64 research outputs found
Pan-cancer analysis of whole genomes
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- Weisenberger
- Welch
- Wendl M. C. z
- wf Amary
- Whalley
- Wheeler
- wi Futreal
- Wigle
- Wilkerson M. D. v
- Williams
- Wilmott
- Wilson G. W. k
- Wilson R. K. z
- Wintersinger
- Wiznerowicz
- Wolf
- Wong
- Wong
- Woo
- Wood
- Wouters
- Wright
- Wright
- Wright A. J. k
- ws Ang
- Wu
- Wu
- Wu
- wv abg
- wz Hupp
- x Eils
- x Yung
- X. abp
- X. at
- X. bk
- X. cq
- X. ez
- X. ez
- X. fh
- X. fv
- X. fv
- X. fv
- X. fv
- X. k Mbabaali
- X. oi
- X. S. wd
- X. tc
- X. zv
- xb Danilova
- xb Felau
- xc Lovat
- xh Curley
- xh Fulton
- Xi
- Xia
- Xiang
- Xiong
- xo Abeshouse
- xp Benz
- xp Edwards
- xr Ghori
- xs Gundem
- Xue
- xv Luxton
- xw McDermott
- xy Visakorpi
- xz Whitaker
- Y. -E. ot
- Y. -J. k
- Y. -J. xn
- Y. abp
- Y. ae
- Y. ae
- Y. ae
- Y. ae
- Y. ai
- Y. aj
- Y. al
- Y. bk
- Y. dg
- Y. dy
- Y. ef
- Y. ep
- Y. ez
- Y. ff
- Y. fr
- Y. fv
- Y. fv
- Y. gl
- Y. hl
- Y. hq
- Y. hq
- Y. ia
- Y. kq
- Y. lw
- Y. nh
- Y. nk
- Y. nz
- Y. rg
- Y. rj
- Y. rm
- Y. S. jf
- Y. uz
- Y. vr
- Y. wt
- Y. yc
- ya Al-Ahmadie
- Yachida
- Yamaguchi
- Yamaguchi T. N. k
- Yamamoto
- Yamaue
- Yang
- Yang
- Yang
- Yang
- Yang
- Yao
- Yaspo
- Yates
- Yau
- yb Ally
- yd Cherniack
- yd Lai
- yd Schadendorf
- ye Auman
- ye Umbricht
- Yellapantula
- Yellapantula
- yh Bathe
- yj Baylin
- Yoon
- Yu
- Yu
- Yu
- Yuan
- Yugawa
- z ah
- Z. ej
- Z. ep
- Z. fr
- Z. hv
- Z. hy
- Z. jq
- Z. kt
- Z. oe
- Zaikova
- Zapatka
- zd Gershenwald
- Zenklusen
- Zeps
- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
- Zhu
- zi zj
- zm Jayaseelan
- Zou
- Zou
- zt Kim
- zw Lewis
- Ó. A. th
- Ø. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Notes for genera: basal clades of Fungi (including Aphelidiomycota, Basidiobolomycota, Blastocladiomycota, Calcarisporiellomycota, Caulochytriomycota, Chytridiomycota, Entomophthoromycota, Glomeromycota, Kickxellomycota, Monoblepharomycota, Mortierellomycota, Mucoromycota, Neocallimastigomycota, Olpidiomycota, Rozellomycota and Zoopagomycota)
- Author
- A Abe
- A Alastruey-Izquierdo
- A Alastruey-Izquierdo
- A Amiri
- A Ballvora
- A Bonifaz
- A Burmester
- A Cali
- A Cali
- A Cali
- A Canet
- A Clum
- A Cunningham
- A Desirò
- A Desirò
- A Desirò
- A Diamant
- A Diamant
- A Doweld
- A Garcia
- A Herivaux
- A Hermet
- A Hussain
- A Justo
- A Justo
- A Mahmud
- A Martel
- A Martinez
- A Nováková
- A Sapir
- A Saroj
- A Schüßler
- A Schüßler
- A Siri
- A Valencakova
- A Valencáková
- A Willis
- AA Abdel-Baki
- AA Madden
- AB Jensen
- AC Batista
- AD Winters
- Adebola Azeez Lateef
- AE Hajek
- AE Hajek
- AG Babu
- AI Colmenero
- AI Vedmed
- AJ Mathuram
- AK Dube
- AL Santiago
- AL Santiago
- ALCM Santiago de
- Aleksandra Gęsiorska
- Alicja Okrasińska
- AM Aluoch
- AM Ardila-Garcia
- AM Bronnvall
- AM Brown
- AM Ghizelini
- AM Millanes
- AN Hernandez-Lauzardo
- Anna Muszewska
- AP Bellanger
- AP Gryganskyi
- AP Gryganskyi
- AP Gryganskyi
- AP Gryganskyi
- AP Gryganskyi
- AP Gryganskyi
