Deriving time discounting correction factors for TTO tariffs

The Time Tradeoff (TTO) method is a popular method for valuing health state utilities and is frequently used in economic evaluations. However, this method produces utilities that are distorted by several biases. One important bias entails the failure to incorporate time discounting. This paper aims to measure time discounting for health outcomes in a sample representative for the general population. In particular, we estimate TTO scores alongside time discounting in order to derive a set of correction factors that can be employed to correct raw TTO scores for the downward bias caused by time discounting. We find substantial positive correction factors, which are increasing with the severity of the health state. Furthermore, higher discounting is found when using more severe health states in the discounting elicitation task. More research is needed to further develop discount rate elicitation procedures and test their validity, especially in general public samples. Moreover, future research should investigate the correction of TTO score for other biases as well, such as loss aversion, and to develop a criterion to test the external validity of TTO scores.Discounting; QALY model; Time Tradeoff; Utility Measurement

In search of a preferred preference elicitation method: A test of the internal consistency of choice and matching tasks

The numerous reports on preference reversals in preference elicitations pose a great challenge to empirical economics. Many studies have found that different procedures may generate substantially different preferences. However, little is known about whether one procedure is more susceptible to preference reversals than another. Therefore, taking the preference reversals as a robust behavioral pattern, guidelines are called for to provide directions regarding a preferred preference elicitation task. This paper puts forward a new test of the internal consistency of choice and matching tasks, based on “internal preference reversals”. We replicate the preference reversal phenomenon and find a significant higher consistency within choice tasks than within matching tasks.preference reversal; internal consistency; scale compatibility; loss aversion; choice; matching

Asymptotics of class numbers

A "simple trace formula" is used to derive an asymptotic result for class numbers of complex cubic orders.Comment: 37 page

Constantly Proving The Opposite? A test of CPTO using a broad time horizon and correcting for discounting

Purpose: An important assumption underlying the quality-adjusted life year (QALY) model is that people trade off life years against health in the same proportion irrespective of the number of remaining life years. This is known as the constant proportional trade-offs (CPTO) condition. Previous studies have produced mixed empirical evidence about the validity of CPTO. This paper is the first to test CPTO using the time trade-off (TTO) method for a broad time horizon. Methods: In a sample of 83 students, we use a choice based TTO protocol to elicit TTO scores for back pain, using ten different gauge durations ranging between 1 and 46 years. The TTO scores are corrected for discounting, which is elicited by means of the direct method. Results: We find average TTO scores varying between 0.72 and 0.81. Although the scores do not differ much for different durations in absolute terms, some differences are significant, rejecting CPTO, with and without correcting for discounting. No clear relationship between TTO scores and gauge duration is found. An anchoring and rounding heuristic to some extent explains our results. Conclusions: Our findings highlight the importance of elicitation methods and context dependencies in QALY measurement and warrant detailed investigation of their influence

The role of drug, dose and the tolerance/intolerance of new drugs in multiple drug hypersensitivity syndrome (MDH).

BACKGROUND Multiple drug hypersensitivity syndrome (MDH) is used to describe persons with a drug hypersensitivity reaction (DHR) to at least two chemically unrelated drugs, confirmed by skin test or in vitro assay. METHODS Medical records of 25 patients with MDH, tested and confirmed at our allergy division were retrospectively evaluated in terms of clinical course, involved drugs, daily drug dose, latency periods, test results of skin test and cellular assays and tolerated drugs in subsequent pharmacological treatments. RESULTS MDH almost exclusively appeared as a delayed, often severe DHR and started in 14/25 with a drug reaction with eosinophilia and systemic symptoms (DRESS). Penicillins (13/25, 52.0%) and cephalosporins (6/25, 24.0%), typical high dose drugs, were most often identified as elicitors of MDH, especially at the first DHR, followed by aromatic antiepileptics (7/25, 28.0%), vancomycin (4/25, 16.0%) and antibiotic sulfonamides (4/25, 16.0%). Cephalosporins, clindamycine and radio contrast media (RCM) were mainly involved in subsequent DHR. The median daily drug dose of all drug trigger was 1875.0 mg (662.5; 2100.0) at the first DHR and 600.0 mg (300.0; 1300.0) at subsequent DHR, p=0.0420. CONCLUSION High dose drugs, especially betalactam antibiotics, RCM and clindamycin are common elicitors of subsequent DHR in patients with MDH. Macrolides, quinolones, doxycycline, non-aromatic antiepileptics and paracetamol were often tolerated. As the same drugs elicited both flare-up reactions and real DHR, drug induced flare-up reactions may be precursors of a possible second DHR and MDH. The administration of highly dosed drugs should be avoided in patients at risk for MDH

Historical Foundations: Studies of Literary References to Hesban and Vicinity

Historical contextualization is vitally important in attaining a view of Tell Hesban as its contemporaries described it. A spectrum of periods are analyzed from their contemporary literary sources: pre-classical and classical sources (Werner K. Vyhmeister), Arab sources (Malcolm B. Russell), a review of critical studies of Old Testament references to the site (Arthur J. Ferch), and traveller\u27s accounts since 1806 (Werner K. Vyhmeister). AU Press cataloguehttps://digitalcommons.andrews.edu/books/1068/thumbnail.jp

In search of a preferred preference elicitation method: A test of the internal consistency of choice and matching tasks

The numerous reports on preference reversals in preference elicitations pose a great challenge to empirical economics. Many studies have found that different procedures may generate substantially different preferences. However, little is known about whether one procedure is more susceptible to preference reversals than another. Therefore, taking the preference reversals as a robust behavioral pattern, guidelines are called for to provide directions regarding a preferred preference elicitation task. This paper puts forward a new test of the internal consistency of choice and matching tasks, based on “internal preference reversals”. We replicate the preference reversal phenomenon and find a significant higher consistency within choice tasks than within matching tasks

In search of a preferred preference elicitation method: A test of the internal consistency of choice and matching tasks

The numerous reports on preference reversals in preference elicitations pose a great challenge to empirical economics. Many studies have found that different procedures may generate substantially different preferences. However, little is known about whether one procedure is more susceptible to preference reversals than another. Therefore, taking the preference reversals as a robust behavioral pattern, guidelines are called for to provide directions regarding a preferred preference elicitation task. This paper puts forward a new test of the internal consistency of choice and matching tasks, based on “internal preference reversals”. We replicate the preference reversal phenomenon and find a significant higher consistency within choice tasks than within matching tasks