56 research outputs found

    Correlation of cutaneous tension distribution and tissue oxygenation with acute external tissue expansion

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    Today, the biomechanical fundamentals of skin expansion are based on viscoelastic models of the skin. Although many studies have been conducted in vitro, analyses performed in vivo are rare. Here, we present in vivo measurements of the expansion at the skin surface as well as measurement of the corresponding intracutaneous oxygen partial pressure. In our study the average skin stretching was 24%, with a standard deviation of 11%, excluding age or gender dependency. The measurement of intracutaneous oxygen partial pressure produced strong inter-individual fluctuations, including initial values at the beginning of the measurement, as well as varying individual patient reactions to expansion of the skin. Taken together, we propose that even large defect wounds can be closed successfully using the mass displacement caused by expansion especially in areas where soft, voluminous tissue layers are present

    Basic Science Considerations in Primary Total Hip Replacement Arthroplasty

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    Total Hip Replacement is one of the most common operations performed in the developed world today. An increasingly ageing population means that the numbers of people undergoing this operation is set to rise. There are a numerous number of prosthesis on the market and it is often difficult to choose between them. It is therefore necessary to have a good understanding of the basic scientific principles in Total Hip Replacement and the evidence base underpinning them. This paper reviews the relevant anatomical and biomechanical principles in THA. It goes on to elaborate on the structural properties of materials used in modern implants and looks at the evidence base for different types of fixation including cemented and uncemented components. Modern bearing surfaces are discussed in addition to the scientific basis of various surface engineering modifications in THA prostheses. The basic science considerations in component alignment and abductor tension are also discussed. A brief discussion on modular and custom designs of THR is also included. This article reviews basic science concepts and the rationale underpinning the use of the femoral and acetabular component in total hip replacement

    Solvent-Free Melting Techniques for the Preparation of Lipid-Based Solid Oral Formulations

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    Birmingham Hip Resurfacing: Kurzfristige klinische und röntgenologische Ergebnisse

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    Horrorvision "ökonomischer Verteilungskampf" - aber mit welchen Waffen?

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    Kosteneffektivität der Hüft-Endoprothetik aus Perspektive der Kostenträger

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    Meta-Analyse zur Quantifizierung des Patienten-bezogenen Nutzens der Hüft-Endoprothetik

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