The interpretation of TIROS radiation data for practical use in synoptic weather analysis

Interpretation of TIROS III radiation data to demonstrate practical applications in synoptic weather analyse

Is High Dose Radioactive Iodine-131 More Effective than Low Dose Iodine-131 in the Therapy of Patients with Hyperthyroidism?

OBJECTIVE: The objective of this selective EBM review is to determine whether or not high dose radioactive iodine-131 is more effective than low dose iodine-131 in the therapy of patients with hyperthyroidism.STUDY DESIGN: The review included three primary English language studies that were peer reviewed articles published in 2003, 2010 and 2011.DATA SOURCES: This paper evaluates three randomized control trials (one prospective randomized and two comparative randomized) looking at the effectiveness of high dose and low dose radioactive iodine-131 for the treatment of hyperthyroidism.OUTCOMES MEASURED: Each study examined patients being treated with high or low dose radioactive iodine-131. The outcomes measured include 1) incidence of failed treatment that required further therapy 2) patients that maintained a euthyroid state 3) patients needing therapy for hypothyroidism caused by the radioactive therapy. The measurements were evaluated with laboratory values as well as a 5- point scoring system and clinical symptoms of hyperthyroidism and hypothyroidism. Statistical evaluation is based on p-values and NNT.RESULTS: Three randomized controlled trials were included in this review. Results from Leslie et al. 2003, found that low dose regimen is as effective as high dose regimen. The conclusion and statistical analysis of Pusuwan et al. 2011, found that high dose regimen would be more effective than low dose regimen. Lastly, the Thientunyakit et al. 2010, study found that neither dose regimen was shown to be more effective in the treatment of hyperthyroidism.CONCLUSION: All three of the randomized trials in this EBM review contradicted findings in the other. That being said, at this time there is no conclusive evidence to support whether high or low dose radioactive iodine regimen is more effective in the treatment of hyperthyroidism. There has to be continued research and development in this field of study to better determine a dose regimen that is effective in managing patients with this disease

Scale-dependence of magnetic helicity in the solar wind

We determine the magnetic helicity, along with the magnetic energy, at high latitudes using data from the Ulysses mission. The data set spans the time period from 1993 to 1996. The basic assumption of the analysis is that the solar wind is homogeneous. Because the solar wind speed is high, we follow the approach first pioneered by Matthaeus et al. (1982, Phys. Rev. Lett. 48, 1256) by which, under the assumption of spatial homogeneity, one can use Fourier transforms of the magnetic field time series to construct one-dimensional spectra of the magnetic energy and magnetic helicity under the assumption that the Taylor frozen-in-flow hypothesis is valid. That is a well-satisfied assumption for the data used in this study. The magnetic helicity derives from the skew-symmetric terms of the three-dimensional magnetic correlation tensor, while the symmetric terms of the tensor are used to determine the magnetic energy spectrum. Our results show a sign change of magnetic helicity at wavenumber k~2 AU^{-1} (or frequency nu~2 uHz) at distances below 2.8 AU and at k~30 AU^{-1} (or nu~25 uHz) at larger distances. At small scales the magnetic helicity is positive at northern heliographic latitudes and negative at southern latitudes. The positive magnetic helicity at small scales is argued to be the result of turbulent diffusion reversing the sign relative to what is seen at small scales at the solar surface. Furthermore, the magnetic helicity declines toward solar minimum in 1996. The magnetic helicity flux integrated separately over one hemisphere amounts to about 10^{45} Mx^2/cycle at large scales and to a 3 times lower value at smaller scales.Comment: 8 pages, 6 figures, ApJ (in press

Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes

Biased usage of amino acids near exon-intron boundaries is phylogenetically widespread and characteristic of species for which there are expected to be problems defining exons

Characterisation of a Coriolis flow meter for fuel consumption measurements in realistic drive cycle tests

When testing light-duty and heavy-duty vehicles on chassis dynamometers, as in the WLTP, or engines on engine test benches, as in the WHDC, it is required to measure the fuel consumption. In the preferable case, the measurement of the fuel consumption is carried out with suitable flow meters. These require high measurement accuracy in a wide flow range, independent of the fuel type, as the flow rate range is often very large and depends on the power range of the vehicle engines. Moreover, the fuel flow rate in the test cycles is very dynamically related to the loads. In the scope of the ongoing EMPIR Joint Research Project 20IND13 SAFEST the dynamic flow behaviour as well as the measurement accuracy of flow meters for different types of fuels are investigated. This paper presents first results from the realisation of dynamic flow profiles, and flow measurements with a Coriolis Flow Meter with different representative fuels in a wide density and viscosity range and a wide flow rate range at different fuel temperatures

Practice setting and physician influences on judgments of colon cancer treatment by community physicians.

OBJECTIVE: This article compares judgments about the treatment of Dukes' B2 and C colon cancer made by general surgeons to those of internists and family practitioners. Physician and practice variables were specialty, affiliation with a Community Clinical Oncology Program (CCOP) hospital, time in practice, professional centrality (level of participation in cancer information networks), solo practice, and number of colon cancer patients. DATA COLLECTION METHODS: Data are combined from national probability samples of CCOP- and non-CCOP-affiliated physicians. This study focused on 1,138 internists, family physicians, and general surgeons who participated in decision making for patients diagnosed with Dukes' B2 or C stage colon cancer. Judgments were elicited using brief vignettes. METHODS OF ANALYSIS: Judgments of adjuvant therapy are classified as (a) consistent with the National Institutes of Health Consensus Conference recommendations (experimental for Dukes' B2, accepted for Dukes' C); (b) accepted treatment for both stages; or (c) experimental for both stages. Multinomial logit analyses were used to examine the association of practice setting and physician characteristics to judgments of treatment. RESULTS: Surgeons and CCOP-affiliated physicians were more likely to endorse the NIH consensus conference position. Surgeons, younger physicians, and those in group practice were more likely to approve of chemotherapy for both cancer stages. The most common position (chemotherapy experimental) was more likely from nonsurgeons, solo practitioners, and non-CCOP physicians. CONCLUSION: Physician and practice setting characteristics, including organized structures such as the CCOP, are possible mediating structures that can facilitate dissemination of standards of treatment