Movable Antenna-Aided Hybrid Beamforming for Multi-User Communications

In this correspondence, we propose a movable antenna (MA)-aided multi-user hybrid beamforming scheme with a sub-connected structure, where multiple movable sub-arrays can independently change their positions within different local regions. To maximize the system sum rate, we jointly optimize the digital beamformer, analog beamformer, and positions of subarrays, under the constraints of unit modulus, finite movable regions, and power budget. Due to the non-concave/non-convex objective function/constraints, as well as the highly coupled variables, the formulated problem is challenging to solve. By employing fractional programming, we develop an alternating optimization framework to solve the problem via a combination of Lagrange multipliers, penalty method, and gradient descent. Numerical results reveal that the proposed MA-aided hybrid beamforming scheme significantly improves the sum rate compared to its fixed-position antenna (FPA) counterpart. Moreover, with sufficiently large movable regions, the proposed scheme with sub-connected MA arrays even outperforms the fully-connected FPA array

Multiplexed Frequency-Selective Incoherent Holography

We propose a new incoherent optical holographic spectrum stripping reconstruction method, called incoherent multiplexing frequency-selective holography, which compresses two or more on-axis holograms into a single multiplexed on-axis hologram without loss of magnification and resolution. The technique described in this chapter effectively suppresses the background bias term and conjugate term. The acquired spectrum is obtained by stripping in the overlapping confounding correlation terms. The experimental results show the potential of the method in areas such as compressed holography and extended field of view imaging

Robust Transceiver Design for Covert Integrated Sensing and Communications With Imperfect CSI

We propose a robust transceiver design for a covert integrated sensing and communications (ISAC) system with imperfect channel state information (CSI). Considering both bounded and probabilistic CSI error models, we formulate worst-case and outage-constrained robust optimization problems of joint trasceiver beamforming and radar waveform design to balance the radar performance of multiple targets while ensuring communications performance and covertness of the system. The optimization problems are challenging due to the non-convexity arising from the semi-infinite constraints (SICs) and the coupled transceiver variables. In an effort to tackle the former difficulty, S-procedure and Bernstein-type inequality are introduced for converting the SICs into finite convex linear matrix inequalities (LMIs) and second-order cone constraints. A robust alternating optimization framework referred to alternating double-checking is developed for decoupling the transceiver design problem into feasibility-checking transmitter- and receiver-side subproblems, transforming the rank-one constraints into a set of LMIs, and verifying the feasibility of beamforming by invoking the matrix-lifting scheme. Numerical results are provided to demonstrate the effectiveness and robustness of the proposed algorithm in improving the performance of covert ISAC systems

2-Deoxyglucose alleviates migraine-related behaviors by modulating microglial inflammatory factors in experimental model of migraine

BackgroundTargeting metabolic pathways has emerged as a new migraine treatment strategy as researchers realize the critical role metabolism plays in migraine. Activated inflammatory cells undergo metabolic reprogramming and rely on glycolysis to function. The objective of this study was to investigate the glycolysis changes in the experimental model of migraine and the effect of glycolysis inhibitor 2-Deoxy-D-glucose (2-DG) in the pathophysiology of migraine.MethodsWe used a rat model of migraine that triggered migraine attacks by applying inflammatory soup (IS) to the dura and examined changes in glycolysis. 2-DG was used to inhibit glycolysis, and the effects of 2-DG on mechanical ectopic pain, microglial cell activation, calcitonin gene-related peptides (CGRP), c-Fos, and inflammatory factors induced by inflammatory soup were observed. LPS stimulated BV2 cells to establish a model in vitro to observe the effects of 2-DG on brain-derived neurotrophic factor (BDNF) after microglia activation.ResultsIn the experimental model of migraine, key enzymes involved in glycolysis such as phosphofructokinase platelet (PFKP), hexokinase (HK2), hypoxia inducible factor-1α (HIF-1α), lactate dehydrogenase (LDH) and pyruvate kinase (PKM2) were expressed in the medullary dorsal horn. While the expression of electronic respiratory transport chain complex IV (COXIV) decreased. There were no significant changes in glucose 6-phosphate dehydrogenase (G6PD), a key enzyme in the pentose phosphate pathway. The glycolysis inhibitor 2-DG alleviated migraine-like symptoms in an experimental model of migraine, reduced the release of proinflammatory cytokines caused by microglia activation, and decreased the expression of CGRP and c-Fos. Further experiments in vitro demonstrated that glycolysis inhibition can reduce the release of Iba-1/proBDNF/BDNF and inhibit the activation of microglia.ConclusionThe migraine rat model showed enhanced glycolysis. This study suggests that glycolytic inhibitor 2-DG is an effective strategy for alleviating migraine-like symptoms. Glycolysis inhibition may be a new target for migraine treatment

