12 research outputs found
Development of ASIC for SiPM sensor readout
L'abstract è presente nell'allegato / the abstract is in the attachmen
Design and characterization of the readout ASIC for the BESIII CGEM detector
TIGER (Turin Integrated Gem Electronics for Readout) is a mixed-mode ASIC for the readout of signals from CGEM (Cylindrical Gas Electron Multiplier) detector in the upgraded inner tracker of the BESIII experiment, carried out at BEPCII in Beijing. The ASIC includes 64 channels, each of which features a dual-branch architecture optimized for timing and energy measurement. The input signal time-of-arrival and charge measurement is provided by low-power TDCs, based on analogue interpolation techniques, and Wilkinson ADCs, with a fully-digital output. The silicon results of TIGER first prototype are presented showing its full functionality.Peer Reviewe
Bhlhe40 deficiency attenuates LPS-induced acute lung injury through preventing macrophage pyroptosis
Abstract Background Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) as common life-threatening lung diseases with high mortality rates are mostly associated with acute and severe inflammation in lungs. Recently, increasing evidence supports activated inflammation and gasdermin D (GSDMD)-mediated pyroptosis in macrophage are closely associated with ALI. Basic helix-loop-helix family member e40 (Bhlhe40) is a transcription factor that is comprehensively involved in inflammation. However, there is little experimental evidence connecting Bhlhe40 and GSDMD-driven pyroptosis. The study sought to verify the hypothesis that Bhlhe40 is required for GSDMD-mediated pyroptosis in lipopolysaccharide (LPS)-induced inflammatory injury. Method We performed studies using Bhlhe40-knockout (Bhlhe40 −/−) mice, small interfering RNA (siRNA) targeting Bhlhe40 and pyroptosis inhibitor disulfiram to investigate the potential roles of Bhlhe40 on LPS-induced ALI and the underlying mechanisms. Results Bhlhe40 was highly expressed in total lung tissues and macrophages of LPS-induced mice. Bhlhe40 −/− mice showed alleviative lung pathological injury and inflammatory response upon LPS stimulation. Meanwhile, we found that Bhlhe40 deficiency significantly suppressed GSDMD-mediated pyroptosis in macrophage in vivo and in vitro. By further mechanistic analysis, we demonstrated that Bhlhe40 deficiency inhibited GSDMD-mediated pyroptosis and subsequent ALI by repressing canonical (caspase-1-mediated) and non-canonical (caspase-11-mediated) signaling pathways in vivo and in vitro. Conclusion These results indicate Bhlhe40 is required for LPS-induced ALI. Bhlhe40 deficiency can inhibit GSDMD-mediated pyroptosis and therefore alleviate ALI. Targeting Bhlhe40 may be a potential therapeutic strategy for LPS-induced ALI
Additional file 1 of Bhlhe40 deficiency attenuates LPS-induced acute lung injury through preventing macrophage pyroptosis
Supplementary Material
Evaluation of river hydrological regime changes under the influence of Gangkouwan Reservoir
Oligo[2]catenane That Is Robust at Both the Microscopic and Macroscopic Scales
Polycatenanes are extremely attractive
topological architectures
on account of their high degrees of conformational freedom and multiple
motion patterns of the mechanically interlocked macrocycles. However,
exploitation of these peculiar structural and dynamic characteristics
to develop robust catenane materials is still a challenging goal.
Herein, we synthesize an oligo[2]catenane that showcases mechanically
robust properties at both the microscopic and macroscopic scales.
The key feature of the structural design is controlling the force-bearing
points on the metal-coordinated core of the [2]catenane moiety that
is able to maximize the energy dissipation of the oligo[2]catenane via dissociation of metal-coordination bonds and then activation
of sequential intramolecular motions of circumrotation, translation,
and elongation under an external force. As such, at the microscopic
level, the single-molecule force spectroscopy measurement exhibits
that the force to rupture dynamic bonds in the oligo[2]catenane reaches
a record high of 588 ± 233 pN. At the macroscopic level, our
oligo[2]catenane manifests itself as the toughest catenane material
ever reported (15.2 vs 2.43 MJ/m3). These
fundamental findings not only deepen the understanding of the structure-property
relationship of poly[2]catenanes with a full set of dynamic features
but also provide a guiding principle to fabricate high-performance
mechanically interlocked catenane materials
The new CGEM Inner Tracker and the new TIGER ASIC for the BES III Experiment
A new detector exploiting the technology of Gas Electron Multipliers is under construction to replace the innermost drift chamber of BESIII experiment, since its efficiency is compromised owing the high luminosity of Beijing Electron Positron Collider. The new inner tracker with a cylindrical shape will deploy several new features. The analogue readout and two complementary algorithms to reconstruct the position will allow achieving a spatial resolution of 130 µm in a 1 T magnetic field. For this purpose, TIGER, a new custom 64-channel ASIC, providing time and charge measurements, has been developed. Here, a summary of the most recent results on detector and electronics prototypes is given
CEPC Conceptual Design Report: Volume 2 - Physics & Detector
The Circular Electron Positron Collider (CEPC) is a large international scientific facility proposed by the Chinese particle physics community to explore the Higgs boson and provide critical tests of the underlying fundamental physics principles of the Standard Model that might reveal new physics. The CEPC, to be hosted in China in a circular underground tunnel of approximately 100 km in circumference, is designed to operate as a Higgs factory producing electron-positron collisions with a center-of-mass energy of 240 GeV. The collider will also operate at around 91.2 GeV, as a Z factory, and at the WW production threshold (around 160 GeV). The CEPC will produce close to one trillion Z bosons, 100 million W bosons and over one million Higgs bosons. The vast amount of bottom quarks, charm quarks and tau-leptons produced in the decays of the Z bosons also makes the CEPC an effective B-factory and tau-charm factory. The CEPC will have two interaction points where two large detectors will be located. This document is the second volume of the CEPC Conceptual Design Report (CDR). It presents the physics case for the CEPC, describes conceptual designs of possible detectors and their technological options, highlights the expected detector and physics performance, and discusses future plans for detector R&D and physics investigations. The final CEPC detectors will be proposed and built by international collaborations but they are likely to be composed of the detector technologies included in the conceptual designs described in this document. A separate volume, Volume I, recently released, describes the design of the CEPC accelerator complex, its associated civil engineering, and strategic alternative scenarios