon E
- Partridge J
- Patel B
- Patel J
- Patel M
- Patel R
- Patel R
- Patel S
- Patino Jm
- Patole T
- Patsilinakos S
- Paulweber B
- Pavlickova L
- Paysor C
- Paz S
- Peck C
- Pella D
- Pena A
- Pencz I
- Peng L
- Penzes J
- Pereira S
- Perez Manghi F
- Perez A
- Perez M
- Perkins H
- Perkins L
- Perlstein T
- Perotti M
- Perperis A
- Perry B
- Pesce F
- Petelina T
- Peter Y
- Peterka M
- Petrauskiene B
- Petrescu L
- Petrillo C
- Petrov D
- Petrova I
- Petrusheva T
- Pettersen Ki
- Peukert Am
- Phillippi C
- Phillips A
- Phillips A
- Piacente R
- Pieretti Hb
- Pinheiro L
- Pintado M
- Pirenne B
- Pish R
- Piskorz D
- Pitt W
- Planinc I
- Ploechl A
- Plotz M
- Podoleanu C
- Pogson A
- Pokorna B
- Polato C
- Poling T
- Pomposini D
- Ponce T
- Poock J
- Pool T
- Poor F
- Pop Cf
- Popa V
- Popescu E
- Popovic Z
- Potts J
- Poudrier R
- Poulimenos L
- Pradhan A
- Pramatarova I
- Praveen M
- Prenner A
- Price D
- Price R
- Prior J
- Priori S
- Pritchard C
- Procter K
- Pupic L
- Purighalla R
- Pye M
- Qing L
- Quddusi K
- Quinones J
- Quinton D
- R Rauch
- R Recoaro
- R Reyes
- R Roettges
- R Rummel
- Racca V
- Radde I
- Radeljic V
- Radhakrishnan V
- Radin M
- Radoi M
- Radojcsics B
- Radvan M
- Raev D
- Ragghianti B
- Raghu C
- Rajan B A
- Rajasekhar D
- Rajput B
- Raju Ss
- Rama B
- Ramdas S
- Ramos G
- Ramos M
- Rancane G
- Randvee L
- Ranjith N
- Rao M
- Rao Mb
- Rao Nm
- Rassi S
- Rathnavel S
- Rathore A
- Rathore Srs
- Ratnik E
- Rau T
- Rawat S
- Raynes K
- Reber Am
- Reddy J
- Reddy Nc
- Redfearn H
- Rees Dh
- Reeves M
- Regner S
- Reichenbach D
- Reilly K
- Reimand M
- Reimer D
- Reinmets S
- Reis G
- Reis H
- Ren L
- Renaud K
- Renda G
- Repin A
- Resende I
- Resnick H
- Rewbury J
- Reznakova S
- Reznik I
- Rhudy Jm
- Richardson M
- Richert L
- Rickova Z
- Ridker Pm
- Riethof M
- Righini V
- Rinke A
- Risberg K
- Risenfors M
- Riser J
- Rivis L
- Robbins K
- Roberts-Thomson P
- Robinson S
- Rodero M
- Rodriguez Araya E
- Rodriguez A
- Rodriguez D
- Rodriguez J
- Rodriguez Lm
- Rodriguez Sm
- Roel A
- Romano A
- Romanski A
- Roos J
- Roper L
- Ross B
- Rossi Prf
- Rost N
- Roszkowska P
- Rotreklova M
- Roy A
- Roy C
- Roy M
- Rozeman P
- Ruder D
- Rudys A
- Ruffini L
- Rugo H
- Runev N
- Runquist L
- Rupka D
- Ruschel K
- Ryding A
- Rönndahl M
- Rønnevik P
- Rønnevik Td
- S Sarah
- S Sasaki
- S Sathe
- S Seki
- S Sharma
- S Shayani
- S Shetty
- S Shustov
- S Srivastava
- S Stadelmeier
- S Stoltz
- S Strand
- S Strugatsky
- S Such
- Sabo L
- Sack G
- Sahin M
- Sahin T
- Saini R
- Saint-Jacques H
- Saka B
- Sakamoto Y
- Sakurada M
- Salfity M
- Salinger M
- Salko T
- Sall N
- Saloustros I
- Salvador L
- Sam K
- Samal A
- Samer H
- Samkova D
- Sanchez Vallejo G
- Sanchez A
- Sanchez D
- Sang X
- Santiago J Jr
- Santosh Mj
- Sanuri M
- Saporito W
- Saraiva Jf
- Saravia Ma
- Sarbu I
- Sarcone M
- Sarjanovich R
- Sarma R
- Sarnighausen He
- Sarszegi Z
- Sattar N
- Saunders K
- Savard D
- Savignano C
- Saylor R
- Sazonova E
- Scaro G
- Scheffel M
- Scheibner T
- Schermaul Kh
- Schiavi Lb
- Schifferdecker B
- Schindler A
- Schindler A
- Schindler E
- Schlundt C
- Schmidt E
- Schmidt K
- Schnabel A
- Schneider P
- Schneider R
- Schnitzler R
- Schoen N
- Schorn K
- Schrager B
- Schroeder T
- Schulenburg D
- Schultz C
- Schulz M
- Schulze J
- Schulze U
- Schumacher M
- Schwartz A
- Schwerin G
- Schwerin M
- Schäfer B
- Sciborski R
- Scott J
- Scott R
- Seals A
- Senni M
- Sergienko T
- Seroqui M
- Servaes V
- Sesto I
- Seung Kb
- Shah A
- Shah Av
- Shah J
- Shaikh P
- Shanahan T
- Shaposhnik I
- Shapovalova Y
- Sharma K
- Sharma T
- Sharp A
- Shatsky K
- Shaw P
- Shealy N
- Sheets L
- Shelley J
- Shepard P
- Shetty P
- Shimokawa H
- Shimomura H
- Shinozaki T
- Shvarts Y
- Sidhu G
- Siemann M
- Sigurdadottir E
- Sigurdsson A
- Silva R
- Silver K
- Simay A
- Sime I
- Simon J
- Simon M
- Simons N
- Simpson H
- Singerling M
- Singh K
- Singh N
- Singh V
- Singhal A
- Sinnaeve P
- Siostrzonek P
- Sirakova-Taseva A
- Sirnes Pa
- Sizemore Bc
- Skalicka H
- Skatrud L
- Skjelvan G
- Skopets I
- Skubova K
- Skuladottir F
- Skuratova M
- Slanina M
- Slapikas R
- Slayton C
- Slechticka A
- Slimak V
- Sloane G
- Smallwood B
- Smeele F
- Smik R
- Smith B
- Smith G
- Smith J
- Smith J
- Smith M
- Smith M
- Smith P
- Smith T
- Smith W
- Smith W
- Smolenskaya O
- Soca Y
- Socoteanu E
- Socoteanu G
- Sofley C
- Sohi Gs
- Solares A
- Soler J
- Solovev O
- Song M
- Sopko K
- Soro E
- Sorodoc L
- Sosa-Padilla M
- Sotolongo R
- Sotomayor A
- Soucy D
