3,032 research outputs found
Adrenocorticotropic hormone, but not trilostane, causes severe adrenal hemorrhage, vacuolization, and apoptosis in rats
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Adrenal necrosis has been reported as a complication of trilostane application in dogs with hyperadrenocorticism. One suspicion was that necrosis results from the increase of adrenocorticotropic hormone (ACTH) during trilostane therapy. The aim of the current study was to assess the effects of ACTH and trilostane on adrenal glands of rats. For experiment 1, 36 rats were divided into 6 groups. Groups 1.1 to 1.4 received ACTH in different doses (60, 40, 20, and 10 μg/d) infused subcutaneously with osmotic minipumps for 16 wk. Group 1.5 received saline, and group 1.6 received no therapy. For experiment 2, 24 rats were divided into 3 groups. Group 2.1 and 2.2 received 5 and 50 mg/kg trilostane/d orally mixed into chocolate pudding for 16 wk. Eight control rats received pudding alone. At the end of the experiments, adrenal glands were assessed for necrosis by histology and immunohistochemistry; levels of endogenous ACTH and nucleosomes were assessed in the blood. Rats treated with 60 μg ACTH/d showed more hemorrhage and vacuolization and increased numbers of apoptotic cells in the adrenal glands than rats treated with 20 or 10 μg ACTH/d, trilostane, or control rats. Rats treated with 60 μg ACTH/d had a higher amount of nucleosomes in the blood compared with rats treated with 10 μg ACTH/d, trilostane, or saline. We conclude that in healthy rats ACTH, but not trilostane, causes adrenal degeneration in a dose-dependent manner. Results of this study support the hypothesis that adrenal gland lesions seen in trilostane-treated dogs are caused by ACTH and not by trilostane
Consistent alpha-cluster description of the 12C (0^+_2) resonance
- Author
- A. G. W. Cameron
- A. N. Danilov
- A. V. Malykh
- C. W. Cook
- D. M. Brink
- D. R. Tilley
- E. A. J. M. Offermann
- F. Ajzenberg-Selove
- F. Hoyle
- H. O. U. Fynbo
- H. Oberhummer
- I. Filikhin
- I. Fushiki
- I. Sick
- K. Nomoto
- K. Ogata
- M. Chernykh
- M. Chernykh
- M. Freer
- O. I. Kartavtsev
- O. S. Kirsebom
- P. Descouvemont
- P. Strehl
- R. Bijker
- R. Álvarez-Rodríguez
- R. Álvarez-Rodríguez
- S. I. Fedotov
- S. I. Fedotov
- S. I. Fedotov
- S. Schramm
- S. Wüstenbecker
- W. Ruckstuhl
- Y. Funaki
- Publication venue
- 'Pleiades Publishing Ltd'
- Publication date
- 09/09/2010
- Field of study
The near-threshold 12C (0^+_2) resonance provides unique possibility for fast
helium burning in stars, as predicted by Hoyle to explain the observed
abundance of elements in the Universe. Properties of this resonance are
calculated within the framework of the alpha-cluster model whose two-body and
three-body effective potentials are tuned to describe the alpha - alpha
scattering data, the energies of the 0^+_1 and 0^+_2 states, and the
0^+_1-state root-mean-square radius. The extremely small width of the 0^+_2
state, the 0_2^+ to 0_1^+ monopole transition matrix element, and transition
radius are found in remarkable agreement with the experimental data. The
0^+_2-state structure is described as a system of three alpha-particles
oscillating between the ground-state-like configuration and the elongated chain
configuration whose probability exceeds 0.9
Altered serum thyrotropin concentrations in dogs with primary hypoadrenocorticism before and during treatment
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2017
- Field of study
BACKGROUND: Thyrotropin (TSH) can be increased in humans with primary hypoadrenocorticism (HA) before glucocorticoid treatment. Increase in TSH is a typical finding of primary hypothyroidism and both diseases can occur concurrently (Schmidt's syndrome); therefore, care must be taken in assessing thyroid function in untreated human patients with HA.