The Impact of Chronic Heat Stress on the Growth, Survival, Feeding, and Differential Gene Expression in the Sea Urchin Strongylocentrotus intermedius

To explore the impact of chronic heat stress on commercial echinoderms, the present study assessed the effects of chronic high temperature on the growth, survival, feeding, and differential gene expression in the sea urchin Strongylocentrotus intermedius cultured in northern Yellow Sea in China. One suitable seawater condition (20°C) and one laboratory-controlled high temperature condition (25°C) were set up. After 28 days incubation, our results showed that: (1) The specific growth, survival, and ingestion rates of S. intermedius reared under high temperature (25°C) decreased compared to those reared under optimal temperature (20°C) conditions; (2) comparative transcriptome analysis identified 2,125 differentially expressed genes (DEGs) in S. intermedius reared under high temperature (25°C) compared to those subjected to optimal temperature condition (20°C), which included 1,015 upregulated and 1,100 downregulated genes. The accuracy of the transcriptome profiles was verified by quantitative real-time PCR (qRT-PCR). Further Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analyses revealed that these DEGs mainly enriched the functional categories of ribosome, protein processing in endoplasmic reticulum, and prion diseases. A total of 732 temperature-induced expressed genes, such as ATP5, heat shock protein 70, and heat shock protein 90, were identified as candidates that were closely correlated with heat resistance in S. intermedius. Differentially expressed transcription factors (TFs), such as AP-1, Fos, CREB, and ZNF, were also identified as potential regulators that regulate the molecular network that was associated with responses to heat stress in sea urchins. Observations in the present study provide additional information that improves our understanding of the molecular mechanism of temperate echinoid species in response to heat stress, as well as theoretical basis for the molecular-assisted breeding of heat-resistant sea urchins

Research Progression of Extralevator Abdominoperineal Excision for Low Rectal Cancer

Abstract It has been reported that the conventional abdominoperineal excision has the disadvantages of higher rates of positive circumferential resection margin and intraoperative bowel perforation. Extralevator abdominoperineal excision (ELAPE) has become increasingly used because of some evidence of improved oncological outcome. The superiority of extralevator abdominoperineal excision (ELAPE) over conventional abdominoperineal excision (APE) remains controversial, despite the publication of many studies on this issue. The aim of this paper was to review the research progression of extralevator abdominoperineal excision for low rectal cancer

High-Throughput Measurement of the Contact Resistance of Metal Electrode Materials and Uncertainty Estimation

Low and stable contact resistance of metal electrode materials is mainly demanded for reliable and long lifetime electrical engineering. A novel test rig is developed in order to realize the high-throughput measurement of the contact resistance with the adjustable mechanical load force and load current. The contact potential drop is extracted accurately based on the proposed periodical current chopping (PCC) method in addition to the sliding window average filtering algorithm. The instrument is calibrated by standard resistors of 1 mΩ, 10 mΩ, and 100 mΩ with the accuracy of 0.01% and the associated measurement uncertainty is evaluated systematically. Furthermore, the contact resistance between standard indenter and rivet specimen is measured by the commercial DMM-based instruments and our designed test rig for comparison. The variations in relative expanded uncertainty of the measured contact resistance as a function of various mechanical load force and load current are presented

Modeling and Experimental Verification of Material Welding Characteristics for Low Current Switching Devices

Material welding failure considerably influences the electrical lifetime and reliability of low current switching devices. However, relevant studies on methods for calculating the threshold welding current and welding area under milli-Newton scale load forces are very limited. In this paper, the welding characteristics of metal material, including the threshold welding current, welding area and welding force are studied by using theoretical calculations and experiments. The comparison between the theoretical calculation and experimental results shows the accuracy of the built model. Further, the effects of mechanical load force and load current on welding force and welding area of representative metal materials are investigated. It is found that the anti-welding ability of metal materials depends not only on the exerted load force and current, but also the electrical resistivity, the thermal conductivity, the tensile strength, and the melting temperature of the materials