6 research outputs found
Insights on pathogenesis of type 2 diabetes from MODY genetics
- Author
- A. Gloyn
- A. Stride
- A. Stride
- A. Vella
- A.F. Reis
- A.L. Gloyn
- A.T. Hattersley
- B.L. Triggs-Raine
- C.S. Rose
- D. Altshuler
- D.A. Stoffers
- D.A. Stoffers
- D.T. Odom
- E.H. Hani
- E.R. Pearson
- E.R. Pearson
- E.R. Pearson
- F. Matschinsky
- F.K. Kavvoura
- H. Raeder
- H. Thomas
- I. Barroso
- I. Reynisdottir
- International HapMap Consortium
- J. Ek
- J. Weng
- J.C. Florez
- K. Hara
- K. Owen
- K. Silander
- K. Silver
- K. Yamagata
- K. Yamagata
- K.L. Mohlke
- K.R. Owen
- L. Hansen
- L.D. Love-Gregory
- L.L. Bonnycastle
- M. Weedon
- M.I. McCarthy
- M.M. Byrne
- M.M. Mahtani
- M.N. Weedon
- M.N. Weedon
- M.N. Weedon
- M.N. Weedon
- M.N. Weedon
- M.T. Malecki
- M.Y. Shiau
- Michael N. Weedon
- N. Babaya
- N. Vionnet
- P. Froguel
- P.M. Thomas
- R.A. Hegele
- R.A. Hegele
- S. Ellard
- S.A. Urhammer
- S.C. Elbein
- S.K. Hansen
- S.K. Hansen
- S.Y. Kristinsson
- T.M. Frayling
- Timothy M. Frayling
- W. Macfarlane
- W. Marz
- W. Winckler
- W. Winckler
- W.M. Macfarlane
- W.M. Macfarlane
- Y. Horikawa
- Y.L. Muller
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Disentangling the genetics of lean mass
- Author
- Aghdassi A.
- Akesson K.
- Amin N.
- Barroso I.
- Bennett D.A.
- Bertram L.
- Biffar R.
- Bochud Murielle
- Borecki I.B.
- Broer L.
- Buchman A.S.
- Byberg L.
- Campbell H.
- Campos-Obando N.
- Cauley J.A.
- Cawthon P.M.
- Chambers J.C.
- Chen Z.
- Cho Nam H.
- Choi Hyung Jin
- Chou W.C.
- Cummings S.R.
- de Groot L.C.P.G.M.
- de Jager P.L.
- Demissie Serkalem
- Demuth Ilja
- DIatchenko Luda
- Econs Michael J.
- Eiriksdottir Gudny
- Enneman A.W.
- Eriksson J.
- Eriksson J.G.
- Estrada K.
- Evans D.S.
- Feitosa M.F.
- Fu Mao
- Gieger C.
- Grallert Harald
- Gudnason V.
- Harris T.B.
- Hayward C.
- Hofman A.
- Homuth Georg
- Hsu Y.H.
- Huffman Kim M.
- Husted L.B.
- Illig Thomas
- Ingelsson Erik
- Ittermann T.
- J Wareham Nicholas
- Jansson J.O.
- Johnson T.
- Jordan J.M.
- Jula Antti
- Karasik D.
- Karlsson Magnus
- Khaw K.T.
- Kiel D.P.
- Kilpeläinen T.O.
- Klopp N.
- Kloth Jacqueline S.L.
- Koller D.L.
- Kooner J.S.
- Kraus William E.
- Kritchevsky S.
- Kutalik Zoltan
- Kuulasmaa T.
- Kuusisto Johanna
- Laakso M.
- Lahti Jari
- Lang Thomas
- Langdahl B.L.
- Lenore Launer J.
- Lerch M.M.
- Lewis J.R.
- Lill C.M.
- Lind L.
- Lindgren C.M.
- Liu Y
- Livshits Gregory
- Ljunggren O.
- Loos R.J.F.
- Lorentzon Matthias
- Luan Jian’an
- Luben R.N.
- Malkin Ida
- McGuigan F.E.
- Medina-Gómez Carolina
- Meitinger Thomas
- Melhus H.
- Mellstrom Dan
- Michaelsson Karl
- Mitchell B.D.
- Morris A.P.
- Mosekilde L.
- Nethander Maria
- Newman A.B.
- Nielson C.M.
- O'Connell J.R.
- Ohlsson C.
- Oostra B.A.
- Orwoll Eric S.
- Palotie Aarno
- Peacock Munro
- Perola Markus
- Peters A.
- Prince R.L.
- Psaty B.M.
- Raikkonen Katri
- Ralston Stuart H.
- Ripatti S.
- Rivadeneira F.
- Robbins John A.
- Rotter J.I.
- Rudan I.
- Salomaa Veikko
- Satterfield Suzanne
- Schipf Sabine
- Shin Chan Soo
- Smith A.V.
- Smith S.
- Soranzo Nicole
- Spector Tim D.
- Stancakova Alena
- Stefansson K.
- Steinhagen-Thiessen Elisabeth
- Stolk L.
- Streeten E.A.
- Styrkarsdottir Unnur
- Swart KMA
- Thompson P.
- Thomson C. A.
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tikkanen Emmi
- Tranah G.J.
- Uitterlinden A. G.
- van Duijn C.M.
- van Schoor NM
- Vandenput Liesbeth
- Vollenweider Peter
- Volzke Henry
- Wactawski-Wende Jean
- Walker M.
- Waterworth D.
- Weedon M.N.
- Wichmann H.E.
- Widen E.
- Williams Frances M.K.
- Wilson J.F.
- Wright Nicole C.
- Yerges-Armstrong L.M.
- Yu L.
- Zhang W.
- Zhao J.H.
- Zhou Y.
- Zillikens M.C.
- Publication venue
- Publication date
- 01/02/2019
- Field of study
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
- Author
- Abecasis G. (Goncalo)
- Abecasis G.R. (Gonçalo)
- Abecasis G.R. (Gonçalo)
- Aben K.K.H. (Katja)
- Absher D. (Devin)
- Absher D. (Devin)
- Aherrahrou Z. (Zouhair)
- Ahlqvist E. (Emma)
- Ahmadi K.R. (Kourosh)
- Ahmed N. (Nabeel)
- Alavere H. (Helene)
- Alibrandi M.T.S. (Maria)
- Allayee H. (Hooman)
- Allen H.L.
- Almgren P. (Peter)
- Altshuler D. (David)
- Amin N. (Najaf)
- Anand S.S. (Sonia)
- Andersen K.K. (Karl)
- Ardissino D. (Diego)
- Ardlie K.G. (Kristin)
- Armitage J. (Jane)
- Arnold A.M. (Alice)
- Aspelund T. (Thor)
- Assimes T.L. (Themistocles)
- Assmann G. (Gerd)
- Aulchenko Y.S. (Yurii)
- Azhar M. (Muhammad)
- Balkau B. (Beverley)
- Ball S.G. (Stephen G.)
- Barbalic M. (maja)
- Barker A.M. (Adam)
- Barlassina C. (Christina)
- Barlera S. (Simona)
- Barnes D. (Daniel)
- Barnes T.A. (Timothy)
- Barrett A. (Angela)
- Barroso I.E. (Inês)
- Bataille V. (Veronique)
- Becker D.M. (Diane)
- Becker L.C. (Lewis)
- Beckmann J.S. (Jacques)
- Beckmann J.S. (Jacques)
- Beilby J.P. (John)
- Bell J.T. (Jordana)
- Ben-Shlomo Y.
- Ben-Shlomo Y. (Yoav)
- Bennett A.J. (Amanda)
- Berger K. (Klaus)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Berndt S.I. (Sonja)
- Biebermann H. (Heike)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Blakemore A.I.F. (Alexandra)
- Blankenberg S. (Stefan)
- Boehm B.O. (Bernhard)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boeing H. (Heiner)
- Boeing H. (Heiner)
- Boekholdt S.M. (Matthijs)
- Boerwinkle E.A. (Eric)
- Boes T. (Tanja)
- Bonnycastle L.L. (Lori)
- Boomsma D.I. (Dorret)
- Borecki I.B. (Ingrid)
- Bornstein S.R. (Stefan R.)
- Bornstein S.R. (Stefan)
- Boström K.B. (Kristina Bengtsson)
- Bouatia-Naji N. (Nabila)
- Bowman L.
- Braund P.S. (Peter)
- Bravenboer B. (Bert)
- Buchanan T.A. (Thomas)
- Bumpstead S. (Suzannah)
- Burnett M.S.
- Burtt N.P. (Noël)
- Busonero F.
- Buysschaert I. (Ian)
- Cambien F. (François)
- Campbell H. (Harry)
- Cappuccio F.P. (Francesco P.)
- Cappuccio F.P. (Francesco)
- Carlquist J.F. (John)
- Cauchi S. (Stephane)
- Caulfield M. (Mark)
- Cavalcanti-Proença C. (Christine)
- Chambers J.C. (John C.)
- Chambers J.C. (John)
- Chanock S.J. (Stephen)
- Charpentier G. (Guillaume)
- Chasman D.I. (Daniel)
- Chatterjee N. (Nilanjan)
- Chen C.-M. (Chih-Mei)
- Chen H. (Han)
- Chen L. (Li)
- Chines P.S. (Peter)
- Cichon S. (Sven)
- Clarke R.
- Clarke R. (Robert)
- Codd V. (Veryan)
- Coin L. (Lachlan)
- Coin L. (Lachlan)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis)
- Collins F.S. (Francis)
- Connell J. (John)
- Cooper C. (Charles)
- Cooper C.C. (Cyrus C.)
- Cooper M.N. (Matthew N.)
- Cooper M.N. (Matthew)
- Cornelis M. (Marilyn)
- Couper D.J. (David)
- Crawford G. (Gabe)
- Cupples L.A. (Adrienne)
- Daly M.J. (Mark)
- Dam R.M. (Rob) van
- Danesh J. (John)
- Davies R.W. (Robert)
- Day I.N.M. (Ian N.M.)
- Day I.N.M. (Ian)
- Dedoussis G.V. (George)
- Dedoussis G.V. (George)
- Dedoussis G.V. (George)
- Dehghan A. (Abbas)
- Deloukas P. (Panagiotis)
- Demissie S. (Serkalem)
- Den Heijer M. (Martin)
- Dennison E.M. (Elaine)
- Dermitzakis E.T. (Emmanouil T.)
- Devaney J.M. (Joseph M.)
