193 research outputs found
Державна грошова допомога як одна із форм соціального захисту дітей-сиріт та дітей, позбавлених батьківського піклування
В статті аналізуються види державної грошової допомоги, які передбачені чинним законодавством України щодо дітей-сиріт та дітей, позбавлених батьківського піклування, а також осіб з їх числа. Сформульовані пропозиції по удосконаленню законодавства про державну соціальну допомогу, застосуванню нових підходів у забезпеченні такою допомогою зазначених осіб.В статье анализируются виды государственной денежной помощи, предусмотренные действующим законодательством Украины по отношению к детям-сиротам и детям, лишенным родительского попечения, а также лицам из их числа. Сформулированы предложения по усовершенствованию законодательства о государственной социальной помощи, применению новых подходов в обеспечении такой помощью вышеуказанных лиц.The article is devoted to the analysis of types of the state monetary (financial) aid, foreseen by the current Ukrainian legislation for children-orphans and children who lost the parental care, as well as persons with the same status. The elaborated proposals on improvement of the legislation concerning the state social aid, as well as introducing new approaches of its granting to the mentioned persons
Stable Noncrossing Matchings
Given a set of men represented by points lying on a line, and
women represented by points lying on another parallel line, with each
person having a list that ranks some people of opposite gender as his/her
acceptable partners in strict order of preference. In this problem, we want to
match people of opposite genders to satisfy people's preferences as well as
making the edges not crossing one another geometrically. A noncrossing blocking
pair w.r.t. a matching is a pair of a man and a woman such that
they are not matched with each other but prefer each other to their own
partners in , and the segment does not cross any edge in . A
weakly stable noncrossing matching (WSNM) is a noncrossing matching that does
not admit any noncrossing blocking pair. In this paper, we prove the existence
of a WSNM in any instance by developing an algorithm to find one in a
given instance.Comment: This paper has appeared at IWOCA 201
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Nonlinear formation of holographic images of obscurations in laser beams
Computer models are used to simulate the nonlinear formation of images of obscurations in laser beams. The predictions of the model are found to be in good agreement with measurements conducted in the nonlinear regime corresponding to a typical solid-state laser operation. In this regime, peak-to-mean fluence ratios large enough to induce damage in optical components are observed. The amplitude of the images and their location along the propagation axis are accurately predicted by the simulations. This indicates that the model is a reliable design tool for specifying component staging and optical specifications to avoid optical damage by this mechanism
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Recent performance results of the National Ignition Facility Beamlet demonstration project
The laser driver for the National Ignition Facility will be a departure from previous inertial confinement fusion laser architecture of a master oscillator single pass power amplifier (MOPA) design. The laser will use multi-segment Nd:Glass amplifiers in a multipass cavity arrangement, which can be assembled into compact and cost effective arrays to deliver the required multi- megajoule energy to target. A single beam physics prototype, the Beamlet, has been in operation for over two years and has demonstrated the feasibility of this architecture. We present a short review of Beamlet`s performance and limitations based on beam quality both at its fundamental and frequency converted wavelengths of 1.053 and 0.351 {mu}m
Improved Performance of High Areal Density Indirect Drive Implosions at the National Ignition Facility using a Four-Shock Adiabat Shaped Drive
Hydrodynamic instabilities can cause capsule defects and other perturbations to grow and degrade implosion performance in ignition experiments at the National Ignition Facility (NIF). Here, we show the first experimental demonstration that a strong unsupported first shock in indirect drive implosions at the NIF reduces ablation front instability growth leading to a 3 to 10 times higher yield with fuel ρR > 1 g/cm[superscript 2]. This work shows the importance of ablation front instability growth during the National Ignition Campaign and may provide a path to improved performance at the high compression necessary for ignition
Measurement of w-InN/h-BN Heterojunction Band Offsets by X-Ray Photoemission Spectroscopy
X-ray photoelectron spectroscopy has been used to measure the valence band offset (VBO) of the w-InN/h-BN heterojunction. We find that it is a type-II heterojunction with the VBO being −0.30 ± 0.09 eV and the corresponding conduction band offset (CBO) being 4.99 ± 0.09 eV. The accurate determination of VBO and CBO is important for designing the w-InN/h-BN-based electronic devices
Sensing of Fatty Acids for Octanoylation of Ghrelin Involves a Gustatory G-Protein
Ghrelin is an important regulator of energy--and glucose homeostasis. The octanoylation at Ser(3) is essential for ghrelin's biological effects but the mechanisms involved in the octanoylation are unknown. We investigated whether the gustatory G-protein, α-gustducin, and the free fatty acid receptors GPR40 and GPR120 are involved in the fatty acid sensing mechanisms of the ghrelin cell.Wild-type (WT) and α-gustducin knockout (gust(-/-)) mice were fed a glyceryl trioctanoate-enriched diet (OD) during 2 weeks. Ghrelin levels and gastric emptying were determined. Co-localization between GPR40, GPR120 and ghrelin or α-gustducin/α-transducin was investigated by immunofluorescence staining. The role of GPR120 in the effect of medium and long chain fatty acids on the release of ghrelin was studied in the ghrelinoma cell line, MGN3-1. The effect of the GPR40 agonist, MEDICA16, and the GPR120 agonist, grifolic acid, on ghrelin release was studied both in vitro and in vivo.Feeding an OD specifically increased octanoyl ghrelin levels in the stomach of WT mice but not of gust(-/-) mice. Gastric emptying was accelerated in WT but not in gust(-/-) mice. GPR40 was colocalized with desoctanoyl but not with octanoyl ghrelin, α-gustducin or α-transducin positive cells in the stomach. GPR120 only colocalized with ghrelin in the duodenum. Addition of octanoic acid or α-linolenic acid to MGN3-1 cells increased and decreased octanoyl ghrelin levels, respectively. Both effects could not be blocked by GPR120 siRNA. MEDICA16 and grifolic acid did not affect ghrelin secretion in vitro but oral administration of grifolic acid increased plasma ghrelin levels.This study provides the first evidence that α-gustducin is involved in the octanoylation of ghrelin and shows that the ghrelin cell can sense long- and medium-chain fatty acids directly. GPR120 but not GPR40 may play a role in the lipid sensing cascade of the ghrelin cell
In Situ Observations during Chemical Vapor Deposition of Hexagonal Boron Nitride on Polycrystalline Copper.
