Evidence of epistasis between Interleukin-1 and Selenoprotein-S with susceptibility to rheumatoid arthritis

Objective: Selenoprotein-S (SELS) is involved in the stress response within the endoplasmic reticulum (ER) and inflammation. Recently, promoter variants in the SELS gene were shown to be associated with plasma levels of interleukin (IL)6, IL1β and tumour necrosis factor (TNF). It was hypothesised that these variants could influence rheumatoid arthritis (RA) susceptibility and may interact with functional single nucleotide polymorphisms (SNPs) in the genes for IL1, IL6 and TNF. Methods: Genotyping was performed in 988 unrelated healthy controls and 965 patients with RA. Stratified analysis was used to test for interactions. Single gene effects and evidence of epistasis were investigated using the Mantel–Haenszel (M–H) test and the linkage disequilibrium (LD)-based statistic. Results: No association of SELS −105 genotype and RA susceptibility was detected. Stratification of SELS −105 genotypes by IL1 −511 genotypes showed that the disease risk (comparing AA/GA to GG at the SELS −105 locus) in individuals with the GG/AG genotype at the IL1β −511 locus was significantly lower than that in individuals having the AA genotype at the IL1β −511 locus (odds ratio (OR): 0.9 and 2.3, respectively; p = 0.004 by M–H test). Significant epistasis was also detected using the LD-based statistic (p = <0.001). No interaction was observed between SELS −105 and IL6 or TNF variants. Conclusion: Our results reveal evidence of strong epistasis in two genes in the IL1 production pathway and highlight the potential importance of gene–gene interactions in the pathogenesis of RA

Group algebras and enveloping algebras with nonmatrix and semigroup identities

Let K be a field of positive characteristic p, let R be either a group algebra K[G] or a restricted enveloping algebra u(L), and let I be the augmentation ideal of R. We first characterize those R for which I satisfies a polynomial identity not satisfied by the algebra of all 2-by-2 matrices over K. Then we examine those R for which I satisfies a semigroup identity (that is, a polynomial identity which can be written as the difference of two monomials).Comment: 11 pages. Written in LaTeX2

Parameters of the attenuated schistosome vaccine evaluated in the olive baboon

Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response

A developmental cascade model for early adolescent onset substance use: The role of early childhood stress

Contains fulltext : 199688.pdf (publisher's version ) (Open Access)Backgrounds and aims: Despite the link between stress and addictive behavior in adulthood, little is known about how early life stress in families predicts the early emergence of substance use in adolescence. This study tested a developmental cascade model, proposing that early stressful life events and negative parent-child interaction covary, and both disrupt the refinement of inhibitory control, which evolves into problem behavior in middle/late childhood and subsequent substance use exploration in early adolescence. Methods: Data came from the Early Steps Multisite study, a community sample of at-risk families in the metropolitan US areas of Pittsburgh (Pennsylvania), Eugene (Oregon), and Charlottesville (Virginia) with children aged 2 at the start of the study and 14 at the last measurement (N = 364). Structural equation modeling was used to test the proposed model. Results: Early stressful life events and negative parent-child interaction assessed at ages 2 to 5 were negatively related to inhibitory control at ages 7 and 8. Low levels of inhibitory control were prognostic of childhood problem behavior at ages 9 and 10. Finally, late childhood problem behavior was associated with substance use at age 14. Parental drug use was directly related to substance use at age 14. Conclusions: Early life stress may disrupt child inhibitory control, which can cascade into behavioral and peer problem behavior in childhood and, in turn, heighten the risk for early adolescent substance use.9 p

The Anderson-Mott Transition as a Random-Field Problem

The Anderson-Mott transition of disordered interacting electrons is shown to share many physical and technical features with classical random-field systems. A renormalization group study of an order parameter field theory for the Anderson-Mott transition shows that random-field terms appear at one-loop order. They lead to an upper critical dimension $d_{c}^{+}=6$ for this model. For $d>6$ the critical behavior is mean-field like. For $d<6$ an $\epsilon$-expansion yields exponents that coincide with those for the random-field Ising model. Implications of these results are discussed.Comment: 8pp, REVTeX, db/94/

Current-density functional for disordered systems

The effective action for the current and density is shown to satisfy an evolution equation, the functional generalization of Callan-Symanzik equation. The solution describes the dependence of the one-particle irreducible vertex functions on the strength of the quenched disorder and the annealed Coulomb interaction. The result is non-perturbative, no small parameter is assumed. The a.c. conductivity is obtained by the numerical solution of the evolution equation on finite lattices in the absence of the Coulomb interaction. The static limit is performed and the conductivity is found to be vanishing beyond a certain threshold of the impurity strength.Comment: final version, 28 pages, 17 figures, to appear in Phys. Rev.

