27 research outputs found
Employer Defenses to Sexual Harassment Claims
- Author
- Publication venue
- Duke University School of Law
- Publication date
- 01/04/1999
- Field of study
Exchange of functional domains between a bacterial conjugative relaxase and the integrase of the human adeno-associated virus
- Author
- A Guasch
- AB Hickman
- AB Hickman
- Anita F. Meier
- B Gonzalez-Perez
- B Hirt
- B Ton-Hoang
- C Giraud
- C Gonzalez-Prieto
- C Gonzalez-Prieto
- CA Lee
- Carlos R. Escalante
- CE CĂ©sar
- D Huser
- D Kazlauskas
- DH Smith
- DM McCarty
- DS Im
- DS Im
- E Henckaerts
- E MartĂnez
- Els Henckaerts
- Eric Cascales
- EV Koonin
- F de la Cruz
- F Dyda
- F Zarate-Perez
- F Zarate-Perez
- F Zarate-Perez
- FL Graham
- FN Musayev
- Francisco ZĂĄrate-PĂ©rez
- G Di Pasquale
- G Grandoso
- G Grandoso
- GD Cassell
- GM Allan
- H Teramoto
- J Mansilla-Soto
- JA James
- JD Tratschin
- JH Ryan
- JL Yates
- K Petri
- L AgĂșndez
- L AgĂșndez
- Leticia AgĂșndez
- M Bardelli
- M Chandler
- M del Pilar Garcillan-Barcia
- M Llosa
- M Llosa
- M Llosa
- M Lucas
- M Yoon
- M Yoon-Robarts
- Martino Bardelli
- Matxalen Llosa
- MD Weitzman
- MD Weitzman
- MV Mendiola
- MV Mendiola
- N Carraro
- N Chejanovsky
- N Dutheil
- N Zeltner
- O Draper
- P Schuck
- P Ward
- PD Baas
- PL Hermonat
- R Platt
- R. Michael Linden
- RH Smith
- RH Smith
- RH Smith
- RM Kotin
- RM Linden
- S Lamartina
- S Uliel
- S Zolotukhin
- SA Khan
- SA Khan
- SG Grant
- T Janovitz
- TV Ilyina
- V Canfield
- V de Lorenzo
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2018
- Field of study
Endonucleases of the HUH family are specialized in processing single-stranded DNA in a variety of evolutionarily highly conserved biological processes related to mobile genetic elements. They share a structurally defined catalytic domain for site-specific nicking and strand-transfer reactions, which is often linked to the activities of additional functional domains, contributing to their overall versatility. To assess if these HUH domains could be interchanged, we created a chimeric protein from two distantly related HUH endonucleases, containing the N-terminal HUH domain of the bacterial conjugative relaxase TrwC and the C-terminal DNA helicase domain of the human adeno-associated virus (AAV) replicase and site-specific integrase. The purified chimeric protein retained oligomerization properties and DNA helicase activities similar to Rep68, while its DNA binding specificity and cleaving-joining activity at oriT was similar to TrwC. Interestingly, the chimeric protein could catalyse site-specific integration in bacteria with an efficiency comparable to that of TrwC, while the HUH domain of TrwC alone was unable to catalyze this reaction, implying that the Rep68 C-terminal helicase domain is complementing the TrwC HUH domain to achieve site-specific integration into TrwC targets in bacteria. Our results illustrate how HUH domains could have acquired through evolution other domains in order to attain new roles, contributing to the functional flexibility observed in this protein superfamily.This work was supported by the Medical Research Council (MRC) grant MR/N022890/1 to EH and grant 1001764 to RML; National Institutes of Health (NIH) grant RO1-GM09285 to CRE; Spanish Ministry of Economy and competitiveness (MINECO) grant BIO2013-46414-P to ML and AFM is supported by a Doc.Mobility fellowship from the Swiss National Science Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A DĂĄvalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
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- AA Andreadis
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- AB Parsons
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- AB Thomson
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- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
- ADL van der
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- B Chakravarti
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- TW Rademacher
- TY Tsai
- U Alon
- U Bartels
- U Buescher
- U Cha'on
- U Eckstein-Ludwig
- U Heinz
- U Laufs
- U Schönbeck
- UN Das
- V Adam-Vizi
- V Adam-Vizi
- V Atanasiu
- V Braun
- V Braun