OBJECTIVE: Evaluate whether alterations in cTSH can be observed in dogs with HA in absence of primary hypothyroidism.
ANIMALS: Thirty dogs with newly diagnosed HA, and 30 dogs in which HA was suspected but excluded based on a normal ACTH stimulation test (controls) were prospectively enrolled.
METHODS: cTSH and T4 concentrations were determined in all dogs and at selected time points during treatment (prednisolone, fludrocortisone, or DOCP) in dogs with HA.
RESULTS: cTSH concentrations ranged from 0.01 to 2.6 ng/mL (median 0.29) and were increased in 11/30 dogs with HA; values in controls were all within the reference interval (range: 0.01-0.2 ng/dL; median 0.06). There was no difference in T4 between dogs with increased cTSH (T4 range 1.0-2.1; median 1.3 μg/dL) compared to those with normal cTSH (T4 range 0.5-3.4, median 1.4 μg/dL; P=0.69) and controls (T4 range 0.3-3.8, median 1.8 μg/dL; P=0.35). After starting treatment, cTSH normalized after 2-4 weeks in 9 dogs and after 3 and 4 months in 2 without thyroxine supplementation.
CONCLUSIONS AND CLINICAL RELEVANCE: Evaluation of thyroid function in untreated dogs with HA can lead to misdiagnosis of hypothyroidism; treatment with glucocorticoids for up to 4 months can be necessary to normalize cTSH
Production characteristics of Ko and light meson resonances in hadronic decays of the Zo
- Author
- Publication venue
- Publication date
- 01/01/1995
- Field of study
Comparison of Several Methods of Chromatographic Baseline Removal with a New Approach Based on Quantile Regression
- Author
- Publication venue
- Vieweg Verlag
- Publication date
- 01/01/2011
- Field of study
The article is intended to introduce and discuss a new quantile regression method for baseline detrending of chromatographic signals. It is compared with current methods based on polynomial fitting, spline fitting, LOESS, and Whittaker smoother, each with thresholding and reweighting approach. For curve flexibility selection in existing algorithms, a new method based on skewness of the residuals is successfully applied. The computational efficiency of all approaches is also discussed. The newly introduced methods could be preferred to visible better performance and short computational time. The other algorithms behave in comparable way, and polynomial regression can be here preferred due to short computational time
Correlation of psychomotor findings and the ability to partially weight bear
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2012
- Field of study
<p>Abstract</p> <p>Background</p> <p>Partial weight bearing is thought to avoid excessive loading that may interfere with the healing process after surgery of the pelvis or the lower extremity. The object of this study was to investigate the relationship between the ability to partially weight bear and the patient's psychomotor skills and an additional evaluation of the possibility to predict this ability with a standardized psychomotor test.</p> <p>Methods</p> <p>50 patients with a prescribed partial weight bearing at a target load of 15 kg following surgery were verbally instructed by a physical therapist. After the instruction and sufficient training with the physical therapist vertical ground reaction forces using matrix insoles were measured while walking with forearm crutches. Additionally, psychomotor skills were tested with the Motorische Leistungsserie (MLS). To test for correlations Spearman's Rank correlation was used. For further comparison of the two groups a Mann-Withney test was performed using Bonferroni correction.