555 research outputs found
Recommended from our members
Characterizing Sympathetic Neurovascular Transduction in Humans
Despite its critical role for cardiovascular homeostasis in humans, only a few studies have directly probed the transduction of sympathetic nerve activity to regional vascular responses â sympathetic neurovascular transduction. Those that have variably relied on either vascular resistance or vascular conductance to quantify the responses. However, it remains unclear which approach would better reflect the physiology. We assessed the utility of both of these as well as an alternative approach in 21 healthy men. We recorded arterial pressure (Finapres), peroneal sympathetic nerve activity (microneurography), and popliteal blood flow (Doppler) during isometric handgrip exercise to fatigue. We quantified and compared transduction via the relation of sympathetic activity to resistance and to conductance and via an adaptation of Poiseuilleâs relation including pressure, sympathetic activity, and flow. The average relationship between sympathetic activity and resistance (or conductance) was good when assessed over 30-second averages (mean R=0.49±0.07) but lesser when incorporating beat-by-beat time lags (R=0.37±0.06). However, in a third of the subjects, these relations provided relatively weak estimates (R0.50 in 20 of 21 individuals), and provided reproducible estimates of transduction. The gain derived from the relation of resistance (but not conductance) was inversely related to transduction (R=0.37, p<0.05), but with a proportional bias. Thus, vascular resistance and conductance may not always be reliable surrogates for regional sympathetic neurovascular transduction, and assessment from a Poiseuille relation between pressure, sympathetic nerve activity, and flow may provide a better foundation to further explore differences in transduction in humans
Regulation of cerebrovascular compliance compared with forearm vascular compliance in humans:a pharmacological study
Increasing evidence indicates that cerebrovascular compliance contributes to the dynamic regulation of cerebral blood flow but the mechanisms regulating cerebrovascular compliance in humans are unknown. This retrospective study investigated the impact of neural, endothelial, and myogenic mechanisms on the regulation of vascular compliance in the cerebral vascular bed compared with the forearm vascular bed. An index of vascular compliance (C(i)) was assessed using a Windkessel model applied to blood pressure waveforms (finger photoplethysmography) and corresponding middle cerebral artery blood velocity or brachial artery blood velocity waveforms (Doppler ultrasound). Data were analyzed during a 5-min baseline period (10 waveforms) under control conditions and during distinct sympathetic blockade (experiment 1, phentolamine; 10 adults), cholinergic blockade (experiment 2, glycopyrrolate; 9 adults), and myogenic blockade (experiment 3, nicardipine; 14 adults). In experiment 1, phentolamine increased C(i) similarly in the cerebral vascular bed (131 ± 135%) and forearm vascular bed (93 ± 75%; P = 0.45). In experiment 2, glycopyrrolate increased cerebrovascular C(i) (72 ± 61%) and forearm vascular C(i) (74 ± 64%) to a similar extent (P = 0.88). In experiment 3, nicardipine increased C(i) but to a greater extent in the cerebral vascular bed (88 ± 88%) than forearm vascular bed (20 ± 45%; P = 0.01). Therefore, adrenergic, cholinergic, and myogenic mechanisms contribute to the regulation of cerebrovascular and forearm vascular compliance. However, myogenic mechanisms appear to exert more specific control over vascular compliance in the brain relative to the forearm. NEW & NOTEWORTHY Vascular compliance represents an important determinant in the dynamics and regulation of blood flow through a vascular bed. However, the mechanisms that regulate vascular compliance remain poorly understood. This study examined the impact of neural, endothelial, and myogenic mechanisms on cerebrovascular compliance compared with forearm vascular compliance. Distinct pharmacological blockade of α-adrenergic, endothelial muscarinic, and myogenic inputs altered cerebrovascular and forearm vascular compliance. These results further our understanding of vascular control and blood flow regulation in the brain
The effect of metabolic phenotype on sociability and social group size preference in a coral reef fish
