Mood Effects on Memory

Forty-eight subjects were given a questionnaire testing their memory for objects in a picture and a computerized navigation task testing their ability to remember and follow navigation instructions while they were in both a happy mood and a sad mood. Music and an object finding task were used to manipulate their mood. The Positive Affect and Negative Affect Schedule (PANAS) was used to verify their mood in each condition. The hypothesis was that subjects would do better and be more efficient on both tasks when they are in a good mood. The results did not yield significant main effects of mood on either task, but they did verify that the music and object finding task changed the subjects’ mood as expected and they suggested more improvement on the navigation task in the sad than in the happy mood

Dynamic RACH Partition for Massive Access of Differentiated M2M Services

In machine-to-machine (M2M) networks, a key challenge is to overcome the overload problem caused by random access requests from massive machine-type communication (MTC) devices. When differentiated services coexist, such as delay-sensitive and delay-tolerant services, the problem becomes more complicated and challenging. This is because delay-sensitive services often use more aggressive policies, and thus, delay-tolerant services get much fewer chances to access the network. To conquer the problem, we propose an efficient mechanism for massive access control over differentiated M2M services, including delay-sensitive and delay-tolerant services. Specifically, based on the traffic loads of the two types of services, the proposed scheme dynamically partitions and allocates the random access channel (RACH) resource to each type of services. The RACH partition strategy is thoroughly optimized to increase the access performances of M2M networks. Analyses and simulation demonstrate the effectiveness of our design. The proposed scheme can outperform the baseline access class barring (ACB) scheme, which ignores service types in access control, in terms of access success probability and the average access delay

Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

We transplanted kidneys from α1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans. © 2005 Nature Publishing Group

Correction: Computer-aided design of high-efficiency GeTe-based thermoelectric devices

Correction for ‘Computer-aided design of high-efficiency GeTe-based thermoelectric devices’ by Min Hong et al., Energy Environ. Sci., 2020, DOI: 10.1039/d0ee01004a. The authors regret errors in the author affiliations in the original manuscript. The corrected list of authors and affiliations for this paper is as shown above. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers

IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population

<p><b>Background:</b> The interleukin-28B gene (IL28B) locus has been associated with host resistance to hepatitis C virus (HCV) infection and response to PEG-IFN/RBV treatment in western populations. This study was to determine whether this gene variant is also associated with spontaneous clearance of HCV infection, treatment response and IL-28B protein production in Chinese patients.</p> <p><b>Methods:</b> We genotyped IL28B genetic variations (rs12980275, rs8103142, rs8099917 and rs12979860) by pyrosequencing DNA samples from cohorts consisting of 529 subjects with persistent HCV infection, 196 subjects who cleared the infection, 171 healthy individuals and 235 chronic HCV patients underwent IFN/RBV treatment. The expression of IL-28B were measured by ELISA and RT-PCR.</p> <p><b>Results:</b> We found that the four IL28B variants were in complete linkage disequilibrium (r2 = 0.97–0.98). The rs12979860 CC genotype was strongly associated with spontaneously HCV clearance and successful IFN/RBV treatment compared to the CT/TT. IL-28B levels in persistent HCV patients were significantly lower than subjects who spontaneously resolved HCV and healthy controls and were also associated with high levels of ALT (alanine aminotransferase) and AST (aspartate aminotransferase). IL-28B levels were also significantly lower in individuals carrying T alleles than CC homozygous.</p> <p><b>Conclusions:</b> Thus, the rs12979860-CC variant upstream of IL28B gene is associated with spontaneous clearance of HCV, susceptible to IFN/RBV treatment and increased IL-28B levels in this Chinese population.</p&gt

Estimation of Layered Ground Thermal Properties for Deep Coaxial Ground Heat Exchanger

A ground heat exchanger (GHE) can efficiently exploit geothermal energy, and a ground source heat pump (GSHP) is an important type of geothermal application. The distributed thermal response test (DTRT) is widely used to measure layered ground thermal properties for shallow GHEs, but nowadays, there is a lack of studies applying the DTRT to deep coaxial GHEs (DCGHEs). This study proposes a new parameter estimation method (PEM) by adopting the DTRT data of a DCGHE to estimate layered ground thermal properties and applies the proposed PEM to simulated DTRTs under different boundary conditions, and the estimated values of the layered ground thermal properties are compared with the true values. Under heat output rate or inlet temperature boundary conditions, the relative errors of the thermal conductivities and heat capacities of ground estimated using the proposed PEM are basically within 2% and 4%, respectively, except for shallower layers with a depth range of 0–800 m. The larger errors for shallower layers may be caused by weaker heat transfer between the fluid and ground, and the errors are basically lower for higher heat output rates. The predicted fluid temperature distributions during 120 d using the estimated values of the layered ground thermal properties match well with those using the true values. The results show that the proposed PEM is viable for DCGHE DTRT interpretation under heat output rate and inlet temperature boundary conditions, is a cost-effective way to establish key parameters for GSHP design, and would promote geothermal development

Enhancing the Anticancer Efficacy of Immunotherapy through Combination with Histone Modification Inhibitors

In the nucleus of each cell, the DNA is wrapped around histone octamers, forming the so-called “nucleosomal core particles„. The histones undergo various modifications that influence chromatin structure and function, including methylation, acetylation, ubiquitination, phosphorylation, and SUMOylation. These modifications, known as epigenetic modifications (defined as heritable molecular determinants of phenotype that are independent of the DNA sequence), result in alterations of gene expression and changes in cell behavior. Recent work has shown that epigenetic drugs targeting histone deacetylation or methylation modulate the immune response and overcome acquired resistance to immunotherapy. A number of combination therapies involving immunotherapy and epigenetic drugs, which target histone deacetylation or methylation, are currently under various clinical/pre-clinical investigations and have shown promising anticancer efficacy. These combination therapies may provide a new strategy for achieving sustained anticancer efficacy and overcoming resistance

Impact of the COVID-19 outbreak and interventions on hand, foot and mouth disease in Zhengzhou, China, 2014–2022: a retrospective study

Abstract Background Since December 2019, COVID-19 has spread rapidly around the world, and studies have shown that measures to prevent COVID-19 can largely reduce the spread of other infectious diseases. This study explored the impact of the COVID-19 outbreak and interventions on the incidence of HFMD. Methods We gathered data on the prevalence of HFMD from the Children’s Hospital Affiliated to Zhengzhou University. An autoregressive integrated moving average model was constructed using HFMD incidence data from 2014 to 2019, the number of cases predicted from 2020 to 2022 was predicted, and the predicted values were compared with the actual measurements. Results From January 2014 to October 2022, the Children’s Hospital of Zhengzhou University admitted 103,995 children with HFMD. The average number of cases of HFMD from 2020 to 2022 was 4,946, a significant decrease from 14,859 cases from 2014 to 2019. We confirmed the best ARIMA (2,0,0) (1,1,0)12 model. From 2020 to 2022, the yearly number of cases decreased by 46.58%, 75.54%, and 66.16%, respectively, compared with the forecasted incidence. Trends in incidence across sexes and ages displayed patterns similar to those overall. Conclusions The COVID-19 outbreak and interventions reduced the incidence of HFMD compared to that before the outbreak. Strengthening public health interventions remains a priority in the prevention of HFMD