Using a combination of complementary in situ X-ray photoelectron spectroscopy and X-ray diffraction, we study the fundamental mechanisms underlying the chemical vapor deposition (CVD) of hexagonal boron nitride (h-BN) on polycrystalline Cu. The nucleation and growth of h-BN layers is found to occur isothermally, i.e., at constant elevated temperature, on the Cu surface during exposure to borazine. A Cu lattice expansion during borazine exposure and B precipitation from Cu upon cooling highlight that B is incorporated into the Cu bulk, i.e., that growth is not just surface-mediated. On this basis we suggest that B is taken up in the Cu catalyst while N is not (by relative amounts), indicating element-specific feeding mechanisms including the bulk of the catalyst. We further show that oxygen intercalation readily occurs under as-grown h-BN during ambient air exposure, as is common in further processing, and that this negatively affects the stability of h-BN on the catalyst. For extended air exposure Cu oxidation is observed, and upon re-heating in vacuum an oxygen-mediated disintegration of the h-BN film via volatile boron oxides occurs. Importantly, this disintegration is catalyst mediated, i.e., occurs at the catalyst/h-BN interface and depends on the level of oxygen fed to this interface. In turn, however, deliberate feeding of oxygen during h-BN deposition can positively affect control over film morphology. We discuss the implications of these observations in the context of corrosion protection and relate them to challenges in process integration and heterostructure CVD.P.R.K. acknowledges funding from the Cambridge Commonwealth Trust and the Lindemann
Trust Fellowship. R.S.W. acknowledges a research fellowship from St. John’s College,
Cambridge. S.H. acknowledges funding from ERC grant InsituNANO (no. 279342), EPSRC
under grant GRAPHTED (project reference EP/K016636/1), Grant EP/H047565/1 and EU FP7
Work Programme under grant GRAFOL (project reference 285275). The European Synchrotron
Radiation Facility (ESRF) is acknowledged for provision of synchrotron radiation and assistance
in using beamline BM20/ROBL. We acknowledge Helmholtz-Zentrum-Berlin Electron storage
ring BESSY II for synchrotron radiation at the ISISS beamline and continuous support of our
experiments.This is the final version. It was first published by ACS at http://pubs.acs.org/doi/abs/10.1021/cm502603
Cross-Species Comparison of Genes Related to Nutrient Sensing Mechanisms Expressed along the Intestine
Introduction Intestinal chemosensory receptors and transporters are able to detect food-derived molecules and are involved in the modulation of gut hormone release. Gut hormones play an important role in the regulation of food intake and the control of gastrointestinal functioning. This mechanism is often referred to as “nutrient sensing”. Knowledge of the distribution of chemosensors along the intestinal tract is important to gain insight in nutrient detection and sensing, both pivotal processes for the regulation of food intake. However, most knowledge is derived from rodents, whereas studies in man and pig are limited, and cross-species comparisons are lacking. Aim To characterize and compare intestinal expression patterns of genes related to nutrient sensing in mice, pigs and humans. Methods Mucosal biopsy samples taken at six locations in human intestine (n = 40) were analyzed by qPCR. Intestinal scrapings from 14 locations in pigs (n = 6) and from 10 locations in mice (n = 4) were analyzed by qPCR and microarray, respectively. The gene expression of glucagon, cholecystokinin, peptide YY, glucagon-like peptide-1 receptor, taste receptor T1R3, sodium/glucose cotransporter, peptide transporter-1, GPR120, taste receptor T1R1, GPR119 and GPR93 was investigated. Partial least squares (PLS) modeling was used to compare the intestinal expression pattern between the three species. Results and conclusion The studied genes were found to display specific expression patterns along the intestinal tract. PLS analysis showed a high similarity between human, pig and mouse in the expression of genes related to nutrient sensing in the distal ileum, and between human and pig in the colon. The gene expression pattern was most deviating between the species in the proximal intestine. Our results give new insights in interspecies similarities and provide new leads for translational research and models aiming to modulate food intake processes in man
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