</p> <p>Results</p> <p>The patient's age and body weight significantly correlated with the ability to partially weight bear at a 15 kg target load. There were significant correlations between several subtests of the MLS and ground reaction forces measured while walking with crutches. Patients that were able to correctly perform partial weight bearing showed significant better psychomotor skills especially for those subtests where both hands had to be coordinated simultaneously.</p> <p>Conclusions</p> <p>The ability to partially weight bear is associated with psychomotor skills. The MLS seems to be a tool that helps predicting the ability to keep within the prescribed load limits.</p
Inclusive V0 Production Cross Sections from 920 GeV Fixed Target Proton-Nucleus Collisions
- Author
- Abt I
- Abyzov A
- Adams M
- Albrecht H
- Amaral V
- Amorim A
- Aplin SJ
- Arefiev A
- Arino I
- Atiya M
- Aushev V
- Bagaturia Y
- Baghshetsyan R
- Balagura V
- Bargiotti M
- Barsuk S
- Barsukova O
- Bassetti V
- Bastos J
- Bauer C
- Bauer TS
- Beck M
- Belkov A
- Belkov A
- Belotelov I
- Belyaev I
- Berkhan K
- Bertin A
- Bobchenko B
- Bocker M
- Bogatyrev A
- Bohm G
- Borgmeier C
- Brauer M
- Broemmelsiek D
- Brunisma M
- Bruschi M
- Buchholz P
- Buchler M
- Buran T
- Capeans M
- Capponi M
- Carvalho J
- Chamanina J
- Chen BX
- Chistov R
- Chmeissani M
- Christensen A
- Conde P
- Cruse C
- Dam M
- Danielsen KM
- Danilov M
- De Castro S
- de Vera MTNP
- Deckers H
- Dehmelt K
- Deppe H
- Dolgoshein B
- Dong X
- Dreis HB
- Dressel M
- Dujmic D
- Eckmann R
- Egorytchev V
- Ehret K
- Eiges V
- Eisele F
- Emeliyanov D
- Erhan S
- Essenov S
- Fabbri L
- Faccioli P
- Fallot-Burghardt W
- Feuerstack-Raible M
- Flammer J
- Fleckenstein H
- Fominykh B
- Fourletov S
- Fuljahn T
- Funcke M
- Galli D
- Garcia A
- Garrido L
- Gascon D
- Gellrich A
- Gerndt KEK
- Giacobbe B
- Glass J
- Glebe T
- Goloubkov D
- Golutvin A
- Golutvin I
- Gorbounov I
- Gorisek A
- Gouchtchine O
- Goulart DC
- Gradl S
- Gradl W
- Guilitsky Y
- Hamacher T
- Hansen JD
- Harr R
- Hast C
- Hausmann S
- Hernandez JM
- Hildebrandt M
- Hofmann W
- Hohlmann M
- Holscher A
- Hopfner K
- Hott T
- Hulsbergen W
- Husemann U
- Igonkina O
- Ispiryan M
- Issever S
- Itterbeck H
- Ivarsson Jenny
- Jagla T
- Jia Y
- Jiang C
- Kaoukher A
- Kapitza H
- Karabekyan S
- Karchin P
- Karpenko N
- Ke Z
- Keller S
- Khasanov F
- Kim H
- Kiryushin Y
- Kisel I
- Klefenz F
- Knopfle KT
- Kochetkov V
- Kolanoski H
- Korpar S
- Krauss C
- Kreuzer P
- Krizan P
- Krucker D
- Kvaratskheliia T
- Lange A
- Lanyov A
- Lau K
- Leffers G
- Legrand I
- Lewendel B
- Liu YQ
- Lohse T
- Loke R
- Lomonosov B
- Ludemann J
- Mankel R
- Manner R
- Marconi U
- Masciocchi S
- Massa I
- Matchikhilian I
- Medin G
- Medinnis M
- Mevius M
- Michetti A
- Mikhailov Y
- Miquel R
- Mizuk R
- Mohapatra A
- Moshkin A
- Moshous B
- Muresan R
- Nam S
- Negodaev M
- Negri I
- Norenberg M
- Nowak S
- Oest T
- Oliveira A
- Ouchrif M
- Ould-Saada F
- Padilla C
- Pakhlov P
- Pavlenko Y
- Peralta D
- Pernack R
- Perschke T
- Pestotnik R
- Petersen BAA
- Piccinini M
- Pleier MA
- Poli M
- Popov V
- Pose A
- Pose D
- Potashnikova I
- Pugatch V
