7 research outputs found
Synthesis and Evaluation of 11C-Labeled Triazolones as Probes for Imaging Fatty Acid Synthase Expression by Positron Emission Tomography
- Author
- Publication venue
- DigitalCommons@University of Nebraska - Lincoln
- Publication date
- 01/02/2022
- Field of study
Cancer cells require lipids to fulfill energetic, proliferative, and signaling requirements. Even though these cells can take up exogenous fatty acids, the majority exhibit a dependency on de novo fatty acid synthesis. Fatty acid synthase (FASN) is the rate-limiting enzyme in this process. Expression and activity of FASN is elevated in multiple cancers, where it correlates with disease progression and poor prognosis. These observations have sparked interest in developing methods of detecting FASN expression in vivo. One promising approach is the imaging of radiolabeled molecular probes targeting FASN by positron emission tomography (PET). However, although [11C]acetate uptake by prostate cancer cells correlates with FASN expression, no FASN-specific PET probes currently exist. Our aim was to synthesize and evaluate a series of small molecule triazolones based on GSK2194069, an FASN inhibitor with IC50 = 7.7 ± 4.1 nM, for PET imaging of FASN expression. These triazolones were labeled with carbon-11 in good yield and excellent radiochemical purity, and binding to FASN-positive LNCaP cells was significantly higher than FASN-negative PC3 cells. Despite these promising characteristics, however, these molecules exhibited poor in vivo pharmacokinetics and were predominantly retained in lymph nodes and the hepatobiliary system. Future studies will seek to identify structural modifications that improve tumor targeting while maintaining the excretion profile of these first-generation 11C-methyltriazolones
Characterization of Insect Immune Systems from Genomic Data
- Author
- A Conesa
- A Dobin
- A Löytynoja
- AL Mitchell
- AM Altenhoff
- AM Bolger
- Anurag Priyam
- Assel Mussabekova
- B Altincicek
- B Li
- Bart Bryant
- BG Hall
- BJ Haas
- Bruno Lemaitre
- C Camacho
- C Holt
- C Soneson
- CG Elsik
- CW Law
- D Kim
- Daniel E. Neafsey
- Dominique Ferrandon
- E Pennisi
- E. De Gregorio
- EV Todd
- EW Sayers
- F Legeai
- F Ramírez
- G Baruzzo
- George K. Christophides
- GI Giraldo-Calderón
- H Pimentel
- H. Myllymäki
- Helge Schlüns
- Henna Myllymäki
- Hiromitsu Tanaka
- I. Matetovici
- J Rolff
- J Thurmond
- J. D. Evans
- JA Robles
- Jacob E. Crawford
- Jean-Luc Imler
- JF Hillyer
- JM Gaspar
- K Katoh
- K Troha
- Katherine Taylor
- L Yi
- L. C. Bartholomay
- LC Bartholomay
- MD Robinson
- MF Poelchau
- MI Love
- Miao Li
- N Terrapon
- N. Buchon
- NA Dunn
- Nicolas Buchon
- Nicole M Gerardo
- NJ Schurch
- NL Bray
- P Jones
- P Ligoxygakis
- PJ Kersey
- PS Hosmani
- R Buels
- R Patro
- R. M. Waterhouse
- RM Brucker
- RM Waterhouse
- RM Waterhouse
- RM Waterhouse
- RM Waterhouse
- RM Waterhouse
- SK Gupta
- SM Barribeau
- Sophia Ekengren
- SR Eddy
- Susanna Valanne
- Sylvain Brun
- T Ching
- TB Sackton
- Timothy B Sackton
- Timothy B Sackton
- Timothy B. Sackton
- V Doublet
- Y. Apidianakis
- Z Zou
- Zach Adelman
- Zhen Zou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Dual Transfer Pricing with Internal and External Trade
- Author
- A Amershi
- A Arya
- A S Edlin
- B Holmstrom
- C Emmanuel
- C Kanodia
- E J Slof
- Edward G. Johnson
- I Vaysman
- I Vaysman
- J Christensen
- J Hirshleifer
- J Hirshleifer
- J Ronen
- J Ronen
- K Merchant
- L G Eldenburg
- M Alles
- M Harris
- M W Maher
- N Johnson
- Nicole Bastian Johnson
- P Cook
- P Milgrom
- Price Waterhouse
- R Anctil
- R Eccles
- R Eccles
- R G�x
- R Lambert
- S Dikolli
- S Dutta
- S Sahay
- T Baldenius
- T Baldenius
- T Baldenius
- T Pfeiffer
- Thomas Pfeiffer
