Post-Fire Assessment of Prestressed Concrete Bridges in Indiana

This project focused on evaluating the effects of fire-induced damage on concrete bridge elements, including prestressed concrete bridge girders. A series of controlled heating experiments, pool fire tests, material tests, and structural loading tests were conducted. Experimental results indicate that the portion of concrete subjected to temperatures higher than 400°C loses significant amounts of calcium hydroxide (CH). Decomposition of CH increases porosity and causes significant cracking. The portion of concrete exposed to temperatures higher than 400°C should be repaired or replaced. When subjected to ISO-834 standard fire heating, approximately 0.25 in. and 0.75 in. of concrete from the exposed surface are damaged after 40 minutes and 80 minutes of heating, respectively. Prestressed concrete girders exposed to about 50 minutes of hydrocarbon fire undergo superficial concrete material damage with loss of CH and extensive cracking and spalling extending to the depth of 0.75–1.0 in. from the exposed surface. These girders do not undergo significant reduction in flexural strength or shear strength. The reduction in the initial stiffness may be notable due to concrete cracking and spalling. Bridge inspectors can use these findings to infer the extent of material and structural damage to prestressed concrete bridge girders in the event of a fire and develop a post-fire assessment plan

Superconductivity above 30 K achieved in dense scandium

Superconductivity is one of most intriguing quantum phenomena, and the quest for elemental superconductors with high critical temperature (Tc) is of great scientific significance due to their relatively simple material composition and the underlying mechanism. Here we report the experimental discovery of densely compressed scandium (Sc) becoming the first elemental superconductor with Tc breaking into 30 K range, which is comparable to the Tc values of the classic La-Ba-Cu-O or LaFeAsO superconductors. Our results show that Tconset of Sc increases from ~3 K at around 43 GPa to ~32 K at about 283 GPa (Tczero ~ 31 K), which is well above liquid neon temperature. Interestingly measured Tc shows no sign of saturation up to the maximum pressure achieved in our experiments, indicating that Tc might be even higher upon further compression.Comment: 22 pages, 16 figure

Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair

Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23

The Genome of Ganderma lucidum Provide Insights into Triterpense Biosynthesis and Wood Degradation

BACKGROUND: Ganoderma lucidum (Reishi or Ling Zhi) is one of the most famous Traditional Chinese Medicines and has been widely used in the treatment of various human diseases in Asia countries. It is also a fungus with strong wood degradation ability with potential in bioenergy production. However, genes, pathways and mechanisms of these functions are still unknown. METHODOLOGY/PRINCIPAL FINDINGS: The genome of G. lucidum was sequenced and assembled into a 39.9 megabases (Mb) draft genome, which encoded 12,080 protein-coding genes and ∼83% of them were similar to public sequences. We performed comprehensive annotation for G. lucidum genes and made comparisons with genes in other fungi genomes. Genes in the biosynthesis of the main G. lucidum active ingredients, ganoderic acids (GAs), were characterized. Among the GAs synthases, we identified a fusion gene, the N and C terminal of which are homologous to two different enzymes. Moreover, the fusion gene was only found in basidiomycetes. As a white rot fungus with wood degradation ability, abundant carbohydrate-active enzymes and ligninolytic enzymes were identified in the G. lucidum genome and were compared with other fungi. CONCLUSIONS/SIGNIFICANCE: The genome sequence and well annotation of G. lucidum will provide new insights in function analyses including its medicinal mechanism. The characterization of genes in the triterpene biosynthesis and wood degradation will facilitate bio-engineering research in the production of its active ingredients and bioenergy