Podolskys Generalized Fractional Order Model

We study the electromagnetic field in this work because we are particularly interested in the gauge sector of Podolskys generalized electrodynamics, where higher-order derivatives form. To represent Podolskys generalized electrodynamics, canonical quantizations and a lower-order derivatives model are applied. We demonstrate that Podolskys model is equivalent to one with reduced-order derivatives. The differential equations for both models should then be compared. After obtaining the Hamiltonian formulation, we applied this new formula to the Podolsky Generalized equation. This method is used to construct a combined Riemann-Liouville fractional derivative operator as well as a fractional variational theory. The fraction variational notion is utilized to build fractional Euler equations and fraction Hamilton equations. The Hamilton equations of motion are compatible with the Euler-Lagrange equations

Psychological effects of quarantine on Syrian refugees, compared to the Jordanian populations

To ward off the outbreak of the coronavirus disease (COVID-19) in 2019, the Jordanian government applied quarantine to the Jordanian population in addition to Syrian refugees. We evaluated the quarantine's psychological effect on people in Jordan after three weeks of quarantine. The prevalence of post-traumatic stress disorder (PTSD) in our sample population was determined using a higher than twenty score on the Impact of Event Scale-Revised (IES-R). The 2380 people who received the survey online demonstrated a high prevalence of PTSD, in which PTSD showed incidence of 82.5% and 66.5 in Syrian refugees and Jordanian populations, respectively. This study also reports the trend towards more increased PTSD prevalence in Syrian refugees compared to the Jordanian population depending on age, education and the household's combined monthly income. Knowledge and awareness of quarantined people's interactions are crucial to optimizing control of infectious diseases and reducing adverse impacts on those quarantined. © 2021 The Authors. International Migration © 2021 IO

Association of KDR rs1870377 genotype with clopidogrel resistance in patients with post percutaneous coronary intervention

Background: Clopidogrel is an antiplatelet therapy that is widely used in pre and post percutaneous (PCI) coronary intervention procedures to prevent platelet aggregation and stent restenosis. However, there is a wide inter-individual variation in clopidogrel response and some patients showed resistance against the activity of Clopidogrel. Kinase insert domain receptor (KDR) gene is responsible for the transcription of vascular endothelial growth factor receptor 2 (VEGFR2) that plays a major role in the cardiovascular diseases (CVDs) and platelet aggregation. The aim of this study was to find out the association of KDR rs1870377 genotype with clopidogrel resistance (CR) in CVD patients, of Iraqi Arabic origin, hospitalized for elective PCI. Materials and methods: This study was a case-control study with a total of 324 PCI patients. Those patients were classified into 213 patients with non-clopidogrel resistant and 111 patients with CR, depending on the analysis of platelet activity phenotype after clopidogrel administration. KDR rs1870377 was genotyped for all patients using polymerase chain reaction-restriction fragment length polymorphism technique and confirmed by DNA Sänger sequencing through applying Biosystems Model (ABI3730x1). Results: KDR rs1870377 SNP is strongly associated (Chi-sqaure, p vale <0.05) with CR under dominant, co-dominant and recessive models. Additionally, A allele in the rs1870377 SNP may have an impact on the serum levels of VEGFR2 and low density lipoprotein. Conclusions: KDR rs1870377 SNP is a potential genetic biomarker of CR among CVD patients of Iraqi Arabic origin. Further clinical studies, with larger sample, are required to confirm the findings of this study. KDR; clopidogrel resistance; VEGFR2; Post Percutaneous Coronary Intervention; SNP. © 2021 The Author(s

View point. Can indo-mediterranean-style diets in father and mother influence fetal growth, inflammation, genetic profile, and cardio-metabolic risk in mother and infant?

Four publications in Nature and Cell followed by WHO advise on “life-course approach” on preconception and perinatal factors; these factors appear to be essential for achieving the population health goals of the UNO in 2030. The interaction of the genes and the internal and external environment can influence fetal development, the health of mothers and offspring. The role of pre-conception and perinatal behavioral factors of parents on genetic/epigenetic inheritance of cardio-metabolic diseases (CMDs) risk in the off-spring in humans is not least known. The role of epigenetic inheritance, the passing of phenotypic change to subsequent generations in ways that are outside the genetic code of DNA, are not well known. It is unclear whether a complex set of factors, including nutritional factors, come into play during epigenetic inheritance from father and mother to offspring. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring inducing obesity and insulin resistance not yet known in humans [1]. Pregnant women require more energy, protein, iron, iodine, vitamin A, folate, and other nutrients because nutrient deficiencies are associated with maternal complications and death, fetal and newborn death, birth defects, and decreased physical and mental potential of the child. Deficiency of omega-3 fatty acid and flavonoids during pregnancy can increase oxidative stress and systemic inflammation, which may predispose to impaired beta-cell function, and smooth muscle dysfunction leading to increased risk of CMDs. There is an unmet need to find out that adequate energy intake and a diversified diet that includes fruit, vegetables, and animal products throughout the life cycle helps ensure that women enter pregnancy and lactation without deficiencies and obtain adequate nutrients during periods of heightened demand. Since CMDs may develop due to transgenerational inheritance, our strategy is to find out the effects of Indo-Mediterranean diets vs control diet, among father and mother, on complications of pregnancy, fetal development and cardio-metabolic risk factors in the offspring. The outcome of this study may indicate beneficial effects on the mother's health, fetal development, insulin sensitivity, in infancy, mediated by epigenetic and genetic alterations. © 2020 Nova Science Publishers, Inc