- V Narayanan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Mechanisms of Anxiety Related Attentional Biases in Children with Autism Spectrum Disorder
- Author
- AC Puliafico
- AK Roy
- AM Chalfant
- AM Waters
- American Psychiatric Association
- American Psychiatric Association
- BN Moree
- C Ames
- C Hughes
- C MacLeod
- C Musa
- CM Kerns
- CS Monk
- D Wechsler
- DS Pine
- E Fombonne
- E Russell
- E Salemink
- E Simonoff
- EA Storch
- EH Koster
- F Faul
- F Happe
- GA Georgiou
- JJ Wood
- JM Cisler
- JN Constantino
- JN Constantino
- JS Legerstee
- K Mogg
- K Mogg
- Kim Cornish
- KM Dalton
- L Lecavalier
- L Waterhouse
- L-AR Sacrey
- M Braverman
- M Ghaziuddin
- M Solomon
- MH Nauta
- MJ Hollocks
- N Amir
- N Tottenham
- N Wong
- Nicole J. Rinehart
- NM Kleinhans
- R Adolphs
- R Lang
- S Baron-Cohen
- S Farrugia
- S Ozonoff
- S Watts
- SH Spence
- SH Spence
- SW White
- Tamara May
- V Hallett
- Y Bar-Haim
- Y Bar-Haim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Exogenous t-PA Administration Increases Hippocampal Mature BDNF Levels. Plasmin- or NMDA-Dependent Mechanism?
- Author
- A Baron
- A Madinier
- A Quirie
- AE Autry
- Agnès Jacquin
- AK McAllister
- AL Samson
- AM Martin
- Anne Prigent-Tessier
- B Lu
- Christine Marie
- Claude Mossiat
- CM Anderson
- CM Yeh
- CR Sartori
- D Vivien
- DK Binder
- E Kawashita
- EG Waterhouse
- G Liot
- G Nagappan
- H Park
- HW Horch
- J Parcq
- J Tanaka
- K Benchenane
- K Benchenane
- KK Cowansage
- LF Reichardt
- M Aas
- M Segawa
- M Yepes
- M Zhuo
- Marion Rodier
- ME Greenberg
- MP Mattson
- N Horii-Hayashi
- O Nicole
- P Obiang
- P Obiang
- P Paoletti
- PA Barker
- PA Menoud
- Philippe Garnier
- PT Pang
- Q Ding
- R Echeverry
- R Furtmuller
- R Kolarow
- R Lee
- R Madani
- R Pawlak
- RH Lipsky
- S Cohen-Cory
- S Vaynman
- SE Kotermanski
- SL Patterson
- Thierry Amédée
- Y Taniguchi
- Yannick Béjot
- YY Huang
- ZL Chen
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Structural basis for iron piracy by pathogenic Neisseria
- Author
- A Deasy
- AB Mason
- AB Schryvers
- AB Schryvers
- AJ McCoy
- Alasdair C. Steven
- AM Waterhouse
- AN Steere
- Andrew R. Gorringe
- Anne B. Mason
- Ashley N. Steere
- B Rokbi
- BE Eckenroth
- C Calmettes
- C Gille
- CN Cornelissen
- CN Cornelissen
- DI Svergun
- E Blanc
- EF Pettersen
- Emad Tajkhorshid
- Evzen Boura
- GA Price
- IC Boulton
- J Gumbart
- J Gumbart
- J Wally
- James Gumbart
- JB Heymann
- JC Phillips
- JE Anderson
- JM Noto
- K Arnold
- LP Silva
- M Scarselli
- M Sotomayor
- MK Yost-Daljev
- MM Hobbs
- Muse Oke
- MV Petoukhov
- N Noinaj
- Naoko Mizuno
- Nicholas Noinaj
- Nicole C. Easley
- O Svergun
- O Zak
- Olga Zak
- P Emsley
- PD Adams
- Philip Aisen
- PJ Halbrooks
- R Grifantini
- RH Stokes
- Robert W. Evans
- SJ Ludtke
- Susan K. Buchanan
- SW Irwin
- T Krell
- TF Moraes
- TR Shaikh
- VE Weynants
- VV Volkov
- W Humphrey
- Y Cheng
- Z Otwinowski
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Über die (aseptische) Harnstauungsniere
- Author
- A Adler-Ràcz von
- A Akerlund
- A Androulakakis
- A Androulakakis
- A Angelov
- A Babies
- A Babies
- A Barella
- A Batzenschlager
- A Berndorfer
- A Binz
- A Boone
- A Bouteau
- A Brenner
- A Christensen
- A Dufour
- A Döderlein
- A Feustel
- A Fritjofsson
- A Fritjofsson
- A Fränkel
- A Gabriele
- A Gaca
- A Gaca
- A Gaca
- A Gaca
- A Gentile
- A Giordano
- A Grunberg
- A Guetgemann
- A Guichard
- A Hagen
- A Hauge
- A Hauge
- A Homb
- A Hottinger
- A Illich
- A Israel
- A Kalo
- A Kohn
- A Kuntz
- A Lakos
- A Lardelli
- A Levievre
- A Lhez
- A Lichtenberg
- A Lichtenberg
- A Lisnell
- A Litwak
- A Ljungqvist
- A MacKellar
- A Martinez-Pineiro
- A Megevand
- A Napolitano
- A Paalanen
- A Paalanen
- A Paalanen
- A Pasqualino
- A Pena De la
