Prevalence and associated factors of depressive and anxiety symptoms among healthcare workers in the post-pandemic era of COVID-19 at a tertiary hospital in Shenzhen, China: A cross-sectional study

BackgroundHealthcare workers were at high risk of psychological problems during the COVID-19 pandemic, but it remains not well-investigated in the post-pandemic era of COVID-19, with regular epidemic prevention and control embedded in burdened healthcare work. This study aimed to investigate the prevalence and potential risk factors of the symptoms of depression and anxiety among healthcare workers at a tertiary hospital in Shenzhen.MethodOur cross-sectional study was conducted among 21- to 64-year-old healthcare workers in December 2021 at a tertiary hospital in Shenzhen, using a simple random sampling strategy. A wide range of socio-demographic characteristics, individual information, and psychological condition of the subjects were extracted. Healthcare workers' psychological conditions were tested with the Center for Epidemiologic Studies Depression (CESD-10), General Anxiety Disorder (GAD-7), Insomnia Severity Index (ISI), Work-Family Conflict Scale (WFCS), 10-item Connor-Davidson Resilience Scale (CD-RISC-10), and 17-item of Maslach's Burnout Inventory-Human Services Survey (MBI-HSS-17). Data were collected based on these questionnaires. Descriptive statistics were used to assess the difference between healthcare workers with depressive and anxiety symptoms among different groups. Hierarchical logistic regression analyses were conducted to investigate the association between focused variables and mental health outcomes.ResultsA total of 245 healthcare workers were enrolled. The proportion of depressive symptoms, anxiety symptoms and their co-occurrence were 34.7, 59.6, and 33.1%, respectively. Logistic regression showed that for the three outcomes, no history of receiving psychological help and self-rated good or higher health were protective factors, whereas more severe insomnia and job burnout were risk factors. Junior or lower job title and higher psychological resilience were related to a lower prevalence of depressive symptoms, while relatively longer working hours and larger work-family conflict were positively associated with the anxiety symptoms. Psychological resilience was inversely associated with the co-occurrence of depressive and anxiety symptoms.ConclusionsOur study revealed a high proportion of psychological problems and proved that several similar factors which were significant during the pandemic were also associated with the symptoms of depression and anxiety among healthcare workers in the post-pandemic era of COVID-19. These results provide scientific evidence for psychological interventions for healthcare workers

Exploring the interplay of new energy vehicle enterprises, consumers, and government in the context of the "dual carbon" target: An evolutionary game and simulation analysis.

To achieve low-carbon and green mobility, the government needs to encourage people to buy and use new energy vehicles. This study proposes a tripartite evolutionary game model among new energy vehicle manufacturers, consumers, and government agencies. The game strategy combinations of each party and the stability conditions of the equilibrium point in the evolutionary game system are analyzed, and the validity of the conclusions is verified by simulation results. Compared with traditional studies that suggest the government should adopt the direct subsidy policy, this study shows that in the early stage of new energy vehicle development, government subsidies are still important for the rapid growth of new energy vehicle production and sales, but indirect policies can play a key role as the new energy vehicle industry matures. In addition to the price, the attractiveness of vehicle brands, the perceived utility of the products among consumers, and the coverage of charging infrastructure in cities also determine whether consumers decide to purchase and use new energy vehicles. The findings could provide useful recommendations for governments and manufacturers of new energy vehicles to meet their "dual carbon" targets

The Practical Experience of “Zero Waste City” Construction in Foshan City Condenses the Chinese Solution to the Sustainable Development Goals