- Pylypchenko Y
- Pyrlik J
- Ramachandran S
- Ratnikov F
- Reeves K
- Ressing D
- Riechmann K
- Rieling J
- Rietz M
- Riu I
- Robmann P
- Rosen J
- Rothe C
- Ruckstuhl W
- Rusinov V
- Rybnikov V
- Ryzhikov D
- Saadi-Ludemann F
- Samtleben D
- Sanchez F
- Sang M
- Saveliev V
- Sbrizzi A
- Schaller S
- Schlein P
- Schmelling M
- Schmidt B
- Schmidt S
- Schmidt-Parzefall W
- Schreiner A
- Schroder H
- Schultz HD
- Schwanke U
- Schwartz AJ
- Schwarz AS
- Schwenninger B
- Schwingenheuer B
- Schwitters R
- Sciacca F
- Semenov S
- Semprini-Cesari N
- Sexauer E
- Seybold L
- Shiu J
- Shuvalov S
- Siccama I
- Skrk D
- Soldatov A
- Solunin S
- Somov A
- Somov S
- Souvorov V
- Sozuer L
- Spahn M
- Spengler J
- Spighi R
- Spiridonov A
- Spratte S
- Stanovnik A
- Staric M
- Stdenis R
- Stegmann C
- Steinbeck S
- Steinkamp O
- Stieler D
- Straumann U
- Sun F
- Sun H
- Symalla M
- Takach S
- Tesch N
- Thurn H
- Tikhomirov I
- Titov M
- Trunk U
- Truol P
- Tsakov I
- Uwer U
- Vagnoni V
- van Eldik C
- van Staa R
- Vassiliev Y
- Villa M
- Vitale A
- Vukotic I
- Wagner G
- Wagner W
- Wahlberg H
- Walenta AH
- Walter M
- Walter T
- Wang JJ
- Wang YM
- Wanke R
- Wegener D
- Werthenbach U
- Weyers PJ
- Wolters H
- Wurth R
- Wurz A
- Xella-Hansen S
- Yang J
- Zaitsev Y
- Zavertyaev M
- Zech G
- Zeuner T
- Zhelezov A
- Zheng Z
- Zhu Z
- Zimmermann R
- Zivko T
- Zoccoli A
- Zweizig J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/12/2002
- Field of study
Inclusive differential cross sections dσpA/dxF and
dσpA/dpt2 for the production of \kzeros, \lambdazero, and
\antilambda particles are measured at HERA in proton-induced reactions on C,
Al, Ti, and W targets. The incident beam energy is 920 GeV, corresponding to
s=41.6 GeV in the proton-nucleon system. The ratios of differential
cross sections \rklpa and \rllpa are measured to be 6.2±0.5 and 0.66±0.07, respectively, for \xf ≈−0.06. No significant dependence upon the
target material is observed. Within errors, the slopes of the transverse
momentum distributions dσpA/dpt2 also show no significant
dependence upon the target material. The dependence of the extrapolated total
cross sections σpA on the atomic mass A of the target material is
discussed, and the deduced cross sections per nucleon σpN are
compared with results obtained at other energies.Comment: 17 pages, 7 figures, 5 table
Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics
- Author
- \uc5kesson T P A
- \uc5sman B
- Aad G
- Abat E
- Abbott B
- Abdallah J
- Abdelalim A A
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Acharya B S
- Adams D L
- Addy T N
- Adorisio C
- Adragna P
- Adye T
- Aguilar-Saavedra J A
- Aharrouche M
- Ahlen S P
- Ahles F
- Ahmad A
- Ahmed H
- Aielli G
- Akdogan T
- Akimoto G
- Alam M A
- Alam S M
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov I N
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alison J
- Aliyev M
- Allport P P
- Allwood-Spiers S E
- Aloisio A
- Alon R
- Alonso A
- Alonso J
- Alviggi M G
- Amako K
- Amaral P
- Amelung C
- Ammosov V V
- Amor\uf3s G
- Amorim A
- Amram N
- Anastopoulos C
- Anders C F
- Anderson K J
- Andreazza A
- Andrei V
- Andrieux M L
- Anduaga X S
- Anghinolfi F
- Antonaki A
- Antonelli M
- Antonelli S
- Antunovic B
- Anulli F A
- Arabidze G
- Aracena I
- Arai Y
- Arce A T H
- Archambault J P
- Arfaoui S
- Arguin J F
- Argyropoulos T
- Arik E
- Arik M