- V Calabrese
- V Campuzano
- V Campuzano
- V Curcin
- V Emilsson
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- V Gordeuk
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- V Irazusta
- V Kaushal
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- VA Kostyuk
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- W Aerbajinai
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- X Chen
- X Chen
- X He
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- X Huang
- X Huang
- X Li
- X Zhang
- X Zhu
- X Zhu
- XD Huang
- XJ Li
- XM Yuan
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- XP Huang
- Y Almog
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- Y Bao
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- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Beyond equilibrium climate sensitivity
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- A Borodina
- A Donohoe
- A Ganopolski
- A Gettelman
- A Gettelman
- A Hall
- A Hannart
- A Jarvis
- A Millner
- A Modak
- A Ollila
- A Otto
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- AC Clement
- AE Dessler
- AE Dessler
- AE Dessler
- AG Libardoni
- AH MacDougall
- AJ Majda
- AP Schurer
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- AP Weigel
- AS von der Heydt
- B Hare
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- BM Sanderson
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- C Covey
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- C Loehle
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- C Lorius
- C Monckton
- C Piani
- C Proistosescu
- C Tebaldi
- C Zhai
- C Zhou
- C Zhou
- CA Senior
- CE Forest
- CE Forest
- CE Forest
- CE Leith
- CH Bishop
- CS Bretherton
- D Ehlert
- D Klocke
- D Masson
- D Masson
- D Paynter
- D Swingedouw
- DA Stainforth
- DB Kirk-Davidoff
- DH Douglass
- DI Stern
- DJ Frame
- DJ Frame
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- DJ Lunt
- DJ Lunt
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- DJ Rowlands
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- DL Royer
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- DM Lemoine
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- DM Murphy
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- DT Shindell
- DW Lea
- DW Pierce
- E Anagnostou
- E Hawkins
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- GS Callendar
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- SFB Tett
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- SH Schneider
- SP Harrison
- T Andrews
- T Andrews
- T Andrews
- T Andrews
- T Augustsson
- T DelSole
- T DelSole
- T Dunkley Jones
- T Friedrich
- T Masters
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- T Mauritsen
- T Mauritsen
- T Reichler
- T Schneider
- T Schneider von Deimling
- T Storelvmo
- T Yokohata
- TL Bell
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- Y Kamae
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- 'Springer Science and Business Media LLC'
- Publication date
- 04/09/2017
- Field of study
ISSN:1752-0908ISSN:1752-089
Climate Policy to Defeat the Green Paradox
- Author
- A Angelsen
- D Gately
- D Popp
- DL Greene
- DL Greene
- E Hirst
- G Allan
- H Weinblatt
- H-W Sinn
- IO Walker
- J Bentzen
- J Dimitropolous
- J Haughton
- J Roy
- JA Laitner
- JD Khazzoom
- JM Dubin
- Johan Nyström
- JW Mayo
- K Mizobuchi
- L Greening
- M Binswanger
- M Fowles
- M Hoel
- MH Babiker
- ML Weitzman
- PS Leung
- R BrÀnnlund
- RD Blair
- S Glomsrod
- S Rubio
- S Sorrell
- SH Schurr
- Stefan Fölster
- SV Paltsev
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
INCORPORATING ECONOMIC ANALYSIS INTO UNDERGRADUATE BUSINESS LAW AND LEGAL ENVIRONMENT COURSES: EMPLOYER LIABILITY FOR SEXUAL HARASSMENT AS A MODEL
- Author
- Anderson Teresa
- Bland Timothy S.
- Canoni John
- Coleman David
- Dilglio John J.
- Ehrlich Isaac
- Ehrlich Isaac
- Glenn George B.
- Goch Lynna
- Johnson Marjorie A.
- Marshall Alison B.
- Milite George A.
- Mitchell Polinsky A.
- Prince Michael
- Risser Rita
- Roberts Sally
- Sandler Debbie R.
- Sclafane Susanne
- Sclafane Susanne
- Segal Jonathan
- Smile-Marquez Carolyna
- Sunoo Brenda
- Trevor David
- Weitzman Allan H.