- Arthur Schüßler
- AS Al-Maani
- AS Gsell
- AS Liggenstoffer
- AS Urquhart
- AV Adrianov
- AV Marano
- AV Simakova
- AV Simakova
- AV Simakova
- AV Simakova
- AV Simakova
- AV Simakova
- AV Simakova
- AV Simakova
- AV Simakova
- AV Simakova
- AW Guzmán-Franco
- B Estrada
- B Kendrick
- B Luo
- B Min
- B Ortiz-Santana
- B Satari
- B Scholz
- B-P Cai
- BA Williams
- BE Arenz
- Belle D. Shenoy
- BJ Cassone
- BS Batson
- BT Goto
- BT Goto
- BT Goto
- BT Goto
- BV Agboton
- BV Agboton
- C Azevedo
- C Azevedo
- C Azevedo
- C Azevedo
- C Azevedo
- C Franzen
- C Ge
- C Kalavati
- C Levaditi
- C Loubès
- C Mathur
- C Merheb-Dini
- C Paquette
- C Pomport-Castillon
- C Pomport-Castillon
- C Russ
- C Sanz
- C Sanz
- C Schofield
- C Strullu-Derrien
- C Subramanian
- C Tkaczyk
- C Truong
- C Walker
- C Walker
- CA Quandt
- CAF Souza de
- CC Chuang
- CC Tully
- CE Lange
- CE Lange
- CE Lange
- CG Matthews
- CG Vélez
- CG Vélez
- Christopher Walker
- CM Morrison
- CM Whipps
- CMA Mello de
- CMR Pereira
- CMR Pereira
- CP Vivares
- CP Vivarès
- CP Vivarès
- CR Penton
- CR Vossbrinck
- CR Vossbrinck
- CR Vossbrinck
- CR Vossbrinck
- CV Joshi
- CY Wang
- D Bass
- D Codreanu-Bălcescu
- D Corsaro
- D Corsaro
- D Corsaro
- D Corsaro
- D Garcia-Hermoso
- D Hirose
- D Hirose
- D John
- D Kang
- D Magyar
- D Redecker
- D Refardt
- D Refardt
- D Refardt
- D Refardt
- D Schachtschabel
- D Takov
- D Vinckier
- D. Siril A. Wijesundara
- DB Pinho
- DB Strongman
- DB Strongman
- DB Strongman
- DB Strongman
- DB Strongman
- DC Steinkraus
- DH Oi
- DJ Morris
- DJ Morris
- DK Pilarska
- DM Beyer
- DM Moss
- DM Wolk
- DNN Wijayawardene
- DO Andrey
- DO Simelane
- DP Jouvenaz
- DR Hospenthal
- DR Simmons
- DR Simmons
- DR Simmons
- DR Simmons
- DS Hibbett
- DS Smith
- DX Lima
- DX Lima
- E Alvarez
- E Baquero
- E Fiałkowska
- E Furrazola
- E Furrazola
- E González-Tortuero
- E Heinz
- E Hirotani-Akabane
- E Myšková
- E Sagristà
- E Sakuradani
- E Weidner
- E Álvarez
- E Álvarez
- E Álvarez
- ED Tretter
- ED Tretter
- EG Meissner
- EI Hazard
- EK Bylén
- EK Bylén
- EK Pathan
- ER Wilson
- ES Didier
- ES Reda
- ET Hillman
- EU Canning
- EU Canning
- EU Canning
- EU Canning
- EU Canning
- EU Canning
- F Lanternier
- F Lepelletier
- F Mantzouridou
- F Marinho
- F Oehl
- F Oehl
- F Oehl
- F Oehl
- F Oehl
- F Oehl
- F Oehl
- F Oehl
- F Oehl
- F Oehl
- F Oehl
- F Oehl
- F Oehl
- F Oehl
- F Oehl
- F Scholz
- F Seye
- F Tajdini
- FH Gleason
- FH Gleason
- FJ Pastor
- FR Santos
- FSP Godoi De
- G Casal
- G Casal
- G Casal
- G Hao
- G Hao
- G Hao
- G Kyei-Poku
- G Kyei-Poku
- G Kyei-Poku
- G Rodríguez-Gutiérrez
- G Tawil
- G Walther
- GD Stentiford
- GD Stentiford
- GD Stentiford
- GD Stentiford
- GD Stentiford
- GD Stentiford
- GD Stentiford
- GF Cavalheiro
- GG Paskerova
- GJ Li
- GL Benny
- GL Benny
- GL Benny
- GM Mascarin
- Grit Walther
- GS Gunnarsson
- GW Griffith
- H Baki
- H Iwano
- H Kito
- H Kubo
- H Kubo
- H Liu
- H Prakash
- H Prakash
- H Sato
- H Silveira
- H Voglmayr
- H Wang
- H Wang
- H Xiang
- H Zhang
- H Zhang
- HA Ariyawansa
- HA Gamper
