41,049 research outputs found
Low energy gamma ray emission from the Cygnus OB2 association
According to our newly developed model of gamma-ray emission from chaotic early-type stellar winds, we predict the combined gamma-ray flux from the circumstellar winds of many very luminous early-type stars in the Cyg OB2 association can be detectable by the Energetic Gamma Ray Experiment Telescope (EGRET) (and maybe also by OSSE) on CGRO. Due to different radiation mechanisms, the gamma-ray spectrum from stellar winds can be quite different from that of CYG X-3; this spectral difference and the time-variation of Cyg X-3 flux will help to distinguish the gamma-ray components from different sources in this small region, which is spatially unresolvable by CGRO
Extension of Martian orbits using continuous low-thrust propulsion
There has recently been significant interest in exploration of the Martian surface and atmosphere with a view to future human exploration. Thus missions must be developed which are responsive to these scientific goals. This work therefore develops novel orbits around Mars using continuous low-thrust propulsion to enable new and unique investigations of the red planet. This paper considers the use of continuous acceleration, using Solar Electric Propulsion, to alter the critical inclination of Highly Elliptical Orbits away from the conventional values, to any inclination required to optimally fulfill the mission objectives. This allows the spacecraft to spend a large amount of time over a region of interest as a result of apoareion dwell, thus allowing enhanced opportunities for remote sensing. In addition to this, the extension of existing circular Sun-synchronous orbits is considered as well as the development of Sun-synchronous Highly Elliptical Orbits, which force the ascending node angle to rotate at the same rate as the mean rotation of the Sun, whilst maintaining a constant argument of perihelion over the orbit. Thus, allowing simplification of the spacecraft thermal environment. Notably, we can enable these orbits using existing Electric Propulsion technology
Is the Kelvin Theorem Valid for High-Reynolds-Number Turbulence?
The Kelvin-Helmholtz theorem on conservation of circulations is supposed to
hold for ideal inviscid fluids and is believed to be play a crucial role in
turbulent phenomena, such as production of dissipation by vortex
line-stretching. However, this expectation does not take into account
singularities in turbulent velocity fields at infinite Reynolds number. We
present evidence from numerical simulations for the breakdown of the classical
Kelvin theorem in the three-dimensional turbulent energy cascade. Although
violated in individual realizations, we find that circulations are still
conserved in some average sense. For comparison, we show that Kelvin's theorem
holds for individual realizations in the two-dimensional enstrophy cascade, in
agreement with theory. The turbulent ``cascade of circulations'' is shown to be
a classical analogue of phase-slip due to quantized vortices in superfluids and
various applications in geophysics and astrophysics are outlined.Comment: 4 pages, 3 figure
Surface Spectral Function of Momentum-dependent Pairing Potentials in a Topological Insulator: Application to CuBiSe
We propose three possible momentum-dependent pairing potentials for candidate
of topological superconductor (for example CuBiSe), and calculate
the surface spectral function and surface density of state with these pairing
potentials. We find that the first two can give the same spectral functions as
the fully-gapped and node-contacted pairing potentials given in [Phys. Rev.
Lett. 105, 097001], and that the third one can obtain topological non-trivial
case which exists flat Andreev bound state and preserves the rotation
symmetry. We hope our proposals and results be judged by future experiment.Comment: 5 pages, 3 figure
Nonlinear ER effects in an ac applied field
The electric field used in most electrorheological (ER) experiments is
usually quite high, and nonlinear ER effects have been theoretically predicted
and experimentally measured recently. A direct method of measuring the
nonlinear ER effects is to examine the frequency dependence of the same
effects. For a sinusoidal applied field, we calculate the ac response which
generally includes higher harmonics. In is work, we develop a multiple image
formula, and calculate the total dipole moments of a pair of dielectric
spheres, embedded in a nonlinear host. The higher harmonics due to the
nonlinearity are calculated systematically.Comment: Presented at Conference on Computational Physics (CCP2000), held at
Gold Coast, Australia from 3-8, December 200
Repeating platinum/bevacizumab in recurrent or progressive cervical cancer yields marginal survival benefits
Our objective was to assess overall survival of cervical cancer patients following prior platinum/bevacizumab chemotherapy, comparing retreatment with platinum/bevacizumab with alternative therapies.
A retrospective analysis was performed of women who received platinum/bevacizumab (PB) chemotherapy for cervical cancer at Washington University between July 1, 2005 and December 31, 2015. Wilcoxon rank-sum exact test and Fisher's exact test were used to compare the treatment groups, and Kaplan Meier curves were generated. Cox regression analyses were performed, with treatment free interval and prior therapy response included as covariates.
Of 84 patients who received PB chemotherapy, 59 (70%) received no second line chemotherapy, as they did not recur, progressed without further chemotherapy, were lost to follow up, or expired. Of the remaining 25 patients, 9 were retreated with the combination of platinum/bevacizumab (PB), 6 were retreated with a platinum regimen without bevacizumab (P), and 10 were retreated with neither (not-P). The only long-term survivor was in the not-P group and was treated with an immunotherapy agent. Median overall survival of all patients was 7.1 months. There was a marginal difference in survival between women in the PB and not-PB groups (11.8 versus 5.7 months; HR 3.02, 95% CI, 0.98–9.28). There was no difference in survival based on platinum interval (HR 0.81; 95% CI, 0.27–2.45).
Outcomes are grim for women retreated after platinum/bevacizumab therapy and are only marginally improved by retreatment with a platinum/bevacizumab regimen. Rather than additional PB therapy, women with cervical cancer who recur after platinum/bevacizumab should consider supportive care or clinical trials
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