- Di Meglio P. (Paola)
- Diemert P. (Patrick)
- Dimas A.S. (Antigone)
- Dina C. (Christian)
- Dixon A.L. (Anna)
- Do R. (Ron)
- Doering A. (Angela)
- Doney A.S.F. (Alex)
- Donnelly P. (Peter)
- Duan J. (Jubao)
- Duijn C.M. (Cornelia) van
- Dupuis J. (Josée)
- Durbin R. (Richard)
- Ebrahim S. (Shah)
- Ebrahim S. (Shanil)
- Eifert S. (Sandra)
- Eiriksdottir G. (Gudny)
- El Mokhtari N.E. (Nour Eddine)
- Elliott A.L. (Amanda)
- Elliott K.S. (Katherine)
- Elliott P. (Paul)
- Ellis S.G. (Stephen)
- Elosua R. (Roberto)
- Engert J.C. (James C.)
- Epstein S.E. (Stephen)
- Erdmann J. (Jeanette)
- Erdos M.R. (Michael)
- Eriksson P. (Per)
- Esko T. (Tonu)
- Esko T. (Tõnu)
- Estrada Gil K. (Karol)
- Eury E. (Elodie)
- Faire U. (Ulf) de
- Farooqi I.S. (I. Sadaf)
- Farooqi I.S. (Sadaf)
- Farrall M. (Martin)
- Feitosa M.F. (Mary Furlan)
- Felix S.B. (Stephan)
- Ferrannini E. (Ele)
- Ferreira T. (Teresa)
- Fischer M. (Marcus)
- Fischer-Posovszky P. (Pamela)
- Florez J.C. (Jose)
- Folkersen L. (Lasse)
- Folsom A.R. (Aaron)
- Forsen T. (Tom)
- Fox C.S. (Caroline)
- Franklin C.S. (Christopher)
- Frants R.R. (Rune)
- Franzosi M.
- Frayling T.M. (Timothy)
- Freimer N.B. (Nelson B.)
- Freyer J. (Jennifer)
- Friedrich N. (Nele)
- Froguel P. (Philippe)
- Frossard R.
- Fu M. (Mao)
- Gaget S. (Stefan)
- Ganser M. (Martha)
- Gardezi A. (Ali)
- Gejman P.V. (Pablo)
- Geus E.J. (Eeco)
- Gieger C. (Christian)
- Gigante B. (Bruna)
- Girelli D. (Domenico)
- Gjesing A.P. (Anette)
- Glass D. (Daniel)
- Glazer N.L. (Nicole)
- Gloyn A.L. (Anna)
- Goddard M.E. (Michael E.)
- Goddard M.E. (Michael)
- Goel A. (Anuj)
- Goodall A.H. (Alison)
- Goyette P. (Philippe)
- Grallert H. (Harald)
- Grarup N. (Niels)
- Green F. (Fiona)
- Green T. (Todd)
- Greenawalt D.M. (Danielle M.)
- Griffin S. (Simon)
- Groop L. (Leif)
- Groop L. (Leif)
- Groop L. (Leif)
- Groves C.J. (Christopher)
- Grundberg E. (Elin)
- Gräsler J. (Jürgen)
- Grönberg H. (Henrik)
- Gu H.F. (Harvest F.)
- Gudnason V. (Vilmundur)
- Gudnason V. (Vilmundur)
- Guiducci C. (Candace)
- Gulcher J.R. (Jeffrey)
- Gustafsson S. (Stefan)
- Gyllensten U. (Ulf)
- Hadjadj S. (Samy)
- Haeften T.W. (Timon) van
- Hagen K. (Knut)
- Hall A.S. (Alistair S.)
- Hall P. (Per)
- Halperin E. (Eran)
- Hammond C.J. (Christopher J.)
- Hammond C.J. (Christopher)
- Hammond N. (Naomi)
- Hamsten A. (Anders)
- Hansen T. (T.)
- Haritunians T. (Talin)
- Harris T.B. (Tamara)
- Hartikainen A.-L. (Anna-Liisa)
- Hassanali N. (Neelam)
- Hattersley A.T. (Andrew)
- Havulinna A.S. (Aki)
- Hayes R.B. (Richard)
- Hayes R.B. (Richard)
- Hayward C. (Caroline)
- Hazen S.L. (Stanley)
- Heard-Costa N.L. (Nancy)
- Heath A.C. (Andrew C.)
- Hebebrand J. (Johannes)
- Hedman A.K. (Asa)
- Heid I.M. (Iris)
- Heijer M. (Martin) den
- Heinrich J. (Joachim)
- Hellénius M.-L. (Mai-Lis)
- Hengstenberg C. (Christian)
- Herder C. (Christian)
- Herpt T.W. (Thijs) van
- Hicks A.A. (Andrew)
- Hide W.A. (Winston)
- Hinney A. (Anke)
- Hirschhorn J.N. (Joel)
- Hitman G.A. (Graham)
- Hoek M. (Mandy) van
- Hoesel V. (Volker)
- Hofman A. (Albert)
- Hofmann O.M. (Oliver)
- Holm H. (Hilma)
- Homuth G. (Georg)
- Hopewell J.
- Horikoshi M. (Momoko)
- Hottenga J.J. (Jouke Jan)
- Hu F.B. (Frank)
- Hui J. (Jennie)
- Huikuri H.V. (Heikki)
- Hunter D.J. (David J.)
- Huth C. (Cornelia)
- Hveem K. (Kristian)
- Igl W. (Wilmar)
- Illig T. (Thomas)
- Illig T. (Thomas)
- Ingelsson E. (Erik)
- Iribarren C. (Carlos)
- Ishaq M. (Muhammad)
- Isomaa B. (Bo)
- Jackson A.U. (Anne)
- Jacobs K.B. (Kevin)
- James A. (Alan)
- Jameson K. (Karen)
- Jansson J.-O. (John-Olov)
- Jarick I. (Ivonne)
- Jarvelin M.-R. (Marjo-Riitta)
- Jewell E. (Eelizabeth)
- Johansson A. (Asa)
- John U. (Ulrich)
- Johnson P. (Paul)
- Johnson P.R.V. (Paul R.V.)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Jones G.T. (Gregory)
- Jorgensen T. (Torben)
- Jousilahti P. (Pekka)
- Jukema J.W. (Jan Wouter)
- Jula A. (Antti)
- Kaakinen M. (Marika)
- Kajantie E. (Eero)
- Kanoni S. (Stavroula)
- Kao W.H.L. (Wen)
- Kaplan L. (Lee)
- Kaplan R.C. (Robert)
- Kaprio J. (Jaakko)
- Kaprio J. (Jaakko)
- Karpe F. (Fredrik)
- Karpe F. (Fredrik)
- Kastelein J.J.P. (John)
- Kathiresan S. (Sekar)
- Kerr-Conte J. (Julie)
- Kettunen J. (Johannes)
- Khaw K.T.
- Kiemeney L.A.L.M. (Bart)
- Kilpeläinen T.O. (Tuomas)
- Klopp N. (Norman)
- Knowles J.W. (Joshua)
- Kolovou G. (Genovefa)
- Kong A. (Augustine)
- Kooner J.S. (Jaspal S.)
- Kooner J.S. (Jaspal S.)
- Kooner J.S. (Jaspal)
- Koskinen S. (Seppo)
- Kovacs P. (Peter)
- Kraft P. (Peter)
- Krude H.
- Kutalik Z. (Zoltán)
- Kuusisto J. (Johanna)
- Kyriakou T. (Theodosios)
- Kähönen M. (Mika)
- König I.R. (Inke)
- Laakso M. (Markku)
- Laaksonen R. (Reijo)
- Laitinen J. (Jaana)
- Lambrechts D. (Diether)
- Lamina C. (Claudia)
- Langenberg C. (Claudia)
- Lantieri O. (Olivier)
- Lanzani C. (Chiara)
- Launer L.J. (Lenore)
- Lauritzen T. (Torsten)
- Lawlor D.A. (Debbie)
- Lawrence R.W. (Robert)
- Lecoeur C. (Cécile)
- Lehtimäki T. (Terho)
- Lettre G. (Guillaume)
- Levinson D.F. (Douglas F.)
- Levinson D.F. (Douglas)
- Li M. (Man)
- Li S. (Shengxu)
- Li X. (Xiaohui)
- Liang L. (Liming)
- Lieb W. (Wolfgang)
- Lieverse A.G. (Aloysius)
- Linksted P. (Pamela)
- Liu J. (Jianjun)
- Liu J. (Jianjun)
- Lokki M.L.
- Loley C. (Christina)
- Loos R.J.F. (Ruth)
- Lorentzon M. (Mattias)
- Lotery A.J. (Andrew)
- Luan J.
- Ludwig B. (Barbara)
- Lyssenko V. (Valeriya)
- Macciardi F. (Fabio)
- Makrilakis K. (Konstantinos)
- Mallick C.B. (Chandana Basu)
- Mannila M.N. (Maria Nastase)
- Manning A.K. (Alisa)
- Mannucci P.M. (Pier)
- Manunta P. (Paolo)
- Maouche S. (Seraya)
- Marek D. (Diana)
- Marre M. (Michel)
- Martin N.G. (Nicholas)
- Martinez-Larrad M.T. (Maria Teresa)
- McCarroll S.A. (Steven)
- McCarthy A. (Anne)
- McCarthy M. (Mark)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark)
- McCulloch L.J. (Laura)
- McKnight B. (Barbara)
- McPherson R. (Ruth)
- Meigs J.B. (James)
- Meisinger C. (Christa)
- Meitinger T. (Thomas)
- Melander O. (Olle)
- Merlini P.A. (Pier Angelica)
- Metspalu A. (Andres)
- Meyre D. (David)
- Midthjell K. (Kristian)
- Min J. (Josine)
- Mohlke K.L. (Karen L.)
- Monda K.L. (Keri)
- Montgomery G.W. (Grant)
- Montgomery G.W. (Grant)
- Mooser V. (Vincent)
- Morgan T. (Thomas)
- Morken M.A. (Mario)
- Morris A.D. (Andrew)
- Morris A.P. (Andrew)
- Muhlestein J.B. (Joseph)
- Mulic R. (Rosanda)
- Munroe P. (Patricia)
- Munroe P.B. (Patricia B.)
- Munzel T. (Thomas)
- Musunuru K. (Kiran)
- Myers R.H. (Richard)
- Mägi R. (Reedik)
- Mälarstig A. (Anders)
- März W. (Winfried)
- Nahrstaedt J. (Janja)
- Narisu N. (Narisu)
- Narisu N. (Narisu)
- Navarro P. (Pau)
- Nelis M. (Mari)
- Nelson C.P. (Christopher P.)
- Nemesh J. (James)
- Nestle F.O. (Frank)
- Neville M.J. (Matthew)
- Ngwa J.S.
- Nica A. (Alexandra)
- Nieminen M.S. (Markku)
- Nilsson P. (Peter)
- Nisbet J. (James)
- North K.E. (Kari)
- Nyholt D.R. (Dale)
- Nöthen M.M. (Markus)
- O'Connell J.R. (Jeffrey R.)