- HE Qin
- HM Ho
- HM Ho
- HM Ho
- HM Ho
- HM Ho
- HT Lumbsch
- HY Yun
- I Bargielowski
- I Cruz-Lachica
- I Foissner
- I Maurand
- I Morgenstern
- I Nyilasi
- I Paperna
- I Paperna
- I Singh
- I Takeda
- I Xess
- IA Al-Zaydani
- IV Grigoriev
- IV Grushevaya
- IV Issi
- IV Issi
- IV Issi
- IV Senderskiy
- J Akerstedt
- J Baszkowski
- J Bojko
- J Budziszewska
- J Błaszkowski
- J Błaszkowski
- J Błaszkowski
- J Błaszkowski
- J Błaszkowski
- J Błaszkowski
- J Błaszkowski
- J Błaszkowski
- J Błaszkowski
- J Błaszkowski
- J Błaszkowski
- J Błaszkowski
- J Błaszkowski
- J Błaszkowski
- J Chander
- J Dorin
- J García-Martínez
- J Guarro
- J Leiro
- J Leiro
- J Linde
- J Lom
- J Lovy
- J Medina
- J Menotti
- J Palenzuela
- J Palenzuela
- J Palenzuela
- J Palenzuela
- J Palenzuela
- J Palenzuela
- J Panek
- J Sanders
- J Sun
- J Uehling
- J Vavra
- J Vávra
- J Vávra
- J Vávra
- J Vávra
- J Wang
- J Weiser
- J Weiser
- J Weiser
- J Weiser
- J Weiser
- J Xu
- J Yu
- JB Bertumen
- JB Morton
- JD Bard
- JD Poley
- JD Pyle
- JD Vaingankar
- JE Ironside
- JE Longcore
- JE Longcore
- JE Longcore
- JE Obidiegwu
- JF Pombert
- JGM Slothouber Galbreath
- JI Souza de
- JI Souza De
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JIR Larsson
- JJ Becnel
- JJ Becnel
- JJ Becnel
- JJ Garcia
- JJ Garcia
- JK Misra
- JK Misra
- JK Misra
- JK Pell
- JK Pell
- JL Fowler
- JL Matthews
- JL Sanders
- JL Sanders
- JL Sanders
- JM Amigó
- JM Doby
- JM Malysh
- JM Wilson
- JR Cooley
- JR Foltz
- JR Fuxa
- JR Ralphs
- JR Voos
- JS Baggio
- JS Heilveil
- JS Pontes
- JS Pontes de
- Julia Pawłowska
- JV Hopper
- JW Spatafora
- K Furuya
- K Hoffmann
- K Hoffmann
- K Hoffmann
- K Hoffmann
- K Hoffmann
- K Jacobs
- K Kaerger
- K Karimi
- K Karimi
- K Laisutisan
- K Leśniańska
- K Lukášová
- K Němejc
- K Seto
- K Seto
- K Seto
- K Yamamoto
- K Yamamoto
- K Yamamoto
- K Zawadzka
- KA Etienne
- KA Etienne
- KD Hyde
- KD Hyde
- KD Hyde
- KD Hyde
- KD Hyde
- Kevin D. Hyde
- KJ Kennedy
- KJ Kwon-Chung
- KL Haag
- KL Haag
- KL Lazarus
- KM Foos
- KR Freeman
- KS Bateman
- KT Picard
- Kunhiraman C. Rajeshkumar
- KV Mikhailov
- KW Kroll
- L Chen
- L Gade
- L Li
- L Mansour
- L Mendoza
- L Tedersoo
- L Wagner
- L Wang
- LD Racsa
- LDA André
- LF Khodzhaeva
- LFN Rocha
- LG Poddubnaya
- LG Valle
- LG Valle
- LG Valle
- LG Valle
- LG Valle
- LG Valle
- LJ Ma
- LJ Ryan
- LL Lima
- LM Corrochano
- LM Lorenz
- LP Camino
- LRR Berger
- LW Guo
- LY Mou
- Lysett Wagner
- M Alarcón
- M Alonso
- M Blooi
- M Burjanadze
- M Ellerbeck
- M Ganjali Dashti
- M Gerphagnon
- M Greaves
- M Hyliš
- M Hyliš
- M Kereselidze
- M Kimura
- M Krings
- M Krüger
- M Krüger
- M Lihme
- M Mrva
- M Ovcharenko
- M Ovcharenko
- M Ovcharenko
- M Pekkarinen
- M Richardson
- M Saikawa
- M Saikawa
- M Sakai
- M Saleh
- M Saleh
- M Santín
- M Schweikert
- M Siddiqui
- M Sridhar
- M Strittmatter
- M Tabaković-Tošić
- M Taha
- M Takó
- M Thellier
- M Videira
- M Yaman
- M Žižić
- M-S Benitez
- MA Aluoch
- MA Freeman
- MA Freeman
- MA Freeman
- MA Freeman
- MA Freeman
- MA Maier