- A Pena De la
- A Pena De la
- A Pichler
- A Pieper
- A Pieper
- A Pozzan
- A Randall
- A Rossier
- A Rothschild
- A Sadi
- A Sadi
- A Sadi
- A Saint-Aubert
- A Schabadasch
- A Schimatzek
- A Schwyzer
- A Sigel
- A Sigel
- A Sigel
- A Sigel
- A Surtshin
- A Szkodny
- A Theilhaber
- A Theilhaber
- A Thelen
- A Thelen
- A Thelen
- A Thiemann
- A Tormene
- A Trabucco
- A Tzank
- A Villanueva
- A Weicheisbaum
- A Wojewski
- A Wojewski
- A Wolf
- A Wolotzky
- A Wöller
- A Zinner
- A-A Kollwitz
- A-O Büchner
- AB Bhajekar
- AB Cecil
- AB Cecil
- AB Novikoff
- AB Stewart
- AC Abbott
- AC Allen
- AC Bratton
- AC Burton
- AC Smid
- AC Uson
- AC Uson
- AC Uson
- AD Amar
- AD Dias
- AD Merrit
- AE Brule
- AE Brule
- AE Cohen
- AE Comarr
- AE Melnikoff
- AE Roche
- AH Baggenstoss
- AH Loufti
- AH Samily
- AH Smith
- AH Ulm
- AH Ulm
- AI Murphy
- AJ Bland
- AJ Botting
- AJ Fink
- AJ Leader
- AJ McQueeney
- AJ Paquin
- AJ Paquin
- AJ Paquin
- AJ Spriggs
- AK Doss
- AK Doss
- AL Dean
- AL Finkle
- AL Finkle
- AL Finkle
- AL Hodgkin
- AL Hodgkin
- AL Miller
- Alcalá-Santacella Nunez y Montesinos
- AM Behnam
- AM Hogben
- AM Lefkovits
- AM Lotfi
- AN Green
- AP Briggs
- AP Carritano
- AP Carvalho
- AP Harris
- AP Harris
- AR Banham
- AR Cushny
- AR Mackenzie
- AR Stevens
- AS Maximovitsch
- AS Relman
- AS Tucker
- ATK Coekett
- AV Lichtenberg
- AV Montgomery
- AW Adams
- AW Adams
- AW Badenoch
- AW Badenoch
- AW Bohne
- AW Kneucker
- B Antoine
- B Bibus
- B Bibus
- B Bibus
- B Bibus
- B Bibus
- B Bibus
- B Bibus
- B Bibus
- B Bibus
- B Bochkor
- B Darget
- B Davidson
- B Duhamel
- B Eiseman
- B Escudero
- B Fey
- B Fey
- B Fey
- B Fey
- B Fey
- B Gaedele
- B Garrelts
- B Gibb
- B Golsabez
- B Gottlob
- B Grüttner
- B Hoffmann
- B Ivemark
- B Ivemark
- B Johanson
- B Johanson
- B Krälikovä
- B Laqueur
- B Lewicka-Urbanska
- B Lücke
- B Nordmark
- B Paccagnini
- B Pak
- B Perissinotto
- B Posta
- B Rihmer
- B Rütte
- B Schenker
- B Szenci
- B Szenci
- B Süli
- B Thom
- B Wall
- B Wall
- B Witherington
- BA Breakey
- BA Smith
- BB Weinstein
- BC Corbus
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- BEC Nordin
- BG Clarke
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- BJ Wilson
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- BVP Sinha
- BW Haie
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- C Baron
- C Bell
- C Brandt
- C Brückner
- C Burger
- C Cavara
- C Chiaudano
- C Dubach
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- C Hierholzer
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- C Lange De
- C Ludwig
- C Maquinay
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- C Moutzouris
- C Palavatana
- C Popesco
- C Posner
- C Ransom
- C Schneiderman
- C Semb
- C Stockard
- C Weigert
- C Wells
- C Wüllenweber
- CA Furey
- CA Isaac
- CA Wagenvoort
- CA Wells
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- CC Winter
- CD Bergstrand
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- CM Stewart
- CM Suosa
- CM Woolf
- CMS Pasquier
- CO Schmidt
- CP Howze
- CP Mathe
- CV Chenoweth
- CV Pryles
- CW Gottschalk
- CW Gurney
- CY Bidgiid
- D Ashley
- D Csata
- D Edwards
- D Eisendrath
- D Falk
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- D Frantz
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- D Gregg
- D Hallwachs
- D Hilson
- D Holmlund
- D Kirchheim
- D Langner
- D Lenaghan
- D Magner
- D Michelson
- D Moucha
- D Munro
- D Palazzi
- D Pearson
- D Presman
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- D Saratoff
- D Steffens-Krebs
- D Stephens
- D Sykes
- D Tille
- D Wallace
- D Wossidlo
- D Zoedler
- DA Gordon
- DAL Dick
- DB Lathrop
- DB Lester
- DC Utz
- DD Albers
- DD Arnhold
- DD Reismann
- DE Govan
- DE Leuzinger
- Dermatas J.