- O'Donnell C.J. (Christopher)
- O'Rahilly S. (Stephen)
- O'Rahilly S. (Stephen)
- O'Rahilly S. (Steve)
- Offer A. (Alison)
- Ohlsson C. (Claes)
- Olivieri O. (Oliviero)
- Olsson G.
- Ongen H. (Halit)
- Oostra B.A. (Ben)
- Osmond C. (Clive)
- Ouwehand W.H. (Willem)
- Owen K.R. (Katharine)
- O´Connell J.R.
- Palmer C.N.A. (Colin)
- Pankow J.S. (James)
- Pare G. (Guillame)
- Park J.H.
- Parker A.N. (Alex)
- Parts L. (Leopold)
- Pascoe L. (Laura)
- Patel R.S. (Riyaz)
- Patterson C.C. (Chris C.)
- Payne F. (Felicity)
- Peden J. (John)
- Pedersen O. (Oluf)
- Pellikka N. (Niina)
- Peltonen L. (Leena Johanna)
- Penninx B.W.J.H.
- Perola M. (Markus)
- Perola M. (Markus)
- Perry J.R.B. (John)
- Peters A. (Annette)
- Peters M.J. (Marjolein)
- Petersen A.K.
- Peto R. (R.)
- Petrie J.R. (John)
- Peyvandi F. (Flora)
- Pichler I. (Irene)
- Pietilainen K.H. (Kirsi Hannele)
- Platou C. (Carl)
- Platou C.P. (Carl)
- Polasek O. (Ozren)
- Potter S.C. (Simon)
- Pramstaller P.P. (Peter P.)
- Preuss M. (Michael)
- Proença C. (Christine)
- Prokopenko I. (Inga)
- Prokopenko I. (Inga)
- Purcell S. (Shaun)
- Qi L. (Lu)
- Quertermous T. (Thomas)
- Quyyumi A.A. (Arshed)
- Rader D.J. (Daniel)
- Rafelt S. (Suzanne)
- Raitakari O. (Olli)
- Raitakari O.T. (Olli T.)
- Rallidis L.S. (Loukianos)
- Randall J.C. (Joshua)
- Rasheed A. (Asif)
- Rathmann W. (Wolfgang)
- Rathmann W. (Wolfgang)
- Raychaudhuri S. (Soumya)
- Rayner N.W. (N. William)
- Rayner N.W. (Nigel William)
- Reilly M.P. (Muredach P.)
- Reinehr T. (Thomas)
- Ridderstråle M. (Martin)
- Ridker P.M. (Paul)
- Rij A.M. (Andre) van
- Ripatti S. (Samuli)
- Rissanen A. (Aila)
- Rivadeneira Ramirez F. (Fernando)
- Roberts R. (Robert)
- Rocheleau G. (Ghislain)
- Roden M. (Michael)
- Rosendaal F.R. (Frits R.)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Rust S. (Stephan)
- Rybin D. (Denis)
- Rzehak P. (Peter)
- Sabater-Lleal M. (Maria)
- Saleheen D. (Danish)
- Salomaa V. (Veikko)
- Samad A. (Adbus)
- Samani N.J. (Nilesh)
- Samani N.J. (Nilesh)
- Sampietro M.L. (Maria Lourdes)
- Sampson M.J. (Michael)
- Samuel M. (Maria)
- Sanders A.R. (Alan R.)
- Sandholt C. (Camilla)
- Sandhu M.S. (Manjinder)
- Sandhu M.S. (Manjinder)
- Sanna S. (Serena)
- Saramies J. (Jouko)
- Savolainen M.J. (Markku)
- Saxena R. (Richa)
- Sayer A.A.
- Schadt E.E. (Eric)
- Scherag A. (Andre)
- Schillert A. (Arne)
- Schipf S. (Sabine)
- Schlessinger D. (David)
- Schreiber S. (Stefan)
- Schrezenmeir J. (Jürgen)
- Schunkert H. (Heribert)
- Schwartz S.M. (Stephen)
- Schwarz P.E.H. (Peter)
- Schäfer A. (Arne)
- Scott J. (James)
- Scott L.J. (Laura)
- Scott L.J. (Laura)
- Seedorf U. (Udo)
- Segrè A.V. (Ayellet)
- Sehmi J.S. (Joban)
- Sekowska M. (Magdalena)
- Sennblad B. (Bengt)
- Serrano-Ríos M. (Manuel)
- Shah N. (Nisha)
- Shi J. (Jianxin)
- Shi J. (Jianxin)
- Shields B.M. (Beverley)
- Shields B.M. (Beverley)
- Shrader P. (Peter)
- Shuldiner A.R. (Alan)
- Shuldiner A.R. (Alan)
- Sigurdsson G. (Gunnar)
- Sijbrands E. (Eric)
- Sijbrands E.J.G. (Eric)
- Silander K. (Kaisa)
- Sinisalo J. (Juha)
- Siscovick D.S. (David)
- Sivapalaratnam S. (Suthesh)
- Sladek R. (Rob)
- Sleight P. (Peter)
- Smit J.H. (Jan)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith T.B. (Tamara B.)
- Snoep J.D. (Jaapjan)
- Soranzo N. (Nicole)
- Sparsø T. (Thomas)
- Spector T.D. (Timothy)
- Speliotes E.K. (Elizabeth)
- Spertus J.A. (John)
- Stančcáková A. (Alena)
- Stark K. (Klaus)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Stephens J. (Jonathan)
- Stewart A.F. (Alexandre F.)
- Stirrups K. (Kathy)
- Stoll M. (Monika)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Strawbridge R.J. (Rona)
- Strawbridge R.J. (Rona)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Sun Q. (Qi)
- Surdulescu G. (Gabriela)
- Swift A.J. (Amy)
- Syvänen A.C.
- Tammesoo M.L.
- Taneera J. (Jalal)
- Tang W. (W.)
- Tardif J.-C. (Jean-Claude)
- Tennstedt S. (Stephanie)
- Teslovich T.M. (Tanya M.)
- Thiering E. (Eelisabeth)
- Thiering E. (Elisabeth)
- Thompson J.R. (John)
- Thomson B. (Brian)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorgeirsson G. (Gudmundur)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Tichet J. (Jean)
- Timpson N.J. (Nicholas)
- Tognoni G.
- Tomaszewski M. (Maciej)
- Travers M.E. (Mary E.)
- Travers M.E. (Mary)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Turrini F. (Fabiola)
- Tyrer J.P. (Jonathan)
- Tönjes A. (Anke)
- Uda M. (Manuela)
- Uitterlinden A.G. (André)
- Valle T.T. (Timo T.)
- Van Dam R.M. (Rob M.)
- van't Hooft F. (Ferdinand)
- Van't Hooft F. (Ferdinand)
- Vatin V. (Vincent)
- Vedantam S. (Sailaja)
- Visscher P.M. (Peter M.)
- Visscher P.M. (Peter)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Voight B.F. (Benjamin)
- Wabitsch M. (Martin)
- Waeber G. (Gérard)
- Waite L. (Lindsay)
- Walker M. (Mark)
- Wallaschofski H. (Henri)
- Walters G.B. (Bragi)
- Wareham N.J. (Nicholas J.)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R. (Ryan)
- Welch R.P. (Ryan)
- Wells G.A. (George)
- Weyant R.J. (Robert)
- Wheeler E. (Eleanor)
- White C.C. (Charles)
- Wichmann H.-E. (H-Erich)
- Wichmann H.E. (Heinz Erich)
- Widen E. (Elisabeth)
- Wiegand S. (Susanna)
- Wijmenga C. (Cisca)
- Wiklund F. (Fredrik)
- Wild P.S. (Philipp)
- Wild S.H. (Sarah)
- Wilk A. (Alicja)
- Willemsen G.A.H.M. (Gonneke)
- Willenborg C. (Christina)
- Willer C.J. (Cristen)
- Wilson J.F. (James F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Witte D.R. (Daniel R.)
- Witte D.R. (Deniel)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C.M.)
- Wood A.R. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A.F. (Alan)
- Wright B.J. (Benjamin)
- Wu G. (Guanming)
- Xie W. (Weijia)
- Xu J. (Jianfeng)
- Yang J. (Jian)
- Yang J. (Joanna)
- Yang T.-P. (Tsun-Po)
- Ye S. (Shu)
- Zabena C. (Carina)
- Zaidi M.A. (Aghar)
- Zaman K.S. (Khan Shah)
- Zeggini E. (Eleftheria)
- Zeller T. (Tanja)
- Zethelius B. (Björn)
- Zgaga L. (Lina)
- Zhang Q. (Qunyuan)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zitting P. (Paavo)
- Zondervan K.T. (Krina T.)
- Zondervan K.T. (Krina)
- Zwart J-A. (John-Anker)
- Öhrvik J. (John)
- Östenson C.-G. (Claes-Göran)
- Publication venue
- Publication date
- 01/10/2011
- Field of study
OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 × 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals
- Author
- Abecasis G.R. (Goncalo R.)
- Abecasis G.R. (Goncalo R.)
- Abecasis G.R. (Gonçalo R.)
- Abecasis G.R. (Gonçalo)
- Adair L.S. (Linda)
- Allison M.A. (Matthew)
- Altshuler D. (David)
- Altshuler D. (David)
- Amin N. (Najaf)
- An P. (Ping)
- Ardlie K.G. (Kristin)
- Ardlie K.G. (Kristin)
- Ariyurek Y. (Yavuz)
- Aulchenko Y.S. (Yurii S.)
- Aulchenko Y.S. (Yurii S.)
- Aulchenko Y.S. (Yurii)
- Bacquer O.L. (Olivier)
- Balkau B. (Beverley)
- Balkau B. (Beverley)
- Ballantyne C. (Christie)
- Ballantyne C.M. (Christie M.)
- Ballantyne C.M. (Christie M.)
- Bandinelli S. (Stefania)
- Bandinelli S. (Stefania)
- Barbalic M. (maja)
- Barroso I.
- Barroso I.E. (Inês)
- Barroso I.E. (Inês)
- Barter P. (Phil)
- Beekman M. (Marian)
- Beilby J.P. (John)
- Ben-Shlomo Y.
- Benediktsson R. (Rafn)
- Benediktsson R. (Rafn)
- Bennett A.J. (Amanda)
- Bennett A.J. (Amanda)
- Bergman R.N. (Richard N.)
- Bergman R.N. (Richard N.)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Bidulescu A. (Aurelian)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Bochud M. (Murielle)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boehnke M. (Michael)
- Boehnke M. (Michael)
- Boekholdt S.M. (Matthijs)
- Boerwinkle E. (Eric)
- Boerwinkle E. (Eric)
- Boerwinkle E.A. (Eric)
- Bonnefond A. (Amélie)
- Bonnycastle L.L. (Lori L.)
- Bonnycastle L.L. (Lori L.)
