Ensaio estadual de linhagens e cultivares de feijão em Santa Catarina: VCU - safra 2010/2011.

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Intramolecular Allenolate Acylations in Studies toward a Synthesis of FR182877

During our efforts to synthesize the cytotoxic natural product FR182877, we discovered intramolecular reductive acylations that offer a stereocontrolled alternative to the classical Knoevenagel condensation for the formation of α-alkylidene β-keto-δ-lactones. Other progress toward a synthesis of FR182877 includes a π-allyl Stille coupling and a bromo Horner−Wadsworth−Emmons reaction that forms a 12-membered ring. Structural relationships among FR182877, hexacyclinic acid, macquarimicin A, and cochleamycin A are also discussed