A Distributed Approach for Networked Flying Platform Association with Small Cells in 5G+ Networks

The densification of small-cell base stations in a 5G architecture is a promising approach to enhance the coverage area and facilitate the ever increasing capacity demand of end users. However, the bottleneck is an intelligent management of a backhaul/fronthaul network for these small-cell base stations. This involves efficient association and placement of the backhaul hubs that connects these small-cells with the core network. Terrestrial hubs suffer from an inefficient non line of sight link limitations and unavailability of a proper infrastructure in an urban area. Seeing the popularity of flying platforms, we employ here an idea of using networked flying platform (NFP) such as unmanned aerial vehicles (UAVs), drones, unmanned balloons flying at different altitudes, as aerial backhaul hubs. The association problem of these NFP-hubs and small-cell base stations is formulated considering backhaul link and NFP related limitations such as maximum number of supported links and bandwidth. Then, this paper presents an efficient and distributed solution of the designed problem, which performs a greedy search in order to maximize the sum rate of the overall network. A favorable performance is observed via a numerical comparison of our proposed method with optimal exhaustive search algorithm in terms of sum rate and run-time speed.Comment: Submitted to IEEE GLOBECOM 2017, 7 pages and 4 figure

In silico investigation of the mechanism of action of kojic acid effects via protein-protein interaction network

Purpose: To evaluate the molecular mechanism of kojic acid by network pharmacology.Methods: This study was conducted by designing a protein-protein interaction network through the STITCH database and analyzing biological processes via Cytoscape plugin ClueGO.Results: A total of 19 protein targets of kojic acid including TYR, NOS3, NOS2, and NOS1 were found. The PPI network helped to understand the mode of action of kojic acid at a molecular level. Gene Ontology (GO) analysis resulted in the retrieval of 104 GO terms which were related to variousphysiological processes. GO analysis revealed that kojic acid might be involved in the regulation of several biological processes such as circadian gene expression and transcription initiation of RNA polymerase 2.Conclusion: The findings from this study reveal that the retrieved GO pathways are known to be involved in several diseases such as inflammation, cancer, aging, pigmentation, and melisma. Furthermore, these pathways are directly or indirectly related to kojic acid. Thus, this study has contributed to a better understanding of the mode of action of kojic acid

A Case Of Diphenhydramine With Alcohol Induced Rhabdomyolysis

ABSTRACT Rhabdomyolysis is muscle necrosis and the release of intracellular muscle components into circulation. Approximately 26,000 cases of rhabdomyolysis are reported annually in the United States. The severity varies greatly from asymptomatic individuals to individuals with life-threatening muscle enzyme elevations along with severe electrolyte abnormalities, acute other organ damage, and compartment syndrome. The mortality rates are as high as 59% in critically ill patients. There are multiple causes of rhabdomyolysis that can be classified as traumatic or non-traumatic. The traumatic cases are usually evident at presentation however, in a non-traumatic setting, the presentation may be misleading. In this specific case report, we discuss a case of rhabdomyolysis with shock liver and acute kidney injury in a 23-year-old male that presented with complaints of back pain and blood in his urine following the recreational use of alcohol and diphenhydramine. Given the frequent use and easy accessibility of both alcohol and diphenhydramine (DPH), it is crucial to be aware of the potential risk of rhabdomyolysis as early recognition and treatment can prevent life-threatening complications

The budding and depth of invasion model in oral cancer : A systematic review and meta-analysis

Background Tumour budding (B) and depth of invasion (D) have both been reported as promising prognostic markers in oral squamous cell carcinoma (OSCC). This meta-analysis assessed the prognostic value of the tumour budding and depth of invasion combination (BD model) in OSCC. Methods Databases including Ovid MEDLINE, PubMed, Scopus and Web of Science were searched for articles that studied the BD model as a prognosticator in OSCC. PICO search strategy was "In OSCC patients, does BD model have a prognostic power?" We used the reporting recommendations for tumour marker prognostic studies (REMARK) criteria to evaluate the quality of studies eligible for systematic review and meta-analysis. Results Nine studies were relevant as they analysed the BD model for prognostication of OSCC. These studies used either haematoxylin and eosin (HE) or pan-cytokeratin (PCK)-stained resected sections of OSCC. Our meta-analysis showed a significant association of BD model with OSCC disease-free survival (hazard ratio = 2.02; 95% confidence interval = 1.44-2.85). Conclusions The BD model is a simple and reliable prognostic indicator for OSCC. Evaluation of the BD model from HE- or PCK-stained sections could facilitate individualized treatment planning for OSCC patients.Peer reviewe

Impact of Astroprincin (FAM171A1) Expression in Oral Tongue Cancer

Astroprincin (APCN, FAM171A1) is a recently characterized transmembrane glycoprotein that is abundant in brain astrocytes and is overexpressed in some tumors. However, the expression and role of APCN is unknown in oral tongue squamous cell carcinoma (OTSCC). Aim of this study was to investigate the expression of APCN in OTSCC tissue samples and to analyze possible association of APCN with clinicopathological features and survival rates. This study included 76 patients treated for OTSCC. Expression of APCN in OTSCC tissue sections was examined by immunohistochemistry with a rabbit polyclonal antibody (MAP346) against APCN. All tumors were scored for intensity and percentage of APCN staining at the superficial, middle, and invasive front areas. High expression of APCN was significantly associated with increased tumor size (P = 0.013) and with OTSCC recurrence (P = 0.026). In this pilot study, we observed that the amount of APCN is associated with the size and recurrence of OTSCC. This finding suggests a role of APCN during OTSCC progression.Peer reviewe

