1,938 research outputs found
Achieving Ethical Trade through Social Tariffs: The SITS Regime
In the 1990s many heterodox economists joined labor, human rights and environmental advocates in calling for the inclusion of binding labor and environmental standards in trade agreements, along with other measures to ensure that deepening economic integration would serve the goals of promoting human development. Neoclassical trade theorists universally opposed these measures, arguing that countries’ choices over standards represented an entirely legitimate source of comparative advantage. In the end, the free traders prevailed. Over the past five years several mainstream trade theorists have reversed course, and begun to call for fair trade. In this context, fair trade is back on the policy agenda. This paper explores the fair trade proposals that emerged in the 1990s, and counterpoises the multilateral Social Index Tariff Structure (SITS) as an alternative fair trade regime. A SITS regime seeks to protect high standards in those countries where they prevail, while providing both the incentives and means for countries that perform poorly in this regard to improve their standards over time. This working paper explores the construction of a hypothetical SITS regime; estimates the effects of the regime on bilateral trade flows; and generates estimates of the development funds that SITS would make available to promote human development in low-income countries. The authors find that a global system of social tariffs that are very small in magnitude would generate new, substantial and stable flows of development funds while incentivizing a race to the top in labor and environmental standards.
Interview with Lloyd Watkins, President Emeritus
Oral history interview with Illinois State University Emeritus President Lloyd Watkins. The interview was conducted on January 23, 2007, by Kate O\u27Toole, as part of the Illinois State University Oral History Project.https://ir.library.illinoisstate.edu/soh/1013/thumbnail.jp
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The neurological underpinnings of cluttering: Some initial findings
Background
Cluttering is a fluency disorder characterised by overly rapid or jerky speech patterns that compromise intelligibility. The neural correlates of cluttering are unknown but theoretical accounts implicate the basal ganglia and medial prefrontal cortex. Dysfunction in these brain areas would be consistent with difficulties in selection and control of speech motor programs that are characteristic of speech disfluencies in cluttering. There is a surprising lack of investigation into this disorder using modern imaging techniques. Here, we used functional MRI to investigate the neural correlates of cluttering.
Method
We scanned 17 adults who clutter and 17 normally fluent control speakers matched for age and sex. Brain activity was recorded using sparse-sampling functional MRI while participants viewed scenes and either (i) produced overt speech describing the scene or (ii) read out loud a sentence provided that described the scene. Speech was recorded and analysed off line. Differences in brain activity for each condition compared to a silent resting baseline and between conditions were analysed for each group separately (cluster-forming threshold Z > 3.1, extent p 30 voxels, uncorrected).
Results
In both conditions, the patterns of activation in adults who clutter and control speakers were strikingly similar, particularly at the cortical level. Direct group comparisons revealed greater activity in adults who clutter compared to control speakers in the lateral premotor cortex bilaterally and, as predicted, on the medial surface (pre-supplementary motor area). Subcortically, adults who clutter showed greater activity than control speakers in the basal ganglia. Specifically, the caudate nucleus and putamen were overactive in adults who clutter for the comparison of picture description with sentence reading. In addition, adults who clutter had reduced activity relative to control speakers in the lateral anterior cerebellum bilaterally.
Eleven of the 17 adults who clutter also stuttered. This comorbid diagnosis of stuttering was found to contribute to the abnormal overactivity seen in the group of adults who clutter in the right ventral premotor cortex and right anterior cingulate cortex. In the remaining areas of abnormal activity seen in adults who clutter compared to controls, the subgroup who clutter and stutter did not differ from the subgroup who clutter but do not stutter.
Conclusions
Our findings were in good agreement with theoretical predictions regarding the neural correlates of cluttering. We found evidence for abnormal function in the basal ganglia and their cortical output target, the medial prefrontal cortex. The findings are discussed in relation to models of cluttering that point to problems with motor control of speech
Approaches to measuring language lateralisation: an exploratory study comparing two fMRI methods and functional transcranial doppler ultrasound
In this exploratory study we compare and contrast two methods for deriving a laterality index (LI) from functional magnetic resonance imaging (fMRI) data: the weighted bootstrapped mean from the LI Toolbox (toolbox method), and a novel method that uses subtraction of activations from homologous regions in left and right hemispheres to give an array of difference scores (mirror method). Data came from 31 individuals who had been selected to include a high proportion of people with atypical laterality when tested with functional transcranial Doppler ultrasound (fTCD). On two tasks, word generation and semantic matching, the mirror method generally gave better agreement with fTCD laterality than the toolbox method, both for individual regions of interest, and for a large region corresponding to the middle cerebral artery. LI estimates from this method had much smaller confidence intervals (CIs) than those from the toolbox method; with the mirror method, most participants were reliably lateralised to left or right, whereas with the toolbox method, a higher proportion were categorised as bilateral (i.e., the CI for the LI spanned zero). Reasons for discrepancies between fMRI methods are discussed: one issue is that the toolbox method averages the LI across a wide range of thresholds. Furthermore, examination of task-related t-statistic maps from the two hemispheres showed that language lateralisation is evident in regions characterised by deactivation, and so key information may be lost by ignoring voxel activations below zero, as is done with conventional estimates of the LI
Elevated iron concentration in putamen and cortical speech motor network in developmental stuttering
Theoretical accounts of developmental stuttering implicate dysfunctional cortico-striatal-thalamo-cortical motor loops through the putamen. However, the analysis of conventional MRI brain scans in individuals who stutter has failed to yield strong support for this theory in terms of reliable differences in the structure or function of the basal ganglia. Here, we performed quantitative mapping of brain tissue, which can be used to measure iron content alongside markers sensitive to myelin and thereby offers particular sensitivity to the measurement of iron-rich structures such as the basal ganglia. Analysis of these quantitative maps in 41 men and women who stutter and 32 individuals who are typically fluent revealed significant group differences in maps of R2∗, indicative of higher iron content in individuals who stutter in the left putamen and in left hemisphere cortical regions important for speech motor control. Higher iron levels in brain tissue in individuals who stutter could reflect elevated dopamine levels or lysosomal dysfunction, both of which are implicated in stuttering. This study represents the first use of these quantitative measures in developmental stuttering and provides new evidence of microstructural differences in the basal ganglia and connected frontal cortical regions
Active music
We are a group of eleven young people with intellectual disability and three music therapists. We did action research at a university. We wanted to find out how a music group might be helpful for young people with intellectual disabilities. We wanted to tell our own story and use our own words because we have a lot to say. We wanted people to read our story and to use our ideas to help young people with intellectual disabilities to have good lives. We went to twenty sessions of music research, and five more sessions of research analysis. We also did a lot of research work in between sessions.