“Zero Waste City” (ZWC) is an urban development model that minimizes the environmental impact of solid waste at the city level and is a specific practice of the Sustainable Development Goals (SDGs). This paper aims to summarize the key points for realizing the construction of ZWC and the SDGs and make suggestions for promoting the construction of ZWC and forming a Chinese solution for the SDGs. It takes Foshan City, one of the second batch of ZWC pilot projects, as a case study, analyzes the relationship between the construction of ZWC and sustainable urban development from the relevance of the ZWC index system in Foshan City and the SDGs, and analyzes the foundation and problems of its ZWC construction in adjusting the industrial structure and improving the protection system. We find that the concept of the ZWC index system in Foshan City and the SDGs are consistent in the objectives of solid waste, resource utilization, management, sustainability, and multi-stakeholder partnerships. The construction of ZWC in Foshan City is built through two intertwined paths by (1) adjusting the industrial structure of solid waste generation areas such as industrial waste, domestic waste, agricultural solid waste, and hazardous waste and promoting the refinement of the whole industrial chain in these fields and (2) improving the institutional, technical, market, regulatory and other protection systems in the solid waste generation fields. This paper condenses the construction of ZWC in Foshan as a Chinese solution for SDGs, providing a practical example of sustainable transformation for other manufacturing cities, with implications for both China and other manufacturing-oriented cities

Bilayer-functionalized mesoporous silica nanoparticles for overcoming multiple barriers of mucus clearance, intestinal epithelium and P-glycoprotein efflux

Mucus clearance, epithelium mucosal barrier and P-glycoprotein (P-gp) efflux are the main gastrointestinal barriers that limit the oral delivery of nanoparticles. Inspired by tunable particles surface properties-dependent trans-mucus and trans-mucosal abilities, novel bilayer-functionalized mesoporous silica nanoparticles (MSN) containing D-α-tocopheryl polyethylene glycol succinate (TPGS) and sulfobetaine 12 (SB12) were designed by layer-to-layer assembly. The amino-grafted MSN (MSN-NH2) was firstly functionalized with TPGS as hydrophobic layer (MSN-TPGS), and then SB12 was self-assembled on the hydrophobic surface of MSN-TPGS to generate a neutral and hydrophilic MSN (MSN-TPGS@SB12). Compared with MSN-NH2, MSN-TPGS, and MSN-TPGS@P123, the MSN-TPGS@SB12 possessed “one stone three birds” functions that enhanced mucus penetration, increased trans-mucosal absorption, as well as suppressed P-gp efflux. The pharmacokinetics study demonstrated that the MSN-TPGS@SB12 loading puerarin (MSN-TPGS@SB12-PUE) exhibited much higher bioavailability compared to other PUE-loaded formulations. Furthermore, the MSN-TPGS@SB12-PUE could significantly enhance the anti-inflammatory efficacy of PUE in vitro and in vivo. In summary, bilayer-functionalized MSN-TPGS@SB12 is a promising vehicle for overcoming the multiple gastrointestinal barriers (mucus clearance, intestinal epithelium barrier and P-gp efflux). Meanwhile, this study also provides a better understanding of the importance of tunable surface property of MSN on oral delivery of drugs

The Practical Experience of “Zero Waste City” Construction in Foshan City Condenses the Chinese Solution to the Sustainable Development Goals

“Zero Waste City” (ZWC) is an urban development model that minimizes the environmental impact of solid waste at the city level and is a specific practice of the Sustainable Development Goals (SDGs). This paper aims to summarize the key points for realizing the construction of ZWC and the SDGs and make suggestions for promoting the construction of ZWC and forming a Chinese solution for the SDGs. It takes Foshan City, one of the second batch of ZWC pilot projects, as a case study, analyzes the relationship between the construction of ZWC and sustainable urban development from the relevance of the ZWC index system in Foshan City and the SDGs, and analyzes the foundation and problems of its ZWC construction in adjusting the industrial structure and improving the protection system. We find that the concept of the ZWC index system in Foshan City and the SDGs are consistent in the objectives of solid waste, resource utilization, management, sustainability, and multi-stakeholder partnerships. The construction of ZWC in Foshan City is built through two intertwined paths by (1) adjusting the industrial structure of solid waste generation areas such as industrial waste, domestic waste, agricultural solid waste, and hazardous waste and promoting the refinement of the whole industrial chain in these fields and (2) improving the institutional, technical, market, regulatory and other protection systems in the solid waste generation fields. This paper condenses the construction of ZWC in Foshan as a Chinese solution for SDGs, providing a practical example of sustainable transformation for other manufacturing cities, with implications for both China and other manufacturing-oriented cities