- Dermatas J.
- DF Herdwick
- DG Bratherton
- DH Connor
- DHP Streeten
- DI Williams
- DI Williams
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- DJ Megan
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- DJB Ashley
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- DK Rose
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- DL Williams
- DM Davis
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- DM Seitzman
- DM Sklaroff
- DN Eisendraht
- DP Simpson
- DR Brock
- DR Smith
- DR Smith
- DS Baldwin
- DW Branham
- DW Macevan
- DW Smith
- DW Williams
- E Asshauer
- E Ballowitz
- E Becher
- E Beer
- E Bergenfeldt
- E Berne
- E Bjelke
- E Boijsen
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- E Bozler
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- E Braun-Menendez
- E Brecher
- E Buchmann
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- E Dahl
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- E Dragonas
- E Enderlein
- E Faierman
- E Frisell
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- E Guggemos
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- E Hienzsch
- E Hill
- E Holder
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- E Kornitzer
- E Kretschmar
- E Küster
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- E Lexer
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- E True
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- Evaluation of intubation ureterotomy with description of surgical technique
- EW Campbell
- EW Rugendorff
- Experimental hydronephrosis without mechanical obstruction of the ureter
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- F Hinman
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- RM Nesbit
- RM Nesbit
- RM Nesbit
- RM Nesbit
- RN Pierce
- RO Wyrens
- RO Wyrens
- RP Allen
- RP Allen
- RP Beames
- RP Buffin
- RP Lyon
- RR Bradham
- RR Landes
- RR Lopez
- RR Zimet
- RS Alexander
- RS Alexander
- RS Alexander
- RS Alexander
- RS Hagstrom
- RS Rose
- RT Soper
- RT Woodburne
- RV Daut
- RV Stagner
- RW Barnes
- RW Barnes
- RW Berliner
- RW Herrmann
- RW Rundles
- RW Wright
- S Bergendahl
- S Boyarsky
- S Boyarsky
- S Boyarsky
- S Csata
- S Fedoroff
- S Gil-Vernet
- S Gil-Vernet
- S Göstay
- S Haastert
- S Jona
- S Killmann
- S Levey
- S Palocz
- S Petrovic
- S Petrovic
- S Petrovic
- S Petrovic
- S Petrovic
- S Petrovic
- S Rummelhardt
- S Rummelhardt
- S Rummelhardt
- S Rummelhardt
- S Rummelhardt
- S Sanz
- S Shishito
- S Shnster
- S Switzer
- S Takai
- S Temelkoff
- S Teufel
- S Tomizawa
- S Wallach
- S Wesolowski
- SA Askari
- SA Mahoney
- SAK Rudhe
- SD Hemley
- SE Bradley
- SE Englund
- SE Levy
- SG Jamsson
- SH Barron
- SI Björklund
- SJ Landau
- SJ Seidinger
- SK Kim
- SL Haber
- SL Roland
- SP Fedoroff
- SR Greenberg
- SR Kjellberg
- SR Weinberg
- SR Weinberg
- SR Weinberg
- SR Woodruff
- SS Ambrose
- SS Ambrose
- SS Ambrose
- SS Schmidt
- ST Knappenberger
- SW Litzenberger
- SW Stanbury