- Armbruster A J
- Arnaez O
- Arnault C
- Artamonov A
- Arutinov D
- Asai M
- Asai S
- Ask S
- Asner D
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atkinson T
- Atoian G
- Auerbach B
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- Axen A
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- Baccaglioni G
- Bacci C
- Bachacou H
- Bachas K
- Backes M
- Badescu E
- Bagnaia P
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- Banerjee S
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- Baranov S
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- Bastos J
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- Bechtle P
- Beck G A
- Beck H P
- Beckingham M
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- Bedajanek I
- Beddall A
- Beddall A J
- Bedn\ue1r P
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- Behera P K
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- Bingul A
- Bini C
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- Boscherini D
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- Bruckmande Renstrom P A
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- CabreraUrb\ue1n S
- Caforio D
- Cakir O
- Calafiura P
- Calderini G
- Calkins R
- Caloba L P
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- Ciocio A
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- Consonni M
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- Cooke M
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- Copic K
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- Czyczula Z
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- Dabrowski W
- Dai T
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- Weingarten J
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- Wienemann P
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- Wilhelm I
- Wilkens H G
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- Wingerter-Seez I
- Winklmeier F W
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- Yao W M
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- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
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- Youssef S P
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- Yuan L
- Yurkewicz A
- Zaidan R
- Zaitsev A M
- Zajacova Z
- Zanello L
- Zarzhitsky P
- Zaytsev A
- Zdrazil M
- Zeitnitz C
- Zeller M
- Zema P F
- Zendler C
- Zenin A V
- Zenis T
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
- Zhang H
- Zhang J
- Zhang Q
- Zhang X
- Zhao L
- Zhao T
- Zhao Z
- Zhelezko A
- Zhemchugov A
- Zheng S
- Zheng W
- Zhong J
- Zhou B
- Zhou N
- Zhou S
- Zhou Y
- Zhu C G
- Zhu H
- Zhu Y
- Zhuang X A
- Zhuravlov V
- Zilka B
- Zimmermann R
- Zimmermann S
- Zinna M
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko V V
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zychacek V
- Publication venue
- Publication date
- 01/01/2008
- Field of study
A detailed study is presented of the expected performance of the ATLAS
detector. The reconstruction of tracks, leptons, photons, missing energy and
jets is investigated, together with the performance of b-tagging and the
trigger. The physics potential for a variety of interesting physics processes,
within the Standard Model and beyond, is examined. The study comprises a series
of notes based on simulations of the detector and physics processes, with