- Spiridon M
- Sprinkle B
- Squire I
- Srdos V
- Srinath Vs
- St Amour E
- Stahl A
- Stahl Hd
- Stanciulescu G
- Starzec M
- Stefanescu M
- Steinhoff J
- Stelly L
- Steringer-Mascherbauer R
- Stern M
- Sternthal P
- Stinson J
- Stitova M
- Stockhausen G
- Stockhausen J
- Stoddard M
- Stoessel J
- Stofkova D
- Stokuca-Korac N
- Stolze K
- Stone B
- Stonkute K
- Storey R
- Stover T
- Strain J
- Stratmann M
- Strazdiene D
- Strbova J
- Stroes E
- Strohner-Kaestenbauer H
- Stys T
- Sugimoto N
- Suleman A
- Sullivan P
- Sun Z
- Sundelin R
- Suorra I
- Sutalo K
- Suzuki A
- Swart Hp
- Szacinski G
- Szakal I
- Szatmarine V
- Szocs A
- Szpajer M
- Szymanowski N
- T Tase
- T Tekten
- T Thuren
- T Tjaden
- Taguchi S
- Tahk S
- Tahon S
- Takahashi J
- Takase S
- Talliard C
- Tamburrini P
- Tamesby G
- Tamez W
- Tan M
- Tan R
- Tanabe K
- Tanaka A
- Tanaseanu C
- Tandon N
- Tani S
- Taqueti V
- Taran A
- Taverner P
- Tawfik R
- Teenan M
- Telekes P
- Teltser M
- Ten Holt W
- Terry K
- Terry Ps
- Tesak M
- Teschner Ab
- Teske A
- Tessmar C
- Thakkar B
- Thekkoott D
- Theunissen E
- Thiessen S
- Thomas D
- Thomas Dm
- Thomas H
- Thompson E
- Thompson J
- Thornton A
- Tijuneliene E
- Tinnirello V
- Tisheva-Gospodinova S
- Tobias C
- Todorova A
- Tomassi A
- Tomioka J
- Toom M
- Topper J
- Torgersruud M
- Torstensson I
- Torun A
- Toth P
- Townend J
- Tran A
- Treasure C
- Trenkamp P
- Trevelyan J
- Trevino M
- Trofimov V
- Troquay Rpt
- Tsai Mc
- Tsao Hm
- Tsioufis K
- Tsorbatzoglou K
- Tsou L
- Tsuboi H
- Tsuji M
- Tsujita K
- Tsujiyama S
- Tudoran M
- Tuholske C
- Turner F
- Tusek S
- Tzekova M
- Tzong L
- Ucar N
- Uecker C
- Ueng Kc
- Umesu A
- Unterkircher B
- Urbonas G
- Uresin S
- Urgeova L
- Urina M
- Urina-Triana M
- Uy W
- V Vahula
- V Vijan
- V Vora
- Vahtel M
- Vaid B
- Valenzuela M
- Valle M
- Vallejo Ma
- Vallone L
- Van Der Wal M
- Van Der Zwaan C
- Van Genechten G
- Van Kempen Ww
- Van Maarseveen M
- Van Stein I
- Vanagiene S
- Vance A
- Vandam J
- Vanhecke T
- Vanness WC Iii
- Vardas P
- Vargas R
- Varigos J
- Vasiliev M
- Vaz S
- Vazquez Tanus J
- Veerina K
- Vega J
- Vegsundvåg J
- Veit S
- Velusamy K
- Vento A
- Venturini C
- Vertes G
- Vervoort G
- Vesely J
- Vesely P
- Vesga B
- Vettus R
- Veze I
- Vezikova N
- Vezina M
- Vibert J
- Vicente C
- Vico Ml
- Vida-Simiti L
- Vieira N
- Viergever Ep
- Viezelis M
- Vijay N
- Villani Gq
- Vinanska D
- Vincelli G
- Vins P
- Viola Hg
- Visseren Flj
- Vissers C
- Vitovec M
- Vodnansky P
- Voelker F
- Voeller H
- Vogel M
- Vogt E
- Vold D
- Volpe M
- Voors C
- Vora K
- Vorster M
- Voyzey Ej
- Vozzhaev A
- Vranckx P
- Vrolix M
- Vuriya Ak
- W Wu
- Wade Rd
- Wadell C
- Wakeling J
- Waksman R
- Walker K
- Walker K
- Wallace K
- Walter I
- Walter J
- Walther I
- Walukiewicz P
- Wanderley Ff
- Wang Cp
- Wang Hc
- Wang J
- Wang Y
- Wang Yl
- Warren M
- Washam M
- Watson B
- Webel R
- Weber Hg
- Wei J
- Wei N
- Weimer J
- Weisnagel Sj
- Wells T
- West M
- Westberg Jc
- Whitaker J
- White A
- White A
- White C
- White J
- Wichterich K
- Wiebusch A
- Wilhoit G
- Wilkins M
- Wilkinson S
- William M
- Willingham K
- Willmerdinger M
- Willner C
- Wilson S
- Wilson V
- Winkelmann B
- Winkler J
- Wise J
- Wistuba T
- Woehrle J
- Woelcke J
- Wohnlich T
- Wolf S
- Woodall S
- Woods A
- Woyczak D
- Wrage P
- Wright J
- Wu J
- Wu J
- Wujkowski M
- Wyss F
- Xavier Jp
- Xu H
- Xu Zj
- Yakovova S
- Yakushin S
- Yamada T
- Yamaguchi E
- Yamamoto H
- Yamamoto T
- Yamane M
- Yan J
- Yanase T
- Yanev T
- Yang Cc
- Yang K
- Yang P
- Yao Z
- Yaoqing H
- Yarows S
- Yasuoka S
- Yasutake M
- Yigit Z
- Yilmaz Mb
- Yim Kh
- Yim S
- Yokoyama M
- Yong H
- Yoshida M
- Yoshimoto E
- Yossen M
- Young A
- Younis L
- Youssef G
- Yuan Z
- Yunoki C
- Yupanqui H
- Z Zhai
- Z Zilahi
- Zadionchenko V
- Zadra R
- Zagozen P
- Zaidman C
- Zalazar L
- Zaman A
- Zangroniz P
- Zarate J
- Zareczky P
- Zarifis I
- Zdrenghea D
- Zebrack J
- Zena N
- Zhang J
- Zhang W
- Zhang Y
- Zhao R
- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
- Author
- A A
- Abbott Jd
- Abdullah S
- Abib E Jr
- Ables Lr
- Abrantes Ja
- Acosta R
- Adams A
- Adams F
- Adroer Martori R
- Agafina As
- Agaiby Jm
- Aggarwala G
- Agraou B
- Aguilarsalinas Ca
- Ahmad A
- Ajala B
- Akdeniz B
- Akhtar N
- Akright L
- Aksentiev S
- Al-Zoebi A
- Alappat P
- Albert M
- Alfieri Ad
- Alhakim M
- Allaw Ma
- Alpizar-Salazar M
- Altafullah Im
- Alvarado Op
- Alvarez Ca
- Alvarez Jg
- Alvarez Ms
- Alvarez-Sala Walther La
- Alves AR Jr
- Alwine Lk
- Alzand B
- Amarenco P.