- T Bledsoe
- T Burchele
- T Burghele
- T Burkhart
- T Caniani
- T Covington
- T Ekström
- T Erdmann
- T Fahr
- T Hashmoto
- T Haskimoto
- T Hryntschak
- T Hryntschak
- T Hryntschak
- T Hryntschak
- T Hryntschak
- T James
- T Kusunoki
- T Kusunoki
- T Kusunoki
- T Minami
- T Omae’
- T Rovsing
- T Schultheiß
- T Shiratori
- T Strom
- T Tomoyoshi
- T Widen
- T Widen
- TB Wayman
- TD Moore
- TD Moore
- TE Gibson
- TE Gibson
- TE Gibson
- TF Yu
- TH Brodie
- TH Fracier
- TK Goodhand
- TL Chapman
- TL Horward
- TN Aas
- TR Fetter
- TW Engelmann
- U Heim
- U James
- V Becker
- V Blum
- V Blum
- V Borell
- V Brosch
- V Capek
- V Franciskovic
- V Frizzi
- V Gioustremes
- V Goldberg
- V Irving
- V Libro
- V Paces
- V Paces
- V Pliveric
- V Prat
- V Prät
- V Sitprija
- V Vintici
- VA Politano
- VA Politano
- VF Henderson
- VF Marshall
- VF Marshall
- VG Rodriguez-Acosta
- VJ Longo
- VJ O’Conor
- VJ O’Conor
- VJ O’Conor
- VJ O’Conor
- VL Robards
- VS Horwath
- VW Dix
- W Arnemann
- W Baumann
- W Berlin
- W Borgard
- W Brandt
- W Brinkmann
- W Brinkmann
- W Brosig
- W Brosig
- W Brosig
- W Brosig
- W Catel
- W Coppridge
- W Felix
- W Forssmann
- W Gregoir
- W Gregoir
- W Gregoir
- W Gregoir
- W Gütter
- W Heckenbach
- W Heintze
- W Henberger
- W Hinz
- W Hoffmann
- W Huth
- W Hüther
- W Kny
- W Kny
- W Kolmer
- W Kosenow
- W Lehmann
- W Lindemann
- W Lindemann
- W Lindemann
- W Lindemann
- W Lorbeck
- W Ludvik
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Marquardz
- W Modelski
- W Nonnenbruch
- W Pagel
- W Pagel
- W Pagel
- W Pagel
- W Pfeifer
- W Rattner
- W Samellas
- W Samellas
- W Schega
- W Schneider
- W Selberg
- W Singh
- W Sinner
- W Sinner
- W Sinner
- W Sleator
- W Staehler
- W Staehler
- W Suter
- W Teschendorf
- W Tlnnemeyer
- W Walters
- W Walters
- W Walters
- W Weibel
- W Weibel
- W Weiner
- W Weiner
- W Weisel
- W Wirbatz
- W Wüseke
- W Zaunbauer
- W Zimmer
- WA Griesbach
- WA Moonen
- WA Moonen
- WA Moonen
- WA Pepper
- WA Roll
- WA Roll
- WB Carpenter
- WB Schwartz
- WC Bailey
- WC Casey
- WC Quinby
- WC Quinby
- WD Jarman
- WE Goodwin
- WE Goodwin
- WE Goodwin
- WE Goodwin
- WE Lado
- WF Braasch
- WF Braasch
- WF Braasch
- WF Braasch
- WF Katzenstein
- WF Melick
- WF Melick
- WF Melick
- WFW Southwood
- WH Brinkmann
- WH Falor
- WH Howell
- WJ Baker
- WJ Engel
- WJ Forsythe
- WJ Forsythe
- WJ Israel
- WJ Rapp
- WJ Rapp
- WL Fitzgerald
- WM Bayliss
- WM Bochove van
- WM Davidson
- WM Drake
- WM Perelman
- WP Mulvaney
- WR McCune
- WR Schmalhorst
- WR Smart
- WS Kerr
- WS Kerr
- WS Kerr
- WS Mack
- WT Hunter
- WT Snodgrass
- WW Davey
- WW Milner
- WW Scott
- WW Summerville
- WW Woodward
- Y Fumio
- Y Kitani
- Y Lazebnik
- Y Satani
- Y Suzuki
- YG Miterev
- YJ Katz
- Z Kairis
- Z Kairis
- Z Kairis
- Z Kairis
- Z Nagy
- Z Piasecki
- ZHJ Vuurst Van Der
- Zur Behandlung postoperativer bzw. posttraumatischer Harnleiterfibrosen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1968
- Field of study