Identification of a novel population of Langerin+ dendritic cells

Langerhans cells (LCs) are antigen-presenting cells that reside in the epidermis of the skin and traffic to lymph nodes (LNs). The general role of these cells in skin immune responses is not clear because distinct models of LC depletion resulted in opposite conclusions about their role in contact hypersensitivity (CHS) responses. While comparing these models, we discovered a novel population of LCs that resides in the dermis and does not represent migrating epidermal LCs, as previously thought. Unlike epidermal LCs, dermal Langerin+ dendritic cells (DCs) were radiosensitive and displayed a distinct cell surface phenotype. Dermal Langerin+ DCs migrate from the skin to the LNs after inflammation and in the steady state, and represent the majority of Langerin+ DCs in skin draining LNs. Both epidermal and dermal Langerin+ DCs were depleted by treatment with diphtheria toxin in Lang-DTREGFP knock-in mice. In contrast, transgenic hLang-DTA mice lack epidermal LCs, but have normal numbers of dermal Langerin+ DCs. CHS responses were abrogated upon depletion of both epidermal and dermal LCs, but were unaffected in the absence of only epidermal LCs. This suggests that dermal LCs can mediate CHS and provides an explanation for previous differences observed in the two-model systems

Outcome of infants with acute lymphoblastic leukemia treated with the Chinese Children's Cancer Group Acute Lymphoblastic Leukemia 2015 study protocol

Not available

Regional organization of fibre types in normal and reinnervated hindlimb muscles

The present thesis concerns the spatial distribution of the "slow" type I fibres within muscles of the hindlimb. It is known since long ago that some muscles may have strikingly heterogeneous distributions of type I and II fibres, but this phenomenon of "fibre type regionalization" has still not attracted much quantitative analysis and is not well understood. ... Zie: Chapter

Application of anakinra in inflammatory dermatoses

Interleukin 1(IL-1) is an important cytokine, which is involved in the development of many inflammatory diseases. IL-1 inhibitors have become an effective approach in the treatment of these diseases. Anakinra is the first and the most widely used IL-1 inhibitor on the market. Studies have shown satisfactory efficacy in the treatment of some inflammatory dermatoses. This review mainly summarizes applications of anakinra in adult-onset Still's disease, Schnitzler syndrome, hidradenitis suppurativa, pustular psoriasis, Bechet disease and pyoderma gangrenosum