- Ambrovicova V
- Amerena J
- Andersen Jl
- Andersen Lt
- Anderson P
- Anderson Tj
- Andrassy P
- Andrei Ld
- Andreka P
- Angoulvant D
- Angun M
- Annamalai N
- Ansari Sh
- Anselmi M
- Antonicelli R
- Appel Kf
- Aracil Villar J
- Arain S
- Arambula Rm
- Araz M
- Arca M
- Arcanese Ml
- Arden C
- Areas Ca
- Ari H
- Ariani Mk
- Arif I
- Aroney C
- Aronson R
- Arstall M
- Arstila L
- Arya Kw
- Asamoah-Owusu N
- Askonen K
- Aslam Aa
- Assadourian A
- Assef V
- Atar S
- Auriel E
- Avaca H
- Averna M
- Avornyo Aa
- Avram Ri
- Axthelm C
- Ayesu K
- Aylward Pe
- Ayoub Jc
- Baar M
- Babapulle M
- Badat Ae
- Bailey Sr
- Bajaj H
- Bajcsi D
- Baker J
- Bakhai A
- Baldari D
- Ball Em
- Ballantyne Cm
- Ballyuzek M
- Balo T
- Banaszkiewicz K
- Bandeira e Farias FA
- Banerjee M
- Banik M
- Banyai M
- Baranova E
- Barbarash Ol
- Barbieri Ds
- Barettella Mb
- Barker Ba
- Barnum O
- Barreda Gonzalez Mj
- Barrera Cm
- Barrington P
- Baultrukonis D
- Bax Wa
- Bayat J
- Bayron Cj
- Bays He
- Beaudry P
- Beckett Pl
- Begg A
- Behmanesh B
- Behnke T
- Belenkiy Di
- Belicova M
- Bellido Guerrero D
- Bellingar B
- Beltran Lg
- Benacka J
- Benatar Jr
- Benczur B
- Benitez O
- Benjamin Sa
- Berenguer Ra
- Bergeron J
- Bergerot C
- Berk Mr
- Berli M
- Berlingieri Jc
- Bernard Jv
- Berrouschot J
- Bertolet Bd
- Bhindi R
- Bianco Ht
- Bijata-Bronisz R
- Bilz S
- Bittar Gd
- Bitzur R
- Bjasker Kr
- Blach E
- Black H
- Blagden Md
- Blaha V
- Blake G
- Blanco Coronado Jl
- Blaze K
- Blignault Sc
- Blokhin A
- Bloom Sa
- Bocek P
- Bod E
- Bogaard K
- Bogdanov E
- Bokern Mj
- Boman K
- Bonansea Tc
- Bonfanti Ja
- Bonner Jh
- Bonora E
- Boonyavarakul A
- Borer Js
- Botas Rodrigues J
- Botelho Rv
- Botella Serrano M
- Botero-Lopez R
- Botta Ce
- Bourgeois R
- Bourhaial H
- Boye A
- Boyett Be
- Brandon Dm
- Brar Hs
- Brauer C
- Bravo P
- Bredlau Ce
- Breedveld Rw
- Brenner H
- Breton Cf
- Bretton Em
- Brito Sanfiel Ma
- Broncel M
- Bronnum Schou J
- Brotons Cuixart C
- Broughton R
- Bruguera Cortada J
- Brunell R.
- Bruno Rl
- Budassi N
- Budoff Mj
- Bueno Diez M
- Bufka V
- Buganova I
- Bulanova N
- Buonanno M
- Burgess Lj
- Burnier M
- Burova N
- Busch Rs
- Busegeanu M
- Butuk Dj
- Buynak Rj
- Buysschaert I
- Bybee Ka
- Cabella Pr
- Cabezas Mc
- Caccavo A
- Calin A
- Calvo Gomez C
- Camp Ad
- Capiau L
- Caputo Rp
- Caramori Pr
- Carlier M
- Carlier Sg
- Carmena R
- Carnero Gs
- Carroll Pa
- Casabella Te
- Casaubon L
- Castro Montes Be
- Castro Ma
- Castro Nm
- Catano Js
- Caudmont S
- Cayla G
- Cech V
- Cecil Jt
- Cequier Fillat Ar
- Cerci R
- Ceska R
- Ceyhan C
- Cha Jy
- Chahin M
- Chakrabarti A
- Chambers Jd
- Chandna H
- Chang Ar
- Chang Kc
- Changlani M
- Chati Z
- Chaudhuri S
- Cheek Hb
- Chen J
- Chen Jc
- Cherlin Rs
- Chernyatina Ma
- Cheung Ss
- Chiang Ce
- Chilka S
- Chiong R
- Cho Br
- Cho Ys
- Chochinov Rh
- Chorin E
- Chouinard G
- Chueca Fernandez Je
- Chun H
- Cifkova R
- Ciomag Rm
- Civeira Murillo F
- Civeira F.