Although individuals within social groups experience reduced predation risk and find food patches more consistently, there can be competition for food among groupmates. Individuals with a higher standard metabolic rate (SMR) may be less social, to prioritize food acquisition over defense, while a greater maximum metabolic rate (MMR) may modulate sociability through increased competitive ability. Therefore, in theory, individuals with a higher SMR may prefer smaller groups and those with greater MMR may prefer larger groups. We examined links among metabolic phenotype, sociability, and choice of group size in the redbelly yellowtail fusilier Caesio cuning. Individuals were exposed to three association tests: (a) a choice between two fish or zero fish; (b) a choice between five fish or zero fish; and (c) a choice between two fish and five fish. The first two tests quantified sociability while the third measured relative group size choice. Although there was no link between SMR and sociability, fish with a higher MMR were more social than those individuals with a lower MMR. While no correlation was found between MMR and group size choice, there was weak evidence that, if anything, individuals with a higher SMR preferred larger groups, contrary to our hypothesis. As C. cuning is an active fish that spends a large proportion of time operating above SMR, this result could suggest that the links between sociability and SMR may shift depending on a speciesâ routine behavior. Links between sociability and MMR may arise if competitive ability allows individuals to obtain resources within groups. Although metabolic traits had no significant influence on group size choice, variation in food availability or predation risk could alter the effects of metabolism on group size choice
Grey solitons in a strongly interacting superfluid Fermi Gas
The Bardeen-Cooper-Schrieffer to Bose-Einstein condensate (BCS to BEC)
crossover problem is solved for stationary grey solitons via the Boguliubov-de
Gennes equations at zero temperature. These \emph{crossover solitons} exhibit a
localized notch in the gap and a characteristic phase difference across the
notch for all interaction strengths, from BEC to BCS regimes. However, they do
not follow the well-known Josephson-like sinusoidal relationship between
velocity and phase difference except in the far BEC limit: at unitary the
velocity has a nearly linear dependence on phase difference over an extended
range. For fixed phase difference the soliton is of nearly constant depth from
the BEC limit to unitarity and then grows progressively shallower into the BCS
limit, and on the BCS side Friedel oscillations are apparent in both gap
amplitude and phase. The crossover soliton appears fundamentally in the gap; we
show, however, that the density closely follows the gap, and the soliton is
therefore observable. We develop an approximate power law relationship to
express this fact: the density of grey crossover solitons varies as the square
of the gap amplitude in the BEC limit and a power of about 1.5 at unitarity.Comment: 10 pages, 6 figures, part of New Journal of Physics focus issue
"Strongly Correlated Quantum Fluids: From Ultracold Quantum Gases to QCD
Plasmas," in pres
Prevalence of pelagic dependence among coral reef predators across an atoll seascape
1)Coral reef food webs are complex, vary spatially and remain poorly understood. Certain large predators, notably sharks, are subsidised by pelagic production on outer reef slopes, but how widespread this dependence is across all teleost fishery target species and within atolls is unclear.
2)North MalĂ© Atoll (Maldives) includes oceanic barrier as well as lagoonal reefs. Nine fishery target predators constituting ca. 55% of the local fishery target species biomass at assumed trophic levels 3â5 were selected for analysis. Data were derived from carbon (ÎŽ13C), nitrogen (ÎŽ15N) and sulfur (ÎŽ34S) stable isotopes from predator white dorsal muscle samples, and primary consumer species representing production source endâmembers.
3)Threeâsource Bayesian stable isotope mixing models showed that uptake of pelagic production extends throughout the atoll, with predatory fishes showing equal planktonic reliance between inner and outer edge reefs. Median plankton contribution was 65â80% for all groupers and 68â88% for an emperor, a jack and snappers.