- Bonnycastle L.L. (Lori)
- Boomsma D.I. (Dorret I)
- Boomsma D.I. (Dorret I.)
- Boomsma D.I. (Dorret)
- Borch-Johnsen K.
- Borecki I.B. (Ingrid B)
- Borja J.B. (Judith)
- Boström K.B. (Kristina Bengtsson)
- Bouatia-Naji N. (Nabila)
- Bravenboer B. (Bert)
- Brunner E. (Eric)
- Buchanan T.A. (Thomas)
- Bumpstead S. (Suzannah)
- Bumpstead S. (Suzannah)
- Burtt N.P. (Noël P.)
- Burtt N.P. (Noël)
- Buxbaum S.G. (Sarah)
- Böhringer S. (Stefan)
- Böttcher Y. (Yvonne)
- Campbell H. (Harry)
- Campbell H. (Harry)
- Campbell H. (Harry)
- Cao A. (Antonio)
- Carlson O.D. (Olga)
- Cauchi S. (Stephane)
- Caulfield M. (Mark)
- Caulfield M.J. (Mark J.)
- Cavalcanti-Proença C. (Christine)
- Chambers J. (John)
- Chambers J.C. (John C.)
- Charpentier G. (Guillaume)
- Charpentier G. (Guillaume)
- Chasman D.I. (Daniel)
- Chen I. (Ida)
- Chen Y.-D.I. (Yii-Der Ida)
- Chen Y.D.I. (Yii-Der Ida)
- Chines P.S. (Peter S.)
- Chines P.S. (Peter)
- Cho Y.S. (Yoon Shin)
- Clarke R. (Robert)
- Coassin S. (Stefan)
- Coin L. (Lachlan)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis)
- Cooper C. (Charles)
- Cooper C. (Cyrus)
- Cooper M.N. (Matthew)
- Cornelis M. (Marilyn)
- Cornelis M. (Marilyn)
- Couper D.J. (David J.)
- Couper D.J. (David)
- Crawford G. (Gabe)
- Crawford G. (Gabe)
- Crawford G. (Gabriel)
- Crisponi L. (Laura)
- Croteau-Chonka D.C. (Damien)
- Daly M.J. (Mark)
- Dam R.M. (Rob) van
- Dastani Z. (Zari)
- Day I.N.M. (Ian)
- Dedoussis G.V. (George)
- Dehghan A. (Abbas)
- Deloukas P. (Panagiotis)
- Deloukas P. (Panagiotis)
- Delplanque J. (Jerome)
- DIAGRAM+ Consortium
- Dina C. (Christian)
- Dina C. (Christian)
- Dominiczak A. (Anna)
- Dominiczak A.F. (Anna F.)
- Doney A.S.F. (Alex S. F.)
- Doney A.S.F. (Alex)
- Duijn C.M. (Cornelia) van
- Duncan B.B. (Bruce)
- Dupuis J. (Josée)
- Dupuis J. (Josée)
- Dupuis J. (Josée)
- Döring A. (Angela)
- Ebrahim S. (Shanil)
- Egan J.M. (Josephine)
- Egan J.M. (Josephine)
- Ejebe K.G. (Kenechi)
- Elliott A.L. (Amanda)
- Elliott A.L. (Amanda)
- Elliott K.S. (Katherine)
- Elliott P. (Paul)
- Erdmann J. (Jeanette)
- Erdmann J. (Jeanette)
- Erdos M.R. (Michael)
- Erdos M.R. (Michael)
- Evans D.M. (David)
- Faire U. (Ulf) de
- Fedson A.C. (Annette)
- Feitosa M.F. (Mary Furlan)
- Ferreira T. (Teresa)
- Ferrucci L. (Luigi)
- Ferrucci L. (Luigi)
- Fischer-Rosinsky A. (Antje)
- Florez J.C. (Jose C.)
- Florez J.C. (Jose)
- Florez J.C. (Jose)
- Forouhi N.G. (Nita)
- Fouchier S.W. (Sigrid)
- Fox C.S. (Caroline)
- Fox C.S. (Caroline)
- Franklin C.S. (Christopher)
- Franklin C.S. (Christopher)
- Franks P.W. (Paul)
- Frants R. (Rune)
- Frants R.R. (Rune)
- Franzosi M.
- Frayling T.M. (Timothy M.)
- Frayling T.M. (Timothy M.)
- Frayling T.M. (Timothy M.)
- Frayling T.M. (Timothy)
- Froguel P. (Philippe)
- Froguel P. (Philippe)
- Fuchsberger C. (Christian)
- Gabriel S.B. (Stacey)
- Galan P. (Pilar)
- Ganser M. (Martha)
- Garcia M.E. (M.)
- Geus E.J.C. (Eco) de
- Gieger C. (Christian)
- Gieger C. (Christian)
- Gieger C. (Christian)
- Gieger C. (Christian)
- Glazer N.L. (Nicole)
- GLGC Investigators
- Gloyn A.L. (Anna L.)
- Gloyn A.L. (Anna)
- Go M.J. (Min Jin)
- Goel A. (Anuj)
- Gonzalez E. (Elena)
- Goodarzi M. (Mark)
- Graessler J. (Jürgen)
- Grallert H. (Harald)
- Grallert H. (Harald)
- Grarup N. (Niels)
- Grarup N. (Niels)
- Green T. (Todd)
- Greenwood C.M.T. (Celia)
- Griffin S. (Simon)
- Grimsby J. (Jonna)
- Groop L. (Leif)
- Groop L. (Leif)
- Groop L. (Leif)
- Groves C.J. (Christopher)
- Groves C.J. (Christopher)
- Grundy S.M. (Scott)
- Gudnason V. (Vilmundur)
- Guiducci C. (Candace)
- Guiducci C. (Candace)
- Guo X. (Xiuqing)
- Guo X. (Xiuqing)
- Gwilliam R. (Rhian)
- Gyllensten U. (Ulf)
- Gyllensten U. (Ulf)
- Gyllensten U. (Ulf)
- Hadjadj S. (Samy)
- Hadjadj S. (Samy)
- Haeften T.W. (Timon) van
- Hagen K. (Knut)
- Hall A.S. (Alistair)
- Hallmans G. (Göran)
- Hammond N. (Naomi)
- Hamsten A. (Anders)
- Han X. (Xijing)
- Hansen T. (Torben)
- Haritunians T. (Talin)
- Harris T.B. (Tamara B.)
- Harris T.B. (Tamara)
- Hartikainen A.L.
- Hassanali N. (Neelam)
- Hassanali N. (Neelam)
- Hastie N. (Nick)
- Hattersley A.T. (Andrew)
- Haun M. (Margot)
- Havulinna A.S. (Aki)
- Hayward C.
- Hayward C. (Caroline)
- Heath S.C. (Simon)
- Heemst D. (Diana) van
- Hegele R.A. (Robert)
- Heid I.M. (Iris)
- Heid I.M. (Iris)
- Hengstenberg C. (Christian)
- Henneman P. (Peter)
- Henneman P. (Peter)
- Hercberg S. (Serge)
- Herder C. (Christian)
- Herder C. (Christian)
- Herpt T.W. (Thijs) van
- Hicks A.A. (Andrew A.)
- Hicks A.A. (Andrew)
- Hide W.A. (Winston)
- Hillman D.R. (David)
- Hingorani A. (Aroon)
- Hitman G.A. (Graham)
- Hivert M.-F. (Marie-France)
- Hoek M. (Mandy) van
- Hofman A.
- Hofman A. (Albert)
- Hofman A. (Albert)
- Hofman A. (Albert)
- Hofmann O.M. (Oliver)
- Holm H. (Hilma)
- Hottenga J.J. (Jouke Jan)
- Hottenga J.J. (Jouke Jan)
- Hovingh G.K. (Kees)
- Hu F.B. (Frank B)
- Hu F.B. (Frank B.)
- Hu F.B. (Frank)
- Hui J. (Jennie)
- Hung J. (Joe)
- Hunter D.J. (David)
- Huth C. (Cornelia)
- Hveem K. (Kristian)
- Igl W. (Wilmar)
- Illig T. (Thomas)
- Illig T. (Thomas)
- Ingelsson E. (Erik)
- Ingelsson E. (Erik)
- Ingelsson E. (Erik)
- Isaacs A. (Aaron)
- Isaacs A.J. (Aaron)
- Isomaa B. (Bo)
- Isomaa B. (Bo)
- Jackson A.U. (Anne)
- Jackson A.U. (Anne)
- Jarvelin M.-R. (Marjo-Riitta)
- Jarvelin M.-R. (Marjo-Riitta)
- Jarvelin M.-R. (Marjo-Riitta)
- Johansen C.T. (Christopher)
- Johansson A. (Åsa)
- Johnson P.R.V. (Paul R. V.)
- Johnson P.R.V. (Paul)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Jorgensen T. (Torben)
- Jorgensen T. (Torben)
- Jula A. (Antti)
- Jula A. (Antti)
- Kaakinen M. (Marika)
- Kanaya A. (Alka)
- Kanoni S. (Stavroula)
- Kanoni S. (Stavroula)
- Kao W.H.L. (W. H. Linda)
- Kao W.H.L. (Wen H. L.)
- Kao W.H.L. (Wen)
- Kao W.H.L. (Wen)
- Kaplan L. (Lee)
- Kaprio J. (Jaakko)
- Kapur K. (Karen)
- Karpe F. (Fredrik)
- Kastelein J.J.P. (John)
- Katsareli E. (Efi)
- Kedenko L. (Lyudmyla)
- Kesaniemi Y.A. (Antero)
- Khaw K.-T. (Kay-Tee)
- Khaw K.T.
- Kim Y-J. (Yong-Jin)
- Kim Y.J.
- Kivimaki M. (Mika)
- Kizer J.R. (Jorge)
- Klopp N. (Norman)
- Klopp N. (Norman)
- Kloppenburg M. (Margreet)
- Knight B. (Beatrice)
- Kong A. (Augustine)
- Kong A. (Augustine)
- Kooner J. (Jaspal)
- Koseki M. (Masahiro)
- Koskinen S. (Seppo)
- Kovacs P. (Peter)
- Kraft P. (Peter)
- Kristiansson K. (Kati)
- Kronenberg F. (Florian)
- Kronenberg F. (Florian)
- Kumari M. (Meena)
- Kuusisto J. (Johanna)
- Kuzawa C.W. (Christopher W.)
- Kuzawa C.W. (Christopher)
- Kyvik K.O. (Kirsten O.)
- Kyvik K.O. (Kirsten Ohm)
- Kähönen M. (Mika)
- König I.R. (Inke)
- Laakso M. (Markku)
- Laakso M. (Markku)
- Laakso M. (Markku)
- Laaksonen R. (Reijo)
- Ladouceur M. (Martin)
- Lajunen T. (Taina)
- Lakatta E.G. (Edward G.)
