Pharmacological properties, therapeutic efficacy and safety of use of ustekinumab in immune-mediated inflammatory diseases

Ustekinumab is a fully human monoclonal antibody, generated via molecular engineering from transgenic mice, genetically modified so they cannot produce murine antibodies, but only human antibodies. Ustekinumab binds in a selective manner to the p40 subunit which contributes to the structure of both IL-12 (p35/p40) and IL-23 (p19/p40), which play a key role in the pathogenesis of immune-mediated inflammatory diseases (IMIDs)

Testing the division of household labor as an intervention target and driver of mental and physical health

This study will explore an intervention targeting the division of household labor in a sample of parents with a child born during the first wave of the COVID-19 pandemic (between March and December 2020). The study will investigate 1) the impact of an inequitable division of household labor on parents’ mental and physical health, and 2) the effectiveness of a digital intervention targeting household labor on reducing the household inequities and improving parental outcomes. The digital intervention aims to teach couples how to share the domestic workload more equally through a mix of one-on-one coaching, virtual coursework, and a deck of cards. Each card represents a domestic labor or childcare task. The cards will be used both as part of the digital intervention, as well as part of our study’s battery. We will ask participants to rate the degree to which they are responsible for the “planning” or cognitive labor of each card, as well as the degree to which they are responsible for the “execution” or instrumental elements of each card. For example, an individual may indicate that they are wholly responsible for the “planning” aspects of grocery shopping (e.g., taking stock of pantry items, planning meals for the week, and making a grocery list), but they split the “execution” aspects of grocery shopping (e.g., going to the store) with their partner. Our study aims fall into two categories: in the first, we will analyze the cross-sectional and longitudinal impacts of “holding” more cards on parents’ mental and physical health. In the second, we will analyze the effect of the digital intervention on parents’ division of labor, and especially cognitive labor, and any associated improvement to mental and physical health, as well as romantic relationship functioning

Artificial Reef Deployment Reduces Diving Pressure from Natural Reefs—The Case of Introductory Dives in Eilat, Red Sea

Artificial reefs have been suggested as alternative dive sites to mitigate human pressure on natural reefs. Despite the conceptual appeal of artificial reefs, there is a paucity of empirical evidence regarding their effectiveness in achieving this objective. Here, we report that a small artificial reef deployed adjacent to a local coral marine protected area caused a shift in the routes taken by introductory dives and nearly eliminated their visitations to the natural fringing reef within the MPA. This behavioral shift among divers persisted for more than a decade following the AR deployment. These findings underscore the efficacy of well-designed and appropriately located artificial reefs as valuable instruments in the conservation of coral reefs

Emotion Regulation Strategies and Beliefs About Emotions Predict Psychosocial Outcomes in Response to Multiple Stressors.

UNLABELLED: Emotion regulation (ER) strategies and beliefs about emotions (implicit theories of emotions; ITE) may shape psychosocial outcomes during turbulent times, including the transition to adulthood and college while encountering stressors. The normative stressors associated with these transitions were compounded by the COVID-19 pandemic, providing a novel opportunity to examine how emerging adults (EAs) cope with sustained stressors. Stress exposures can heighten existing individual differences and serve as turning points that predict psychosocial trajectories. This pre-registered study (https://osf.io/k8mes) of 101 EAs (18-19 years old) examined whether ITE (believing emotions can change or not; incremental vs. entity beliefs) and ER strategy usage (cognitive reappraisal and expressive suppression usage) predicted changes in anxiety symptomatology and feelings of loneliness across five longitudinal assessments (across a 6-month period) before and during the initial months of the COVID-19 pandemic. On average, EAs anxiety decreased after the pandemic outbreak but returned to baseline over time, while loneliness remained relatively unchanged across time. ITE explained variance in anxiety across time over and above reappraisal use. Conversely, reappraisal use explained variance in loneliness over and above ITE. For both anxiety and loneliness, suppression use resulted in maladaptive psychosocial outcomes across time. Thus, interventions that target ER strategies and ITE may ameliorate risk and promote resilience in EAs who experience increased instability. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s42761-023-00187-0