4)Lagoonal and atoll edge predators are equally at risk from anthropogenic and climateâinduced changes which may impact the linkages they construct, highlighting the need for management plans that transcend the boundaries of this threatened ecosystem
Racism, anti-racist practice and social work: articulating the teaching and learning experiences of Black social workers
In the mid 1990s a Black practice teacher programme was established in Manchester and Merseyside with the primary aim to increase the number of Black practice teachers in social work organisations, and in turn provide a supportive and encouraging learning environment for Black student social workers whilst on placement. In the northâwest of England research has been undertaken, to establish the quality of the practice teaching and student learning taking place with Black practice teachers and students. This paper is an exploration of the ideas generated within the placement process that particularly focused on the discourse of racism and antâracist practice. Black students and practice teachers explain their understanding of racism and antiâracist practice within social work. From the research, the paper will critique some of the ideas concerning antiâracism. In particular, it will question whether antiâracist social work practice needs to be reâevaluated in the light of a context with new migrants, asylum seekers and refugees. It will concluded, by arguing that whilst the terms antiâracism, Black and Minority Ethnic have resonance as a form of political strategic essentialism, it is important to develop more positive representations in the future
Ocean acidification reduces demersal zooplankton that reside in tropical coral reefs
The in situ effects of ocean acidification on zooplankton communities remain largely unexplored. Using natural volcanic CO2
seep sites around tropical coral communities, we show a threefold reduction in the biomass of demersal zooplankton in
high-CO2 sites compared with sites with ambient CO2. Differences were consistent across two reefs and three expeditions.
Abundances were reduced in most taxonomic groups. There were no regime shifts in zooplankton community composition and
no differences in fatty acid composition between CO2 levels, suggesting that ocean acidification affects the food quantity but
not the quality for nocturnal plankton feeders. Emergence trap data show that the observed reduction in demersal plankton
may be partly attributable to altered habitat. Ocean acidification changes coral community composition from branching to
massive bouldering coral species, and our data suggest that bouldering corals represent inferior daytime shelter for demersal
zooplankton. Since zooplankton represent a major source of nutrients for corals, fish and other planktivores, this ecological
feedback may represent an additional mechanism of how coral reefs will be affected by ocean acidification
Solitary waves in the Nonlinear Dirac Equation
In the present work, we consider the existence, stability, and dynamics of
solitary waves in the nonlinear Dirac equation. We start by introducing the
Soler model of self-interacting spinors, and discuss its localized waveforms in
one, two, and three spatial dimensions and the equations they satisfy. We
present the associated explicit solutions in one dimension and numerically
obtain their analogues in higher dimensions. The stability is subsequently
discussed from a theoretical perspective and then complemented with numerical
computations. Finally, the dynamics of the solutions is explored and compared
to its non-relativistic analogue, which is the nonlinear Schr{\"o}dinger
equation. A few special topics are also explored, including the discrete
variant of the nonlinear Dirac equation and its solitary wave properties, as
well as the PT-symmetric variant of the model
Gill Damage to Atlantic Salmon (Salmo salar) Caused by the Common Jellyfish (Aurelia aurita) under Experimental Challenge
Peer-reviewed. Copyright © 2011 E.J. Baxter et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background: Over recent decades jellyfish have caused fish kill events and recurrent gill problems in marine-farmed salmonids. Common jellyfish (Aurelia spp.) are among the most cosmopolitan jellyfish species in the oceans, with populations increasing in many coastal areas. The negative interaction between jellyfish and fish in aquaculture remains a poorly studied area of science. Thus, a recent fish mortality event in Ireland, involving Aurelia aurita, spurred an investigation into the effects of this jellyfish on marine-farmed salmon.
Methodology/Principal Findings: To address the in vivo impact of the common jellyfish (A. aurita) on salmonids, we exposed Atlantic salmon (Salmo salar) smolts to macerated A. aurita for 10 hrs under experimental challenge. Gill tissues of control and experimental treatment groups were scored with a system that rated the damage between 0 and 21 using a range of primary and secondary parameters. Our results revealed that A. aurita rapidly and extensively damaged the gills of S. salar, with the pathogenesis of the disorder progressing even after the jellyfish were removed. After only 2 hrs of exposure, significant multi-focal damage to gill tissues was apparent. The nature and extent of the damage increased up to 48 hrs from the start of the challenge. Although the gills remained extensively damaged at 3 wks from the start of the challenge trial, shortening of the gill lamellae and organisation of the cells indicated an attempt to repair the damage suffered.
Conclusions: Our findings clearly demonstrate that A. aurita can cause severe gill problems in marine-farmed fish. With aquaculture predicted to expand worldwide and evidence suggesting that jellyfish populations are increasing in some areas, this threat to aquaculture is of rising concern as significant losses due to jellyfish could be expected to increase in the future
- âŠ