- Lamina C. (Claudia)
- Lamina C. (Claudia)
- Lange L.A. (Leslie)
- Lange L.A. (Leslie)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Lathrop G. (GMark)
- Launer L.J. (Lenore J.)
- Lauritzen T. (Torsten)
- Lawlor D.A. (Debbie)
- Lecoeur C. (Cécile)
- Lee J.-Y. (Jong-Young)
- Lehtimäki T. (Terho)
- Lettre G. (Guillaume)
- Li M. (Man)
- Li M. (Man)
- Li X. (Xiaohui)
- Li X. (Xiaohui)
- Li Y. (Yun)
- Lieverse A.G. (Aloysius)
- Lindgren C.M. (Cecilia M.)
- Lindgren C.M. (Cecilia)
- Liu C.-T. (Ching-Ti)
- Liu Y. (YongMei)
- Lohman K. (Kurt)
- Lokki M.L.
- Loo B.-M. (Britt-Marie)
- Loos R.J.F. (Ruth)
- Loos R.J.F. (Ruth)
- Loos R.J.F. (Ruth)
- Luan J. (Jian’an)
- Luan J. (Jian’an)
- Luben R.N. (Robert)
- Lucas G. (Gavin)
- Lyssenko V. (Valeriya)
- Lyssenko V. (Valeriya)
- Lyytikäinen L.-P. (Leo-Pekka)
- MAGIC Consortium
- Magnusson P.K. (Patrik)
- Magnusson P.K.E. (Patrik K. E.)
- Mahley R. (Robert)
- Mangino M. (Massimo)
- Mangino M. (Massimo)
- Manning A.K. (Alisa K.)
- Manning A.K. (Alisa)
- Marmot M. (Michael)
- Marre M. (Michel)
- Marroni F. (Fabio)
- Martin N.G. (Nicholas)
- Martinez-Larrad M.T. (Maria Teresa)
- Masson D. (David)
- McArdle W.L. (Wendy)
- McAteer J.B. (Jarred)
- McCarroll S.A. (Steve)
- McCarroll S.A. (Steven)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark)
- McCulloch L.J. (Laura J.)
- McCulloch L.J. (Laura)
- McPherson R. (Ruth)
- Meigs J.B. (James B.)
- Meigs J.B. (James)
- Meigs J.B. (James)
- Meisinger C. (Christa)
- Meitinger T. (Thomas)
- Meitinger T. (Thomas)
- Meitinger T. (Thomas)
- Melander O. (Olle)
- Melzer D. (David)
- Meneton P. (Pierre)
- Meulenbelt I. (Ingrid)
- Meyre D. (David)
- Midthjell K. (Kristian)
- Mitchell B.D. (Braxton)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen)
- Mooser V. (Vincent)
- Mooser V. (Vincent)
- Mooser V.E. (Vincent E.)
- Morken M.A. (Mario A.)
- Morken M.A. (Mario)
- Morris A.D. (Andrew D.)
- Morris A.D. (Andrew)
- Morris A.P. (Andrew P.)
- Morris A.P. (Andrew P.)
- Morris A.P. (Andrew)
- Mukherjee S. (Sutapa)
- Munroe P. (Patricia)
- Musani S. (Solomon)
- Musunuru K. (Kiran)
- MuTHER Consortium
- Mägi R. (Reedik)
- Naitza S. (Silvia)
- Narisu N. (Narisu)
- Narisu N. (Narisu)
- Nathan D.M. (David)
- Navarro P. (Pau)
- Navarro P. (Pau)
- Neville M.J. (Matthew)
- Nickerson D.A. (Deborah A.)
- Nickerson D.A. (Deborah)
- Nieminen M.S. (Markku)
- Nilsson P. (Peter)
- Nuotio M.-L. (Marja-Liisa)
- Oostra B.A. (Ben A.)
- Oostra B.A. (Ben)
- Oostra B.A. (Ben)
- Ordovas J.M. (Jose M.)
- Ordovas J.M. (Jose)
- Orho-Melander M. (Marju)
- Orrù M. (Marco)
- Owen K.R. (Katharine)
- O’Connell J. (Jeffrey)
- Pakyz R. (Ruth)
- Palmer C. (Cameron)
- Palmer C.N.A. (Colin N. A.)
- Palmer C.N.A. (Colin)
- Pankow J.S. (James S.)
- Pankow J.S. (James)
- Paolisso G. (Giuseppe)
- Pare G. (Guillame)
- Park T. (Taesung)
- Parker A.N. (Alex)
- Pattaro C. (Cristian)
- Pattaro C. (Cristian)
- Pattou F. (François)
- Paulweber B. (Bernhard)
- Payne F. (Felicity)
- Payne F. (Felicity)
- Pearson D. (Daniel)
- Peden J. (John)
- Pedersen N.L. (Nancy)
- Pedersen O. (Oluf)
- Pedersen O. (Oluf)
- Peloso G.M. (Gina)
- Peltonen L. (Leena Johanna)
- Penninx B.W.J.H.
- Penninx B.W.J.H. (Brenda W. J. H.)
- Penninx B.W.J.H. (Brenda)
- Perola M. (Markus)
- Perola M. (Markus)
- Perola M. (Markus)
- Perry J.R.B. (John R. B.)
- Perry J.R.B. (John R. B.)
- Perry J.R.B. (John)
- Petersen A.K.
- Pfeiffer A.F.H. (Andreas)
- Pichler I. (Irene)
- Pichler I. (Irene)
- Platou C.P. (Carl)
- Polasek O. (Ozren)
- Posthuma D. (Danielle)
- Potter S.C. (Simon)
- Pouta A. (Anneli)
- Pramstaller P.P. (Peter P.)
- Pramstaller P.P. (Peter P.)
- Pramstaller P.P. (Peter Paul)
- Pramstaller P.P. (Peter Paul)
- Proença C. (Christine)
- Prokopenko I. (Inga)
- Prokopenko I. (Inga)
- Province M.A. (Mike)
- Psaty B.M. (Bruce M.)
- Psaty B.M. (Bruce)
- Qi L. (Lu)
- Qi L. (Lu)
- Quertermous T. (Thomas)
- Quertermous T. (Thomas)
- Rader D.J. (Daniel)
- Raitakari O. (Olli)
- Randall J.C. (Joshua)
- Rasmussen-Torvik L.J. (Laura)
- Rathmann W. (Wolfgang)
- Rathmann W. (Wolfgang)
- Raychaudhuri S. (Soumya)
- Rayner N.W. (Nigel W.)
- Rayner N.W. (Nigel William)
- Redline S. (Susan)
- Reilly M.P. (Muredach P.)
- Rice K.M. (Kenneth)
- Richards J.B. (J. Brent)
- Ricketts S.L. (Sally)
- Ridker P.M. (Paul)
- Rieder M. (Mark)
- Rieder M. (Mark)
- Ripatti S. (Samuli)
- Ripatti S. (Samuli)
- Rivadeneira Ramirez F. (Fernando)
- Roberts R. (Robert)
- Robertson N.R. (Neil)
- Roccasecca R.M.
- Rocheleau G. (Ghislain)
- Rocheleau G. (Ghislain)
- Roden M. (Michael)
- Roden M. (Michael)
- Rolandsson O. (Olov)
- Rose L.M. (Lynda)
- Rotter J.I. (Jerome I)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Ruokonen A. (Aimo)
- Ruokonen A. (Aimo)
- Rybin D. (Denis)
- Sabatti C. (Chiara)
- Saharinen J. (Juha)
- Salomaa V. (Veikko)
- Salomaa V. (Veikko)
- Salomaa V. (Veikko)
- Samani N.J. (Nilesh)
- Samani N.J. (Nilesh)
- Sampson M.J. (Michael J)
- Sampson M.J. (Michael)
- Sandbaek A. (Annelli)
- Sandhu M. (Manjinder)
- Sandhu M.S. (Manjinder)
- Sanna S. (Serena)
- Sanna S. (Serena)
- Sattar N. (Naveed)
- Saxena R. (Richa)
- Saxena R. (Richa)
- Sayer A.A.
- Schadt E.E. (Eric E.)
- Schadt E.E. (Eric)
- Scheet P. (Paul)
- Schlessinger D. (David)
- Schlessinger D. (David)
- Schunkert H. (Heribert)
- Schwarz P.E.H. (Peter)
- Scott L.J. (Laura J.)
- Scott L.J. (Laura)
- Scott R.A. (Robert)
- Scuteri A. (Angelo)
- Scuteri A. (Angelo)
- Scuteri A. (Angelo)
- Seedorf U. (Udo)
- Segrè A.V. (Ayellet)
- Seielstad M. (Mark)
- Semple R.K. (Robert K.)
- Serrano-Ríos M. (Manuel)
- Sethupathy P. (Praveen)
- Sharp S.J. (Stephen)
- Shields B.M. (Beverley)
- Shields B.M. (Beverley)
- Shrader P. (Peter)
- Shrader P. (Peter)
- Shuldiner A.R. (Alan)
- Sigurdsson G. (Gunnar)
- Sigursson G. (Gunnar)
- Sijbrands E. (Eric)
- Sijbrands E.J.G. (Eric J. G.)
- Sijbrands E.J.G. (Eric)
- Silander K. (Kaisa)
- Silander K. (Kaisa)
- Silveira A. (Angela)
- Sim X. (Xueling)
- Sim X. (Xueling)
- Simpson L. (Laila)
- Singleton A. (Andrew)
- Sinisalo J. (Juha)
- Siscovick D.S. (David)
- Siscovick D.S. (David)
- Sladek R. (Rob)
- Sladek R. (Rob)
- Slagboom P.E. (Eline)
- Small K.S. (Kerrin)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith A.V. (Davey)
- Smith G.D. (George Davey)
- Smith J.D. (Joshua D.)
- Smith N.L. (Nicholas)
- Song K. (Kijoung)
- Soranzo N. (Nicole)
- Soranzo N. (Nicole)
- Sovio U. (Ulla)
- Sparsø T. (Thomas)
- Sparsø T. (Thomas)
- Spector T.D. (Tim D.)
- Spector T.D. (Timothy D.)
- Spector T.D. (Timothy)
- Spranger J. (Joachim)
- St Pourcain B. (Beate)
- Stefansson K. (Kari)
- Stefansson K. (Kari)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Steinthorsdottir V. (Valgerdur)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Stringham H.M. (Heather M.)
- Stringham H.M. (Heather M.)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Stylianou I.M. (Ioannis M.)
- Stylianou I.M. (Ioannis)
- Sun Q. (Qi)
- Surakka I. (Ida)
- Swift A.J. (Amy)
- Swift A.J. (Amy)
- Syddall H. (Holly)
- Syvänen A.C.
- Tai E.-S. (E-Shyong)
- Tai E.S. (Shyong)
- Tall A.R. (Alan R.)