Robust metastable skyrmions with tunable size in the chiral magnet FePtMo3 N

The synthesis of new materials that can host magnetic skyrmions and their thorough experimental and theoretical characterization are essential for future technological applications. The β-Mn-type compound FePtMo3N is one such novel material that belongs to the chiral space group P4132, where the antisymmetric Dzyaloshinskii-Moriya interaction is allowed due to the absence of inversion symmetry. We report the results of small-angle neutron scattering (SANS) measurements of FePtMo3N and demonstrate that its magnetic ground state is a long-period spin helix with a Curie temperature of 222 K. The magnetic field-induced redistribution of the SANS intensity showed that the helical structure transforms to a lattice of skyrmions at ∼13 mT at temperatures just below TC. Our key observation is that the skyrmion state in FePtMo3N is robust against field cooling down to the lowest temperatures. Moreover, once the metastable state is prepared by field cooling, the skyrmion lattice exists even in zero field. Furthermore, we show that the skyrmion size in FePtMo3N exhibits high sensitivity to the sample temperature and can be continuously tuned between 120 and 210 nm. This offers different prospects in the control of topological properties of chiral magnets. © 2020 authors. Published by the American Physical Society

Order Parameter Description of the Anderson-Mott Transition

An order parameter description of the Anderson-Mott transition (AMT) is given. We first derive an order parameter field theory for the AMT, and then present a mean-field solution. It is shown that the mean-field critical exponents are exact above the upper critical dimension. Renormalization group methods are then used to show that a random-field like term is generated under renormalization. This leads to similarities between the AMT and random-field magnets, and to an upper critical dimension $d_{c}^{+}=6$ for the AMT. For $d<6$, an $\epsilon = 6-d$ expansion is used to calculate the critical exponents. To first order in $\epsilon$ they are found to coincide with the exponents for the random-field Ising model. We then discuss a general scaling theory for the AMT. Some well established scaling relations, such as Wegner's scaling law, are found to be modified due to random-field effects. New experiments are proposed to test for random-field aspects of the AMT.Comment: 28pp., REVTeX, no figure

Spin glass transition in a magnetic field: a renormalization group study

We study the transition of short range Ising spin glasses in a magnetic field, within a general replica symmetric field theory, which contains three masses and eight cubic couplings, that is defined in terms of the fields representing the replicon, anomalous and longitudinal modes. We discuss the symmetry of the theory in the limit of replica number n to 0, and consider the regular case where the longitudinal and anomalous masses remain degenerate. The spin glass transitions in zero and non-zero field are analyzed in a common framework. The mean field treatment shows the usual results, that is a transition in zero field, where all the modes become critical, and a transition in non-zero field, at the de Almeida-Thouless (AT) line, with only the replicon mode critical. Renormalization group methods are used to study the critical behavior, to order epsilon = 6-d. In the general theory we find a stable fixed-point associated to the spin glass transition in zero field. This fixed-point becomes unstable in the presence of a small magnetic field, and we calculate crossover exponents, which we relate to zero-field critical exponents. In a finite magnetic field, we find no physical stable fixed-point to describe the AT transition, in agreement with previous results of other authors.Comment: 36 pages with 4 tables. To be published in Phys. Rev.

Ground state non-universality in the random field Ising model

Two attractive and often used ideas, namely universality and the concept of a zero temperature fixed point, are violated in the infinite-range random-field Ising model. In the ground state we show that the exponents can depend continuously on the disorder and so are non-universal. However, we also show that at finite temperature the thermal order parameter exponent one half is restored so that temperature is a relevant variable. The broader implications of these results are discussed.Comment: 4 pages 2 figures, corrected prefactors caused by a missing factor of two in Eq. 2., added a paragraph in conclusions for clarit