2008 American Conference on Theoretical Chemistry

A copy of the of conference Program and the letters of scholarship. Grant was used to present scholarships to students to visit the ACTC conference in 2008

Microwave-Assisted Synthesis of MoS₂/BiVO₄ Heterojunction for Photocatalytic Degradation of Tetracycline Hydrochloride

Compared with traditional hydrothermal synthesis, microwave-assisted synthesis has the advantages of being faster and more energy efficient. In this work, the MoS2/BiVO4 heterojunction photocatalyst was synthesized by the microwave-assisted hydrothermal method within 30 min. The morphology, structure and chemical composition were characterized by X-ray diffraction (XRD), Raman, X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), and high-resolution transmission electron microscopy (HRTEM). The results of characterizations demonstrated that the synthesized MoS2/BiVO4 heterojunction was a spherical structure with dimensions in the nanorange. In addition, the photocatalytic activity of the samples was investigated by degrading tetracycline hydrochloride (TC) under visible light irradiation. Results indicated that the MoS2/BiVO4 heterojunction significantly improved the photocatalytic performance compared with BiVO4 and MoS2, in which the degradation rate of TC (5 mg L−1) by compound where the mass ratio of MoS2/BiVO4 was 5 wt% (MB5) was 93.7% in 90 min, which was 2.36 times of BiVO4. The active species capture experiments indicated that •OH, •O2− and h+ active species play a major role in the degradation of TC. The degradation mechanism and pathway of the photocatalysts were proposed through the analysis of the band structure and element valence state. Therefore, microwave technology provided a quick and efficient way to prepare MoS2/BiVO4 heterojunction photocatalytic efficiently

Characterization and modulation of the unimolecular conformation of integrins with nanopore sensors

Integrins are a large family of heterodimeric mammalian transmembrane receptors that connect extracellular matrix (ECM) and the cytoskeleton. Integrin-mediated adhesion governs the cellular adhesion, mobility, and cell mechanobiology. Investigations on different integrins in cellular and the conformation change regulated by divalent metal ions and oligopeptides have been documented, they mainly adopted the cellular assays or surface manipulation to achieve the information of ensemble integrins with proteins and small molecules. This work presents the nanopore approach for the characterization of unimolecular integrin via resistive pulse sensing. The orientation selection in distinct nanopore in size and pH condition discloses the tiny disparity of the conformation and the local surface charge distribution. The divalent metal ions could efficiently modulate the conformation alteration of integrin, in which Ca2+ and Mn2+ could activate integrin alpha L beta 2 to take larger physical dimension than Mg2+, and Ca2+ is superior to Mn2+ in the activation when integrin alpha L beta 2 is treated in the mixed metal ions. The oligopeptide cRGD (cyclic Arg-Gly-Asp) and its derivatives cRGDfk and cRGDyk show specific binding with integrin alpha V beta 3 and the complex of alpha V beta 3-cRGD exhibits largest geometry upon Ca2+-mediation with characteristic nanopore translocation feature. This work provides a platform for unimolecular integrin sensing and the modulation of the local conformation transition regulated by divalent metal ions and oligopeptides, which will be valuable for the representation of integrin-related cellular behavior and bio-function

Role of lncRNA Has2os in Skeletal Muscle Differentiation and Regeneration

Long non-coding RNAs (lncRNAs) regulate a series of physiological processes and play an important role in development, metabolism and disease. Our previous studies showed that lncRNAs involved in skeletal muscle differentiation. Here, we demonstrated that lncRNA Has2os is highly expressed in skeletal muscle and significantly elevated during skeletal cell differentiation. The knockdown of Has2os inhibited myocyte fusion and impeded the expression of the myogenic factors MyHC and Mef2C. Mechanically, Has2os regulates skeletal muscle differentiation by inhibiting the JNK/MAPK signaling pathway. Furthermore, we also revealed that Has2os is involved in the early stage of regeneration after muscle injury, and the JNK/MAPK signaling pathway is activated at both protein and mRNA levels during early repair. Our results demonstrate the new function of lncRNA Has2os, which plays crucial roles during skeletal muscle differentiation and muscle regeneration, providing a basis for the therapy of lncRNA-related muscle diseases