97 research outputs found
A viscoactive constitutive modeling framework with variational updates for the myocardium
We present a constitutive modeling framework for contractile cardiac mechanics by formulating a single variational principle from which incremental stress-strain relations and kinetic rate equations for active contraction and relaxation can all be derived. The variational framework seamlessly incorporates the hyperelastic behavior of the relaxed and contracted tissue along with the rate - and length - dependent generation of contractile force. We describe a three-element, Hill-type model that unifies the active tension and active deformation approaches. As in the latter approach, we multiplicatively decompose the total deformation gradient into active and elastic parts, with the active deformation parametrizing the contractile Hill element. We adopt as internal variables the fiber, cross-fiber, and sheet normal stretch ratios. The kinetics of these internal variables are modeled via definition of a kinetic potential function derived from experimental force-velocity relations. Additionally, we account for dissipation during tissue deformation by adding a Newtonian viscous potential. To model the force activation, the kinetic equations are coupled with the calcium transient obtained from a cardiomyocyte electrophysiology model. We first analyze our model at the material point level using stress and strain versus time curves for different viscosity values. Subsequently, we couple our constitutive framework with the finite element method (FEM) and study the deformation of three-dimensional tissue slabs with varying cardiac myocyte orientation. Finally, we simulate the contraction and relaxation of an ellipsoidal left ventricular model and record common kinematic measures, such as ejection fraction, and myocardial tissue volume changes
Signals for Lorentz Violation in Electrodynamics
An investigation is performed of the Lorentz-violating electrodynamics
extracted from the renormalizable sector of the general Lorentz- and
CPT-violating standard-model extension. Among the unconventional properties of
radiation arising from Lorentz violation is birefringence of the vacuum. Limits
on the dispersion of light produced by galactic and extragalactic objects
provide bounds of 3 x 10^{-16} on certain coefficients for Lorentz violation in
the photon sector. The comparative spectral polarimetry of light from
cosmologically distant sources yields stringent constraints of 2 x 10^{-32}.
All remaining coefficients in the photon sector are measurable in
high-sensitivity tests involving cavity-stabilized oscillators. Experimental
configurations in Earth- and space-based laboratories are considered that
involve optical or microwave cavities and that could be implemented using
existing technology.Comment: 23 pages REVTe
New insights into the genetic etiology of Alzheimer's disease and related dementias.
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
Introduction to Software Process Improvement
: While software now pervades most facets of modern life, its historical problems have not been solved. This report explains why some of these problems have been so difficult for organizations to address and the actions required to address them. It describes the Software Engineering Institute's (SEI) software process maturity model, how this model can be used to guide software organizations in process improvement, and the various assessment and evaluation methods that use this model. The report concludes with a discussion of improvement experience and some comments on future directions for this work. 1 Introduction The Software Process Capability Maturity Model (CMM) deals with the capability of software organizations to consistently and predictably produce high quality products. It is closely related to such topics as software process, quality management, and process improvement. The drive for improved software quality is motivated by technology, customer need, regulation, and compet..
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