A spectrin membrane skeleton of the Golgi complex

AbstractThe existence of a Golgi-localized membrane cytoskeleton has been revealed by the identification of two major components of the spectrin membrane skeleton, spectrin and ankyrin, that associate with the Golgi complex. Golgi spectrin was identified with an antibody specific for the β-subunit of the erythroid isoform of spectrin (β1Σ1). This antibody recognizes a 220 kDa polypeptide that localizes to discrete regions of the Golgi complex and associates with Golgi membranes in a Brefeldin A sensitive manner. Two isoforms of Golgi ankyrin have been identified: a 119 kDa form (AnkG119) which represents a truncated, alternatively spliced isoform of a recently cloned novel ankyrin of the nervous system AnkG, and a larger 195 kDa ankyrin (Ank195) that cross-reacts with antibodies to erythrocyte ankyrin. A Golgi localized membrane skeleton composed of these unique membrane skeleton isoforms could serve a variety of important functions, including the maintenance of Golgi structural organization and the formation of discrete membrane domains within Golgi compartments

Three-Dimensional Structure of the Armadillo Repeat Region of β-Catenin

Abstractβ-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). A core region of β-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. The three-dimensional structure of a protease-resistant fragment of β-catenin containing the armadillo repeat region has been determined. The 12 repeats form a superhelix of helices that features a long, positively charged groove. Although unrelated in sequence, the β-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove

BFKL dynamics at hadron colliders

Hadron colliders can provide important tests of BFKL `small-x' dynamics. We discuss two examples of such tests, the inclusive dijet jet cross section at large rapidity separation and the number of associated `mini-jets' in Higgs boson production.Hadron colliders can provide important tests of BFKL `small-x' dynamics. We discuss two examples of such tests, the inclusive dijet jet cross section at large rapidity separation and the number of associated `mini-jets' in Higgs boson production

Renormalization Group Improved Heavy Quark Production in Polarized \gamma \gamma Collisions

The experimental determination of the partial width $\Gamma (H \longrightarrow \gamma \gamma)$ of an intermediate mass Higgs is among the most important measurements at a future photon photon collider. Recently it was shown that large non-Sudakov as well as Sudakov double logarithmic (DL) corrections can be summed to all orders in the background process $\gamma \gamma (J_z=0) \longrightarrow q \bar{q}$. It was found that positivity and stability of the cross section was only restored at the four-loop level. One remaining large source of uncertainty stems from the fact that the scale of the strong coupling is unspecified within the double logarithmic approximation. In this paper we include the leading and next-to-leading order running coupling to all orders. We thus remove the inherent scale uncertainty of both the exact one-loop and all-orders DL result without encountering any Landau-pole singularities. The effect is significant and, for the non-Sudakov form factor, is found to correspond to an effective scale of roughly $\alpha_s(9m_q^2)$.Comment: 23 pages, 10 eps-figure

High intensity aerobic exercise training improves deficits of cardiovascular autonomic function in a rat model of type 1 diabetes mellitus with moderate hyperglycemia

© 2016 Kenneth N. Grisé et al. Indices of cardiovascular autonomic neuropathy (CAN) in experimental models of Type 1 diabetes mellitus (T1DM) are often contrary to clinical data. Here, we investigated whether a relatable insulin-treated model of T1DM would induce deficits in cardiovascular (CV) autonomic function more reflective of clinical results and if exercise training could prevent those deficits. Sixty-four rats were divided into four groups: sedentary control (C), sedentary T1DM (D), control exercise (CX), or T1DM exercise (DX). Diabetes was induced via multiple low-dose injections of streptozotocin and blood glucose was maintained at moderate hyperglycemia (9-17 mM) through insulin supplementation. Exercise training consisted of daily treadmill running for 10 weeks. Compared to C, D had blunted baroreflex sensitivity, increased vascular sympathetic tone, increased serum neuropeptide Y (NPY), and decreased intrinsic heart rate. In contrast, DX differed from D in all measures of CAN (except NPY), including heart rate variability. These findings demonstrate that this T1DM model elicits deficits and exercise-mediated improvements to CV autonomic function which are reflective of clinical T1DM

Bagaimana mengajar secara sistematis

Buku ini merupakan terjemahan dari Establishing Instructional Goals and Systematic Instruction, yang isinya sejalan dengan sistem pengajaran yang dianut dalam pembakuan Kurikulum Indonesia (PPSI). Di dalamnya membahas intuisi dan verifikasi, masalah instruksional, keputusan kurikuler, pengelolaan kelas, evaluasi pengajaran, dan masalah guru dalam kelas sebagai pelaksana eksperimen. Bermanfaat bagi guru dan calon guru, serta praktisi pendidikan

Bagaimana Mengajar Secara Sistematis

163 hlm.;21 c

Educational evaluation/ Popham

viii, 328 hal.: ill.; 21 cm