particular emphasis given to the data expected from the first years of
operation of the LHC at CERN
Hunt for new phenomena using large jet multiplicities and missing transverse momentum with ATLAS in 4.7 fb−1 of s√=7TeV proton-proton collisions
- Author
- A. A. ABDELALIM
- A. A. CARTER
- A. A. GRILLO
- A. A. KOMAR
- A. A. MINAENKO
- A. A. NEPOMUCENO
- A. A. SNESAREV
- A. A. SOLODKOV
- A. ABDESSELAM
- A. AHMAD
- A. AKTAS
- A. ALOISIO
- A. ALONSO
- A. AMORIM
- A. ANDREAZZA
- A. ANGERAMI
- A. ANNOVI
- A. ANTONAKI
- A. ARTAMONOV
- A. ASTBURY
- A. ASTVATSATOUROV
- A. B. FENYUK
- A. B. LAZAREV
- A. BANGERT
- A. BARASHKOU
- A. BARONCELLI
- A. BATTAGLIA
- A. BEDDALL
- A. BELLONI
- A. BELYMAM
- A. BINGUL
- A. BLONDEL
- A. BOCCI
- A. BOGOUCH
- A. BOLDYREV
- A. BORISOV
- A. BOVEIA
- A. BRAEM
- A. BRANDT
- A. BRUNI
- A. C. FALOU
- A. C. KONIG
- A. C. MARTYNIUK
- A. C. SCHAFFER
- A. CAMARD
- A. CANEPA
- A. CATINACCIO
- A. CATTAI
- A. CAVALLARI
- A. CAZZATO
- A. CERRI
- A. CHAFAQ
- A. CHEPLAKOV
- A. CHILINGAROV
- A. CHRISTOV
- A. CIOCIO
- A. CLARK
- A. COCCARO
- A. CORSO RADU
- A. CORTES GONZALEZ
- A. CUNHA
- A. D'ORAZIO
- A. D. HERSHENHORN
- A. D. PILKINGTON
- A. DA ROCHA GESUALDI MELLO
- A. DAHLHOFF
- A. DE SALVO
- A. DE SANTO
- A. DELL'ACQUA
- A. DEWHURST
- A. DI CIACCIO
- A. DI DOMENICO
- A. DI GIROLAMO
- A. DI MATTIA
- A. DI SIMONE
- A. DO VALLE WEMANS
- A. DORIA
- A. DOS ANJOS
- A. DOTTI
- A. DOXIADIS
- A. DUDAREV
- A. DUSHKIN
- A. E. KIRYUNIN
- A. E. NUNCIO QUIROZ
- A. ENGL
- A. EPPIG
- A. EREDITATO
- A. F. SAAVEDRA
- A. FARBIN
- A. FARILLA
- A. FERRARI
- A. FERRER
- A. FILIPCIC
- A. FILIPPAS
- A. FIRAN
- A. FORMICA
- A. FORTI
- A. FOUSSAT
- A. G. BUCKLEY
- A. G. GOUSSIOU
- A. G. KHOLODENKO
- A. G. MYAGKOV
- A. G. OLCHEVSKI
- A. G. SCHAMOV
- A. GAPONENKO
- A. GERSHON
- A. GIBSON
- A. GLAZOV
- A. GOMES
- A. GONIDEC
- A. GORISEK
- A. GREWAL
- A. GUIDA
- A. GUPTA
- A. GUTIERREZ
- A. HAAS
- A. HAMILTON
- A. HARVEY
- A. HENRICHS
- A. HIDVEGI
- A. HOECKER
- A. HOLMES
- A. HOUMMADA
- A. I. ETIENVRE
- A. I. KONONOV
- A. I. MINCER
- A. IRLES QUILES
- A. ISHIKAWA
- A. J. ARMBRUSTER
- A. J. BARR
- A. J. BEDDALL
- A. J. FOWLER
- A. J. LANKFORD
- A. J. LOWE
- A. J. MARTIN
- A. JANTSCH
- A. JEREMIE
- A. JONES
- A. K. CIFTCI
- A. K. MORLEY
- A. KACZMARSKA
- A. KALINOWSKI
- A. KAPLIY
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- Z. DOLEZAL
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- ZOCCOLI ANTONIO
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Results are presented of a search for new particles decaying to large numbers of jets in association with missing transverse momentum, using 4.7 fb−1 of pp collision data at s√=7TeV collected by the ATLAS experiment at the Large Hadron Collider in 2011. The event selection requires missing transverse momentum, no isolated electrons or muons, and from ≥6 to ≥9 jets. No evidence is found for physics beyond the Standard Model. The results are interpreted in the context of a MSUGRA/CMSSM supersymmetric model, where, for large universal scalar mass m 0, gluino masses smaller than 840 GeV are excluded at the 95% confidence level, extending previously published limits. Within a simplified model containing only a gluino octet and a neutralino, gluino masses smaller than 870 GeV are similarly excluded for neutralino masses below 100 GeV
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