- Marta Wrzosek
- MB Uloth
- MC Chibucos
- MC Chibucos
- MC Fisher
- MC González
- MD Baker
- ME Bench
- ME Jones
- ME Rabie
- ME Smith
- ME Zain
- MI Bidartondo
- MJ Dillon
- MJ Mitchell
- MJ Powell
- MJ Powell
- MJ Powell
- MJ Powell
- ML Neves
- MM Choudhary
- MM White
- MM White
- Moslem Papizadeh
- MP Hapsari
- MP Nelder
- MR Watts
- MS Ascunce
- MZ Gomes
- N Aziz
- N Biju
- N Corradi
- N Corradi
- N Faye
- N Faye
- N Martin
- N Nwe
- N Saad
- N Sharma
- N Wolkow
- N Woodbury
- N Wüppenhorst
- N Yong
- Nalin N. Wijayawardene
- NB Phelps
- NBD Phelps
- NFL Garcia
- NJ Percival
- NN Wijayawardene
- NN Wijayawardene
- NN Wijayawardene
- NN Wijayawardene
- NN Wijayawardene
- NO Rode
- NRA Silva
- O Lilje
- O Roth
- OA Rajachan
- P Kandel
- P Kelly
- P Kirk
- P Lechevalier
- P Meeuwse
- P Pawłowska
- P Rooij Van
- P Sharma
- P Thélohan
- P Zhang
- Paul M. Kirk
- Paul Mungai
- PCY Woo
- PD Bridge
- PE Mackey
- Peter M. Letcher
- PJ Kilochitskii
- PM Kirk
- PM Letcher
- PM Letcher
- PM Letcher
- PM Letcher
- PM Letcher
- PM Letcher
- PM Letcher
- PM Letcher
- PM Letcher
- PM Letcher
- PM Letcher
- PM Letcher
- PM Letcher
- PO Akinwole
- PW Crous
- PW Crous
- Q Sun
- Q Xu
- R Amatya
- R Borrás
- R Codreanu
- R Czaker
- R Fayer
- R Kumar Verma
- R Larsson
- R Larsson
- R Larsson
- R Larsson
- R Lücking
- R Michel
- R Michel
- R Radek
- R Radek
- R Radek
- R Tsukada
- R Vilela
- R Wang
- R Wang
- R Weissenberg
- RA Hanafy
- RA Healy
- RA Humber
- RA Humber
- RA Matthews
- RA Steiger
- Rajshree V. Singh
- RC Rodrigues
- RE Down
- Renate Radek
- RF Melo
- Richard A. Humber
- RJ Bills
- RJ Gruninger
- RK Vijendravarma
- RM Hoffman
- RM Overstreet
- RM Plowes
- RT William
- RT Williams
- RW Lichtwardt
- RW Lichtwardt
- RW Lichtwardt
- RW Lichtwardt
- RY Zheng
- RY Zheng
- RY Zheng
- RY Zheng
- S Abedinifar
- S Adamčík
- S Al-Quraishy
- S Asha
- S Baby
- S Behnam
- S Bjørnson
- S Calo
- S Chaudhary
- S Dolatabadi
- S Dong
- S Dong
- S Edgington
- S Ellenberger
- S Fakas
- S Jamali
- S Kagiwada
- S Keller
- S Mangaraj
- S Monchy
- S Morin-Sardin
- S Ndikumana
- S Nylund
- S Nylund
- S Papanikolaou
- S Shankar
- S Sveen
- S Symanczik
- S Symanczik
- S Tibpromma
- S Vojvodic
- S Vojvodic
- S Wang
- S Werner
- S Wyngaert Van den
- S-Y Leung
- SA Cheney
- SA Karpov
- SA Karpov
- SA Karpov
- SA Karpov
- SA Karpov
- SA Karpov
- SA Karpov
- SA Shelburne
- Saisamorn Lumyong
- Santiago ALCM Azevedo De
- SB Fu
- SC Chuang
- SC Chuang
- SC Chuang
- SC Weli
- SD Pierce
- SE Campbell
- SE Mozley-Standridge
- SH He
- SH Kia
- SI Fokin
- SJ Mondo
- SJ Oman
- SJ Taj-Aldeen
- SK Das
- SL Li
- SM Choudhari
- Somayeh Dolatabadi
- SR Ahrendt
- SR Jones
- SR Mane
- SR Monaghan
- SS Dagar
- SS Vidtmann
- SW Khade
- T Akar
- T Crossay
- T Frenken
- T Gebremariam
- T Janicki
- T Jayachandra
- T Nagahama
- T Petkovits
- T Tonka
- T Tonka
- TC Wang
- TG Andreadis
- TG Andreadis
- TG Andreadis
- TG Andreadis
- TG Jephcott
- TJ Torres-Cruz
- TJ Wilkinson
- TK Balázs
- TM Callaghan
- TM Porter
- TY James
- TY James
- TY James
- TY James
- TY James