- Tanaka T. (Toshiko)
- Taylor H.A. (Herman A.)
- Taylor H.A. (Herman)
- Teslovich T.M. (Tanya M.)
- Teslovich T.M. (Tanya M.)
- Thompson J.R. (John)
- Thompson J.R. (John)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorleifsson G. (Gudmar)
- Thorleifsson G. (Gudmar)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Tichet J. (Jean)
- Tichet J. (Jean)
- Timpson N.J. (Nicholas J.)
- Timpson N.J. (Nicholas)
- Tracy R.P. (Russell)
- Tuomi T. (Tiinamaija)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Tuomilehto J. (Jaakko)
- Tuomilehto J. (Jaakko)
- Tönjes A. (Anke)
- Uda M. (Manuela)
- Uda M. (Manuela)
- Uh H.-W. (Hae-Won)
- Uitterlinden A. (Andre)
- Uitterlinden A.G. (Andre G.)
- Uitterlinden A.G. (André)
- Valle T.T. (Timo T.)
- van Duijn C. (Cornelia)
- van Duijn C.M. (Cornelia M.)
- van Duijn C.M. (Cornelia M.)
- van Hoek M. (Mandy)
- Varma D. (Dhiraj)
- Viikari J. (Jorma)
- Visvikis-Siest S. (Sophie)
- Vitart V. (Veronique)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Vogelzangs N. (Nicole)
- Voight B.F. (Benjamin F.)
- Voight B.F. (Benjamin F.)
- Voight B.F. (Benjamin)
- Vollenweider P. (Peter)
- Vollenweider P. (Peter)
- Vollenweider P. (Peter)
- Waeber G. (Gérard)
- Waeber G. (Gérard)
- Wagner P.J. (Peter)
- Walker M. (Mark)
- Walley A. (Andrew)
- Walters G. (GBragi)
- Walters G.B. (Bragi)
- Ward K.L. (Kim L.)
- Wareham N.J. (Nick J.)
- Wareham N.J. (Nick)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard M.)
- Watanabe R.M. (Richard)
- Waterworth D. (Dawn)
- Waterworth D. (Dawn)
- Waterworth D.M. (Dawn)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R.P. (Ryan)
- Wheeler E. (Eleanor)
- Whitfield J. (John)
- Wichmann H.-E. (H.-Erich)
- Wichmann H.E. (H. Erich)
- Wichmann H.E. (Heinz Erich)
- Wichmann H.E. (Heinz Erich)
- Wijmenga C. (Cisca)
- Wild S.H. (Sarah)
- Willems van Dijk J.A.P. (Ko)
- Willems S.M. (Sara)
- Willems-vanDijk K. (Ko)
- Willemsen G.
- Willemsen G.A.H.M. (Gonneke)
- Willer C.J. (Cristen J.)
- Willer C.J. (Cristen)
- Williams G.H. (Gordon)
- Wilson J.F. (James F.)
- Wilson J.F. (James)
- Wilson J.G. (James G.)
- Winkler T.W. (Thomas W.)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline C. M.)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C. M.)
- Wong T.Y. (Tien Y.)
- Wood A.R. (Andrew)
- Wright A.F. (Alan)
- Wright A.F. (Alan)
- Wu G. (Guanming)
- Wu Y. (Ying)
- Yarnell J.W.G. (John W.)
- Yuan X. (Xin)
- Zabena C. (Carina)
- Zee R.Y.L. (Robert)
- Zeggini E. (Eleftheria)
- Zeggini E. (Eleftheria)
- Zelenika D. (Diana)
- Zethelius B. (Björn)
- Zhai G. (Guangju)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Zhao J.H. (Jing Hua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zwart J-A. (John-Anker)
- Ódonnell C.J. (Christopher)
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10−8- 1.2 ×10−43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10−4). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10−3, n = 22,044), increased triglycerides (p = 2.6×10−14, n = 93,440), increased waist-to-hip ratio (p = 1.8×10−5, n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10−3, n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL- cholesterol concentrations (p = 4.5×10−13, n = 96,748) and decreased BMI (p = 1.4×10−4, n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance
Genome-wide and fine-resolution association analysis of malaria in West Africa
- Author
- A. Barton
- A. Chaney
- A. Compston
- A. Djimde
- A. Dolo
- A. Dominiczak
- A. Doyle
- A. Duncanson
- A. Elkin
- A. Elzein
- A. Enimil
- A. Farmer
- A. Forbes
- A. Ghansah
- A. Goris
- A. Green
- A. Hussein
- A. Keniry
- A. Ly
- A. Manjurano
- A. Maqbool
- A. Mendy
- A. Onipinla
- A. Sakuntabhai
- A. Tall
- A. Vanderwal
- A.E. Jeffreys
- A.H. Young
- A.J. Balmforth
- A.J. Silman
- A.M. Hinks
- A.P. Attwood
- A.P. Morris
- A.S. Hall
- A.S. Knight
- A.T. Hattersley
- A.V. Hill
- Aarno Palotie
- Abdoulaye Djimde
- Adama Tall
- Alieu Mendy
- Alison Coffey
- Amagana Dolo
- Anavaj Sakuntabhai
- Andrew Dunham
- Andrew E. Fry
- Andrew Morris
- Angela Allen
- Angela Green
- Anna E. Jeffreys
- B. Burke
- B. Cant
- B. Macinnis
- B. Widmer
- B.M. Shields
- B.N. Howie
- Bryan Howie
- C. Bryan
- C. Drakeley
- C. Farrar
- C. Fraser
- C. Hubbart
- C. Hughes
- C. Moyes
- C. Potter
- C. Wallace
- C.A. Braga Marcano
- C.C. Spencer
- C.E. Todhunter
- C.G. Mathew
- C.J. Groves
- C.M. Lewis
- C.M. Lindgren
- C.M. Ndila
- C.M. Onnie
- C.V. Plowe
- C.V. Prowse
- C.W. Lees
- Chris Drakeley
- Christopher V. Plowe
- Claire Widden
- D. Alcock
- D. Barnwell
- D. Bentley
- D. Carucci
- D. Conway
- D. Davison
- D. Easton
- D. Evans
- D. Fernando
- D. Grozeva
- D. Ishengoma
- D. St Clair
- D. Vukcevic
- D. Withers
- D.A. Collier
- D.A. Compston
- D.B. Dunger
- D.G. Clayton
- D.P. Jewell
- D.P. Strachan
- D.P. Symmons
- D.P. Wellcome Trust Case Control Consortium Kwiatkowski
- D.T. Bishop
- David J. Conway
- David Modiano
- David Modiano
- E. Bougouma
- E. Hilton
- E. King
- E. Lin
- E. Meech
- E. Somaskantharajah
- E. Zeggini
- E.K. Green
- E.M. Riley
- E.R. Nimmo
- Eleanor M. Riley
- Elilan Somaskantharajah
- Eric Akum Achidi
- F. Bredin
- F.R. Cummings
- Fatou Sisay-Joof
- Fernando D. Hien Tt
- G. Breen
- G. Kirov
- G. Kokwaro
- G. Maslen
- G. Sirugo
- G.A. Hitman
- G.M. Lathrop
- G.R. Walters
- Gilbert Kokwaro
- Giorgio Sirugo
- H. Donovan
- H. Drummond
- H. Lango
- H. Reyburn
- H.E. Stevens
- H.T. Leung
- Hugh Reyburn
- I. Mueller
- I. Nikolov
- I.B. Hallgrimsdóttir
- I.N. Bruce
- I.N. Ferrier
- I.R. Jones
- Ivo Mueller
- J. Barbour
- J. Connell
- J. Devries
- J. Evans
- J. Farrar
- J. Ghori
- J. Gungadoo
- J. Makani
- J. Pereira-Gale
- J. Ragoussis
- J. Reeder
- J. Rogers
- J. Sanderson
- J. Satsangi
- J. Webster
- J. Worthington
- J.A. Franklyn
- J.A. Todd
- J.C. Barrett
- J.C. Mansfield
- J.D. Jolley
- J.H. Barrett
- J.J. Pointon
- J.L. Marchini
- J.M. Heward
- J.M. Hussey
- J.P. Boorman
- J.R. Perry
- J.R. Thompson
- Jane Rogers
- Jennifer Evans
- Jeremy Farrar
- Jiannis Ragoussis
- John Reeder
- John Sl
- Jonathan Marchini
- Julie Makani
- K. Bojang
- K. Cook
- K. Downes
- K. Fitzpatrick
- K. Gordon-Smith
- K. Kivinen
- K. Koch
- K. Marsh
- K. Rowlands
- K.A. Koram
- K.A. Rockett
- K.L. Lee
- K.S. Elliott
- K.S. Small
- Kalifa A. Bojang
- Kate Rowlands
- Katja Kivinen
- Kerrin S. Small
- Kevin Marsh
- Kirk A. Rockett
- Kwadwo A. Koram
- L. Amenga-Etego
- L. Hart
- L. Jones
- L. Manning
- L.A. Bradbury
- L.R. Cardon
- M. Ban
- M. Caulfield
- M. Diakite
- M. Farrall
- M. Gottlieb
- M. Ibrahim
- M. Inouye
- M. Jallow
- M. Lemnge
- M. Mangino
- M. Manske
- M. Mccreight
- M. Newport
- M. Parker
- M. Parkes
- M. Pembrey
- M. Sanjoaquin
- M. Stevens
- M. Thera
- M. Tremelling
- M. Troye-Blomberg
- M. Walker
- M. Wilson
- M. Xue
- M.A. Brown
- M.C. O'Donovan
- M.D. Tobin
- M.E. Molyneux
- M.I. Mccarthy
- M.J. Brown
- M.J. Owen
- M.J. Simmonds
- M.K. Mohiuddin
- M.L. Hamshere
- M.M. Iles
- M.N. Weedon
- M.R. Stratton
- Mahamadou Thera
- Malaria Genomic E.A. Epidemiology Network: Achidi
- Malcolm E. Molyneux
- Margaret Pinder
- Marita Troye-Blomberg
- Martha Lemnge
- Michael Inouye
- Michael Parker
- Michael Wilson
- Miguel Sanjoaquin
- Muminatou Jallow
- Muntaser Ibrahim
- N. Craddock
- N. Karunaweera
- N. Peshu
- N. Rahman
- N. Yuldasheva
- N.A. Watkins
- N.C. Taylor
- N.J. Cardin
- N.J. Prescott
- N.J. Samani
- N.J. Timpson
- N.M. Walker
- N.T. Quyen
- N.W. Rayner
- Nadira Karunaweera
- Norbert Peshu
- O. Amodu
- O. Doumbo
- O. Duombo
- O. Puijalon
- O. Toure
- Odile Puijalon
- Ogobara K. Doumbo
- Olukemi Amodu
- P. Corran
- P. Deloukas
- P. Donnelly
- P. Duffy
- P. Mcguffin
- P. Michon
- P. Risley
- P. Singhasivanon
- P. Suriyaphol
- P. Whittaker
- P. Wordsworth
- P.A. Holmans
- P.B. Munroe
- P.D. Gilbert
- P.R. Burton
- P.S. Braund
- Pamela Whittaker
- Panos Deloukas
- Pascal Michon
- Patrick Corran
- Peter Donnelly
- Pratap Singhasivanon
- R. Dewasurendra
- R. Dobson
- R. Gwilliam
- R. Mcginnis
- R. Ravindrarajah
- R. Walton
- R. Watson
- R. Williamson
- R. Wrigley
- R.D. Horstmann
- R.J. Dixon
- R.M. Freathy
- R.W. Jones
- Rhian Gwilliam
- Rolf D. Horstmann
- S. Allen
- S. Auburn
- S. Bull
- S. Caesar
- S. Campino
- S. Dunstan
- S. Eyre
- S. Nutland
- S. Potter
- S. Seal
- S. Sirima
- S. Stevens
- S.A. Fisher
- S.C. Gough
- S.E. Hunt
- S.G. Ball
- S.J. Bumpstead
- S.J. Newhouse
- S.J. Sawcer
- S.L. Hider
- S.M. Ring
- Sarah Auburn
- Sarah Dunstan
- Sarah E. Hunt
- Simon Potter
- Sodiomon Sirima
- Stanley Usen
- Susana Campino
- Suzannah J. Bumpstead
- T. Agbenyega
- T. Ahmad
- T. Clark
- T. Ferreira
- T. Mutabingwa
- T. Oluoch
- T. Winzer
- T.E. Taylor
- T.M. Frayling
- T.N. Williams
- T.O. Apinjoh
- Taane G. Clark
- Terrie E. Taylor
- Thomas N. Williams
- Tran Tinh Hien
- Tsiri Agbenyega
- U. Everson
- V. Moskvina
- V. Nyirongo
- Valentina Mangano
- W. Thomson
- W.H. Ouwehand
- W.L. Mcardle
- Y. Teo
- Y.Y. Teo
- Yik Ying Teo
- Z. Su
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
We report a genome-wide association (GWA) study of severe malaria in The Gambia. The initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a replication study included 3,400 children. We used this to examine the performance of GWA methods in Africa. We found considerable population stratification, and also that signals of association at known malaria resistance loci were greatly attenuated owing to weak linkage disequilibrium (LD). To investigate possible solutions to the problem of low LD, we focused on the HbS locus, sequencing this region of the genome in 62 Gambian individuals and then using these data to conduct multipoint imputation in the GWA samples. This increased the signal of association, from P = 4 × 10(-7) to P = 4 × 10(-14), with the peak of the signal located precisely at the HbS causal variant. Our findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index
- Author
- Adamo P. (Pio) d'
- Adan R. (R.)