- Zachary Mary-Kathryn
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Designing Smarter Regulation with Improved Benefit-Cost Analysis
- Author
- A Polinsky
- Allan H Meltzer
- Anne O Krueger
- Anthony Downs
- Ary Bovenberg
- Barry R Weingast
- Bernstein
- Bruce A Ackerman
- Cass R Sunstein
- Charles Wolf
- Clifford Winston
- David L Weimer
- Dennis C Mueller
- Gary S Becker
- Gary S Becker
- George J Stigler
- Harold Demsetz
- Harvey Leibenstein
- James Buchanan
- Jeffrey L Pressman
- John D Graham
- Kenneth J Arrow
- Krutilla
- Lawrence H Goulder
- Mancur R Olson
- Marc J Roberts
- Martin Feldstein
- Martin L Weitzman
- Michael Hazilla
- Michael W Wara
- Oliver Hart
- Paul A Samuelson
- R G Lipsey
- Richard A Musgrave
- Richard L Revesz
- Robert N Stavins
- Robert W Crandall
- Robert W Crandall
- Robert W Hahn
- Robert W. Hahn
- Ronald H Coase
- Sam Peltzman
- Sam Peltzman
- Sam Peltzman
- Steven C Salop
- W Macleod
- William H Riker
- William Niskanen
- William Nordhaus
- Winston Harrington
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2008
- Field of study
Managing Risks and Tradeoffs Using Water Markets
- Author
- A Daigneault
- Alan Ker
- Andrew Coleman
- Anna Alberini
- Arthur Grimes
- Arthur Grimes
- Arthur Grimes
- Arthur Grimes
- Arthur Grimes
- Bruce A Kim
- Corey Allan
- Cy Jones
- Darian Woods
- David C Marïżœ
- Eric Karpas
- Erik Lichtenberg
- Evan Branosky
- H Turral
- H Wijedesa
- Howard Chong
- Hugh Mcdonald
- James S Shortle
- James S Shortle
- John Hadfield
- Juan-Pablo Montero
- Juan-Pablo Montero
- Justine
- Justine Young
- Kit
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- Madeline
- Martin L Weitzman
- Mighty River
- Mindy Selman
- Pinar Celikkol
- R Grafton
- Ran Abramitzky
- Richard D Horan
- Richard Fabling
- Richard Fabling
- Richard Fabling
- Richard G Newell
- Richard G Newell
- Richard T Woodward
- Robert W Hahn
- Ron Crawford
- Sanjay Wadhwa
- Sarah Crichton
- Scott
- Simon Anastasiadis
- Simon Anastasiadis
- Simon Anastasiadis
- Steven Shavell
- Suzi
- Suzi
- Suzi
- Suzi Kerr
- Suzi Kerr
- Suzi Kerr
- Suzi Kerr
- Sylvia Dixon
- Tom Tietenberg
- Tom Tietenberg
- Van Benthem
- Vernon Rive
- William Vant
- Yeo
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Asset Pricing with Learning About Disaster Risk
- Author
- A Timmermann
- Albert N Shiryaev
- Alexander G Tartakovsky
- Allan Timmermann
- Andras Fulop
- Andrew B Abel
- Anisha Ghosh
- Anna Orlik
- Christian Julliard
- Christos Koulovatianos
- Daniele Bianchi
- David M Kreps
- Edouard Schaal
- Emi Nakamura
- Emmanuel Farhi
- Francois Gourio
- George M Constantinides
- H Chen
- Hui Chen
- Itamar Drechsler
- J Fernïżœndez-Villaverde
- Jason Beeler
- Jessica A Wachter
- John Y Campbell
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- Kai Guo
- Kenneth Kasa
- Larry G Epstein
- Luca Benzoni
- M Johannes
- M L Weitzman
- M Piazzesi
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- Max Gillman
- Michael Siemer
- Michael Siemer
- Moshe Pollak
- Nengjiu Ju
- Nicholas Bloom
- Nick Bloom
- P Collin-Dufresne
- P Veronesi
- R Bansal
- Rajnish Mehra
- Ravi Jagannathan
- Robert J Barro
- S W Roberts
- Shmuel Kandel
- Stephen G Cecchetti
- Thomas A Rietz
- Timothy Cogley
- Xavier Gabaix
- Yang K. Lu
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Sustainable Growth and the Green Golden Rule
- Author
- A Beltratti
- A O Herrera
- Andrea Beltratti
- Ann A
- B Andrew
- B Edward
- B Richard
- C Robert
- C Robert
- D Michael
- D Michael
- D W A Pearce
- Donella H Meadows
- E S Phelps
- F Ramsey
- F Steven
- G Chichilnisky
- G Chichilnisky
- G Chichilnisky
- G Chichilnisky
- G David
- G Heal
- G Heal
- G Katherine
- G M Heal
- G M Heal
- G Steven
- Geoffrey M. Heal
- Graciela Chichilnisky
- H E Daly
- H Hotelling
- H P Larry
- J A Krautkraemer
- J Broome
- J E Meade
- J E Wilen
- J Robert
- J Robinson
- James R Hines
- K Karen
- K Maler
- K Yosida
- K Yosida
- L Lauwers
- L Lauwers
- L Nancy
- L Pierre
- L Robert
- London
- M James
- M James
- M Rebecca
- M Weitzman
- N Steven
- Olivia S
- P Dutta
- P J Hammond
- P Robert
- P S Dasgupta
- P S Dasgupta
- R
- R M Solow
- R M Solow
- R Solow
- Robert E Lucas
- S Daniel
- S Robert
- Sara De
- Sergio Rebelo Ingrid
- T Tietenberg
- W Allan
- W Charles
- W Michael
- W Nordhaus
- W R Cline
- Workfare
- Y Kannai
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/1995
- Field of study