914 research outputs found
Judges Are (and Ought to Be) Different
Scott Hawkinsās Perspective on Judicial Merit Retention in Florida makes a number of important points, one of which in particular warrants emphasis as Florida voters prepare to go to the polls to determine the fate of the justices and appellate judges standing for retention. The role a judge plays in our society is (and ought to be) fundamentally different from that played by a politician or other elected representative. Judges do not (and should not) have a constituency. They do not represent anyone; rather, their sole allegiance must be to the rule of law
Judges Are (and Ought to Be) Different
Scott Hawkinsās Perspective on Judicial Merit Retention in Florida makes a number of important points, one of which in particular warrants emphasis as Florida voters prepare to go to the polls to determine the fate of the justices and appellate judges standing for retention. The role a judge plays in our society is (and ought to be) fundamentally different from that played by a politician or other elected representative. Judges do not (and should not) have a constituency. They do not represent anyone; rather, their sole allegiance must be to the rule of law
Relative Roles of Climate Sensitivity and Forcing in Defining the Ocean Circulation Response to Climate Change
Abstract in HTML and technical report in PDF available on the Massachusetts Institute of Technology Joint Program on the Science and Policy of Global Change website (http://mit.edu/globalchange/www/).The response of the oceanās meridional overturning circulation (MOC) to increased greenhouse gas forcing is examined using a coupled model of intermediate complexity, including a dynamic 3D ocean subcomponent. Parameters are the increase in CO2 forcing (with stabilization after a specified time interval) and the modelās climate sensitivity. In this model, the cessation of deep sinking in the north āAtlanticā (hereinafter, a ācollapseā), as indicated by changes in the MOC, behaves like a simple bifurcation. The final surface air temperature (SAT) change, which is closely predicted by the product of the radiative forcing and the climate sensitivity, determines whether a collapse occurs. The initial transient response in SAT is largely a function of the forcing increase, with higher sensitivity runs exhibiting delayed behavior; accordingly, high CO2-low sensitivity scenarios can be assessed as a recovering or collapsing circulation shortly after stabilization, whereas low CO2-high sensitivity scenarios require several hundred additional years to make such a determination. We also systemically examine how the rate of forcing, for a given CO2 stabilization, affects the ocean response. In contrast with previous studies based on results using simpler ocean models, we find that except for a narrow range of marginally stable to marginally unstable scenarios, the forcing rate has little impact on whether the run collapses or recovers. In this narrow range, however, forcing increases on a time scale of slow ocean advective processes results in weaker declines in overturning strength and can permit a run to recover that would otherwise collapse.This research was supported in part by the Methods and Models for Integrated Assessments Program of the National Science Foundation, Grant ATM-9909139, by the Office of Science (BER), U.S. Department of Energy, Grant No. DE-FG02-93ER61677, and by the MIT Joint Program on the Science and Policy of Global Change (JPSPGC)
Role of social environment and social clustering in spread of opinions in co-evolving networks
Taking a pragmatic approach to the processes involved in the phenomena of
collective opinion formation, we investigate two specific modifications to the
co-evolving network voter model of opinion formation, studied by Holme and
Newman [1]. First, we replace the rewiring probability parameter by a
distribution of probability of accepting or rejecting opinions between
individuals, accounting for the asymmetric influences in relationships among
individuals in a social group. Second, we modify the rewiring step by a
path-length-based preference for rewiring that reinforces local clustering. We
have investigated the influences of these modifications on the outcomes of the
simulations of this model. We found that varying the shape of the distribution
of probability of accepting or rejecting opinions can lead to the emergence of
two qualitatively distinct final states, one having several isolated connected
components each in internal consensus leading to the existence of diverse set
of opinions and the other having one single dominant connected component with
each node within it having the same opinion. Furthermore, and more importantly,
we found that the initial clustering in network can also induce similar
transitions. Our investigation also brings forward that these transitions are
governed by a weak and complex dependence on system size. We found that the
networks in the final states of the model have rich structural properties
including the small world property for some parameter regimes. [1] P. Holme and
M. Newman, Phys. Rev. E 74, 056108 (2006)
In Vitro Antitumour Activity of Some Triorganophosphinegold(I) Thionucleobases
A series of phosphinegold(I) thionucleobase analogues, [R3PAu(SRx)] (R = Et, Ph or chexyl; HSR1 = 2-mercaptobenzoic acid, HSR2 = 2-thiouracil, HSR3 = 6-mercaptopurine
and HSR4 = 6-thioguanine) have been examined for their in vitro cytotoxicity in L1210
murine leukemia cells in culture. The range of ID50 values (continuous 48 h exposure) for
the complexes is 0.041 - 0.131 Ī¼M. The complexes with SR3 and SR3 are generally the
most active; however, there is no clear trend associated with the phosphine ligands
Projection on Segre varieties and determination of holomorphic mappings between real submanifolds
It is shown that a germ of a holomorphic mapping sending a real-analytic
generic submanifold of finite type into another is determined by its projection
on the Segre variety of the target manifold. A necessary and sufficient
condition is given for a germ of a mapping into the Segre variety of the target
manifold to be the projection of a holomorphic mapping sending the source
manifold into the target. An application to the biholomorphic equivalence
problem is also given.Comment: 16 page
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The 2007 WHO Classification of Tumours of the Central Nervous System
The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneuronal tumour of the fourth ventricle, papillary tumour of the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis. Histological variants were added if there was evidence of a different age distribution, location, genetic profile or clinical behaviour; these included pilomyxoid astrocytoma, anaplastic medulloblastoma and medulloblastoma with extensive nodularity. The WHO grading scheme and the sections on genetic profiles were updated and the rhabdoid tumour predisposition syndrome was added to the list of familial tumour syndromes typically involving the nervous system. As in the previous, 2000 edition of the WHO āBlue Bookā, the classification is accompanied by a concise commentary on clinico-pathological characteristics of each tumour type. The 2007 WHO classification is based on the consensus of an international Working Group of 25 pathologists and geneticists, as well as contributions from more than 70 international experts overall, and is presented as the standard for the definition of brain tumours to the clinical oncology and cancer research communities world-wide
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The Gsp-1 genes encode the 1 wheat arabinogalactan peptide
Western blotting, ELISA and 1H-NMR spectroscopy showed that RNAi down-regulation of the wheat Gsp-1 gene resulted in reduced contents of both arabinogalactan peptide (AGP) and grain softness protein (GSP-1) in mature wheat grains confirming that these components are encoded by the same gene. A small increase in grain hardness and decrease in the viscosity of aqueous extracts of the transgenic lines also indicated small effects on functional properties. Immunolocalisation using a novel wheat AGP monoclonal antibody in conjunction with confocal microscopy showed that the major form of AGP which was eliminated in knockout lines is located within the cell, probably in the vacuole, and not in the plasma membrane or cell wall. However, clear localisation of the AGP epitope to the plasma membrane was observed in both control and transgenic lines and probably resulted from the presence of one or more separate forms of arabinogalactan protein. The existence of such additional form(s) was also indicated by 1H-NMR spectroscopy which showed that the ratio of arabinose to galactose differed between the control and transgenic line
Serologic Evidence of West Nile Virus Transmission, Jamaica, West Indies
In spring 2002, an intensive avian serosurvey was initiated in Jamaica, Puerto Rico, and Mexico. We collected >1,600 specimens from resident and nonresident neotropical migratory birds before their northerly migrations. Plaque reduction neutralization test results indicated specific neutralizing antibodies to West Nile virus in 11 resident species from Jamaica
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