- Alavere H. (Helene)
- Albrecht E. (Eva)
- Alexander G. (Graeme)
- Alfredsson L. (Lars)
- Amin N. (Najaf)
- Amin N. (Najaf)
- Anderson C.A. (Carl A)
- Ando T. (Tetsuya)
- Ang W.Q. (Wei)
- Antel J. (J.)
- Aspelund T. (T.)
- Aspelund T. (Thor)
- Atalay M. (Mustafa)
- Baker J.H. (Jessica H)
- Barrett J.C. (Jeffrey)
- Barroso I.E. (Inês)
- Beijsterveldt C.E.M. (Toos) van
- Bencko V. (Vladimir)
- Benke K. (K.)
- Berenson G. (Gerald)
- Bergen A.W. (Andrew)
- Bergen N. (N.)
- Bergmann S.M. (Sven)
- Berrettini W. (Wade)
- Berry D. (Diane)
- Bierut L.J. (L. J.)
- Bierut L.J. (Laura)
- Blackburn H. (Hannah)
- Boerwinkle E. (E.)
- Boerwinkle E.A. (Eric)
- Boni C. (Claudette)
- Boomsma D.I. (Dorret)
- Boraska Perica V. (V.)
- Boyd H.A. (H. A.)
- Bradfield J.P. (Jonathan)
- Brandys M. (M.)
- Breen G. (Gerome)
- Breen G. (Gerome)
- Bruson A. (Alice)
- Bulik C.M. (C. M.)
- Burghardt R. (Roland)
- Buring J.E. (Julie)
- Busonero F.
- Busonero F. (F.)
- Byrne E.M. (E. M.)
- Byrne E.M. (Enda)
- Bühren K. (Katharina)
- Carlberg L. (Laura)
- Chanock S.J. (S. J.)
- Chanock S.J. (Stephen)
- Charoen P. (Pimphen)
- Chasman D.I. (Daniel)
- Cichon S. (Sven)
- Clementi M. (Maurizio)
- Cohen-Woods S. (Sarah)
- Coin L. (Lachlan)
- Collier D.A. (David)
- Cone R.D. (Roger D)
- Conlon P. (Peter)
- Conlon P.J. (Peter J)
- Cooper C. (C.)
- Cooper C. (Charles)
- Cornelis M. (Marilyn)
- Corre T. (Tanguy)
- Couper D.J. (David)
- Cousminer D.L. (Diana)
- Coviello A.D. (Andrea)
- Crawford S. (Steve)
- Crisponi L. (Laura)
- Crow S. (Scott)
- Danner U.N. (Unna N)
- Das S. (Shikta)
- Davey Smith G. (G.)
- Davis O.S.P. (Oliver S.)
- de Geus E.J. (E. J.)
- de Kove C. (Carolien)
- De Zwaan M. (M.)
- Dedoussis G.V. (G. V.)
- Dedoussis G.V. (George)
- Degortes D. (Daniela)
- Deloukas P. (Panagiotis)
- Demerath E.W. (E. W.)
- Demerath E.W. (Ellen)
- DeSocio J.E. (Janiece E)
- Dick D.M. (Danielle)
- Dmitrzak-Weglarz M. (Monika)
- Docampo E. (Elisa)
- Dominiczak A. (Anna)
- Dominiczak A. (Anna)
- Duijn C.M. (Cornelia) van
- Duncanson A. (Audrey)
- Döring A. (Angela)
- Econs M.J. (M. J.)
- Econs M.J. (Michael)
- Edkins T. (Ted)
- Egberts K. (Karin)
- Ehrlich S.M. (Stefan)
- Eiriksdottir G. (Gudny)
- Elburg A.A. (Annemarie) van
- Elks C.E. (Cathy)
- Elliott P. (P.)
- Elliott P. (Paul)
- Esko T. (T.)
- Esko T. (Tõnu)
- Espeseth T. (Thomas)
- Estivill X. (Xavier)
- Evans D.M. (D. M.)
- Faire U. (Ulf) de
- Farmer A.E. (Anne E)
- Favaro A. (Angela)
- Feenstra B. (B.)
- Feenstra B. (Bjarke)
- Fernández-Aranda F. (Fernando)
- Ferreli L. (Liana)
- Ferrucci L. (L.)
- Fichter M.M. (M. M.)
- Finan C. (Chris)
- Fischer K. (Krista)
- Flexeder C. (Claudia)
- Floyd J. (Jamie)
- Folsom A.R. (A. R.)
- Folsom A.R. (Aaron)
- Foretova L. (Lenka)
- Foroud T. (T.)
- Foroud T. (Tatiana)
- Forzan M. (Monica)
- Franceschini N. (Nora)
- Frayling T.M. (Timothy)
- Freathy R.M. (Rachel)
- Furth E.F. (Eric) van
- Föcker M. (M.)
- Gaborieau V. (Valerie)
- Gaillard R. (R.)
- Gambaro G. (Giovanni)
- Garcia M.E. (M.)
- Gasparini P. (P.)
- Gasparini P. (Paolo)
- Geller F. (Frank)
- Geus E.J.C. (Eco) de
- Gieger C. (Christian)
- Giegling I. (Ina)
- Gillman M.W. (Matthew W.)
- Goh L.K. (L. K.)
- Gonidakis F. (Fragiskos)
- Gorwood P. (Philip)
- Grant S.F.A. (S. F.A.)
- Grant S.F.A. (Struan)
- Gratacos M. (Monica)
- Gray E. (Emma)
- Groen-Blokhuis M. (Maria)
- Gudbjartsson D.F. (Daniel)
- Gudnason V. (V.)
- Guo Y. (Yongli)
- Guxens Junyent M. (Mònica)
- Hadley D. (D.)
- Hagen K. (Knut)
- Hakonarson H. (Hakon)
- Halmi K.A. (K. A.)
- Hankinson S.E. (S. E.)
- Harris T.B. (Tamara)
- Hattersley A.T. (Andrew)
- Hauser J. (J.)
- Haworth C.M.A. (Claire M.)
- Hayward C. (Caroline)
- He C. (C.)
- Hebebrand J. (J.)
- Heid I.M. (Iris)
- Heinrich J. (J.)
- Helder S. (Sietske)
- Hendriks J. (Judith)
- Herms S. (Stefan)
- Hernandez D.G. (Dena)
- Herpertz-Dahlmann B. (B.)
- Herzog W. (W.)
- Hilliard C.E. (Christopher E)
- Hinney A. (Anke)
- Hirschhorn J.N. (Joel)
- Hocher B. (Berthold)
- Hofman A. (Albert)
- Holloway J.W. (J. W.)
- Holst J.J.
- Horikoshi M. (Momoko)
- Hottenga J.J. (Jouke Jan)
- Hu F.B. (F. B.)
- Huckins L.M. (Laura M)
- Hudson J.I. (James I)
- Huemer J. (Julia)
- Huikari V. (Ville)
- Hunt S.E. (Sarah E)
- Hypponen E. (E.)
- Hypponen E. (Elina)
- Iezebrink K. (Kirsty)
- Illig T. (T.)
- Imgart H. (Hartmut)
- Ingelsson E. (Erik)
- Inoko H. (Hidetoshi)
- Iñiguez C. (C.)
- Jaddoe V.W. (V. W.)
- Jaddoe V.W.V. (Vincent)
- Jall S. (S.)
- Janout V. (Vladimir)
- Jarvelin M.-R. (Marjo-Riitta)
- Jarvelin M.R. (M. R.)
- Jiménez-Murcia G.E.S. (Geòrgia Escaramí Susana)
- Johnson A.D. (Andrew)
- Julia A. (Antonio)
- Kaakinen M. (M.)
- Kalsi G. (Gursharan)
- Kaplan A.S. (Allan S)
- Kaprio J. (Jaakko)
- Kaprio J. (Jaakko)
- Karasik D. (David)
- Karhunen L. (Leila)
- Karwautz A. (Andreas)
- Kas M.J.H. (Martien)
- Keel P. (Pamela)
- Kennedy J.L.
