Absolute sets of rigid local systems

The absolute sets of local systems on a smooth complex algebraic variety are the subject of a conjecture of N. Budur and B. Wang based on an analogy with special subvarieties of Shimura varieties. An absolute set should be the higher-dimensional generalization of a local system of geometric origin. We show that the conjecture for absolute sets of simple cohomologically rigid local systems reduces to the zero-dimensional case, that is, to Simpson's conjecture that every such local system with quasi-unipotent monodromy at infinity and determinant is of geometric origin. In particular, the conjecture holds for this type of absolute sets if the variety is a curve or if the rank is two.Comment: 33 pages, v2: references adde

Application of bioabsorbable screw fixation for anterior cervical decompression and bone grafting

OBJECTIVES: To examine the application of bioabsorbable screws for anterior cervical decompression and bone grafting fixation and to study their clinical effects in the treatment of cervical spondylosis. METHODS: From March 2007 to September 2012, 56 patients, 36 males and 20 females (38-79 years old, average 58.3±9.47 years), underwent a novel operation. Grafts were fixed by bioabsorbable screws (PLLA, 2.7 mm in diameter) after anterior decompression. The bioabsorbable screws were inserted from the midline of the graft bone to the bone surface of the upper and lower vertebrae at 45 degree angles. Patients were evaluated post-operatively to observe the improvement of symptoms and evaluate the fusion of the bone. The Japanese Orthopaedic Association (JOA) score was used to evaluate the recovery of neurological functions. RESULTS: All screws were successfully inserted, with no broken screws. The rate of symptom improvement was 87.5%. All of the grafts fused well with no extrusion. The average time for graft fusion was 3.8±0.55 months (range 3-5 months). Three-dimensional reconstruction of CT scans demonstrated that the grafts fused with adjacent vertebrae well and that the screws were absorbed as predicted. The MRI findings showed that the cerebrospinal fluid was unobstructed. No obvious complications appeared in any of the follow-up evaluations. CONCLUSIONS: Cervical spondylosis with one- or two-level involvement can be effectively treated by anterior decompression and bone grafting with bioabsorbable screw fixation. This operative method is safe and can avoid the complications induced by metal implants

Unsupervised Multi-document Summarization with Holistic Inference

Multi-document summarization aims to obtain core information from a collection of documents written on the same topic. This paper proposes a new holistic framework for unsupervised multi-document extractive summarization. Our method incorporates the holistic beam search inference method associated with the holistic measurements, named Subset Representative Index (SRI). SRI balances the importance and diversity of a subset of sentences from the source documents and can be calculated in unsupervised and adaptive manners. To demonstrate the effectiveness of our method, we conduct extensive experiments on both small and large-scale multi-document summarization datasets under both unsupervised and adaptive settings. The proposed method outperforms strong baselines by a significant margin, as indicated by the resulting ROUGE scores and diversity measures. Our findings also suggest that diversity is essential for improving multi-document summary performance.Comment: Findings of IJCNLP-AACL 202

A CRISPR-Based Toolbox for Studying T Cell Signal Transduction

CRISPR/Cas9 system is a powerful technology to perform genome editing in a variety of cell types. To facilitate the application of Cas9 in mapping T cell signaling pathways, we generated a toolbox for large-scale genetic screens in human Jurkat T cells. The toolbox has three different Jurkat cell lines expressing distinct Cas9 variants, including wild-type Cas9, dCas9-KRAB, and sunCas9. We demonstrated that the toolbox allows us to rapidly disrupt endogenous gene expression at the DNA level and to efficiently repress or activate gene expression at the transcriptional level. The toolbox, in combination with multiple currently existing genome-wide sgRNA libraries, will be useful to systematically investigate T cell signal transduction using both loss-of-function and gain-of-function genetic screens

Worcester Chamber of Commerce: Recruiting Minority Business Owners

Our capstone project was to help the Worcester Regional Chamber of Commerce identify how to re-frame their marketing so it would be appealing to immigrant and minority owned businesses. Based on interviews and external research, our group was able to create a tangible and resourceful data set that provided justified recommendations and ideas on how the Chamber could make adjustments to their marketing plan to attract more businesses of this particular demographic in the city of Worcester. By implementing these recommendations, we believe the Chamber has the opportunity to create a more diverse group of Chamber members, add value to a previously underserved community, and support minority and immigrant owned small businesses through Worcester’s growth in the coming years

Discussion of “Validation of a Novel Sensing Approach for Continuous Pavement Monitoring Using Full-Scale APT Testing”

202407 bcchAccepted ManuscriptSelf-fundedPublishedGreen (AAM

Note on absolute sets of rigid local systems

In this note we give a description up to a quasi-finite morphism of the absolute sets of simple cohomologically rigid local systems on a smooth complex quasi-projective algebraic variety. In dimension one or rank two, this proves a conjecture of Budur–Wang on the structure of these sets

Boron-Made N2: Realization of a B≡B Triple Bond in the B2Al3− Cluster

Until now, all B≡B triple bonds have been achieved by adopting two ligands in the L→B≡B←L manner. Herein, we report an alternative route of designing the B≡B bonds based on the assumption that by acquiring two extra electrons, an element with the atomic number Z can have properties similar to those of the element with the atomic number Z+2. Specifically, we show that due to the electron donation from Al to B, the negatively charged B≡B kernel in the B2Al3− cluster mimics a triple N≡N bond. Comprehensive computational searches reveal that the global minimum structure of B2Al3− exhibits a direct B–B distance of 1.553 Å, and its calculated electron vertical detachment energies are in excellent agreement with the corresponding values of the experimental photoelectron spectrum. Chemical bonding analysis revealed one σ and two π bonds between the two B atoms, thus confirming a classical textbook B≡B triple bond, similar to that of N2

Note on absolute sets of rigid local systems

In this note we give a description up to a quasi-finite morphism of the absolute sets of simple cohomologically rigid local systems on a smooth complex quasi-projective algebraic variety. In dimension one or rank two, this proves a conjecture of Budur–Wang on the structure of these sets

Cache attack on MISTY1

Side-channel attacks exploit information from physical implementations of cryptographic systems. Cache attacks have improved at recovering information by combining observations of the victim\u27s cache access and knowledge of the cipher’s structure. Cache attacks have been implemented for most Feistel- and SPN-structured block cipher algorithms, but the security of algorithms for special structures has seen little attention. We perform a Flush+Reload attack on MISTY1, a class of block cipher with a recursive structure. The function is performed before the plaintext input S-box and after the ciphertext output S-box, making it difficult to attack the first and last rounds. However, the key scheduling part of MISTY1 leaks many bits of the key, which, together with the leakage of partial bits of the round key during encryption, is sufficient to recover it. We design an algorithm that can recover the MISTY1 128-bit key after observing encryption one time, and then use leakage during encryption to reduce its complexity. We experiment on 32- and 64-byte cache line environments. An adversary need observe as little as 5 encryptions to recover the 128-bit key in 0.035 second in the first case, and 10 encryptions to recover the key in 2.1 hours in the second case