We found out that music groups can be fun. They can also be hard work. They help us develop skills like listening and waiting. They are places where we can be independent. But music groups are also good places to practice working as a team. They can be safe places for people to express emotions. Music helps us to know people. It brings us together. Playing musical instruments can also help physical development. A good life for us would include having the chance to play music with others or to have music lessons. But it is not always easy for us to go to ordinary lessons or music groups. It might be important for young people with intellectual disability to have support from people who understand them at first. We want to be independent but we need help to develop our dreams in practical ways.
We found that doing research is fun and interesting. We were all researchers but we had different things to do. The adults had to be the organisers, setting up the research. We knew from the start the research would be about what young people think about music. The adults had done their reading and had written the literature review. The young people decided on other questions, and gathered data in lots of different ways. They also did some of the analysis, and decided on the findings of each cycle. The findings of each cycle, with more of the young people’s words, are in the appendices. Later, the adults wrote the main findings, the discussion and conclusion.
We all discussed the things we wrote along the way and at the end of the research. The adults have tried to help the young people understand what has been written. The research took a lot of time and it was hard work for everybody. To be a good researcher you need to learn research skills. It is important that young people with intellectual disabilities are not exhausted by research. They need to be able to enjoy the things they are doing. We all liked being involved in research even though it was hard work. We think that research is important and helpful. Young people should be involved in research that is about them.
We learnt that young people with intellectual disabilities can go to university. Going to university was scary at first but we got used to it and we started to enjoy it. We need to do more research to make sure universities are ready to welcome students with intellectual disabilities. We can use our research to show universities that it can be a good idea to support people with intellectual disabilities to go to university. We can also use our research show people what we can do; what we like to do; and what we want to do in the future. Most of us would like to do more music and research in future
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Separation of trait and state in stuttering
Stuttering is a disorder in which the smooth flow of speech is interrupted. People who stutter show structural and functional abnormalities in the speech and motor system. It is unclear whether functional differences reflect general traits of the disorder or are specifically related to the dysfluent speech state. We used a hierarchical approach to separate state and trait effects within stuttering. We collected sparse‐sampled functional MRI during two overt speech tasks (sentence reading and picture description) in 17 people who stutter and 16 fluent controls. Separate analyses identified indicators of: (1) general traits of people who stutter; (2) frequency of dysfluent speech states in subgroups of people who stutter; and (3) the differences between fluent and dysfluent states in people who stutter. We found that reduced activation of left auditory cortex, inferior frontal cortex bilaterally, and medial cerebellum were general traits that distinguished fluent speech in people who stutter from that of controls. The stuttering subgroup with higher frequency of dysfluent states during scanning (n = 9) had reduced activation in the right subcortical grey matter, left temporo‐occipital cortex, the cingulate cortex, and medial parieto‐occipital cortex relative to the subgroup who were more fluent (n = 8). Finally, during dysfluent states relative to fluent ones, there was greater activation of inferior frontal and premotor cortex extending into the frontal operculum, bilaterally. The above differences were seen across both tasks. Subcortical state effects differed according to the task. Overall, our data emphasise the independence of trait and state effects in stuttering
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No evidence of altered language laterality in people who stutter across different brain imaging studies of speech and language
A long-standing neurobiological explanation of stuttering is the incomplete cerebral dominance theory, which refers to competition between two hemispheres for ‘dominance’ over handedness and speech, causing altered language lateralization. Renewed interest in these ideas came from brain imaging findings in people who stutter of increased activity in the right hemisphere during speech production or of shifts in activity from right to left when fluency increased. Here, we revisited this theory using functional MRI data from children and adults who stutter, and typically fluent speakers (119 participants in total) during four different speech and language tasks: overt sentence reading, overt picture description, covert sentence reading and covert auditory naming. Laterality indices were calculated for the frontal and temporal lobes using the laterality index toolbox running in Statistical Parametric Mapping. We also repeated the analyses with more specific language regions, namely the pars opercularis (Brodmann area 44) and pars triangularis (Brodmann area 45). Laterality indices in people who stutter and typically fluent speakers did not differ, and Bayesian analyses provided moderate to anecdotal levels of support for the null hypothesis (i.e. no differences in laterality in people who stutter compared with typically fluent speakers). The proportions of the people who stutter and typically fluent speakers who were left lateralized or had atypical rightward or bilateral lateralization did not differ. We found no support for the theory that language laterality is reduced or differs in people who stutter compared with typically fluent speakers
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