Introducing the Fission-Fusion Reaction Process: Using a Laser-Accelerated Th Beam to produce Neutron-Rich Nuclei towards the N=126 Waiting Point of the r Process

We propose to produce neutron-rich nuclei in the range of the astrophysical r-process around the waiting point N=126 by fissioning a dense laser-accelerated thorium ion bunch in a thorium target (covered by a CH2 layer), where the light fission fragments of the beam fuse with the light fission fragments of the target. Via the 'hole-boring' mode of laser Radiation Pressure Acceleration using a high-intensity, short pulse laser, very efficiently bunches of 232Th with solid-state density can be generated from a Th layer, placed beneath a deuterated polyethylene foil, both forming the production target. Th ions laser-accelerated to about 7 MeV/u will pass through a thin CH2 layer placed in front of a thicker second Th foil closely behind the production target and disintegrate into light and heavy fission fragments. In addition, light ions (d,C) from the CD2 production target will be accelerated as well to about 7 MeV/u, inducing the fission process of 232Th also in the second Th layer. The laser-accelerated ion bunches with solid-state density, which are about 10^14 times more dense than classically accelerated ion bunches, allow for a high probability that generated fission products can fuse again. In contrast to classical radioactive beam facilities, where intense but low-density radioactive beams are merged with stable targets, the novel fission-fusion process draws on the fusion between neutron-rich, short-lived, light fission fragments both from beam and target. The high ion beam density may lead to a strong collective modification of the stopping power in the target, leading to significant range enhancement. Using a high-intensity laser as envisaged for the ELI-Nuclear Physics project in Bucharest (ELI-NP), estimates promise a fusion yield of about 10^3 ions per laser pulse in the mass range of A=180-190, thus enabling to approach the r-process waiting point at N=126.Comment: 13 pages, 6 figure

Efficient ion acceleration by collective laser-driven electron dynamics with ultra-thin foil targets

Experiments on ion acceleration by irradiation of ultra-thin diamond-like carbon (DLC) foils, with thicknesses well below the skin depth, irradiated with laser pulses of ultra-high contrast and linear polarization, are presented. A maximum energy of 13MeV for protons and 71MeV for carbon ions is observed with a conversion efficiency of > 10%. Two-dimensional particle-in-cell (PIC) simulations reveal that the increase in ion energies can be attributed to a dominantly collective rather than thermal motion of the foil electrons, when the target becomes transparent for the incident laser pulse

Dynamics of Nanometer-Scale Foil Targets Irradiated with Relativistically Intense Laser Pulses

In this letter we report on an experimental study of high harmonic radiation generated in nanometer-scale foil targets irradiated under normal incidence. The experiments constitute the first unambiguous observation of odd-numbered relativistic harmonics generated by the $\vec{v}\times\vec{B}$ component of the Lorentz force verifying a long predicted property of solid target harmonics. Simultaneously the observed harmonic spectra allow in-situ extraction of the target density in an experimental scenario which is of utmost interest for applications such as ion acceleration by the radiation pressure of an ultraintense laser.Comment: 5 pages, 4 figure

Contemporary Issues in Translantic Relations

This report summarises the interdisciplinary seminar hosted by the Jean Monnet Chair in Transatlantic Relations at City Law School and the Institute for the Study of European Law (ISEL). The event consisted of three sessions: The Transatlantic Relationship; Transatlantic Defence, Security and Civil Liberties; Transatlantic and Global Trade. It examined topical issues in transatlantic relations across a range of subjects and issues, from trade, security and data, to defence. The seminar reflected upon the state of the art in transatlantic relations, with speakers from a broad variety of disciplines and practice. It considered inter alia: How should we understand the future of ‘American First’ at the end of the Trump Presidency? What is the current state of the US-Sino tech war and what are its implications for EU-US relations? How do UK-US relations impact upon this equation, in light of the Huawei 5G affair? What is the future of the EU-UK-US triangle in international security, where the EU loses the heft of one of its largest members? Will the UK increasingly align in sectoral fields to the US? What do the negotiation objectives of the EU-US and UK-US indicate to us about the future of the special partnerships? With the world’s largest sanctions regimes, the EU and US will pose a challenge for the UK to alignment purposes- will it inevitably be the EU first? What are its implications for a more significant FTA between the respective parties? How does the rise of the EU as a global data actor influence contemporary politics? Has the US succeeded in taming the global mobility of its social media giants through taxation threats? How does a multilateralist such as the EU deal with the future of American First after the next US election and the development of the uncertain path of Global Britain? Does Churchill’s call for a United States of Europe with the UK outside but closely aligned within the Commonwealth of Nations have any resonance going forward? In any field at all? What developments in the breakdown of the WTO DS system can occur with the aid of the EU, US and UK? Is the US sincere about its reform? Can Global Britain survive a shift outside of the EU without a WTO DS

The Cystic Fibrosis-Like Airway Surface Layer Is not a Significant Barrier for Delivery of Eluforsen to Airway Epithelial Cells