- Clark Gb
- Clark R
- Claudio J
- Clemens Pc
- Codutti Or
- Coetzer Tf
- Cohen Aj
- Cohen Ss
- Coisne D
- Collier Dj
- Colombo Hr
- Colquhoun D
- Colquhoun D
- Comlekci A
- Conde Dg
- Cone Cl
- Connelly T
- Connery L
- Contzen C
- Conway Jr
- Cools F
- Copaci I
- Corder Cn
- Corin A
- Cornett Gm
- Cortada Jb
- Couffinhal T
- Cramer E
- Crater Ta
- Crean P
- Crimmins Ds
- Crisby M
- Cropp A
- Cruz Fernandez Jm
- Csanadi Ma
- Cuadrado Ja
- Cucher Fh
- Cui G
- Curiac D
- Curto M
- Cusimano S
- Czarnecka D
- D'Emden M
- da Costa Fa
- Da Stephan U
- Dada Fa
- Dahl Cf
- Dan Ga
- Dan Ga
- Dart Am
- Dave Kn
- Davidovits Z
- Davidsen F
- Davidson E
- Davis Sm
- Davis T
- de Barros e Silva PG
- De Belder M
- De Bruyne L
- De Castro R
- De Dios Garcia Diaz J
- De La Cuesta Mayor C
- De La Fuente Ra
- de Lima e Silva FA
- De Looze F
- De los Rios Ibarra Mo
- de Mora Martin M
- de Moraes Junior Jb
- De Nooijer C
- de Oliveira Paiva Ms
- de Santos Mo
- de Souza Wk
- De Sutter J
- De Wolf L
- Deak L
- Dearborn-Tomazos J
- Debroye C
- Decaigney Sc
- Deck K
- Decoulx E
- Degertekin M
- Dela Llana A
- Delarche N
- Delforge Md
- Delgado Jp
- Delgado Mi
- Demin A
- Demirci D
- den Hartog Fr
- Denker Ps
- Derwahl Km
- Desai V
- Descamps Os
- Desfontaines P
- Desrosiers D
- Destefano P
- Detweiler Ro
- Di Gennaro Jp
- Diaz Jl
- Digiovanna Mj
- Diller Pm
- Dimas Al
- Dion D
- Distiller La
- Dixon L
- Dominguez Escribano Jr
- Dominguez Lopez M
- Donders Sh
- Dor I
- Dorsel T
- dos Santos Fr
- Doshi A
- Douglas F
- Dracoulakis Md
- Drapkina Om
- Drozdz J
- Du Y
- Dubrava J
- Dufreny A
- Dulkova K
- Duplyakov D
- Duprez D
- Durakoglugil E
- Duran Garcia S
- Duris T
- Dutra Op
- Dy J
- Dyke Ck
- Dzupina A
- Eaves Wb
- Ebrahim Io
- Edes I
- Edes I
- Edris Ma
- Egstrup K
- Eitan A
- El Hafi Se
- El Shahawy M
- El-Shahawy M
- Elbaz M
- Elbl L
- Elegeert I
- Eliaschewitz Fg
- Elis A
- Elizondo Moreno Er
- Ellison Hs
- Elosegui Am
- Emanuel S
- Engelbrecht Iv
- Engelbrecht Jm
- Epsley C
- Eraso Am
- Erkan Af
- Eryshev S
- Escudier Villa Jm
- Esperon Ga
- Essandoh Lk
- Estevez R
- Estol Cc
- Evans B
- Fabryova L
- Faes D
- Fagan Tc
- Faghih M
- Fahdi Ie
- Farago K
- Farhat Nz
- Farias Ef
- Farris Nr
- Farsad R
- Fazekas F
- Fedacko J
- Fedele Francesco
- Feldman J
- Felicio Js
- Felix S
- Felten Wr
- Ferkl R
- Fernandez Aa
- Ferrari E
- Fialkow Ja
- Field A
- Field Jc
- Figueiredo El
- Figueras Camos R
- Figueroa-Cruz Wl
- Filardi Pp
- Filippov A
- Fiore G
- First Bp
- Fiserova N
- Fishbein Gj
- fitz-Patrick D
- Flather M.
- Flores E
- Fonseca Fa
- Foody J
- Fordan S
- Forgosh Lb
- Fortes Ja
- Fouche L
- Fox Ke
- Fragoso Vg
- Franceschini E
- Francyk Dm
- Franczek S
- Fraser Nj
- Frederich R
- French Wj
- Frias Jj
- Frisoli A
- Frolova M
- Frost L
- Fruntelata Ag
- Fuchs S
- Fujita K
- Fulmer Jj
- Funk Gs
- Furie Kl
- Gabra Nw
- Gabriel Jd
- Galatius S
- Gallo Hj
- Gammon Rs
- Ganesh S
- Gao R
- Garcia Castillo A
- Garcia Hernandez Pa
- Garcia Puig J
- Garcia B
- Garcia Dk
- Garcia Hl
- Garcia-Moll Marimon X
- Garden Pi
- Garzone P
- Gaspar L
- Gaudet D
- Gavish D
- Gaztambide Saenz Ms
- Gelersztein E
- Gelfand E
- Gelormini J
- Geohas Jg
- George Ar
- Gerke S
- Geskin G
- Gibson Jm
- Gilbert Jm
- Gilfillan Cp
- Gilford T
- Gillespie E
- Gilmore Rm
- Gimness Mp
- Ginzburg M
- Glaser La
- Gleason Gp
- Glenny Ja
- Glover R
- Glynn R. J.
- Godoy Jg
- Goetsch M
- Gogia Hs
- Goisse M
- Goktekin O
- Goldenberg Rm
- Goldhaber A
- Goloshchekin Bm
- Gomez Je
- Gomez Ni
- Gonzalbez Morgaez Jd
- Gonzalez Juanatey C
- Gonzalez Juanatey Jr
- Gonzalez Ej
- Gonzalez-Gonzalez Jg
- Gonzalez-Ortiz M
- Gordeev Ig
- Gordon Mb
- Gorman Ta
- Gorog Da
- Gorosito Vm
- Gosselink Ma
- Gottlieb Dw
- Gottsater A
- Goube P
- Goyes Ar
- Graff A
- Grant Dc
- Green Cb
- Gregoire J.
