Jorge A. Swieca's contributions to quantum field theory in the 60s and 70s and their relevance in present research

After revisiting some high points of particle physics and QFT of the two decades from 1960 to 1980, I comment on the work by Jorge Andre Swieca. I explain how it fits into the quantum field theory during these two decades and draw attention to its relevance to the ongoing particle physics research. A particular aim of this article is to direct thr readers mindfulness to the relevance of what at the time of Swieca was called "the Schwinger Higgs screening mechanism". which, together with recent ideas which generalize the concept of gauge theories, has all the ingredients to revolutionize the issue of gauge theories and the standard model.Comment: 49 pages, expansion and actualization of text, improvement of formulations and addition of many references to be published in EPJH - Historical Perspectives on Contemporary Physic

A critical look at 50 years particle theory from the perspective of the crossing property

The crossing property is perhaps the most subtle aspect of the particle-field relation. Although it is not difficult to state its content in terms of certain analytic properties relating different matrixelements of the S-matrix or formfactors, its relation to the localization- and positive energy spectral principles requires a level of insight into the inner workings of QFT which goes beyond anything which can be found in typical textbooks on QFT. This paper presents a recent account based on new ideas derived from "modular localization" including a mathematic appendix on this subject. Its main novel achievement is the proof of the crossing property of formfactors from a two-algebra generalization of the KMS condition. The main content of this article is the presentation of the derailments of particle theory during more than 4 decades: the S-matrix bootstrap, the dual model and its string theoretic extension. Rather than being related to crossing, string theory is the (only known) realization of a dynamic infinite component one-particle wave function space and its associated infinite component field. Here "dynamic" means that, unlike a mere collection of infinitely many irreducible unitary Poincar\'e group representation or free fields, the formalism contains also operators which communicate between the different irreducible Poincar\'e represenations (the levels of the "infinite tower") and set the mass/spin spectrum. Wheras in pre-string times there were unsuccessful attempts to achieve this in analogy to the O(4,2) hydrogen spectrum by the use of higher noncompact groups, the superstring in d=9+1, which uses instead (bosonic/fermionic) oscillators obtained from multicomponent chiral currents is the only known unitary positive energy solution of the dynamical infinite component pointlike localized field project.Comment: 66 pages, addition of new results, addition of references, will appear in this form in Foundations of Physic

Physics with the KLOE-2 experiment at the upgraded DAϕ\phiNE

Investigation at a $\phi$--factory can shed light on several debated issues in particle physics. We discuss: i) recent theoretical development and experimental progress in kaon physics relevant for the Standard Model tests in the flavor sector, ii) the sensitivity we can reach in probing CPT and Quantum Mechanics from time evolution of entangled kaon states, iii) the interest for improving on the present measurements of non-leptonic and radiative decays of kaons and eta/eta$^\prime$ mesons, iv) the contribution to understand the nature of light scalar mesons, and v) the opportunity to search for narrow di-lepton resonances suggested by recent models proposing a hidden dark-matter sector. We also report on the $e^+ e^-$ physics in the continuum with the measurements of (multi)hadronic cross sections and the study of gamma gamma processes.Comment: 60 pages, 41 figures; added affiliation for one of the authors; added reference to section

The comorbidity and co-medication profile of patients with progressive supranuclear palsy

Background Progressive supranuclear palsy (PSP) is usually diagnosed in elderly. Currently, little is known about comorbidities and the co-medication in these patients. Objectives To explore the pattern of comorbidities and co-medication in PSP patients according to the known different phenotypes and in comparison with patients without neurodegenerative disease. Methods Cross-sectional data of PSP and patients without neurodegenerative diseases (non-ND) were collected from three German multicenter observational studies (DescribePSP, ProPSP and DANCER). The prevalence of comorbidities according to WHO ICD-10 classification and the prevalence of drugs administered according to WHO ATC system were analyzed. Potential drug–drug interactions were evaluated using AiDKlinik®. Results In total, 335 PSP and 275 non-ND patients were included in this analysis. The prevalence of diseases of the circulatory and the nervous system was higher in PSP at first level of ICD-10. Dorsopathies, diabetes mellitus, other nutritional deficiencies and polyneuropathies were more frequent in PSP at second level of ICD-10. In particular, the summed prevalence of cardiovascular and cerebrovascular diseases was higher in PSP patients. More drugs were administered in the PSP group leading to a greater percentage of patients with polypharmacy. Accordingly, the prevalence of potential drug–drug interactions was higher in PSP patients, especially severe and moderate interactions. Conclusions PSP patients possess a characteristic profile of comorbidities, particularly diabetes and cardiovascular diseases. The eminent burden of comorbidities and resulting polypharmacy should be carefully considered when treating PSP patients

Gastrointestinal involvement in Parkinson’s disease: pathophysiology, diagnosis, and management

Growing evidence suggests an increasing significance for the extent of gastrointestinal tract (GIT) dysfunction in Parkinson’s disease (PD). Most patients suffer from GIT symptoms, including dysphagia, sialorrhea, bloating, nausea, vomiting, gastroparesis, and constipation during the disease course. The underlying pathomechanisms of this α-synucleinopathy play an important role in disease development and progression, i.e., early accumulation of Lewy pathology in the enteric and central nervous systems is implicated in pharyngeal discoordination, esophageal and gastric motility/peristalsis impairment, chronic pain, altered intestinal permeability and autonomic dysfunction of the colon, with subsequent constipation. Severe complications, including malnutrition, dehydration, insufficient drug effects, aspiration pneumonia, intestinal obstruction, and megacolon, frequently result in hospitalization. Sophisticated diagnostic tools are now available that permit more detailed examination of specific GIT impairment patterns. Furthermore, novel treatment approaches have been evaluated, although high-level evidence trials are often missing. Finally, the burgeoning literature devoted to the GIT microbiome reveals its importance for neurologists. We review current knowledge about GIT pathoanatomy, pathophysiology, diagnosis, and treatment in PD and provide recommendations for management in daily practice