Background: Eluforsen (previously known as QR-010) is a 33-mer antisense oligonucleotide under development for oral inhalation in cystic fibrosis (CF) patients with the delta F508 mutation. Previous work has shown that eluforsen restores CF transmembrane conductance regulator (CFTR) function in vitro and in vivo. To be effective, eluforsen has first to reach its primary target, the lung epithelial cells. Therefore, it has to diffuse through the CF airway surface layer (ASL), which in CF is characterized by the presence of thick and viscous mucus, impaired mucociliary clearance, and persistent infections. The goal of this study was to assess delivery of eluforsen through CF-like ASL. Methods and Results: First, air-liquid interface studies with cultured primary airway epithelial cells revealed that eluforsen rapidly diffuses through CF-like mucus at clinically relevant doses when nebulized once or repeatedly, over a range of testing doses. Furthermore, eluforsen concentrations remained stable in CF patient sputum for at least 48 hours, and eluforsen remained intact in the presence of various inhaled CF medications for at least 24 hours. When testing biodistribution of eluforsen after orotracheal administration in vivo, no differences in lung, liver, trachea, and kidney eluforsen concentration were observed between mice with a CF-like lung phenotype (ENaC-overexpressing mice) and control wild-Type (WT) littermates. Also, eluforsen was visualized in the airway epithelial cell layer of CF-like muco-obstructed mice and WT littermates. Finally, studies of eluforsen uptake and binding to bacteria prevalent in CF lungs, and diffusion through bacterial biofilms showed that eluforsen was stable and not absorbed by, or bound to bacteria. In addition, eluforsen was found to be able to penetrate Pseudomonas aeruginosa biofilms. Conclusions: The thickened and concentrated CF ASL does not constitute a significant barrier for delivery of eluforsen, and feasibility of oral inhalation of eluforsen is supported by these data

Laser Ion Acceleration: Status and Perspectives for Fusion

High power short-pulse lasers presently reach peak powers of a few hundred Terawatts up to a Petawatt, and routinely reach focal intensities of 1018 - 1021 W/cm2 . These lasers are able to produce various secondary radiation, from relativistic electrons and multi-MeV/nucleon ions to high-energetic X-rays and γ-rays. In many laboratories world-wide large efforts are presently devoted to a rapid development of this novel tool of particle acceleration, targeting nuclear, fundamental and high-field physics studies as well as various applications. Based on the Radiation Pressure Acceleration mechanism, laser-accelerated ion beams can be generated with solid-state density, thus exceeding beams from conventional accelerators by about 14 orders of magnitudes. This opens the perspective of a novel reaction scheme called ’f ssion-fusion’, where in a first step f ssion is induced both in laser-accelerated f ssile projectiles from a ’production target’ and in a second ’reaction target’ again from f ssile material hit by the accelerated projectiles. Due to the unprecedented ion density, (neutron-rich) light f ssion fragments from projectile and target can fuse again, forming extremely exotic species approaching the region of the N = 126 waiting point of the r-process. Within the next 5 years a new EU-funded large-scale research infrastructure (ELI: Extreme Light Infrastructure) will be constructed, with one of its four pillars exclusively devoted to nuclear physics based on high intensity lasers (ELI-Nuclear Physics, to be built in Magurele/Bucharest). Studies of laser-induced nuclear reactions like the ’f ssion-fusion’ mechanism will be amongst the experimental f agship projects pursued there

Research and development project assessment and social impact

Nowadays, organisations increasingly need to adapt to the fast evolution of markets and societies in our globalised world in order to be competitive. Therefore, it is essential to take the right decisions when it comes to invest in research and development (R & D) projects. However, an issue that has not been given much attention is how to measure the social impact (or return) of R & D projects. In this exploratory study, the findings of an analysis of how R & D projects are assessed and selected, including this social perspective, are presented. The methodology which has been used in this research includes both interviews and analysis of the data obtained through them. The major finding is that in the current situation the social impact is not taken into account, but is growing the awareness of this perspective among different types of organizations dealing with R & D activities.(undefined)info:eu-repo/semantics/publishedVersio

Ultra-bright gamma-ray emission and dense positron production from two laser-driven colliding foils

Matter can be transferred into energy and the opposite transformation is also possible by use of high-power lasers. A laser pulse in plasma can convert its energy into γ-rays and then e −e + pairs via the multi-photon Breit-Wheeler process. Production of dense positrons at GeV energies is very challenging since extremely high laser intensity ∼ 1024 Wcm−2 is required. Here we propose an all-optical scheme for ultra-bright γ-ray emission and dense positron production with lasers at intensity of 1022−23 Wcm−2 . By irradiating two colliding elliptically-polarized lasers onto two diamondlike carbon foils, electrons in the focal region of one foil are rapidly accelerated by the laser radiation pressure and interact with the other intense laser pulse which penetrates through the second foil due to relativistically induced foil transparency. This symmetric configuration enables efficient Compton back-scattering and results in ultra-bright γ-photon emission with brightness of ∼ 1025 photons/s/mm2 /mrad2 /0.1%BW at 15 MeV and intensity of 5×1023 Wcm−2 . Our first three-dimensional simulation with quantum-electrodynamics incorporated shows that a GeV positron beam with density of 2.5×1022 cm−3 and flux of 1.6×1010/shot is achieved. Collective effects of the pair plasma may be also triggered, offering a window on investigating laboratory astrophysics at PW laser facilities