- Gregóire Jc
- Greiff J
- Grillo Rs
- Grobbee D
- Grodman R
- Groenemeijer Be
- Grosman I
- Groutars Rg
- Grégoire J
- Guarnieri Tt
- Guenzel A
- Guerrero Ra
- Guice Mj
- Guimarães Filho Fv
- Gullu H
- Gumbiner B
- Gunstone Ae
- Gupta Ak
- Gupta Dk
- Gupta N
- Gutmann Je
- Haddad Tm
- Hagemann D
- Hagstrom E
- Hajdu C
- Hala T
- Halcox J
- Halperin Fa
- Hamilton Me
- Hamroff Gs
- Harding Sa
- Hart Hh
- Hartleib Mc
- Hartley Pa
- Hartman An
- Hassink Rj
- Hastings Wl
- He Y
- Heijmans S
- Heijmeriks Ja
- Heisters J
- Hellig Fs
- Helm Rj
- Henderson Da
- Hendrix El
- Hengstenberg C
- Her Sh
- Herdy Ah
- Hermans K
- Hermans Wr
- Hermany Pr
- Hernandes Me
- Hernandez Garcia Jm
- Herrera-Marmolejo M
- Herrington Dm
- Herrman Jp
- Herrmann Hj
- Herrod Jn
- Hershson Ar
- Hessinger D
- Hiotis L
- Hissa M
- Hoag Gn
- Hoedemaker G
- Hoffman As
- Hoffman Da
- Hollanders G
- Hoogslag Pa
- Hook M
- Horacek T
- Horodecki M
- Horowitz Bs
- Hou C
- Hovingh Gk
- Hranai M
- Humaloja K
- Hurling Rt
- Hussein O
- Hutyra M
- Hwang Jj
- Hwang Jj
- Iglesias C
- Ikehara E
- Illies G
- Imai K
- Imholz Bp
- Ince CS Jr
- Inzerello At
- Isserman Sm
- Isunza Jm
- Ivan P
- Ivanac K
- J. -C. Conde D
- Jacks Rk
- Jackson B
- Jacoby D
- Jacovides A
- Jadbabaie F
- Jaffrani N
- Jagielo Tj
- Jamidar Ha
- Janik Mj
- Janion M
- Jansen van Resburg D
- Janssens S
- Jantzi Cm
- Jattin Fg
- Jayasinghe R
- Jensen Hk
- Jeon Hk
- Jeppensen J
- Jepsen Jm
- Jeserich M
- Jhund Ps
- Jiang J
- Jimenez Hernandez Md
- Jimenez-Sanchez M
- Jintapakorn W
- Jodar Gimeno E
- Joensen A
- Johnson M
- Jones Af
- Joshi Ph
- Jrdavis Mg
- Jrquraishi Am
- Jukema J. W.
- Jure Ho
- Kadr Hh
- Kahan T
- Kahan T
- Kaluski E
- Kamensky G
- Kamphuisen Pw
- Kandath Dd
- Kanderkova D
- Kang Wc
- Kantola I
- Karalis I
- Karim Sn
- Karlsbergg Rp
- Karpov Y.
- Kastelein J. J. P.
- Kaster S
- Katelnitskiy I
- Katz A
- Kay Js
- Kayikcioglu M
- Kekki S
- Kelberman M
- Kellnerova I
- Kemeny V
- Kennett Jd
- Kentgens S
- Kereiakes Dj
- Kerr J
- Kesani Mk
- Keuleers S
- Khaisheva L
- Khalili P
- Khari J
- Khariouzov A
- Khasanov N
- Khokhlov Al
- Khurana S
- Kiatchoosakun S
- Kim C
- Kim Cy
- Kim Dh
- Kim Dk
- Kim K
- Kim Ks
- Kim Mh
- Kim Sh
- Kimmel Ma
- Kinnaman Sj
- Kinzfogl G
- Kipgen W
- Kirby We
- Kirschner R
- Kizko J
- Klausen L
- Klecha A
- Klein C
- Klein G
- Klein Jj
- Kleinecke-Pohl U
- Knickelbine T
- Knobler H
- Knutson Tj
- Kobielusz-Gembala I
- Koenig W.
- Kohler A
- Koilpillai Rn
- Kokles M
- Kolodziejczyk J
- Kondagunta V
- Konieczynska M
- Konstantinov V
- Korecki J
- Kormann Ap
- Kornmann Mo
- Kosinski Ej
- Koskinen P
- Koskinen Pt
- Kosmacheva E
- Kosmider M
- Kostenko Va
- Kostis Jb
- Koszegi Z
- Kotek Lw
- Kotze Hj
- Kouz Sm
- Kracoff Oh
- Krahulec B
- Krawczyk J
- Krichmar P
- Krittayaphong R
- Krolikowski Z
- Kroon Aa
- Kubalski P
- Kuchar L
- Kucharska D
- Kuijper Af
- Kuzin A
- Kuznetsov Va
- Kycina P
- Labissiere Jc
- Lai Wt
- Lain El
- Lakatos F
- Landa K
- Landron-Garcia L
- Landzberg Js
- Larnefeldt H
- Larsen Dc
- Lassus J
- Laszlo Z
- Lauer B
- Laufs U
- Le K
- Leaes Pe
- Lechuga Martin del Campo A
- Ledesma G
- Lee Cw
- Lee Cw
- Lee Mw
- Lee Sy
- Lefebvre Gc
- Lehman R
- Leichter Sb
- Leiva Pons Jl
- Leiva Pons Jl
- Lemke B
- Lemmens Rc
- Lenderink T
- Lenhard Mj
- Lentz Jd
- Lepage S
- Lepor Ne
- Lerman S
- Levinson Dj
- Levisetti M
- Levola J
- Lewis Bs
- Li D
- Li J
- Li S
- Li W
- Li Y
- Lian Y
- Libov Ia
- Licka M
- Liem Ss
- Lihn As
- Lillestol Mj
- Lim Eh
- Linderfalk C
- Lindgren Lm
- Lindholm Cj
- Lip G
- Lipetz Rs
- Liu F
- Llerena Sn
- Lomakin N
- Lomholdt J
- Lopez Cano C
- Lopez Rosas E
- Lorenzatti A.