Chemical constituents, and pharmacological and toxicological effects of Cynomorium songaricum: An overview

Purpose: To review the chemical constituents, and the pharmacological and toxicological effects of Cynomorium songaricum (C. songaricum) and explore its potentials for further development as an alternative medicine.Methods: A large number of research articles related to “Cynomorium songaricum” “pharmacological effects”, “toxicological effects” and “chemical composition” in English and Chinese language were retrieved through an extensive literature review using various electronic databases including Medline(1966 - 2017) and EMBASE (1980 - 2017).Results: Ethyl acetate and aqueous extracts of C. songaricum have promising pharmacological activities, due to the presence of various flavonoids, triterpenes and polysaccharides. In addition to promising effects against inflammation, aging, fatigue, viruses and cancer,/ihas a protective effect on the nervous system and regulates hormones and immune functions. Oxidative regulation of hormone levels has a certain correlation with its pharmacological activities, e.g., cognitive functions, but its mechanism is not yet known, indicating the need for further research. Toxicity studies on C. songaricum have shown that it is not genotoxic to animals, but further toxicological studies are required to ascertain its safety in clinical use.Conclusion: C. songaricum is a biologically important plant which has many proven bioactivities; however, it requires further studies to determine the mechanistic aspects of its pharmacological effects.Keywords: Cynomorium, Chemical constituents, Inflammation, Aging, Fatigue, Virus, Tumor, Toxicological effec

Functional Echocardiography (FNECHO): Experience in NICU of A Tertiary Care Hospital

Objective: To describe the observational findings of functional echocardiography (FnEcho) in neonatal intensive care unit of a tertiary care hospital by evaluating its frequency of use, characteristics of patients and distribution of heart diseases. Methodology: This Prospective descriptive observational study was done in a tertiary neonatal intensive care unit (NICU) in Rawalpindi, from July 2017 to June 2018. A total of two hundred and twelve neonates admitted to the NICU undergoing echocardiographic assessment were included in the study. Qualitative variables like gender, mode of delivery, and diagnostic findings were represented in terms of frequency and percentages. Quantitative data like age, birth weight and gestational age were highlighted as mean and standard deviation. Results: Out of a total of 212 neonates, 111 (52.4%) were male. The mode of delivery was noted to be lower segment cesarean section among 126 (60.0%) neonates. The mean gestational age was found to be 36.47+2.3 weeks, ranging from 28 to 41 weeks, whereas the mean birth weight was 2.56+0.68 kg, ranging from 1.1 to 4.2 kg. A total of 75 neonates were found to have functional heart disease in the form of pulmonary hypertension 37 (17.4%), hemodynamically significant patent ductus arteriosus 24(11.3%), hypoxic ischemic cardiomyopathy 4(1.9%), and systemic hypotension 10 (17.4%). Conclusion: FnEcho was found to be an effective tool for identifying different kinds of functional and structural heart defects. VSD was found to be the most common type of congenital heart disease, followed by PDA. Timely intervention in PPHN was also rewarding with good outcome

Impact of Astroprincin (FAM171A1) Expression in Oral Tongue Cancer

Astroprincin (APCN, FAM171A1) is a recently characterized transmembrane glycoprotein that is abundant in brain astrocytes and is overexpressed in some tumors. However, the expression and role of APCN is unknown in oral tongue squamous cell carcinoma (OTSCC). Aim of this study was to investigate the expression of APCN in OTSCC tissue samples and to analyze possible association of APCN with clinicopathological features and survival rates. This study included 76 patients treated for OTSCC. Expression of APCN in OTSCC tissue sections was examined by immunohistochemistry with a rabbit polyclonal antibody (MAP346) against APCN. All tumors were scored for intensity and percentage of APCN staining at the superficial, middle, and invasive front areas. High expression of APCN was significantly associated with increased tumor size (P = 0.013) and with OTSCC recurrence (P = 0.026). In this pilot study, we observed that the amount of APCN is associated with the size and recurrence of OTSCC. This finding suggests a role of APCN during OTSCC progression

Emerging histopathologic markers in early-stage oral tongue cancer : A systematic review and meta-analysis

Although there are many histopathologic prognosticators, grading of early oral tongue squamous cell carcinoma (OTSCC) is still based on morphological cell differentiation which has low prognostic value. Here we summarize the emerging histopathological markers showing powerful prognostic value, but are not included in pathology reports. Using PubMed, Scopus, Ovid Medline, and Web of Science databases, a systematic literature search was preformed to identify early OTSCC studies that investigated the prognostic significance of hematoxylin-eosin-based histopathologic markers. Our meta-analysis showed that tumor budding was associated with overall survival (hazard ratio [HR] 2.32; 95% CI 1.40-3.84; p < 0.01) and disease-specific survival (DSS) (1.89; 95% CI 1.13-3.15; p = 0.02). Worst pattern of invasion was associated with disease-free survival (DFS) (1.95; 95% CI 1.04-3.64; p = 0.04). Tumor-stroma ratio was also associated with DFS (1.75, 95% CI 1.24-2.48; p < 0.01) and DSS (1.69; 95% CI 1.19-2.42; p < 0.01). Tumor budding, worst pattern of invasion, and tumor-stroma ratio have a promising prognostic value in early OTSCC. The evaluation and reporting of these markers is cost-effective and can be incorporated in daily practice.Peer reviewe