Perceived risk and the marginal value of safety.

[Dataset available: http://hdl.handle.net/10411/15662]

A microscopic equation of state for protoneutron stars

We study the structure of protoneutron stars within the finite temperature Brueckner-Bethe-Goldstone many-body theory. If nucleons, hyperons, and leptons are present in the stellar core, we find that neutrino trapping stiffens considerably the equation of state, because hyperon onsets are shifted to larger baryon density. However, the value of the critical mass turns out to be smaller than the ``canonical'' value 1.44 $M_\odot$. We find that the inclusion of a hadron-quark phase transition increases the critical mass and stabilizes it at about 1.5--1.6 $M_\odot$.Comment: 8 pages, 6 figures, to appear in Astrophysics and Space Science, Proceedings of "Isolated Neutron Stars: from the Interior to the Surface", edited by D. Page, R. Turolla, and S. Zan

Women with type 1 diabetes exhibit a progressive increase in gut Saccharomyces cerevisiae in pregnancy associated with evidence of gut inflammation.

Aims: Studies of the gut microbiome have focused on its bacterial composition. We aimed to characterize the gut fungal microbiome (mycobiome) across pregnancy in women with and without type 1 diabetes. Methods: Faecal samples (n = 162) were collected from 70 pregnant women (45 with and 25 without type 1 diabetes) across all trimesters. Fungi were analysed by internal transcribed spacer 1 amplicon sequencing. Markers of intestinal inflammation (faecal calprotectin) and intestinal epithelial integrity (serum intestinal fatty acid binding protein; I-FABP), and serum antibodies to Saccharomyces cerevisiae (ASCA) were measured. Results: Women with type 1 diabetes had decreased fungal alpha diversity by the third trimester, associated with an increased abundance of Saccharomyces cerevisiae that was inversely related to the abundance of the anti-inflammatory butyrate-producing bacterium Faecalibacterium prausnitzii. Women with type 1 diabetes had higher concentrations of calprotectin, I-FABP and ASCA. Conclusions: Women with type 1 diabetes exhibit a shift in the gut mycobiome across pregnancy associated with evidence of gut inflammation and impaired intestinal barrier function. The relevance of these findings to the higher rate of pregnancy complications in type 1 diabetes warrants further study.Esther Bandala-Sanchez, Alexandra J. Roth-Schulze, Helena Oakey Megan A.S. Penno, Naiara G. Bediaga, Gaetano Naselli, Katrina M. Ngui, Alannah D. Smith, Dexing Huang, Enrique Zozaya-Valdes, Rebecca L. Thomson, James D. Brown, Peter J. Vuillermin, Simon C. Barry, Maria E. Craig, William D. Rawlinson, Elizabeth A. Davis, Mark Harris, Georgia Soldatos, Peter G. Colman, John M. Wentworth, Aveni Haynes, Grant Morahan, Richard O. Sinnott, Anthony T. Papenfuss, Jennifer J. Couper, Leonard C. Harrison, on behalf of the ENDIA Study Grou

Clean air and energy: from conflict to reconciliation. [Cost benefit analysis]

Unconstrained energy resource development in the Rocky Mountain west is likely to threaten the environment and the health and well-being of the people. Impacts may be associated with visibility degradation, toxic concentrations of gases, and deposition of acidic or toxic substances. Because the possible benefits of energy development in the region are very large, there is great concern that constraints imposed by air quality regulation may preclude the use of important resources or make unduly expensive energy produced from the region. The conflict between energy and clean air in the region is exacerbated by non-energy sources, such as copper smelters and urban areas, that already pose significant environmental threats. The hard policy question is not how to preserve clean air resources or how to develop energy but how to achieve and balance both goals. The effects and regulatory costs and benefits of air pollution control are discussed, and policy directions to protect air quality while pursuing energy development are presented