- Lotan C
- Lotan C
- Louwerenburg Jw
- Lovell Jp
- Loy J
- Lozno Hy
- Luedemann J
- Lukac M
- Lukaszewicz M
- Luna Ceballos Ri
- Lupkovics G
- Lupovitch S
- Luquez Ha
- Luts A
- Ma Y
- Maaieh M
- Macdolnald L
- Macek V
- Mach F
- Machkova M
- Mackinnon Ij
- Macneill B
- Madu Ij
- Maffei Le
- Maggiolini S
- Maggioni A
- Magro M
- Mahal Ss
- Mahomed Aa
- Mahon Ng
- Maia Ln
- Mairuhu At
- Maisterra Santos O
- Makam Sk
- Maldonado N
- Malik A
- Malygin A
- Mandviwala M
- Manenti Er
- Manga P.
- Mangili Oc
- Manning Mb
- Manoj A
- Marar Ie
- Margoczy R
- Markovic Tp
- Marshall A
- Marten I
- Martens Fm
- Martin S
- Martinez Deben F
- Martinez Via L
- Martinez Lm
- Martinez Rf
- Martinka E
- Martorell Mateu E
- Martyin T
- Masana L
- Masiukiewicz U.
- Maskova P
- Masri Be
- Maus O
- Maw K
- Maximov Dm
- Maxwell Tg
- May O
- Mayfield Rk
- Maynard Km
- Mcadam B
- Mccartney Mj
- Mccormack T
- Mccullough L
- Mccullough Pa
- Mcgarvey Jf
- Mcgrew F
- Mckaig G
- Mckenzie Me
- Mclean B
- Mcmurray J
- McNally-Dufort C
- Mcnamara R
- Mcneil Dl
- Mcpherson C
- Mcpherson Tp
- Mediavilla Garcia Jd
- Medrano Martinez V
- Mego Dm
- Mehta Pm
- Mellbin L
- Mellbin L
- Mello Yg
- Melucci Mb
- Mendez Bucio A
- Mendoza Ja
- Michalaros Yl
- Micik J
- Miekus P
- Mierzejewski L
- Mikusova T
- Millar-Corte Gd
- Miller Ab
- Miller Ap
- Miller M.
- Minescu B
- Miranda Aa
- Mirek-Bryniarska E
- Miserez Ar
- Missault L
- Missault Lh
- Mistodie Cv
- Moccetti T
- Mociran M
- Molin Cj
- Molina Ca
- Mollerus Me
- Molto-Jorda Jm
- Monhart Z
- Montalescot G
- Montana O
- Montecinos H
- Montenegro Ee
- Montero M
- Montgomery B
- Mooe T
- Moon E
- Mootoo Ki
- Mora A
- Morales Portillo C
- Morales-Villegas E
- Moran G
- Morcos Nc
- Moriarty A
- Moriarty Pm
- Morocco T
- Morocutti G
- Morosanu M
- Morris Fh
- Morytko Ja
- Mosenzon O
- Mosseri M
- Mosterd A.
- Motylev I
- Mridha K
- Mudra H
- Mukherjee A
- Mulder H
- Mulleners T
- Muller C
- Multani P
- Muniz Grijalvo O
- Munoz Cf
- Munoz F
- Munteanu M
- Murcia A
- Murin J.
- Musungaie Db
- Myhill T
- Nadkarni S
- Nadra Ij
- Nagy A
- Nagy K
- Nagy L
- Nair Dr
- Nakandakare Er
- Nanchen D
- Nanji A
- Napoli Mc
- Narayan P
- Narejos S
- Nascimento Cv
- Nash Ml
- Nashed An
- Naudts I
- Neaton J
- Necki M
- Nedoshivin A
- Negrisanu Gd
- Nerg O
- Neuenschwander Fc
- Nguyen T
- Nicol Pr
- Nicolau J. C.
- Nielesen T
- Nielsen Wb
- Nierop Pr
- Nijmeijer R
- Nikolaev Ky
- Nisnisan Jm
- Nissen S.
- Nissen T
- Nixon Wa
- Noble S
- Nociar J
- Northroff J
- Norwood Pc
- Nseir Wb
- Nuriulu Escobar Pl
- Nye R
- Ochala A
- Odekirk Ll
- Okopien B
- Oleynikov V
- Olivares C
- Ong St
- Onrat E
- Opalinska E
- Orkwiszewska-Nalewajko A
- Oroszlan T
- Ostrowski J
- Ovalle F
- Owen Jg
- Ozcan T
- O’Dea Dj
- O’Mahoney M
- O’Neill B
- O’Steen Mb
- Pacheco Tr
- Paillard F
- Pak R
- Palchick Ba
- Palomaki A
- Panchenko E
- Pandey S
- Pantaleoni M
- Papp A
- Paraboschi Cf
- Paragh G
- Pasechnik E
- Pasqualini L
- Pasquini Ja
- Pasternak Da
- Pastrnakova E
- Patel Am
- Patle R
- Peart Bc
- Pegge N
- Pei D
- Pelaez Sv
- Pella D
- Pence D
- Peniston Jh
- Pereira Es
- Perez Martinez P
- Perez Paredes M
- Perez Ja
- Perings C
- Perlman Rl
- Perloff De
- Persson Be
- Pesant Y
- Peterfai E
- Peters Ss
- Peterson Sr
- Petit C
- Petrella J
- Pfuetzner A
- Pham Dn
- Piazza G
- Piepiorka M
- Pierpoint Be
- Pijanowski Z
- Pincetti C
- Pinto Sala X
- Pinto D
- Piovaccari G
- Pirro M
- Piskorz-Wapinska J
- Plaza Perez I
- Plazas Ja
- Pliamm L
- Plowchalk D
- Pluto Tm
- Pock J
- Pohlmeier L
- Polanczyk Ca
- Ponikowski P.