- Keski-Rahkonen A. (Anna)
- Kesselmeier M. (M.)
- Khaw K.T. (K. T.)
- Kiel D.P. (Douglas P.)
- Kilpeläinen T.O. (Tuomas)
- Klump K.L. (K. L.)
- Knudsen G.P.S. (Gun Peggy S.)
- Koeleman B.P.C. (Bobby P. C.)
- Koeleman B.P.C. (Bobby)
- Kolcic I. (Ivana)
- Koller D.L. (Daniel)
- Komaki G. (Gen)
- Koubek D. (Doris)
- Kowgier M. (Matthew)
- Kraft P. (Peter)
- Kutalik Z. (Zoltán)
- La Via M. (Maria)
- Lakka T.A. (Timo)
- Lange L.A. (Leslie)
- Langford C. (Cordelia)
- Launer L.J. (Lenore)
- Laven J.S. (J. S.)
- Lawlor D.A. (D. A.)
- Lawlor D.A. (Debbie)
- Le Hellard S. (Stephanie)
- Lehtimäki T. (Terho)
- Levitan R.D. (Robert D)
- Levy D. (D.)
- Lewin A. (Alex)
- Lewis C.M. (Cathryn)
- Li D. (Dong)
- Li S. (S.)
- Lichtenstein P. (Paul)
- Lilenfeld L. (Lisa)
- Lin P. (P.)
- Lindi V. (Virpi)
- Lissowska J. (Jolanta)
- Liu J. (J.)
- Logan D.W. (Darren W)
- Loos R.J.F. (Ruth)
- Lord G. (Graham)
- Lundervold A.J. (Astri)
- Lunetta K.L. (Kathryn)
- Maggi R. (Reedik)
- Magistretti P. (Pierre)
- Magnusson P.K. (Patrik)
- Maj M. (Mario)
- Mangino M. (Massimo)
- Marsal S. (Sara)
- Marsal S. (Sara)
- Martaskova D. (Debora)
- Martin N.G. (N. G.)
- Mattingsdal M. (Morten)
- Mattingsdal M. (Morten)
- Maxwell A.P. (A.)
- McArdle P.F. (P. F.)
- McCarthy M.I. (M. I.)
- McGinnis R. (Ralph)
- Mcguffin P. (Peter)
- Melbye M. (Mads)
- Merl E. (Elisabeth)
- Metspalu A. (Andres)
- Meulenbelt I. (Ingrid)
- Meurs J.B.J. (Joyce) van
- Middeldorp C.M. (Christel)
- Millwood I.Y. (Iona)
- Mitchell J. (James)
- Mohlke K.L. (Karen)
- Monteleone P. (Palmiero)
- Montgomery G.W. (G. W.)
- Mook-Kanamori D.O. (D. O.)
- Murabito J. (Joanne)
- Murray J.C. (Jeffrey)
- Männik K. (Katrin)
- Müller T.D.
- Nalls M.A. (Michael)
- Navarro P. (Pau)
- Navratilova M. (Marie)
- Nelis M. (M.)
- Nengut S.-G. (Suna-Gumuscu)
- Ness A.R. (A. R.)
- Ness A.R. (Andrew)
- Nivard M. (Michel)
- Nohr C. (Christian)
- Ntalla I. (Ioanna)
- O'Reilly P.F. (P. F.)
- Oken E. (Emily)
- Ong K.K. (K. K.)
- Oostra B.A. (Ben)
- Ophoff R.A. (Roel)
- Ouwehand W.H. (Willem)
- O’Toole J.K. (Julie K)
- Padyukov L. (L.)
- Padyukov L. (Leonid)
- Palmer C. (Cameron)
- Palotie A. (A.)
- Palotie A. (Aarno)
- Panoutsopoulou K. (K.)
- Pantel J. (Jacques)
- Papezova H. (Hana)
- Pararajasingham J. (Jennifer)
- Pare G. (Guillame)
- Parker A.N. (Alex)
- Peacock M. (M.)
- Peacock M. (Munro)
- Pearson E.R. (E. R.)
- Pedersen N.L. (Nancy)
- Peltonen L. (Leena Johanna)
- Pennell C.E. (Craig)
- Perry J.R. (J. R.)
- Pinto D. (Dalila)
- Pinto D. (Duane)
- Plump A.S. (A. S.)
- Polasek O. (Ozren)
- Porcu E. (Eleonora)
- Potter S.C. (Simon)
- Power C. (Christopher)
- Price T.S. (Thomas)
- Prokopenko I. (Inga)
- Rabionet R. (Raquel)
- Raevuori-Helkamaa A. (Anu)
- Rafnar T. (Thorunn)
- Raitakari O.T. (O. T.)
- Rajewski A. (Andrzej)
- Ramoz N. (Nicolas)
- Rayner N.W. (Nigel William)
- Reinvang I. (Ivar)
- Rice J.P. (John)
- Rich S.S. (Stephen)
- Ridker P.M. (Paul)
- Ring S.M. (Susan)
- Ripatti S. (Samuli)
- Ritchie G.R.S. (Graham R.S.)
- Rivadeneira Ramirez F. (Fernando)
- Rivadeneira F. (F.)
- Roberts M. (Marion)
- Rodriguez A. (A.)
- Rotondo A. (Alessandro)
- Rujescu D. (Dan)
- Rybakowski F. (Filip)
- Sala C. (Cinzia)
- Salem R.M. (Rany)
- Salomaa V. (Veikko)
- Sambrook J. (Jennifer)
- Sandford R. (Richard)
- Sanna S. (Serena)
- Santonastaso P. (Paolo)
- Saw S.M. (S. M.)
- Scherag A. (A.)
- Scherag A. (Andre)
- Scherer S.W. (Stephen W)
- Scherer S.W. (Stephen)
- Schlessinger D. (D.)
- Schmidt U. (Ulrike)
- Schosser A. (Alexandra)
- Schreiber S. (Stefan)
- Scuteri A. (A.)
- Scuteri A. (Angelo)
- Sebert S. (S.)
- Segrè A.V. (Ayellet)
- Sheerin N. (Neil)
- Siitonen N. (Niina)
- Simpkin D. (Douglas)
- Slachtova L. (Lenka)
- Sladek R. (Rob)
- Slagboom P.E. (Eline)
- Slof-Op’t Landt M.C.T. (Margarita C. T.)
- Slopien A. (Agnieszka)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith A.V. (Davey)
- Soranzo N. (Nicole)
- Soranzo N. (Nicole)
- Southam L. (Lorraine)
- Sovio U. (Ulla)
- Spector T.D. (Timothy)
- Srinivasan S.R. (Sathanur)
- Steen V.M. (Vidar)
- Stephens J. (Jonathan)
- Stolk L. (Lisette)
- Strachan D.P. (David)
- Streeten E.A. (Elizabeth)
- Strengman E. (Eric)
- Strober M. (Michael)
- Sulem P. (Patrick)
- Sullivan P.F. (Patrick)
- Sunyer J. (J.)
- Sunyer J. (Jordi)
- Szatkiewicz J.P. (Jin P)
- Szeszenia-Dabrowska N. (Neonila)
- Sørensen T.I.A. (Thorkild)
- Taal H.R. (Rob)
- Tachmazidou I. (Ioanna)
- Taico C. (Chrysecolla)
- Tammesoo M.L. (M. L.)
- Tenconi E. (Elena)
- Teo Y.Y. (Y. Y.)
- Teo Y.Y. (Yik Ying)
- Thiering E. (Elisabeth)
- Thornton L.M. (Laura)
- Thorsteinsdottir U. (Unnur)
- Tiesler C. (C.)
- Tikkanen E. (Emmi)
- Timpson N.J. (Nicholas)
- Toniolo D. (Daniela)
- Tortorella A. (Alfonso)
- Tozzi F. (Federica)
- Trace S.E. (Sara E)
- Treasure J. (Janet)
- Tryggvadottir L. (Laufey)
- Tschop M. (Matthias)
- Tschöp M.H. (M. H.)
- Tsitsika A. (Artemis)
- Tsitsika A. (Artemis)
- Tyrer J. (J.)
- Tziouvas K. (Konstantinos)
- Uda M. (M.)
- Uitterlinden A.G. (André)
- Ulivi S. (Shelia)
- Valcárcel B. (Beatriz)
- van Dam R.M. (R. M.)
- Vannberg F.O. (Frederik O)
- Versini A. (Audrey)
- Visser J.A. (Jenny)
- Volckmar A.-L. (A. L.)
- Vollenweider P. (Peter)
- Waeber G. (Gérard)
- Wagner G. (Gudrun)
- Wareham N.J. (Nick)
- Warrington M. (M.)
- Warrington N.M. (Nicole)
- Waterworth D. (Dawn)
- Weedon M.N. (Michael)
- White S.J. (Stefan)
- Whittaker P. (Pamela)
- Wichmann H.E. (Heinz Erich)
- Widen E.
- Widen E. (E.)
- Willemsen G.A.H.M. (Gonneke)
- Wilson J.F. (J. F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Woodside D.B. (D Blake)
- Wright A.F. (Alan)
- Yaghootkar H. (H.)
- Yilmaz Z. (Zeynep)
- Young L. (L.)
- Zeggini E. (Eleftheria)
- Zerwas S. (Stephanie)
- Zgaga L. (L.)
- Zhai G. (G.)
- Zhao J.H. (J. H.)
- Zhuang W.V. (W. V.)
- Zipfel S. (S.)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2017
- Field of study
The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we performed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI-related loci was performed in the AN GWAMA. We detected significant associations (P-values <5 × 10-5, Bonferroni-corrected P<0.05) for nine SNP alleles at three independent loci. Interestingly, all AN susceptibility alleles were consistently associated with increased BMI. None of the genes (chr. 10: CTBP2, chr. 19: CCNE1, chr. 2: CARF and NBEAL1; the latter is a region with high linkage disequilibrium) nearest to these SNPs has previously been associated with AN or obesity. Sex-stratified analyses revealed that the strongest BMI signal originated predominantly from females (chr. 10 rs1561589; Poverall: 2.47 × 10-06/Pfemales: 3.45 × 10-07/Pmales: 0.043). Functional ex vivo studies in mice revealed reduced hypothalamic expression of Ctbp2 and Nbeal1 after fasting. Hypothalamic expression of Ctbp2 was increased in diet-induced obese (DIO) mice as compared with age-matched lean controls. We observed no evidence for associations for the look-up of BMI-related loci in the AN GWAMA. A cross-trait analysis of AN and BMI loci revealed variants at three chromosomal loci with potential joint impact. The chromosome 10 locus is particularly promising given that the association with obesity was primarily driven by females. In addition, the detected altered hypothalamic expression patterns of Ctbp2 and Nbeal1 as a result of fasting and DIO implicate these genes in weight regulation