- U Chiranjeevi
- V Karthikeyan
- V Salas
- V Sprague
- V Sprague
- V Sprague
- V Sprague
- V Verma
- VN Voronin
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- VN Voronin
- VN Voronin
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- VP Baradkar
- VP Dave
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- VPS Shakya
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- VU Schwartze
- VU Schwartze
- W Kaonongbua
- W Schrödl
- W-K Huang
- WH Blackwell
- WH Blackwell
- WH Blackwell
- WJ Chen
- WJ Davis
- WJ Davis
- WJ Davis
- WJ Davis
- WK Huang
- WM Brooks
- WP Shi
- WS Hollister
- WS Wakefield
- X Jiang
- X Ni
- X Qi
- X Tang
- X Wang
- X Wu
- X Xu
- X Zhou
- XA Luo
- XL Lu
- XL Lu
- XX Zhou
- XY Liu
- Y Chen
- Y Chen
- Y Degawa
- Y Hoffman
- Y Kurihara
- Y Nie
- Y Ogawa
- Y Sahadevan
- Y Sato
- Y Siddiqui
- Y Siddiqui
- Y Sokolova
- Y Su
- Y Wang
- Y Wang
- Y Wang
- Y Wang
- Y Wang
- Y Wang
- YA Batta
- YH Ho
- YH Hou
- YK Sokolova
- YN Wang
- YN Wang
- YS Tokarev
- YS Tokarev
- YS Tokarev
- YS Tokarev
- YS Tokarev
- Yuri S. Tokarev
- YY Sokolova
- YY Sokolova
- YY Sokolova
- YY Sokolova
- YY Sokolova
- YY Sokolova
- YY Sokolova
- YY Sokolova
- YY Sokolova
- Z Almoosa
- Z Andrade De
- Z Ding
- Z Ruan
- Z Wang
- ZF Ding
- Łukasz Istel
- Ş Alpat
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/09/2018
- Field of study
Compared to the higher fungi (Dikarya), taxonomic and evolutionary studies on the basal clades of fungi are fewer in number. Thus, the generic boundaries and higher ranks in the basal clades of fungi are poorly known. Recent DNA based taxonomic studies have provided reliable and accurate information. It is therefore necessary to compile all available information since basal clades genera lack updated checklists or outlines. Recently, Tedersoo et al. (MycoKeys 13:1--20, 2016) accepted Aphelidiomycota and Rozellomycota in Fungal clade. Thus, we regard both these phyla as members in Kingdom Fungi. We accept 16 phyla in basal clades viz. Aphelidiomycota, Basidiobolomycota, Blastocladiomycota, Calcarisporiellomycota, Caulochytriomycota, Chytridiomycota, Entomophthoromycota, Glomeromycota, Kickxellomycota, Monoblepharomycota, Mortierellomycota, Mucoromycota, Neocallimastigomycota, Olpidiomycota, Rozellomycota and Zoopagomycota. Thus, 611 genera in 153 families, 43 orders and 18 classes are provided with details of classification, synonyms, life modes, distribution, recent literature and genomic data. Moreover, Catenariaceae Couch is proposed to be conserved, Cladochytriales Mozl.-Standr. is emended and the family Nephridiophagaceae is introduced
Host response mechanisms in periodontal diseases
- Author
- Acosta-Rodriguez EV
- Agnello D
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Composite anodes for lithium-ion batteries: status and trends
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Ground glass hepatocytes provide targets for therapy or prevention of hepatitis B virus-related hepatocellular carcinoma
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