- Pons Amate Jm
- Pop Cf
- Popa Ar
- Popescu A
- Popescu M
- Popescu Ml
- Popov D
- Popova Vb
- Popoviciu Ms
- Porcu M
- Post Jc
- Potthoff S
- Pouzar Je
- Powell C
- Prasada S
- Precoma Db
- Pretorius Ce
- Pretorius Mm
- Price D
- Pride Y
- Probst V
- Proepper F
- Proietto J
- Promisloff Sd
- Pryke Jr
- Przekwas-Jaruchowska M
- Pudi Kk
- Puhakka M
- Purdy Da
- Purnell Pw
- Quyyumi Aa
- Rabahi F
- Radin Dm
- Radoi M
- Rai A
- Ramos Hr
- Ramos Mj
- Ramos Sa
- Ramos-Lopez Ga
- Ramstad Ds
- Randall Wj
- Randhawa Pm
- Range G
- Ranjith N
- Raoof Tj
- Raslova K
- Rasmanis G
- Rasmussen Tk
- Rech Rl
- Reddy Rd
- Redifer P
- Reed R
- Reedy Ma
- Reiber I
- Reis G
- Remmen Jj
- Rendell Ms
- Rensing Bj
- Resende Es
- Reshetko O
- Resk Jh
- Revkin J.
- Reyes Rg
- Reyna Ls
- Reynolds Rd
- Rhee My
- Rhudy Jm
- Rice S
- Rickers H
- Rico-Carrillo Ae
- Rictor Kw
- Ridker P. M.
- Riesenberg Ra
- Rigolosi R
- Rihani R
- Riksen Np
- Rim Sj
- Rinke A
- Riojas Charles Cm
- Ripoll Vera Tv
- Risser Ja
- Ritt Le
- Robertson Dg
- Robinson Jg
- Robinson Mf
- Robles Iniesta A
- Rocco Mb
- Rodriguez Ij
- Rodriguez Wr
- Rodriguez-Briones I
- Roman G
- Roman O
- Romer Tj
- Romero Hinojosa Ja
- Roncon L
- Ronner E
- Roos Js
- Roosen J
- Roquer Gonzalez J
- Rosenfeld Jc
- Rosenstock J
- Roskova E
- Ross S
- Rossi Pr
- Roubille F
- Roux Sm
- Rozpondek P
- Rubenfire M
- Ruiz La
- Ruiz-R L
- Ruoff Ge
- Rusculleda Mm
- Rusicka T
- Russo La
- Saad Ja
- Sachson Ra
- Sack G
- Saeed S
- Sahin T
- Sahul Zh
- Saini S
- Sala J
- Salacata A
- Salbach P
- Saldeen-Nilehn K
- Salter Tj
- Salvioni A
- Samoylova Yg
- Sanchez Alvarez J
- Sanchez Mijangos Jh
- Sanchez Ml
- Sandberg Jh
- Sansing Lh
- Santos R. D.
- Saporito Wf
- Saraiva Jf
- Sarens T
- Sari R
- Saryusz-Wolska M
- Sasson S
- Sathyapalan T
- Sattler C
- Saunders Kk
- Savin V
- Savolainen M
- Savolainen M
- Savonitto S
- Savonitto S
- Saxena S
- Schaap J
- Schade R
- Schaefer A
- Schaufele T
- Scheen A
- Schiele F
- Schiele Fn
- Schifferdecker B
- Schindler J
- Schlager D
- Schmedtje JF Jr
- Schmidberg J
- Schmidt E
- Schmidt U
- Schoell I
- Scholz G
- Schoofs Mw
- Schoors Df
- Schou M
- Schreuder T
- Schroe Hh
- Schuchard Tn
- Schumacher Dr
- Schwartz P. F.
- Schwartz W
- Schwimmbeck P
- Scott Bp
- Scott Dl
- Scott Rs
- Searles G
- Seaton Bl
- Seep Mk
- Segall N
- Segura T
- Seidman B
- Sensebrenner Jw
- Serje J
- Sesti G
- Sganzerla P
- Shah Sa
- Shalaev Sv
- Shammas N
- Shangina Oa
- Shapovalova J
- Sharir T
- Sharma R
- Sharma S
- Shayani Ss
- Sheahan D
- Shear C. L.
- Shechter M
- Shilkina Np
- Shimon I
- Shivaswamy V
- Shogenov Zs
- Shoukfeh M
- Shultz Jh
- Shutemova E
- Shvarts Y
- Sia Sm
- Sibon I
- Sidor M
- Sigal H
- Sillesen H
- Silva Rp
- Silverman Ie
- Simanenkov Vi
- Simon J
- Singal Dk
- Singh B
- Singh S
- Sitterli-Natea Cn
- Skaggs J
- Skripova D
- Smith P
- Smith Sk
- Smith Wb
- Sobolewska J
- Sobrino-Martinez J
- Sogorb Garri F
- Solar M
- Soler Jm
- Solodky A
- Solonev O
- Somogyi A
- Soosova I
- Soran H.
- Soroka E
- Sosa-Padilla Ma
- Soto Gonzalez A
- Soto Jr
- Sotolongo R
- Sotolongo Rp
- Soufflet V
- Sparks J
- Spence Jd
- Srimahachota S
- Sritara P
- Sritara P
- Srivastava S
- St-Amour E
- Staab Pk
- Stamps Hb
- Stawowy P
- Steffensen R
- Steinberg Aa
- Steinhoff Jp
- Stellbrink C
- Sternieri Mv
- Stevlik J
- Stich Ma
- Stobschinski Ca
- Stoessel J
- Stoller Sr
- Strader Jr
- Strain Je
- Strand J
- Strandberg A
- Stranks Sn
- Stratmann M
- Strbova J
- Stringam So
- Strobl Dj
- Strzinek Ra
- Stuckey T
- Styczkiewicz M
- Suarez Garcia S
- Suarez-Fernandez C
- Suarez-Sarmiento A
- Sullivan B
- Sullivan D
- Sultan S
- Sumbal J
- Suomi J
- Supronik J
- Suryanarayana Pg
- Sutton Jc
- Swart Hp
- Sweeney K
- Sydo T
- Sykulski R
- Szilagyi I
- Taeschner H
- Tahirkheli Nk
- Tahk Sj
- Takhar A
- Talano Jv
- Tami Lf
- Tan Ae
- Tanne D
- Tarasenko L
- Tarasov N
- Tardif
- Tase A
- Tatlisumak T
- Taurio J
- Taverna Llaurado E
- Tayoum H
- Teitelbaum I
- Tellier G
- Teltser M
- Tengmark Bo
- Ternouth If
- Terns Riera M
- Terrelonge Ae
- The Sh
- Thoeng J
- Thom S
- Thompson P
- Thomsen Kk
- Thouvenot E
- Ti Z
- Tichelaar P
- Timonen M
- Tinahones Madueno Fj
- Tivadar S
- Tofe Povedano S
- Toldy-Schedel E
- Tolkacheva V
- Torre Amione G
- Tortensson I
- Toth K
- Toth L
- Townsend Jc
- Traboulssi Ma
- Treasure Cb
- Trebacz J
- Trenk D
- Triana Eh
- Trimarco B
- Trippett Jm
- Troquay Rp
- Truban J
- Tsai Wc
- Tsalihin D
- Tumelero R
- Tunon J
- Turner Ta
- Turner W
- Twum-Barima Dy
- Tökgozoğlu L
- Ueng Kc
- Uhliar R
- Ulla Mr
- Underberg Ja
- Updegrove Jd
- Uresin Ay
- Urhammer S
- Urina M
- Urina-Triana Ma
- Uusinarkaus Kt
- Vaca Ce
- Vahed Ya
- Valdez Lopez Hg
- Valtonen M
- Van Alem Ap
- van Beek E
- van Daele Me
- van de Borne P
- van de Wal Rm
- van de Wetering Ml
- van de Wiel A
- van der Meer P
- van der Walt E
- van der Zwaan Ct
- Van Gaal W
- van Hal Jm
- Van het Hof-Wiersma Jj
- van Kempen Ww
- Van Koningsbruggen P
- van Landegem P
- van Leendert Rj
- van Nieuwenhuizen E
- van Rossum P
- van Royen N
- van Zyl Lj
- Vannatta B
- Vanttinen E
- Varleta P
- Vazan A
- Vazquez-Tanus Jb
- Veenendaal A
- Vejar M
- Venereo Jm
- Venter Dj
- Verdeza C
- Vertes A
- Vervoort G
- Verwerft J
- Vesely J
- Vico Ml
- Viergever Ep
- Viklund J
- Vila Belmonte A
- Villaman-Bencosme Y
- Vinanska D
- Vincent J.
- Vincent S
- Vinyoles Bargallo E
- Violante Ortiz R
- Vishlitzky V
- Vishneva E
- Visser Rp
- Visseren F
- Vivekananthan K
- Vizel S
- Vlach Jj
- Vodnansky P
- Voehringer Hf
- Vogel Dr
- Vohnout B
- Vojacek J
- Volkova A
- Voller H
- von Engelhardt Cb
- von Hodenberg Ef
- Vora Kn
- Vora Sk
- Voros P
- Vrablik M.
- Vrkoc J
- Vukotic G
- Wadud K
- Wainstein J
- Wakefield Ph
- Wakeling J
- Walczak M
- Walczewska J
- Walukiewica P
- Wang D
- Wang E
- Wang G
- Wang Y
- Wasserburger B
- Waxler Ar
- Wayne Jd
- Weber D
- Weber K
- Wegner J
- Wei C
- Weigmann I
- Weinstein Dl
- Weiss R
- Welker Ja
- Welty F
- Wenetz Lm
- Wermuth S
- Wesson T
- West Sh
- Westerndorp I
- Wetzel T
- White H.
- Whitlock L
- Whitney Rt
- Wiggers H
- William M
- Williams Dg
- Williams M
- Willis Jg
- Willits Vl
- Winkelmann B
- Witt N
- Wittmann I
- Woehrle J
- Worner Diz F
- Wozniak I
- Wright R. S.
- Wronska D
- Wuerzner G
- Wychota K
- Xu P
- Xue L
- Yakusevich Vv
- Yang P
- Yang X
- Yao Lc
- Yared Z
- Yarows Sa
- Yigit Z
- Yoon J
- Yunis C.
- Zadra R
- Zaidman Cj
- Zamorano Gomez Jl
- Zannad F
- Zarandon Rb
- Zarich Sw
- Zateyshchikov D
- Zavaro Sh
- Zebrack Js
- Zeig S
- Zemek S
- Zemour G
- Zeng X
- Zeno Ml
- Zhang L
- Zhang X
- Zhang Y
- Zhao Y
- Zhou C
- Zhou Y
- Zhu Y
- Zidkova E
- Zieba B
- Zilahi Z
- Zoet-Nugteren Sk
- Zrazhevskiy K
- Zubek V
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin- kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODS In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly assigned the 27,438 patients in the combined trials to receive bococizumab (at a dose of 150 mg) subcutaneously every 2 weeks or placebo. The primary end point was nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death; 93% of the patients were receiving statin therapy at baseline. The trials were stopped early after the sponsor elected to discontinue the development of bococizumab owing in part to the development of high rates of antidrug antibodies, as seen in data from other studies in the program. The median follow-up was 10 months. RESULTS At 14 weeks, patients in the combined trials had a mean change from baseline in LDL cholesterol levels of -56.0% in the bococizumab group and +2.9% in the placebo group, for a between-group difference of -59.0 percentage points (P<0.001) and a median reduction from baseline of 64.2% (P<0.001). In the lower-risk, shorter-duration trial (in which the patients had a baseline LDL cholesterol level of ≥70 mg per deciliter [1.8 mmol per liter] and the median follow-up was 7 months), major cardiovascular events occurred in 173 patients each in the bococizumab group and the placebo group (hazard ratio, 0.99; 95% confidence interval [CI], 0.80 to 1.22; P = 0.94). In the higher-risk, longer-duration trial (in which the patients had a baseline LDL cholesterol level of ≥100 mg per deciliter [2.6 mmol per liter] and the median follow-up was 12 months), major cardiovascular events occurred in 179 and 224 patients, respectively (hazard ratio, 0.79; 95% CI, 0.65 to 0.97; P = 0.02). The hazard ratio for the primary end point in the combined trials was 0.88 (95% CI, 0.76 to 1.02; P = 0.08). Injection-site reactions were more common in the bococizumab group than in the placebo group (10.4% vs. 1.3%, P<0.001). CONCLUSIONS In two randomized trials comparing the PCSK9 inhibitor bococizumab with placebo, bococizumab had no benefit with respect to major adverse cardiovascular events in the trial involving lower-risk patients but did have a significant benefit in the trial involving higher-risk patients